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ACE2 Stable Cell Lines for SARS-CoV-2 Investigation
The outbreak of coronavirus disease 2019 (COVID19) has posed a global threat to public health. A novel coronavirus, SARS-coronavirus 2 (SARS-CoV-2), has been identified as the etiologic agent of this disease. Cell entry of coronavirus depends on the spike (S) protein binding to a cellular receptor and priming by a cellular protease. Recent studies demonstrate that angiotensin-converting enzyme 2 (ACE2) serves as the cell surface receptor to bind S protein in SARS-CoV-2 and facilitates entry of these coronaviruses into the cell. Read More »
Key features
Both HEK293/ACE2 and CHO-K1/ACE2 stable cell lines are generated with the features below:
- Single clone cell line
- Validated for stable hACE2 expression and S protein RBD binding
- Easy to use in binding assays or as immunogens
Applications
- Neutralization assays to screen antibodies or other molecules that can block pseudovirus or live virus infection
- Affinity analysis of antibody or other molecules to Spike protein
- In vitro cell models for investigating SARS-CoV-2 infection mechanism
Examples:
Product list
| Protein of Expression | Cell Line | Cat.No. |
|---|---|---|
| ACE2 | HEK293/ACE2 | M00770 |
| ACE2 | CHO-K1/ACE2 | M00771 |
Related Products Coming Soon!
| Protein of Expression | Cell Line | Cat.No. |
|---|---|---|
| SARS-CoV-2 Spike protein | CHO-K1/Spike Stable Cell Line | M00803 |
| SARS-CoV-2 Spike protein | HEK293/Spike Stable Cell Line | M00804 |
Immune Checkpoint Stable Cell Lines
Inhibitors of immune-checkpoint proteins, such as PD1, PD-L1, VISTA, Tim3 and Lag3, have indicated broad and diverse opportunities to increase antitumor immunity by enhancing T cell activity with the potential to produce durable clinical responses. To meet these needs, we have developed stable cell line products expressing the most popular immune checkpoints to accelerate your immunotherapy discovery and clinical translation. All these stable cells are developed for screening high affinity antibodies against immune checkpoint proteins.
Key features
- High protein expression at the cell surface validated by FACS
- Stable cell lines for increased reliability and reproducibility (over 15 passages)
- Ready to use hot targets, saving 3-5 months
Product list
| Receptor | Cell Line | Cat.No. |
|---|---|---|
| 4-1BB | ||
| CHO-K1/4-1BB New | M00538 | |
| CHO-K1/mouse 4-1BB | ||
| CHO-K1/cyno 4-1BB | ||
| B7-H2 | CHO-K1/B7-H2 | |
| B7-H3 | CHO-K1/B7-H3 | |
| B7-H4 | CHO-K1/B7-H4 | |
| BDCA2 | CHO-K1/BDCA2 | |
| CHO-K1/Cyno BDCA2 | ||
| CHO-K1/BDCA2 and FcER1G | ||
| CHO-K1/ Cyno BDCA2 and FcER1G | ||
| BTLA | CHO-K1/BTLA | |
| CD155 | CHO-K1/CD155 | |
| CHO-K1/Cyno CD155 | ||
| CHO-K1/Mouse CD155 | ||
| CD200 R1 | CHO-K1/CD200 R1 | |
| CD38 | CHO-K1/human CD38 | M00553 |
| CHO-K1/mouse CD38 | M00636 | |
| CD47 | CHO-K1/CD47 | |
| CHO-K1/Mouse CD47 | M00631 | |
| CHO-K1/Cyno CD47 | M00632 | |
| CD112 | CHO-K1/CD112 | |
| CD80 | CHO-K1/CD80 | M00545 |
| CD103 | CHO-K1/ITGAE | |
| CTLA4 | CHO-K1/CTLA4 | |
| CHO-K1/mouse CTLA4 | ||
| CHO-K1/cyno CTLA4 | ||
| GITR | CHO-K1/GITR | |
| HVEM | CHO-K1/HVEM | M00646 |
| CHO-K1/mouse HVEM | M00647 | |
| CHO-K1/Cyno HVEM | M00648 | |
| ICOS | CHO-K1/ICOS | M00649 |
| KIR | CHO-K1/KIR | M00650 |
| Lag3 | CHO-K1/Lag3 New | M00532 |
| OX-40 | CHO-K1/OX-40 | |
| PD-1 | CHO-K1/PD-1 | |
| CHO-K1/mouse PD-1 | ||
| CHO-K1/cyno PD-1 | ||
| Daudi/PD-1 | M00630 | |
| PD-L1 | HEK293/PD-L1 | M00544 |
| CHO-K1/PD-L1 | ||
| CHO-K1/mouse PD-L1 | ||
| CHO-K1/cyno PD-L1 New | M00573 | |
| PD-L2 | CHO-K1/PD-L2 | |
| CHO-K1/cyno PD-L2 | M00629 | |
| VISTA | CHO-K1/VISTA New | M00533 |
| CHO-K1/Mouse VISTA | M00633 | |
| CHO-K1/Cyno VISTA | M00634 | |
| TIGIT | CHO-K1/TIGIT | |
| CHO-K1/mouse TIGIT New | M00585 | |
| Tim3 | CHO-K1/Tim3 |
Fc Receptor Cell Lines
Fc receptor(FcR) types are classified based on the antibodies that they recognize. Different antibody subclasses have unique affinities for each of the Fc receptors. A full portfolio of Fc receptor stable cell lines is here to help you develop in vitro assays and characterize your antibodies, such as antibody binding, affinity, and half-life time test.
