Overview

GenScript's custom rabbit monoclonal antibody development service offers high-quality, specific, and sensitive monoclonal antibodies against a wide range of antigens. Utilizing rabbits as hosts for monoclonal antibody development, this service provides several advantages over traditional mouse monoclonal antibody development.

As a global leader in custom monoclonal antibody generation, GenScript's MonoRab™ B-cell cloning technology can generate a large number of high-quality rabbit monoclonal antibodies to maximize the success of identifying antibodies perfect for specific research applications. Our advanced, proprietary rabbit monoclonal antibody discovery technology involves the isolation and cloning of rabbit B cells, and capitalizes on the rabbit's natural ability to generate high-specificity, high-affinity antibodies towards a wide range of difficult targets such as small molecules, antibody drugs, and even antigens that are non-immunogenic in mice.

Additionally, the Beacon® single B cell screening platform can also be utilized to enable analyzing B cell repertoires at a single-cell level, allowing for the identification of rare B cell populations that may be missed by traditional bulk sequencing approaches.

Highlights

Identify the top mAbs for your application by testing them in-house!

Industry-Leading Delivery TAT

  • Delivers purified specific antibodies as fast as 11 wks
  • Cell screening completed within 1 day and export >500 positive hits
    by Beacon single B cell platform
High Diversity Antibody Delivery

High Diversity Antibody Delivery

  • Guaranteed deliverables with competitive price
  • High affinity and specificity of desired antibodies
  • High success rate for challenging projects
Cutting-Edge  Technology & Facility

Cutting-Edge Technology & Facility

  • MonoExpress™: fast rabbit immunization
  • MonoRab™ B cell cloning & Beacon® single B cell screening
  • AAALAC and OLAW certificated animal facility

Service Details

Customized Rabbit mAb Development Package 1
Standard Rabbit mAb Development Package 2

Customized Rabbit mAb Development Package

Customized Rabbit mAb Development Package
Custom Rabbit Monoclonal Antibody Package TAT Deliverables
Phase I (Optional)
Immunogen Preparation
  • Customer-provided protein/peptide antigen
  • GenScript generated protein/peptide antigen synthesis and conjugation
  • Other antigen types*
  • Customer-provided: starts from 1 wk
  • GenScript-generated: starts from 2 wks
  • Deliver remaining antigen (peptide or protein) when the project is completed
Phase II
Animal Immunization
  • Immunization options:
    • Option 1: Conventional immunization protocol
    • Option 2: MonoExpress™ express immunization protocol
  • Conventional: starts from 6 wks
  • MonoExpress™: ~4 wks
  • Deliver post-immune test samples from conventional immunization
  • Immunization report
Phase III
B Cell Cloning

Option 1: MonoRab™ B-Cell Cloning Platform

  • One round of B cell cloning
  • Supernatants delivery
  • 3~5 wks
  • 1 ml supernatants/clone, up to 20 clones

Option 2: Beacon® Single B Cell Screening Platform

  • One round of single B cell screening on Beacon®
  • Starts from 2 wks
  • 500 immunogen-positive binders
Phase IV
Antibody sequencing & recombinant antibody production
  • Antibody sequencing
  • Small scale recombinant antibody expression and purification
  • Starts from 5 wks
  • Antibody sequencing report & purified antibody
Total TAT MonoRab™ B-Cell Cloning Platform: Starts from 13 wks
Beacon® Single B Cell Sorting Platform: Starts from 12 wks

*Immunogen type: protein, peptides, small molecules, DNA, mRNA, virus-like particles, cell lines, etc.

Standard Rabbit mAb Development Package

9~11 wks (conventional immunization protocol) or ~7 weeks (MonoExpress™ fast immunization protocol)
Standard Rabbit Monoclonal Antibody Package TAT Deliverables
Phase I (Optional)
Immunogen Preparation*
  • Protein: Customer provides/GenScript synthesizes
  • Peptide: GenScript synthesized only (Free of charge)
  • Customer provided: start from 1 wk
  • Peptide synthesis: 1~2 wks
  • Deliver remaining antigen (2mg peptide) when project is finished
Phase II
Animal Immunization & B Cell Cloning
  • Immunization options:
    a) Conventional immunization protocol
    b) MonoExpress™ fast immunization protocol
  • One round of B cell cloning
  • Counter screening if required

no post-immunization test samples delivered for either option

  • Conventional: starts from 9 wks
  • MonoExpress™: ~7 wks
  • 1 ml ELISA (+) supernatants/clone, 20 clones Guaranteed
  • CoA report
Phase III
Antibody sequencing & recombinant antibody production
  • Antibody sequencing
  • Small scale recombinant antibody expression and purification
  • 3~4 wks
  • 3 clones antibody sequencing report Guaranteed
  • 3 clones purified antibodies (0.1 mg/clone), ELISA > 1:64,000 Guaranteed
Total TAT Start from 11 wks

*:
a) Immunogen type: protein or peptide
b) Immunogen requirement for customer-provided protein: Purity ≥ 75%; Quantity: ≥ 5mg, Concentration ≥ 0.4mg/ml; Homology ≤ 95%; MW >10KD; no organic solvents in buffer; His/Flag tag protein

Case Studies

MonoRab™ B-Cell Cloning Platform

Beacon Single B Cell Screening Platform

Click here for more information about Beacon® single B cell screening platform

Related Resources

Related Services

Get in Touch
with GenScript Custom
Antibody Services

Get in Touch with GenScript Custom Antibody Services
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Quotation and Ordering

Our customer service representatives are available 24 hours Monday through Friday. You may contact us anytime for assistance. Orders can be placed online, over the phone, by email or fax. Please have your payment information (credit card, purchase order or bank information) ready.

Fill out the online form and email to [email protected]
A Technical Account Manager will reply you within 24 hours to finalize the quote
To place order, provide credit card/PO information
Production of your project begins immediately
A Project Manager is in contact with you during the production process to give updates

REQUEST A QUOTE

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