Gene Symbol | LEP |
Entrez Gene ID | 403616 |
Full Name | leptin |
Synonyms | OB |
General protein information |
|
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
ORF » Species Summary » Canis lupus familiaris » LEP cDNA ORF clone
Gene Symbol | LEP |
Entrez Gene ID | 403616 |
Full Name | leptin |
Synonyms | OB |
General protein information |
|
Gene Type | protein-coding |
Organism | Canis lupus familiaris(dog) |
mRNA | Protein | Name |
---|---|---|
XM_005628340.2 | XP_005628397.2 | leptin isoform X1 |
XM_022427124.1 | XP_022282832.1 | leptin isoform X3 |
XM_005628340.3 | XP_005628397.2 | leptin isoform X1 |
XM_005628342.3 | XP_005628399.2 | leptin isoform X2 |
XM_005628342.2 | XP_005628399.2 | leptin isoform X2 |
XM_005628341.1 | XP_005628398.1 | leptin isoform X3 |
NM_001003070.1 | NP_001003070.1 | leptin precursor |
XM_005628341.2 | XP_005628398.1 | leptin isoform X3 |
Homo sapiens (human) | LEP | NP_000221.1 |
Rattus norvegicus (Norway rat) | Lep | NP_037208.1 |
Pan troglodytes (chimpanzee) | LEP | NP_001180601.1 |
Bos taurus (cattle) | LEP | NP_776353.2 |
LEP | NP_001036220.1 | |
Canis lupus familiaris (dog) | LEP | NP_001003070.1 |
Mus musculus (house mouse) | Lep | NP_032519.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100486715 | XP_002931881.2 |
Serum concentration dynamic of energy homeostasis hormones, leptin, insulin, thyroid hormones, and cortisol throughout canine pregnancy and lactation.
Cardinali L, Troisi A, Verstegen JP, Menchetti L, Elad Ngonput A, Boiti C, Canello S, Zelli R, Polisca A
Theriogenology97154-158(2017 Jul)
Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs.
M?ller L, Kowalewski MP, Reichler IM, Koll?r E, Balogh O
Reproduction in domestic animals = Zuchthygiene52 Suppl 2187-192(2017 Apr)
Leptin, adiponectin and serotonin levels in lean and obese dogs.
Park HJ, Lee SE, Oh JH, Seo KW, Song KH
BMC veterinary research10113(2014 May)
Leptin and leptin receptor gene expression in the canine corpus luteum during diestrus, pregnancy and after aglepristone-induced luteolysis.
Balogh O, Kowalewski MP, Reichler IM
Reproduction in domestic animals = Zuchthygiene47 Suppl 640-2(2012 Dec)
Compensation for obesity-induced insulin resistance in dogs: assessment of the effects of leptin, adiponectin, and glucagon-like peptide-1 using path analysis.
Verkest KR, Fleeman LM, Morton JM, Ishioka K, Rand JS
Domestic animal endocrinology41(1)24-34(2011 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Leptin and insulin-like growth factor 1 may support spermatogenesis in adult dogs and mediate Leydig cell function
Title: Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs.
This study evaluated the differences in leptin, adiponectin, and serotonin between lean and obese dogs.
Title: Leptin, adiponectin and serotonin levels in lean and obese dogs.
These results indicate that both leptin and leptin receptor mRNA are present in the canine corpus luteum during the non-pregnant luteal phase and pregnancy.
Title: Leptin and leptin receptor gene expression in the canine corpus luteum during diestrus, pregnancy and after aglepristone-induced luteolysis.
fasting plasma leptin concentration was directly negatively associated with fasting insulin sensitivity and positively associated with beta-cell function
Title: Compensation for obesity-induced insulin resistance in dogs: assessment of the effects of leptin, adiponectin, and glucagon-like peptide-1 using path analysis.
Leptin dilates canine small mesenteric arteries and veins by a mechanism involving endothelial release of nitric oxide.
Title: Vasodilator effects of leptin on canine isolated mesenteric arteries and veins.
