Gene Symbol | EBNA1BP2 |
Entrez Gene ID | 10969 |
Full Name | EBNA1 binding protein 2 |
Synonyms | EBP2,NOBP,P40 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » EBNA1BP2 cDNA ORF clone
Gene Symbol | EBNA1BP2 |
Entrez Gene ID | 10969 |
Full Name | EBNA1 binding protein 2 |
Synonyms | EBP2,NOBP,P40 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001159936.1 | NP_001153408.1 | probable rRNA-processing protein EBP2 isoform 1 |
NM_006824.2 | NP_006815.2 | probable rRNA-processing protein EBP2 isoform 2 |
Canis lupus familiaris (dog) | EBNA1BP2 | XP_853475.1 |
Mus musculus (house mouse) | Ebna1bp2 | NP_081208.1 |
Caenorhabditis elegans (roundworm) | C18A3.3 | NP_495125.1 |
EBNA1BP2 | XP_001091939.2 | |
Bos taurus (cattle) | EBNA1BP2 | NP_001029589.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP011383 | XP_317941.4 |
Gallus gallus (chicken) | EBNA1BP2 | XP_422396.1 |
Danio rerio (zebrafish) | ebna1bp2 | NP_001003840.1 |
Homo sapiens (human) | EBNA1BP2 | NP_001153408.1 |
Drosophila melanogaster (fruit fly) | CG1542 | NP_651850.1 |
Xenopus tropicalis (tropical clawed frog) | ebna1bp2 | NP_001017151.1 |
Xenopus tropicalis (tropical clawed frog) | LOC101730438 | XP_004914014.1 |
Rattus norvegicus (Norway rat) | Ebna1bp2 | NP_001008721.1 |
Rattus norvegicus (Norway rat) | LOC100912375 | XP_003750055.1 |
Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)
Epstein-Barr virus latent antigens EBNA3C and EBNA1 modulate epithelial to mesenchymal transition of cancer cells associated with tumor metastasis.
Gaur N, Gandhi J, Robertson ES, Verma SC, Kaul R
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine36(4)3051-60(2015 Apr)
A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation, and tumorigenesis.
Liao P, Wang W, Shen M, Pan W, Zhang K, Wang R, Chen T, Chen Y, Chen H, Wang P
Cell death & disease5e1032(2014 Jan)
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
We further show that the primary tumors as well as metastasized lesions derived from EBV antigen-expressing cancer cells( EBNA3C or EBNA1 ) in nude mice model display EMT markers expression pattern
Title: Epstein-Barr virus latent antigens EBNA3C and EBNA1 modulate epithelial to mesenchymal transition of cancer cells associated with tumor metastasis.
EBP2 is a novel binding partner of c-Myc that regulates cell proliferation, and tumorigenesis via a positive feedback loop.
Title: A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation, and tumorigenesis.
BXDC1 and EBNA1BP2 function in a dynamic scaffold for ribosome biogenesis.
Title: Proteomic and targeted analytical identification of BXDC1 and EBNA1BP2 as dynamic scaffold proteins in the nucleolus.
RNA and protein levels of cyclin E1, a dominant oncoprotein, were elevated in the EBP2- enhanced green fluorescent protein stable clones.
Title: Ectopic EBP2 expression enhances cyclin E1 expression and induces chromosome instability in HEK293 stable clones.
Data show that human EBNA1 binding protein 2 (hEBP2 is essential for the proliferation of human cells and that repression of hEBP2 severely decreases the ability of EBNA1 and EBV-based plasmids to bind mitotic chromosomes.
Title: EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases.
The following EBNA1BP2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EBNA1BP2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu05765 | |
Clone ID Related Accession (Same CDS sequence) | NM_006824.2 | |
Accession Version | NM_006824.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | probable rRNA-processing protein EBP2 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM791254.1, BC009175.2, U86602.1, Z40246.1 and R49106.1. On May 15, 2009 this sequence version replaced NM_006824.1. Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.108571.1, SRR1803613.212372.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACACTC CCCCGCTCTC GGATTCGGAG TCGGAATCCG ATGAATCCCT TGTCACAGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_006815.2 |
CDS | 198..1118 |
Translation |
Target ORF information:
Target ORF information:
|
NM_006824.2 |
1 | ATGGACACTC CCCCGCTCTC GGATTCGGAG TCGGAATCCG ATGAATCCCT TGTCACAGAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu03069 | |
Clone ID Related Accession (Same CDS sequence) | NM_001159936.1 | |
Accession Version | NM_001159936.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1086bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-09 | |
Organism | Homo sapiens(human) | |
Product | probable rRNA-processing protein EBP2 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from CN390915.1, BC009175.2, U86602.1, Z40246.1 and R49106.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.210843.1, SRR1163658.272675.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTATCCAG AGGCGCTACC TGTAGGGATC CTAAGCAACC CGGACACTTT CAAACGCCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001153408.1 |
CDS | 150..1235 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001159936.1 |
1 | ATGTATCCAG AGGCGCTACC TGTAGGGATC CTAAGCAACC CGGACACTTT CAAACGCCGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Architecture of the human interactome defines protein communities and disease networks. |
Epstein-Barr virus latent antigens EBNA3C and EBNA1 modulate epithelial to mesenchymal transition of cancer cells associated with tumor metastasis. |
A positive feedback loop between EBP2 and c-Myc regulates rDNA transcription, cell proliferation, and tumorigenesis. |
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. |