Gene Symbol | FOXO6 |
Entrez Gene ID | 100132074 |
Full Name | forkhead box O6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » FOXO6 cDNA ORF clone
Gene Symbol | FOXO6 |
Entrez Gene ID | 100132074 |
Full Name | forkhead box O6 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001291281.2 | NP_001278210.2 | forkhead box protein O6 |
NM_001291281.3 | NP_001278210.2 | forkhead box protein O6 |
Homo sapiens (human) | FOXO6 | XP_002342143.5 |
Rattus norvegicus (Norway rat) | Foxo6 | XP_001057233.1 |
Danio rerio (zebrafish) | si:ch211-206a7.2 | NP_001128604.1 |
Danio rerio (zebrafish) | LOC101883250 | XP_005157925.1 |
Xenopus tropicalis (tropical clawed frog) | foxo6 | XP_002939401.1 |
Mus musculus (house mouse) | Foxo6 | NP_918949.1 |
Gallus gallus (chicken) | LOC100857767 | XP_004947769.1 |
Danio rerio (zebrafish) | LOC561541 | XP_690041.2 |
Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer.
Wang JH, Tang HS, Li XS, Zhang XL, Yang XZ, Zeng LS, Ruan Q, Huang YH, Liu GJ, Wang J, Cui SZ
Oncotarget8(19)31682-31691(2017 May)
Bipolar disorder risk gene
Shenker JJ, Sengupta SM, Joober R, Malla A, Chakravarty MM, Lepage M
Journal of psychiatry & neuroscience : JPN42(3)172-180(2017 May)
FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7.
Hu HJ, Zhang LG, Wang ZH, Guo XX
Molecular medicine reports12(1)575-80(2015 Jul)
FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc.
Qinyu L, Long C, Zhen-dong D, Min-min S, Wei-ze W, Wei-ping Y, Cheng-hong P
FEBS letters587(14)2105-11(2013 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
In conclusion, the results of the present study indicated that the FOXO6/USP7 molecular network has an important role in the regulation of lung cancer development.
Title: FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7.
Studies indicate that FoxO6 is produced in the liver of both rodents and humans.
Title: FoxO6 in glucose metabolism (FoxO6).
FOXO6 induces C-myc expression by associating to HNF4 and mediating histone acetylation, and the dissociation of HDAC3 from the promoter of the C-myc gene
Title: FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc.
investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in hepatocytes orchestrates insulin regulation of gluconeogenesis.
Title: FoxO6 integrates insulin signaling with gluconeogenesis in the liver.
Studies indictet that the mammalian FoxO family consists of FoxO1, 3, 4 and 6 and are regulated by by AKT and 14-3-3 proteins.
Title: FoxO transcription factors; Regulation by AKT and 14-3-3 proteins.
The following FOXO6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXO6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu80979 | |
Clone ID Related Accession (Same CDS sequence) | NM_001291281.2 , NM_001291281.3 | |
Accession Version | NM_001291281.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | forkhead box protein O6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FO681542.2. On or before Jun 25, 2015 this sequence version replaced XM_011548721.1, NM_001291281.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968832 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGCGA AGCTGCGAGC GCATCAGGTG GACGTGGACC CGGACTTCGC GCCGCAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001278210.2 |
CDS | 1..1680 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001291281.2 |
1 | ATGGCTGCGA AGCTGCGAGC GCATCAGGTG GACGTGGACC CGGACTTCGC GCCGCAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu80979 | |
Clone ID Related Accession (Same CDS sequence) | NM_001291281.2 , NM_001291281.3 | |
Accession Version | NM_001291281.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1680bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Homo sapiens(human) | |
Product | forkhead box protein O6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from FO681542.2. On Nov 3, 2018 this sequence version replaced NM_001291281.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: KY243080.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968540, SAMEA1968832 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCTGCGA AGCTGCGAGC GCATCAGGTG GACGTGGACC CGGACTTCGC GCCGCAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001278210.2 |
CDS | 498..2177 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001291281.3 |
1 | ATGGCTGCGA AGCTGCGAGC GCATCAGGTG GACGTGGACC CGGACTTCGC GCCGCAGAGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer. |
Bipolar disorder risk gene |
FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7. |
FOXO6 promotes gastric cancer cell tumorigenicity via upregulation of C-myc. |