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GAPDH (Glyceraldehyde-3-phosphate dehydrogenase) gene, Homo sapiens
About the GAPDH gene
GAPDH encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]
Genomic context of GAPDH gene
The human GAPDH gene is shown in the context of the human genome below. To see information about the GAPDH gene in other species, please use the Search tool to select your desired species. GenScript has in-stock ORF clones for mouse GAPDH, rat GAPDH, and human GAPDH, as well as on-demand GAPDH ORF clones in other 183 species.
Chromosome 12 - NC_000012.12
Genomic sequence of GAPDH gene