ORF cDNA Clones and Custom Clones » Species Summary » Bos taurus » MYOC cDNA ORF clone

MYOC cDNA ORF clone, Bos taurus(cattle)

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Summary

Gene Symbol	MYOC
Entrez Gene ID	281342
Full Name	myocilin
General protein information	Preferred Names myocilin Names myocilin myocilin 55 kDa subunit myocilin, trabecular meshwork inducible glucocorticoid response trabecular meshwork-induced glucocorticoid response protein
Gene Type	protein-coding
Organism	Bos taurus(cattle)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA	Protein	Name
NM_174118.2	NP_776543.2	myocilin precursor

Homologies

Homo sapiens (human)	MYOC	NP_000252.1
	MYOC	XP_001099905.1
Danio rerio (zebrafish)	myoc	NP_001015062.1
Mus musculus (house mouse)	Myoc	NP_034995.3
Gallus gallus (chicken)	MYOC	XP_422235.4
Xenopus tropicalis (tropical clawed frog)	myoc	XP_002934195.2
Pan troglodytes (chimpanzee)	MYOC	XP_513995.2
Canis lupus familiaris (dog)	MYOC	NP_001041495.2
Bos taurus (cattle)	MYOC	NP_776543.2
Rattus norvegicus (Norway rat)	Myoc	NP_110492.1

A whole-genome assembly of the domestic cow, Bos taurus.
Zimin AV, Delcher AL, Florea L, Kelley DR, Schatz MC, Puiu D, Hanrahan F, Pertea G, Van Tassell CP, Sonstegard TS, Mar?ais G, Roberts M, Subramanian P, Yorke JA, Salzberg SL
Genome biology10(4)R42(2009)

Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227.
Aroca-Aguilar JD, S?nchez-S?nchez F, Ghosh S, Coca-Prados M, Escribano J
The Journal of biological chemistry280(22)21043-51(2005 Jun)

Molecular cloning of the bovine MYOC and induction of its expression in trabecular meshwork cells.
Taniguchi F, Suzuki Y, Kurihara H, Kurihara Y, Kasai H, Shirato S, Araie M
Investigative ophthalmology & visual science41(8)2070-5(2000 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

endoproteolytic processing might regulate the activity of myocilin; the inhibition of the processing by pathogenic mutations impairs the normal role of myocilin
Title: Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227.

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The following MYOC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYOC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OBa01436	NM_174118.2 Latest version!	Bos taurus myocilin (MYOC), mRNA.	pcDNA3.1⁺/C-(K)DYK or customized vector	7-9	$258.30 $369.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MYOC ( NM_174118.2 ) cDNA ORF clone, Bos taurus(cattle) -> NP_776543.2 Bos taurus myocilin (MYOC), mRNA.

Price & Availability↑

CloneID	OBa01436
Clone ID Related Accession (Same CDS sequence)	NM_174118.2
Accession Version	NM_174118.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1⁺/C-(K)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-24
Organism	Bos taurus(cattle)
Product	myocilin precursor
Comment	Comment: PROVISIONAL REFSEQ: This record has not yet been subject to final NCBI review. The reference sequence was derived from BC104571.1. On Sep 18, 2005 this sequence version replaced NM_174118.1. ##Evidence-Data-START## Transcript exon combination :: BC104571.1, AB027758.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03145441 [ECO:0000348] ##Evidence-Data-END##

