BCL2L10 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | BCL2L10 |
| Entrez Gene ID | 10017 |
| Full Name | BCL2 like 10 |
| Synonyms | BCL-B,Boo,Diva,bcl2-L-10 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains conserved BH4, BH1 and BH2 domains. This protein can interact with other members of BCL-2 protein family including BCL2, BCL2L1/BCL-X(L), and BAX. Overexpression of this gene has been shown to suppress cell apoptosis possibly through the prevention of cytochrome C release from the mitochondria, and thus activating caspase-3 activation. The mouse counterpart of this protein is found to interact with Apaf1 and forms a protein complex with Caspase 9, which suggests the involvement of this protein in APAF1 and CASPASE 9 related apoptotic pathway. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001306168.1 | NP_001293097.1 | bcl-2-like protein 10 isoform 1 |
| NM_020396.3 | NP_065129.1 | bcl-2-like protein 10 isoform 2 |
| Mus musculus (house mouse) | Bcl2l10 | NP_038507.1 |
| Bos taurus (cattle) | BCL2L10 | XP_002691010.2 |
| Rattus norvegicus (Norway rat) | Bcl2l10 | NP_446185.1 |
| Homo sapiens (human) | BCL2L10 | NP_065129.1 |
| Pan troglodytes (chimpanzee) | BCL2L10 | XP_523079.2 |
| BCL2L10 | XP_001085850.1 |
Related articles in PubMed
Breast cancer targeting through inhibition of the endoplasmic reticulum-based apoptosis regulator Nrh/BCL2L10.
Nougarede A, Popgeorgiev N, Kassem L, Omarjee S, Borel S, Mikaelian I, Lopez J, Gadet R, Marcillat O, Treilleux I, Villoutreix BO, Rimokh R, Gillet G
Cancer research(2018 Jan)
BCL2L10 positive cells in bone marrow are an independent prognostic factor of azacitidine outcome in myelodysplastic syndrome and acute myeloid leukemia.
Vidal V, Robert G, Goursaud L, Durand L, Ginet C, Karsenti JM, Luciano F, Gastaud L, Garnier G, Braun T, Hirsch P, Raffoux E, Nloga AM, Padua RA, Dombret H, Rohrlich P, Ades L, Chomienne C, Auberger P, Fenaux P, Cluzeau T
Oncotarget8(29)47103-47109(2017 Jul)
BCLB, methylated in hepatocellular carcinoma, is a starvation stress?sensor that induces apoptosis and autophagy through the?AMPK-mTOR signaling cascade.
Liu X, Hu X, Kuang Y, Yan P, Li L, Li C, Tao Q, Cai X
Cancer letters39563-71(2017 Jun)
BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo.
Bai Y, Wang J, Han J, Xie XL, Ji CG, Yin J, Chen L, Wang CK, Jiang XY, Qi W, Jiang HQ
Molecular carcinogenesis56(3)1137-1149(2017 Mar)
IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.
Bonneau B, Ando H, Kawaai K, Hirose M, Takahashi-Iwanaga H, Mikoshiba K
eLife5(2016 12)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
BCLB expression was a starvation stress sensor inducing apoptosis and autophagy simultaneously in HCC cells through the adenosine monophosphate-activated protein kinase AMPK-mTOR signaling cascade.
Title: BCLB, methylated in hepatocellular carcinoma, is a starvation stress?sensor that induces apoptosis and autophagy through the?AMPK-mTOR signaling cascade.
we describe the identification of a structural genetic variant segregating with affective psychosis in a family with multiple members suffering from bipolar I disorder. Using whole-genome sequencing, we delineated the translocation breakpoints as corresponding intragenic events disrupting BCL2L10 and PNLDC1. These data warrant further consideration for BCL2L10 and PNLDC1 as novel candidates for affective psychosis.
Title: A balanced translocation disrupting BCL2L10 and PNLDC1 segregates with affective psychosis.
Results found that BCL2L10 was down-regulated in human hepatocellular carcinoma (HCC) tissues; its overexpression suppresses cell growth and migration of HCC cell lines. These results suggested that BCL2L10 functions as a tumor-suppressor in HCC.
Title: BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo.
These results suggest that by inhibiting Bcl2l10 activity and promoting contact between endoplasmic reticulum and mitochondria, IRBIT facilitates massive Ca(2+) transfer to mitochondria and promotes apoptosis.
Title: IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact.
Identification of a variant in the BCL2L10 gene as a protective factor for the development of therapy-related myeloid neoplasms and de novo myelodysplastic syndrome.
Title: The BCL2L10 Leu21Arg variant and risk of therapy-related myeloid neoplasms and de novo myelodysplastic syndromes.
The following BCL2L10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCL2L10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu03270 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_020396.3 | |
| Accession Version | NM_020396.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 615bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-30 | |
| Organism | Homo sapiens(human) | |
| Product | bcl-2-like protein 10 isoform 2 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF326964.1 and BX119239.1. On Apr 16, 2015 this sequence version replaced NM_020396.2. Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. It encodes isoform 2, which has a shorter and distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279854.238.1, SRR1163657.324728.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGTTGACC AGTTGCGGGA GCGCACCACC ATGGCCGACC CGCTGCGGGA GCGCACCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_065129.1 |
| CDS | 50..664 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_020396.3 |
ORF Insert Sequence:
1 | ATGGTTGACC AGTTGCGGGA GCGCACCACC ATGGCCGACC CGCTGCGGGA GCGCACCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu48048 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001306168.1 | |
| Accession Version | NM_001306168.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 726bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-28 | |
| Organism | Homo sapiens(human) | |
| Product | bcl-2-like protein 10 isoform 1 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023906.7, BC143227.1, AF326964.1 and BX119239.1. On Apr 16, 2015 this sequence version replaced XM_005254103.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.75360.1, SRR1163657.54983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA2144335 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGTTGACC AGTTGCGGGA GCGCACCACC ATGGCCGACC CGCTGCGGGA GCGCACCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001293097.1 |
| CDS | 50..775 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001306168.1 |
ORF Insert Sequence:
1 | ATGGTTGACC AGTTGCGGGA GCGCACCACC ATGGCCGACC CGCTGCGGGA GCGCACCGAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Breast cancer targeting through inhibition of the endoplasmic reticulum-based apoptosis regulator Nrh/BCL2L10. |
|
BCL2L10 positive cells in bone marrow are an independent prognostic factor of azacitidine outcome in myelodysplastic syndrome and acute myeloid leukemia. |
|
BCLB, methylated in hepatocellular carcinoma, is a starvation stress?sensor that induces apoptosis and autophagy through the?AMPK-mTOR signaling cascade. |
|
BCL2L10 inhibits growth and metastasis of hepatocellular carcinoma both in vitro and in vivo. |
|
IRBIT controls apoptosis by interacting with the Bcl-2 homolog, Bcl2l10, and by promoting ER-mitochondria contact. |