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GNB2L1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GNB2L1
Entrez Gene ID 10399
Full Name guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
Synonyms Gnb2-rs1, H12.3, HLC-7, PIG21, RACK1
General protein information
Preferred Names
guanine nucleotide-binding protein subunit beta-2-like 1
Names
guanine nucleotide-binding protein subunit beta-2-like 1
lung cancer oncogene 7
proliferation-inducing gene 21
receptor for activated C kinase 1
human lung cancer oncogene 7 protein
receptor of activated protein kinase C 1
cell proliferation-inducing gene 21 protein
guanine nucleotide-binding protein subunit beta-like protein 12.3
protein homologous to chicken B complex protein, guanine nucleotide binding
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q35.3

Summary lac of sum
Disorder MIM:

176981


mRNA and Protein(s)

mRNA Protein Name
NM_006098 NP_006089 guanine nucleotide-binding protein subunit beta-2-like 1



Homo sapiens (human) GNB2L1 NP_006089.1
Pan troglodytes (chimpanzee) GNB2L1 XP_518165.3
Macaca mulatta (Rhesus monkey) LOC708526 XP_001105066.1
Canis lupus familiaris (dog) GNB2L1 XP_005626337.1
Bos taurus (cattle) GNB2L1 XP_005209294.1
Mus musculus (house mouse) Gnb2l1 NP_032169.1
Rattus norvegicus (Norway rat) Gnb2l1 NP_570090.2
Gallus gallus (chicken) GNB2L1 NP_001004378.1
Danio rerio (zebrafish) gnb2l1 NP_571519.1
Drosophila melanogaster (fruit fly) Rack1 NP_001260218.1
Caenorhabditis elegans rack-1 NP_501859.1
Arabidopsis thaliana (thale cress) ATARCA NP_173248.1
Arabidopsis thaliana (thale cress) RACK1B_AT NP_175296.1
Arabidopsis thaliana (thale cress) RACK1C_AT NP_188441.1
Xenopus (Silurana) tropicalis (western clawed frog) gnb2l1 NP_001004946.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GNB2L1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GNB2L1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price Select
OHu15971
NM_006098 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$154.50-$216.30
$309.00
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu15971
Clone ID Related Accession (Same CDS sequence) NM_006098
Accession Version NM_006098.4 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 954bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product guanine nucleotide-binding protein subunit beta-2-like 1
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AK222488.1, M24194.1 and BC029996.1. On Dec 14, 2005 this sequence version replaced gi:55742675. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK222488.1, BC021993.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968832, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGACTGAGC AGATGACCCT TCGTGGCACC CTCAAGGGCC ACAACGGCTG GGTAACCCAG 
ATCGCTACTA CCCCGCAGTT CCCGGACATG ATCCTCTCCG CCTCTCGAGA TAAGACCATC
ATCATGTGGA AACTGACCAG GGATGAGACC AACTATGGAA TTCCACAGCG TGCTCTGCGG
GGTCACTCCC ACTTTGTTAG TGATGTGGTT ATCTCCTCAG ATGGCCAGTT TGCCCTCTCA
GGCTCCTGGG ATGGAACCCT GCGCCTCTGG GATCTCACAA CGGGCACCAC CACGAGGCGA
TTTGTGGGCC ATACCAAGGA TGTGCTGAGT GTGGCCTTCT CCTCTGACAA CCGGCAGATT
GTCTCTGGAT CTCGAGATAA AACCATCAAG CTATGGAATA CCCTGGGTGT GTGCAAATAC
ACTGTCCAGG ATGAGAGCCA CTCAGAGTGG GTGTCTTGTG TCCGCTTCTC GCCCAACAGC
AGCAACCCTA TCATCGTCTC CTGTGGCTGG GACAAGCTGG TCAAGGTATG GAACCTGGCT
AACTGCAAGC TGAAGACCAA CCACATTGGC CACACAGGCT ATCTGAACAC GGTGACTGTC
TCTCCAGATG GATCCCTCTG TGCTTCTGGA GGCAAGGATG GCCAGGCCAT GTTATGGGAT
CTCAACGAAG GCAAACACCT TTACACGCTA GATGGTGGGG ACATCATCAA CGCCCTGTGC
TTCAGCCCTA ACCGCTACTG GCTGTGTGCT GCCACAGGCC CCAGCATCAA GATCTGGGAT
TTAGAGGGAA AGATCATTGT AGATGAACTG AAGCAAGAAG TTATCAGTAC CAGCAGCAAG
GCAGAACCAC CCCAGTGCAC CTCCCTGGCC TGGTCTGCTG ATGGCCAGAC TCTGTTTGCT
GGCTACACGG ACAACCTGGT GCGAGTGTGG CAGGTGACCA TTGGCACACG CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_006089.1
CDS107..1060
Misc Feature(1)1..1(+)
Misc Feature(2)3..3(+)
Misc Feature(3)107..109(+)
Misc Feature(4)110..1036(+)
Misc Feature(5)110..112(+)
Misc Feature(6)125..1039(+)
Misc Feature(7)143..238(+)
Misc Feature(8)146..1039(+)
Misc Feature(9)287..379(+)
Misc Feature(10)413..505(+)
Misc Feature(11)494..496(+)
Misc Feature(12)542..640(+)
Misc Feature(13)674..766(+)
Misc Feature(14)788..790(+)
Misc Feature(15)788..790(+)
Misc Feature(16)797..886(+)
Misc Feature(17)947..1039(+)
Exon (1)1..215
Gene:GNB2L1
Gene Synonym:
Exon (2)216..387
Gene:GNB2L1
Gene Synonym:
Exon (3)388..535
Gene:GNB2L1
Gene Synonym:
Exon (4)536..631
Gene:GNB2L1
Gene Synonym:
Exon (5)632..742
Gene:GNB2L1
Gene Synonym:
Exon (6)743..883
Gene:GNB2L1
Gene Synonym:
Exon (7)884..994
Gene:GNB2L1
Gene Synonym:
Exon (8)995..1109
Gene:GNB2L1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_006098
Organism Homo sapiens (human)
Definition Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 (GNB2L1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_006098

