×

MRLN cDNA ORF clone, Homo sapiens(Human)

Gene Symbol MRLN
Entrez Gene ID 100507027
Full Name myoregulin
Synonyms LINC00948,Linc-RAM,M1,MLN,MUSER1
General protein information
Preferred Names

myoregulin

Names

myoregulin
long intergenic non-protein coding RNA 948
muscle enriched RNA 1
muscle specific 1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

10

10q21.2

Summary This gene encodes a small peptide that shares structural similarity to the small peptides sarcolipin and phospholamban, which are key regulators of sarcoplasmic reticulum Ca(2+)-ATPases (SERCAs). This protein is thought to have a similar function to these peptides, regulating Ca(2+) reuptake in the sarcoplasmic reticulum by inhibiting the Ca(2+) pump activity of SERCAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2015].
Disorder MIM:

616246


mRNA and Protein(s)

mRNA Protein Name
NM_001304732.1 NP_001291661.1 myoregulin
NM_001304731.1 NP_001291660.1 myoregulin



Related articles in PubMed

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD.
Yu X, Zhang Y, Li T, Ma Z, Jia H, Chen Q, Zhao Y, Zhai L, Zhong R, Li C, Zou X, Meng J, Chen AK, Puri PL, Chen M, Zhu D
Nature communications814016(2017 Jan)

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.
Anderson DM, Anderson KM, Chang CL, Makarewich CA, Nelson BR, McAnally JR, Kasaragod P, Shelton JM, Liou J, Bassel-Duby R, Olson EN
Cell160(4)595-606(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following MRLN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MRLN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu81121 NM_001304731.1
Latest version!
Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00
OHu81121 NM_001304732.1
Latest version!
Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu81121
Clone ID Related Accession (Same CDS sequence) NM_001304732.1 , NM_001304731.1
Accession Version NM_001304732.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 141bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-15
Organism Homo sapiens(Human)
Product myoregulin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB019391.1, BM021470.1 and BG210823.1. On Feb 6, 2015 this sequence version replaced NR_038200.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: BM021470.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2158800 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001291661.1
CDS339..479
Misc Feature(1)228..230
Misc Feature(2)402..464
Exon (1)1..92
Exon (2)93..214
Exon (3)215..318
Exon (4)319..549
Translation

Target ORF information:

RefSeq Version NM_001304732.1
Organism Homo sapiens(Human)
Definition Homo sapiens myoregulin (MRLN), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001304732.1

ORF Insert Sequence:

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu81121
Clone ID Related Accession (Same CDS sequence) NM_001304732.1 , NM_001304731.1
Accession Version NM_001304731.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 141bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-15
Organism Homo sapiens(Human)
Product myoregulin
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB019391.1 and BG210823.1. On Feb 6, 2015 this sequence version replaced NR_038199.1. Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. ##Evidence-Data-START## Transcript exon combination :: AB019391.1, AF086308.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1970526, SAMEA2142586 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001291660.1
CDS217..357
Misc Feature(1)106..108
Misc Feature(2)280..342
Exon (1)1..92
Exon (2)93..196
Exon (3)197..427
Translation

Target ORF information:

RefSeq Version NM_001304731.1
Organism Homo sapiens(Human)
Definition Homo sapiens myoregulin (MRLN), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001304731.1

ORF Insert Sequence:

1
61
121
ATGACTGGTA AAAACTGGAT ATTAATTTCT ACTACTACTC CCAAAAGTCT AGAAGATGAA 
ATTGTGGGAA GACTTCTAAA AATTTTGTTT GTTATCTTTG TTGACTTAAT TTCTATTATA
TATGTTGTGA TAACTTCTTA G

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Long non-coding RNA Linc-RAM enhances myogenic differentiation by interacting with MyoD.
Nature communications814016(2017 Jan)
Yu X,Zhang Y,Li T,Ma Z,Jia H,Chen Q,Zhao Y,Zhai L,Zhong R,Li C,Zou X,Meng J,Chen AK,Puri PL,Chen M,Zhu D


book

A micropeptide encoded by a putative long noncoding RNA regulates muscle performance.
Cell160(4)595-606(2015 Feb)
Anderson DM,Anderson KM,Chang CL,Makarewich CA,Nelson BR,McAnally JR,Kasaragod P,Shelton JM,Liou J,Bassel-Duby R,Olson EN


 
*
*
*
*