Product list
GPCR Stable Cell Lines
GenScript offers a wide selection of GPCR stable cell lines. Proprietary codon optimization and vector design technologies enable GenScript to overcome low functional protein expression at the cell surface. All of the cell lines have been optimized for S/B ratio in calcium flux assays, FRET assays, or chemiluminescent assays.
Key features
- Gα15 expressing cells can be used directly for FLIPR analysis
- Stable cell lines for increased reliability and reproducibility
- Flexible functional readouts are available
Product list
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| 5-Hydroxytryptamine receptor | 5-HT1A/HTR1A | CHO-K1/5-HT1A/Gα15 | |
| 5-HT2A/HTR2A | CHO-K1/5-HT2A | ||
| 5-HT2B/HTR2B | CHO-K1/5-HT2B | ||
| 5-HT2C/HTR2C | CHO-K1/5-HT2C | ||
| 5-HT2C/HTR2C | HEK 293/5-HT2C | ||
| HTR4 | CHO-K1/5-HT4/Gα15 | ||
| Acetylcholine receptor (muscarinic) | M1/CHRM1 | CHO-K1/M1 | |
| M2/CHRM2 | CHO-K1/M2/Gα15 | ||
| M3/CHRM3 | CHO-K1/M3 | ||
| M4/CHRM4 | CHO-K1/M4/Gα15 | ||
| M5/CHRM5 | CHO-K1/M5 | ||
| Adenosine receptor | ADORA1 | CHO-K1/ADORA1/Gα15 | |
| ADORA1 | 293/ADORA1/Gα15 | ||
| ADORA2a | CHO-K1/ADORA2A/Gα15 | ||
| ADORA2a | CHO-K1/mouse ADORA2A | ||
| ADORA2B | CHO-K1/ADORA2B/Gα15 | ||
| ADORA3 | CHO-K1/ADORA3/Gα15 | ||
| Adrenoceptors | ADRA1B | CHO-K1/ADRA1B | |
| ADRA1D | CHO-K1/ADRA1D | ||
| ADRA2A | CHO-K1/ADRA2A/Gα15 | ||
| ADRA2B | CHO-K1/ADRA2B/Gqi5 | ||
| ADRA2C | CHO-K1/ADRA2C/Gα15 | ||
| ADRB1 | CHO-K1/ADRB1/Gα15 | ||
| ADRA1A | CHO-K1/ADRA1A | ||
| Angiotensin receptor | AT1 | HEK 293/AT1 | |
| AT1 | 293T/AT1 | ||
| Apelin receptor | AGTRL1 | CHO-K1/AGTRL1/Gα15 | |
| Bile acid receptor | GPBAR1 | CHO-K1/GPBAR1 |
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| Bombesin receptor | BB1 | CHO-K1/BB1 | |
| BB2/GRPR | CHO-K1/BB2 | ||
| BB3/BRS3 | CHO-K1/BB3 | ||
| Bradykinin receptor | B2 | CHO-K1/B2/Gα15 | |
| Calcitonin | AMY1 | CHO-K1/Gα15/AMY1 | |
| AMY2 | CHO-K1/Gα15/AMY2 | ||
| AMY3 | CHO-K1/Gα15/AMY3 | ||
| Calcitonin receptor | CALCR/CT | CHO-K1/CT/Gα15 | |
| Cannabinoid receptor | CNR1/CB1 | CHO-K1/CB1/Gα15 | |
| CB2 | CHO-K1/CB2 | ||
| Chemerin receptor | CMKLR1 | CHO-K1/CMKLR1/Gα15 | |
| Chemokine receptor | CCR1 | CHO-K1/CCR1/Gα15 | |