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
ATGACTGAGC AGATGACCCT TCGTGGCACC CTCAAGGGCC ACAACGGCTG GGTAACCCAG 
ATCGCTACTA CCCCGCAGTT CCCGGACATG ATCCTCTCCG CCTCTCGAGA TAAGACCATC
ATCATGTGGA AACTGACCAG GGATGAGACC AACTATGGAA TTCCACAGCG TGCTCTGCGG
GGTCACTCCC ACTTTGTTAG TGATGTGGTT ATCTCCTCAG ATGGCCAGTT TGCCCTCTCA
GGCTCCTGGG ATGGAACCCT GCGCCTCTGG GATCTCACAA CGGGCACCAC CACGAGGCGA
TTTGTGGGCC ATACCAAGGA TGTGCTGAGT GTGGCCTTCT CCTCTGACAA CCGGCAGATT
GTCTCTGGAT CTCGAGATAA AACCATCAAG CTATGGAATA CCCTGGGTGT GTGCAAATAC
ACTGTCCAGG ATGAGAGCCA CTCAGAGTGG GTGTCTTGTG TCCGCTTCTC GCCCAACAGC
AGCAACCCTA TCATCGTCTC CTGTGGCTGG GACAAGCTGG TCAAGGTATG GAACCTGGCT
AACTGCAAGC TGAAGACCAA CCACATTGGC CACACAGGCT ATCTGAACAC GGTGACTGTC
TCTCCAGATG GATCCCTCTG TGCTTCTGGA GGCAAGGATG GCCAGGCCAT GTTATGGGAT
CTCAACGAAG GCAAACACCT TTACACGCTA GATGGTGGGG ACATCATCAA CGCCCTGTGC
TTCAGCCCTA ACCGCTACTG GCTGTGTGCT GCCACAGGCC CCAGCATCAA GATCTGGGAT
TTAGAGGGAA AGATCATTGT AGATGAACTG AAGCAAGAAG TTATCAGTAC CAGCAGCAAG
GCAGAACCAC CCCAGTGCAC CTCCCTGGCC TGGTCTGCTG ATGGCCAGAC TCTGTTTGCT
GGCTACACGG ACAACCTGGT GCGAGTGTGG CAGGTGACCA TTGGCACACG CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

RACK1 promoted the growth and migration of the cancer cells in the progression of esophageal squamous cell carcinoma
Tumour Biol. 34 (6), 3893-3899 (2013)
Hu F, Tao Z, Wang M, Li G, Zhang Y, Zhong H, Xiao H, Xie X and Ju M.


book

Forced downregulation of RACK1 inhibits glioma development by suppressing Src/Akt signaling activity
Oncol. Rep. 30 (5), 2195-2202 (2013)
Peng R, Jiang B, Ma J, Ma Z, Wan X, Liu H, Chen Z, Cheng Q and Chen R.


book

Proteomic profiling of endothelial invasion revealed receptor for activated C kinase 1 (RACK1) complexed with vimentin to regulate focal adhesion kinase (FAK)
J. Biol. Chem. 288 (42), 30720-30733 (2013)
Dave JM, Kang H, Abbey CA, Maxwell SA and Bayless KJ.


book

RACK1 promotes prostate cancer cell proliferation, invasion and metastasis
Mol Med Rep 8 (4), 999-1004 (2013)
Shen F, Yan C, Liu M, Feng Y and Chen Y.


book

Modulation of Rack-1/PKCbetaII signalling by soluble AbetaPPalpha in SH-SY5Y cells
Curr Alzheimer Res 10 (7), 697-705 (2013)
Buoso E, Biundo F, Lanni C, Aiello S, Grossi S, Schettini G, Govoni S and Racchi M.


book

A direct interaction between G-protein beta gamma subunits and the Raf-1 protein kinase
J. Biol. Chem. 270 (24), 14251-14254 (1995)
Pumiglia KM, LeVine H, Haske T, Habib T, Jove R and Decker SJ.


book

Construction of a human full-length cDNA bank
Gene 150 (2), 243-250 (1994)
Kato S, Sekine S, Oh SW, Kim NS, Umezawa Y, Abe N, Yokoyama-Kobayashi M and Aoki T.


book

p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C
Biochemistry 31 (35), 8120-8124 (1992)
Mochly-Rosen D, Miller KG, Scheller RH, Khaner H, Lopez J and Smith BL.


book

Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin
J. Infect. 24 (3), 317-320 (1992)
Dawson SJ and White LA.


book

Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex
Proc. Natl. Acad. Sci. U.S.A. 86 (12), 4594-4598 (1989)
Guillemot F, Billault A and Auffray C.


 
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