The following LEP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the LEP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OCe33645 | |
Clone ID Related Accession (Same CDS sequence) | NM_001003070.1 | |
Accession Version | NM_001003070.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2018-12-08 | |
Organism | Canis lupus familiaris(dog) | |
Product | leptin precursor | |
Comment | Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from AB020986.1. ##Evidence-Data-START## Transcript exon combination :: AB020986.1, U95642.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA4547739, SAMEA4547741 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGCGTTGTG GACCTCTGTG CCGATTCCTG TGGCTTTGGC CCTATCTGTC CTGTGTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001003070.1 |
CDS | 32..535 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001003070.1 |
1 | ATGCGTTGTG GACCTCTGTG CCGATTCCTG TGGCTTTGGC CCTATCTGTC CTGTGTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe16490 | |
Clone ID Related Accession (Same CDS sequence) | XM_022427124.1 , XM_005628341.1 , XM_005628341.2 | |
Accession Version | XM_022427124.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | leptin isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGTTGTG GACCTCTGTG CCGATTCCTG TGGCTTTGGC CCTATCTGTC CTGTGTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_022282832.1 |
CDS | 135..638 |
Translation |
Target ORF information:
Target ORF information:
|
XM_022427124.1 |
1 | ATGCGTTGTG GACCTCTGTG CCGATTCCTG TGGCTTTGGC CCTATCTGTC CTGTGTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe16490 | |
Clone ID Related Accession (Same CDS sequence) | XM_022427124.1 , XM_005628341.1 , XM_005628341.2 | |
Accession Version | XM_005628341.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-09-16 | |
Organism | Canis lupus familiaris(Dog) | |
Product | leptin isoform X3 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726084.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGTTGTG GACCTCTGTG CCGATTCCTG TGGCTTTGGC CCTATCTGTC CTGTGTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628398.1 |
CDS | 272..775 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628341.1 |
1 | ATGCGTTGTG GACCTCTGTG CCGATTCCTG TGGCTTTGGC CCTATCTGTC CTGTGTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe16490 | |
Clone ID Related Accession (Same CDS sequence) | XM_022427124.1 , XM_005628341.1 , XM_005628341.2 | |
Accession Version | XM_005628341.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 504bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | leptin isoform X3 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005628341.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGTTGTG GACCTCTGTG CCGATTCCTG TGGCTTTGGC CCTATCTGTC CTGTGTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628398.1 |
CDS | 258..761 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628341.2 |
1 | ATGCGTTGTG GACCTCTGTG CCGATTCCTG TGGCTTTGGC CCTATCTGTC CTGTGTTGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe39857 | |
Clone ID Related Accession (Same CDS sequence) | XM_005628340.2 , XM_005628340.3 | |
Accession Version | XM_005628340.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-09-16 | |
Organism | Canis lupus familiaris(Dog) | |
Product | leptin isoform X1 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726084.1) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005628340.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGCAAGT TGCGCTCGGG CGGCTATAAG AGGGGCGGGC AGGCATGGAG CCCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628397.2 |
CDS | 10..624 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628340.2 |
1 | ATGCGCAAGT TGCGCTCGGG CGGCTATAAG AGGGGCGGGC AGGCATGGAG CCCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe39857 | |
Clone ID Related Accession (Same CDS sequence) | XM_005628340.2 , XM_005628340.3 | |
Accession Version | XM_005628340.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | leptin isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005628340.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGCAAGT TGCGCTCGGG CGGCTATAAG AGGGGCGGGC AGGCATGGAG CCCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628397.2 |
CDS | 12..626 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628340.3 |
1 | ATGCGCAAGT TGCGCTCGGG CGGCTATAAG AGGGGCGGGC AGGCATGGAG CCCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe39858 | |
Clone ID Related Accession (Same CDS sequence) | XM_005628342.3 , XM_005628342.2 | |
Accession Version | XM_005628342.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-09-04 | |
Organism | Canis lupus familiaris(dog) | |
Product | leptin isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_006596.3) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 5, 2017 this sequence version replaced XM_005628342.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 105 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGCAAGT TGCGCTCGGG CGGCTATAAG AGGGGCGGGC AGGCATGGAG CCCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628399.2 |
CDS | 12..623 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628342.3 |
1 | ATGCGCAAGT TGCGCTCGGG CGGCTATAAG AGGGGCGGGC AGGCATGGAG CCCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OCe39858 | |
Clone ID Related Accession (Same CDS sequence) | XM_005628342.3 , XM_005628342.2 | |
Accession Version | XM_005628342.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-09-16 | |
Organism | Canis lupus familiaris(Dog) | |
Product | leptin isoform X2 | |
Comment | MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NW_003726084.1) annotated using gene prediction method: Gnomon. Also see: Documentation of NCBI's Annotation Process On Sep 17, 2015 this sequence version replaced XM_005628342.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Canis lupus familiaris Annotation Release 104 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.4 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCGCAAGT TGCGCTCGGG CGGCTATAAG AGGGGCGGGC AGGCATGGAG CCCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005628399.2 |
CDS | 10..621 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005628342.2 |
1 | ATGCGCAAGT TGCGCTCGGG CGGCTATAAG AGGGGCGGGC AGGCATGGAG CCCCGGAGGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Serum concentration dynamic of energy homeostasis hormones, leptin, insulin, thyroid hormones, and cortisol throughout canine pregnancy and lactation. |
Different expression of leptin and IGF1 in the adult and prepubertal testis in dogs. |
Leptin, adiponectin and serotonin levels in lean and obese dogs. |
Leptin and leptin receptor gene expression in the canine corpus luteum during diestrus, pregnancy and after aglepristone-induced luteolysis. |
Compensation for obesity-induced insulin resistance in dogs: assessment of the effects of leptin, adiponectin, and glucagon-like peptide-1 using path analysis. |