ATGCCAGCGG TCCAGCTGCT ACTGCTGGCC TGTCTGCTAG GGGGTGTGGG GGCCAGGACA 
GCCCAGTTCC AGAAGGCCAA CGACCGGAGT GGCCGATGCC AGTACACCTT CAGCGTGGCC 
AGCCCCAGTG AGTCCAGCTG CCCTGAGCAG GGCCAGGCCA TGTTGGCCAT CCAGGAGCTG 
CAGAGAGACA GCAGCGAACA ACGCGCGACC CTGGAGTCCA CCAAGGCCCG CCTCAGCTCC 
CTGGAGGCCC TCCTCCACCG CCTGACCTCA GGCCAGCCCG CTGGGCCCTT GGAGACCCAC 
CAGGGGCTGC AGAGGGAGCT GGAAGCCCTG AGAAGAGAGC GAGAACAGCT GGAAACCCAA 
ACCCAGGAGC TGGAGTCAGC CTACAGCAAC CTCGTCCGTG ACAAGTCGGC TCTGGAGGAG 
GAGAAGAGGC GGCTGCAGGC GGAGAACGAG GATCTGGCCA GGAGGCTGGA AAGCAGCAGC 
CAGGAGGTAG CAAGCCTGAG GAGGGGCCAG TGTCCGCAGG CCCACAGCAG CTCTCAGGAC 
GTGCCATCAG GCTCCAGGGA AGTTGCTAAA TGGAATTTGG AGAACATGGA CTTCCAGGAA 
CTGAAGTCAG AGTTAACAGA GGTTCCTGCT TCCCAAATCT TGAAGGAGAG CCCATCTGGT 
CATCCCAGGA ATGAAGAAGG AGGCACTGGA TGCGGAGAAC TCGTTTGGGT AGGAGAACCC 
ATCACTCTGA GAACAGCTGA AACAATCACC GGCAAGTACG GAGTGTGGAT GAGAGACCCC 
CAGGCCACCT TCCCCTATAC CGGGGAGACC ACCTGGAGAA TCGACACCGT GGGCACAGAC 
ATCCGCCAGG TGTTTGAGTA CGACCACATC AGGCAGTTCA CGCAGGGCTA CCCGTCCAAG 
GTGCACGTGC TGCCCAGGCC GCTGGAGAGC ACGGGCGCCG TGGTCTACCG GGGCAGCCTC 
TACTTCCAGG CGGCCGAGTC CAGGACAGTG CTCCGGTACG ACCTGCGCAC CGAGACGCTG 
AAGGCGGAGA AGGAGATCCC CGGAGCCGGC TACCACGGGC AGTTCCCCTA TTCCTGGGGC 
GGCTACACCG ACATCGACCT GGCCGTGGAC GAGATAGGCC TCTGGGTCAT CTACAGCACC 
GAGGCGGCCA AAGGCGCCAT CGTCCTCTCC AAGCTGAACC CCGAGACACT GGAGCTCGAA 
CAGACTTGGG AGACCAACAT CCGTAAGCAG TCCGTCGCCA ACGCCTTCAT CATCTGTGGC 
ACCTTGTACA CGGTCAGCAG CTACTCCTCG CCCGACGCCA CTGTCAACTT CGCCTATGAC 
ACAGGCACCG GGAGCAGCAA GGCCCTGACC GTCCCGTTCA AGAACCGCTA CAAGTACAGC 
AGCATGATCG ACTACAACCC CCTGGAGAGG AAGCTCTTTG CCTGGGACAA CTTCAACATG 
GTCTCCTATG ACATCAAGCT CTCCCGGCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_776543.2
CDS	96..1568
Translation	MPAVQLLLLACLLGGVGARTAQFQKANDRSGRCQYTFSVASPSESSCPEQGQAMLAIQELQRDSSEQRATLESTKARLSSLEALLHRLTSGQPAGPLETHQGLQRELEALRREREQLETQTQELESAYSNLVRDKSALEEEKRRLQAENEDLARRLESSSQEVASLRRGQCPQAHSSSQDVPSGSREVAKWNLENMDFQELKSELTEVPASQILKESPSGHPRNEEGGTGCGELVWVGEPITLRTAETITGKYGVWMRDPQATFPYTGETTWRIDTVGTDIRQVFEYDHIRQFTQGYPSKVHVLPRPLESTGAVVYRGSLYFQAAESRTVLRYDLRTETLKAEKEIPGAGYHGQFPYSWGGYTDIDLAVDEIGLWVIYSTEAAKGAIVLSKLNPETLELEQTWETNIRKQSVANAFIICGTLYTVSSYSSPDATVNFAYDTGTGSSKALTVPFKNRYKYSSMIDYNPLERKLFAWDNFNMVSYDIKLSRL

Target ORF information:

RefSeq Version	NM_174118.2
Organism	Bos taurus(cattle)
Definition	Bos taurus myocilin (MYOC), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_174118.2

ORF Insert Sequence:

ATGCCAGCGG TCCAGCTGCT ACTGCTGGCC TGTCTGCTAG GGGGTGTGGG GGCCAGGACA 
GCCCAGTTCC AGAAGGCCAA CGACCGGAGT GGCCGATGCC AGTACACCTT CAGCGTGGCC 
AGCCCCAGTG AGTCCAGCTG CCCTGAGCAG GGCCAGGCCA TGTTGGCCAT CCAGGAGCTG 
CAGAGAGACA GCAGCGAACA ACGCGCGACC CTGGAGTCCA CCAAGGCCCG CCTCAGCTCC 
CTGGAGGCCC TCCTCCACCG CCTGACCTCA GGCCAGCCCG CTGGGCCCTT GGAGACCCAC 
CAGGGGCTGC AGAGGGAGCT GGAAGCCCTG AGAAGAGAGC GAGAACAGCT GGAAACCCAA 
ACCCAGGAGC TGGAGTCAGC CTACAGCAAC CTCGTCCGTG ACAAGTCGGC TCTGGAGGAG 
GAGAAGAGGC GGCTGCAGGC GGAGAACGAG GATCTGGCCA GGAGGCTGGA AAGCAGCAGC 
CAGGAGGTAG CAAGCCTGAG GAGGGGCCAG TGTCCGCAGG CCCACAGCAG CTCTCAGGAC 
GTGCCATCAG GCTCCAGGGA AGTTGCTAAA TGGAATTTGG AGAACATGGA CTTCCAGGAA 
CTGAAGTCAG AGTTAACAGA GGTTCCTGCT TCCCAAATCT TGAAGGAGAG CCCATCTGGT 
CATCCCAGGA ATGAAGAAGG AGGCACTGGA TGCGGAGAAC TCGTTTGGGT AGGAGAACCC 
ATCACTCTGA GAACAGCTGA AACAATCACC GGCAAGTACG GAGTGTGGAT GAGAGACCCC 
CAGGCCACCT TCCCCTATAC CGGGGAGACC ACCTGGAGAA TCGACACCGT GGGCACAGAC 
ATCCGCCAGG TGTTTGAGTA CGACCACATC AGGCAGTTCA CGCAGGGCTA CCCGTCCAAG 
GTGCACGTGC TGCCCAGGCC GCTGGAGAGC ACGGGCGCCG TGGTCTACCG GGGCAGCCTC 
TACTTCCAGG CGGCCGAGTC CAGGACAGTG CTCCGGTACG ACCTGCGCAC CGAGACGCTG 
AAGGCGGAGA AGGAGATCCC CGGAGCCGGC TACCACGGGC AGTTCCCCTA TTCCTGGGGC 
GGCTACACCG ACATCGACCT GGCCGTGGAC GAGATAGGCC TCTGGGTCAT CTACAGCACC 
GAGGCGGCCA AAGGCGCCAT CGTCCTCTCC AAGCTGAACC CCGAGACACT GGAGCTCGAA 
CAGACTTGGG AGACCAACAT CCGTAAGCAG TCCGTCGCCA ACGCCTTCAT CATCTGTGGC 
ACCTTGTACA CGGTCAGCAG CTACTCCTCG CCCGACGCCA CTGTCAACTT CGCCTATGAC 
ACAGGCACCG GGAGCAGCAA GGCCCTGACC GTCCCGTTCA AGAACCGCTA CAAGTACAGC 
AGCATGATCG ACTACAACCC CCTGGAGAGG AAGCTCTTTG CCTGGGACAA CTTCAACATG 
GTCTCCTATG ACATCAAGCT CTCCCGGCTG TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A whole-genome assembly of the domestic cow, Bos taurus.
Genome biology10(4)R42(2009)
Zimin AV,Delcher AL,Florea L,Kelley DR,Schatz MC,Puiu D,Hanrahan F,Pertea G,Van Tassell CP,Sonstegard TS,Mar?ais G,Roberts M,Subramanian P,Yorke JA,Salzberg SL

Myocilin mutations causing glaucoma inhibit the intracellular endoproteolytic cleavage of myocilin between amino acids Arg226 and Ile227.
The Journal of biological chemistry280(22)21043-51(2005 Jun)
Aroca-Aguilar JD,S?nchez-S?nchez F,Ghosh S,Coca-Prados M,Escribano J

Molecular cloning of the bovine MYOC and induction of its expression in trabecular meshwork cells.
Investigative ophthalmology & visual science41(8)2070-5(2000 Jul)
Taniguchi F,Suzuki Y,Kurihara H,Kurihara Y,Kasai H,Shirato S,Araie M

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MYOC cDNA ORF clone, Bos taurus(cattle)

Summary

Reference Sequences (RefSeq)

Pathways from BioSystems

Homologies

Gene Ontology

Bibliography

Reference Sequences (Refseq)

Target ORF information:

Target ORF information:

ORF Insert Sequence:

PubMed

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