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KLLN cDNA ORF clone, Homo sapiens (human)

Gene Symbol KLLN
Entrez Gene ID 100144748
Full Name killin, p53-regulated DNA replication inhibitor
Synonyms CWS4, KILLIN
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q23

Summary The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]. lac of sum
Disorder MIM:

612105


mRNA and Protein(s)

mRNA Protein Name
NM_001126049 NP_001119521 killin


Homo sapiens (human) KLLN NP_001119521.1
Pan troglodytes (chimpanzee) KLLN XP_003312729.1
Macaca mulatta (Rhesus monkey) LOC100426503 XP_002805787.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KLLN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KLLN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu18226
NM_001126049 Homo sapiens killin, p53-regulated DNA replication inhibitor (KLLN), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
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30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18226
Clone ID Related Accession (Same CDS sequence) NM_001126049
Accession Version NM_001126049.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 537bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product killin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from EU552092.1. This sequence is a reference standard in the RefSeqGene project. ##Evidence-Data-START## Transcript exon combination :: EU552092.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
ATGGATCGCC CGGGGCCAGG CTCCGCGCGC CCCGGCCGGA CCGTGCACGT TTGGGGTTAC 
CGGGTTGAGT GGAAAGTACG GAACGGTAGG AAGCTGCAGC CCAGCGAGTG GGCGGGGCGA
GGAGACCTAG GAGGGTTCAA AAGGAGGTGG AAGGATACAC GGGCCACAGT CGGAACTACT
TTCCGAAGGA GGTCACGTGT GTCCCTAGTT GGGGAACTTT CCAAATTCCC ACTCCCCAGT
GATAGCTCCG GAGGCAAGTC GTCTTCTTCC TTTGCTCGGG GTGCTCTTGC CTGGTGCAGG
CAGCGGAACC CCAACCCTTC CTGCGCCGCG GCGGAAACAG GGGCTCGGAC CAGCCTCCCG
AAGGAGCGCT GTCGGGGCTG GCGCTTGGGG AACTGGTTAC ACAAGCACCC ACATCCAAAC
ACGTGCCCCC GCCTCCCCGC CTGCTGGCTG CCGCCGATTC TTACAGAACG CGGGGAGAGA
GTCCCCAAAC TGGTGCCACT CCTCGCCTGC TACCCTAAGA GCAAGCCAAA GGACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001119521.1
CDS951..1487
Misc Feature(1)936..938(+)
Exon (1)1..4277
Gene:KLLN
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001126049
Organism Homo sapiens (human)
Definition Homo sapiens killin, p53-regulated DNA replication inhibitor (KLLN), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001126049

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
ATGGATCGCC CGGGGCCAGG CTCCGCGCGC CCCGGCCGGA CCGTGCACGT TTGGGGTTAC 
CGGGTTGAGT GGAAAGTACG GAACGGTAGG AAGCTGCAGC CCAGCGAGTG GGCGGGGCGA
GGAGACCTAG GAGGGTTCAA AAGGAGGTGG AAGGATACAC GGGCCACAGT CGGAACTACT
TTCCGAAGGA GGTCACGTGT GTCCCTAGTT GGGGAACTTT CCAAATTCCC ACTCCCCAGT
GATAGCTCCG GAGGCAAGTC GTCTTCTTCC TTTGCTCGGG GTGCTCTTGC CTGGTGCAGG
CAGCGGAACC CCAACCCTTC CTGCGCCGCG GCGGAAACAG GGGCTCGGAC CAGCCTCCCG
AAGGAGCGCT GTCGGGGCTG GCGCTTGGGG AACTGGTTAC ACAAGCACCC ACATCCAAAC
ACGTGCCCCC GCCTCCCCGC CTGCTGGCTG CCGCCGATTC TTACAGAACG CGGGGAGAGA
GTCCCCAAAC TGGTGCCACT CCTCGCCTGC TACCCTAAGA GCAAGCCAAA GGACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Germline and somatic KLLN alterations in breast cancer dysregulate G2 arrest
Hum. Mol. Genet. 22 (12), 2451-2461 (2013)
Nizialek EA, Peterson C, Mester JL, Downes-Kelly E and Eng C.


book

Androgen receptor-induced tumor suppressor, KLLN, inhibits breast cancer growth and transcriptionally activates p53/p73-mediated apoptosis in breast carcinomas
Hum. Mol. Genet. 22 (11), 2263-2272 (2013)
Wang Y, He X, Yu Q and Eng C.


book

Transcription factor KLLN inhibits tumor growth by AR suppression, induces apoptosis by TP53/TP73 stimulation in prostate carcinomas, and correlates with cellular differentiation
J. Clin. Endocrinol. Metab. 98 (3), E586-E594 (2013)
Wang Y, Radhakrishnan D, He X, Peehl DM and Eng C.


book

Analysis of KLLN as a high-penetrance breast cancer predisposition gene
Breast Cancer Res. Treat. 134 (2), 543-547 (2012)
Thompson ER, Gorringe KL, Choong DY, Eccles DM, Mitchell G and Campbell IG.


book

Incidence and clinical characteristics of thyroid cancer in prospective series of individuals with Cowden and Cowden-like syndrome characterized by germline PTEN, SDH, or KLLN alterations
J. Clin. Endocrinol. Metab. 96 (12), E2063-E2071 (2011)
Ngeow J, Mester J, Rybicki LA, Ni Y, Milas M and Eng C.


book

Germline and somatic DNA methylation and epigenetic regulation of KILLIN in renal cell carcinoma
Genes Chromosomes Cancer 50 (8), 654-661 (2011)
Bennett KL, Campbell R, Ganapathi S, Zhou M, Rini B, Ganapathi R, Neumann HP and Eng C.


book

Germline epigenetic regulation of KILLIN in Cowden and Cowden-like syndrome
JAMA 304 (24), 2724-2731 (2010)
Bennett KL, Mester J and Eng C.


book

Killin is a p53-regulated nuclear inhibitor of DNA synthesis
Proc. Natl. Acad. Sci. U.S.A. 105 (14), 5396-5401 (2008)
Cho YJ and Liang P.


 
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