| CCR5 | CHO-K1/CCR5/Gα15 | ||
| CXCR1/IL8RA | CHO-K1/CXCR1/Gα15 | ||
| CXCR3 | CHO-K1/CXCR3/Gα15 | ||
| CXCR4 | CHO-K1/CXCR4/Gα15 | ||
| CXCR5/BLR1 | CHO-K1/CXCR5/Gα15 | ||
| Cholecystokinin receptor | CCKA/CCKAR | CHO-K1/CCKA/Gα15 | |
| CCKB/CCKBR | CHO-K1/CCKB | ||
| Class A orphan | GPR68/OGR1 | CHO-K1/GPR68/Gα15 | |
| MRGPRX2 | CHO-K1/MRGPRX2 | ||
| Complement peptide receptor | C5a/C5AR1 | CHO-K1/C5a/Gα15 | |
| Corticotropin releasing factor receptor | CRF1/CRHR1 | CHO-K1/CRF1/Gα15 | |
| CRF2 | CHO-K1/CRF2/Gα15 | ||
| Dopamine receptor | D2 | CHO-K1/D2/Gα15 | |
| D5 | CHO-K1/D5/Gα15 | ||
| D1/DRD1 | CHO-K1/D1 | ||
| D2(Short) | CHO-K1/D2s/Gα15 | ||
| Endothelin receptor | ETA/EDNRA | CHO-K1/EDNRA | |
| ETB/EDNRB | CHO-K1/EDNRB | ||
| Formylpeptide receptor | FPR1 | CHO-K1/FPR1/Gα15 | |
| Free fatty acid receptor | FFA2 | CHO-K1/FFA2/Gα15 | |
| GPR40/FFA1 | CHO-K1/FFA1/Gα15 |
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| Galanin receptor | GALR1 | CHO-K1/GALR1/Gα15 | |
| GALR2 | CHO-K1/GALR2 | ||
| Glucagon receptor | GHRHR | 293/GHRH/Gα15 | |
| GLP1R | CHO-K1/GLP1R/Gα15 | ||
| GLP2R | CHO-K1/GLP2R/Gα15 | ||
| GCGR | CHO-K1/GCGR/Gα15 | ||
| GCGR | HEK 293/GCGR/Gα15 | ||
| GIPR | CHO-K1/GIP/Gα15 | ||
| Gonadotropin releasing hormone receptor | GNRHR | CHO-K1/GNRHR/Gα15 | |
| Growth hormone releaseing peptides receptor | GHSR | CHO-K1/GHSR | |
| Histamine receptor | H1/HRH1 | 293/H1 | |
| H2/HRH2 | CHO-K1/H2/Gα15 | ||
| H3/HRH3 | CHO-K1/H3/Gα15 | ||
| H4/HRH4 | CHO-K1/H4/Gα15 | ||
| Hydroxycarboxlic acid receptor | GPR109A | CHO-K1/NIACR1/Gα15 | |
| Kisspeptin receptor | KiSS1/GPR54 | CHO-K1/KiSS1 | |
| Leukotriene receptor | FPRL1 | CHO-K1/FPRL1/Gα15 | |
| CysLT1 | CHO-K1/CysLT1/Gα15 | ||
| LTB4R | CHO-K1/LTB4/Gα15 | ||
| Lysophospholipid receptor | EDG4/LAP2 | RH7777/EDG4 | |
| Melanin concentrating hormone receptor | MCH1/GPR24 | 293/MCH1 | |
| MCH2/GPR145 | CHO-K1/MCH2 | ||
| Melanocortin receptor | MC2 | CHO-K1/MC2/Gα15 | |
| MC3 | CHO-K1/MC3/Gα15 | ||
| MC4 | CHO-K1/MC4/Gα15 | ||
| MC5 | CHO-K1/MC5/Gα15 | ||
| Melatonin receptor | MTNR1A | CHO-K1/MT1/Gα15 | |
| MT2/MTNR1B | CHO-K1/MT2/Gα15 | ||
| Metabropic glutamate receptor | mGlu2/GRM2 | CHO-K1/GRM2/Gα15 | |
