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ACE2 Stable Cell Lines for SARS-CoV-2 Investigation

The outbreak of coronavirus disease 2019 (COVID19) has posed a global threat to public health. A novel coronavirus, SARS-coronavirus 2 (SARS-CoV-2), has been identified as the etiologic agent of this disease. Cell entry of coronavirus depends on the spike (S) protein binding to a cellular receptor and priming by a cellular protease. Recent studies demonstrate that angiotensin-converting enzyme 2 (ACE2) serves as the cell surface receptor to bind S protein in SARS-CoV-2 and facilitates entry of these coronaviruses into the cell. Read More »

Key features

Both HEK293/ACE2 and CHO-K1/ACE2 stable cell lines are generated with the features below:

• High expression of hACE2 on cell surface validated by FACS assays
• Negative control data provided
• Easy to use in binding assays or as immunogens

Applications

• Neutralization assays to screen antibodies or other molecules that can block pseudovirus or live virus infection
• Affinity analysis of antibody or other molecules to Spike protein
• In vitro cell models for investigating SARS-CoV-2 infection mechanism

Examples:

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Immune Checkpoint Stable Cell Lines

Inhibitors of immune-checkpoint proteins, such as PD1, PD-L1, VISTA, Tim3 and Lag3, have indicated broad and diverse opportunities to increase antitumor immunity by enhancing T cell activity with the potential to produce durable clinical responses. To meet these needs, we have developed stable cell line products expressing the most popular immune checkpoints to accelerate your immunotherapy discovery and clinical translation. All these stable cells are developed for screening high affinity antibodies against immune checkpoint proteins.

Key features

• High protein expression at the cell surface validated by FACS
• Stable cell lines for increased reliability and reproducibility (over 15 passages)
• Ready to use hot targets, saving 3-5 months

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