| Motilin receptor | MTLR/MLNR | CHO-K1/MTLR/Gα15 |
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| Neuromedin receptor | NMU2 | 293T/NMU2 | |
| NMU1/GPR66 | CHO-K1/NMU1 | ||
| Neuropeptide S receptor | NPS1b | CHO-K1/NPS1b/Gα15 | |
| NPSR1 | CHO-K1/NPS1a/Gα15 | ||
| Neuropeptide Y receptor | NPY2 | CHO-K1/NPY2/Gqi5 | |
| NPY4R | CHO-K1/NPY4/Gα15 | ||
| Neurotensin receptor | NTS1/NT1 | CHO-K1/NTS1 | |
| Opioid & opioid-like receptor | OPRD1 | CHO-K1/OPRD1/Gα15 | |
| OPRK1 | CHO-K1/OPRK1/Gα15 | ||
| OPRM1 | CHO-K1/OPRM1/Gα15 | ||
| OPRL1 | CHO-K1/OPRL1/Gα15 | ||
| Orexin receptor | OX1 | CHO-K1/OX1 | |
| OX2 | CHO-K1/OX2 | ||
| P2Y receptor | P2Y1 | 1321N1/P2Y1 | |
| P2Y2 | 1321N1/P2Y2 | ||
| P2Y4 | 1321N1/P2Y4 | ||
| P2Y6 | 1321N1/P2Y6 | ||
| P2Y11 | 1321N1/P2Y11 | ||
| P2Y12 | 1321N1/P2Y12/Gα15 | ||
| Parathyroid hormone receptor | PTH1/PTHR1 | CHO-K1/PTH1/Gα15 | |
| Peptide P518 receptor | QRFP/GPR103 | CHO-K1/GPR103/Gα15 | |
| Platelet activating factor receptor | PAFR/PTAFR | CHO-K1/PTAFR | |
| Prolactin releasing peptide receptor | PRLHR | CHO-K1/PRLHR | |
| Prostanoid receptor | DP2 | CHO-K1/DP2/Gα15 | |
| EP1/PTGER1 | 293/EP1 | ||
| EP2/PTGER2 | CHO-K1/EP2/Gα15 | ||
| FP/PTGFR | 293/FP/Gα15 | ||
| IP1/PTGIR | CHO-K1/IP1/Gα15 | ||
| TP/TBXA2R | 293/TP | ||
| PTGDR/DP1 | CHO-K1/DP1/Gα15 | ||
| Proteinase-activated receptor | PAR2 | CHO-K1/PAR2/Gα15 | |
| PAR4/F2RL3 | CHO-K1/PAR4 |
|
Family
|
Receptor
|
Cell Line
|
Cat.No.
|
|---|---|---|---|
| Somatostatin receptor | SST1 | CHO-K1/SST1/Gqi5 | |
| SST2/SSTR2 | CHO-K1/SST2/Gα15 | ||
| SST3 | CHO-K1/SST3/Gα15 | ||
| SST4/SSTR4 | CHO-K1/SST4/Gα15 | ||
| SST5/SSTR5 | CHO-K1/SST5/Gα15 | ||
| Tachykinin receptor | NK1/TACR1 | CHO-K1/NK1 | |
| NK2/TACR2 | CHO-K1/NK2 | ||
| NK3/TACR3 | CHO-K1/NK3 | ||
| Thyrtropin releasing hormone receptor | TRH1/TRHR | CHO-K1/TRH1 | |
| Urotensin receptor | UTR2 | CHO-K1/UT2/Gα15 | |
| Vasopressin and oxytocin receptor | OT/OXTR | CHO-K1/OXTR | |
| V1B | CHO-K1/V1B | ||
| V2 | CHO-K1/V2/Gα15 | ||
| VIP and PACAP receptor | PAC1 | CHO-K1/PAC1/Gα15 | |
| VPAC2 | CHO-K1/VPAC2/Gα15 | ||
| VPAC1/VIP1 | CHO-K1/VPAC1/Gα15 | ||
| Control | \ | HEK293/Gα15 | |
| \ | CHO-K1/Gα15 | M00257 | |
| \ | CHO-K1/Gqi577 |
