SLITRK1 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | SLITRK1 |
| Entrez Gene ID | 114798 |
| Full Name | SLIT and NTRK like family member 1 |
| Synonyms | LRRC12,TTM |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the SLITRK protein family. Members of this family are integral membrane proteins that are characterized by two N-terminal leucine-rich repeat (LRR) domains and a C-terminal region that shares homology with trk neurotrophin receptors. However, the protein encoded by this gene lacks the region of homology to neurotrophin receptors. This protein is thought to be involved in neurite outgrowth. Mutations in this gene may be associated with Tourette syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]. |
| Disorder MIM: | |
| Disorder Html: | Tourette syndrome, 137580 (3); ?Trichotillomania, 613229 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_052910.2 | NP_443142.1 | SLIT and NTRK-like protein 1 precursor |
| NM_001281503.1 | NP_001268432.1 | SLIT and NTRK-like protein 1 precursor |
| NM_001281503.2 | NP_001268432.1 | SLIT and NTRK-like protein 1 precursor |
| Rattus norvegicus (Norway rat) | Slitrk1 | NP_001100753.1 |
| Danio rerio (zebrafish) | LOC558743 | XP_005174686.1 |
| Homo sapiens (human) | SLITRK1 | NP_001268432.1 |
| SLITRK1 | XP_001093240.1 | |
| Mus musculus (house mouse) | Slitrk1 | NP_951020.1 |
| Gallus gallus (chicken) | SLITRK1 | XP_416993.2 |
| Xenopus tropicalis (tropical clawed frog) | slitrk1 | NP_001096395.1 |
| Bos taurus (cattle) | SLITRK1 | XP_003586770.1 |
| Pan troglodytes (chimpanzee) | SLITRK1 | XP_001143864.1 |
| Canis lupus familiaris (dog) | SLITRK1 | XP_005634067.1 |
Related articles in PubMed
Slitrk1 is localized to excitatory synapses and promotes their development.
Beaubien F, Raja R, Kennedy TE, Fournier AE, Cloutier JF
Scientific reports627343(2016 Jun)
Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer.
Inai A, Tochigi M, Kuwabara H, Nishimura F, Kato K, Eriguchi Y, Shimada T, Furukawa M, Kawamura Y, Sasaki T, Kakiuchi C, Kasai K, Kano Y
Psychiatric genetics25(6)256-8(2015 Dec)
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
Cai DC, Fonteijn H, Guadalupe T, Zwiers M, Wittfeld K, Teumer A, Hoogman M, Arias-V?squez A, Yang Y, Buitelaar J, Fern?ndez G, Brunner HG, van Bokhoven H, Franke B, Hegenscheid K, Homuth G, Fisher SE, Grabe HJ, Francks C, Hagoort P
Genes, brain, and behavior13(7)675-85(2014 Sep)
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
Xie T, Deng L, Mei P, Zhou Y, Wang B, Zhang J, Lin J, Wei Y, Zhang X, Xu R
Neurobiology of aging35(7)1778.e9-1778.e23(2014 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data provide partial support for the implication of SLITRK1 in the pathogenesis of Tourette syndrome.
Title: Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer.
The study of chromosomal aberrations in Tourette syndrome etiology has implicated multiple genes, with SLITRK1 being the most prominent example.
Title: The genetic basis of Gilles de la Tourette Syndrome.
One of the few genes that has been linked to TS is the SLITRK1 (Slit and Trk-like 1) gene, where four variations have been suggested as possible disease-associated changes
Title: Sequence analysis of SLITRK1 for var321 in Danish patients with Tourette syndrome and review of the literature.
the N400I variant of SLITRK1 may have a role in obsessive-compulsive disorder
Title: Characterization of SLITRK1 variation in obsessive-compulsive disorder.
DM1 motoneuron/muscle cell cocultures showed alterations that are consistent with the known role of SLITRK genes in neurite outgrowth, neuritogenesis, and synaptogenesis; functional defects can be directly attributed to SLITRK misexpression.
Title: Mutant human embryonic stem cells reveal neurite and synapse formation defects in type 1 myotonic dystrophy.
The following SLITRK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SLITRK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu20555 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_052910.2 , NM_001281503.1 , NM_001281503.2 | |
| Accession Version | NM_052910.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-04-08 | |
| Organism | Homo sapiens(human) | |
| Product | SLIT and NTRK-like protein 1 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB067497.1, DA240278.1, AA677641.1 and AI500170.1. This sequence is a reference standard in the RefSeqGene project. On Jul 30, 2013 this sequence version replaced NM_052910.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AB067497.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_443142.1 |
| CDS | 887..2977 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_052910.2 |
ORF Insert Sequence:
1 | ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20555 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_052910.2 , NM_001281503.1 , NM_001281503.2 | |
| Accession Version | NM_001281503.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-23 | |
| Organism | Homo sapiens(human) | |
| Product | SLIT and NTRK-like protein 1 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY157227.1, DC334447.1, AB067497.1 and AI500170.1. Transcript Variant: This variant (2) lacks an internal segment compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.133080.1, SRR1660807.27083.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001268432.1 |
| CDS | 444..2534 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001281503.1 |
ORF Insert Sequence:
1 | ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu20555 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_052910.2 , NM_001281503.1 , NM_001281503.2 | |
| Accession Version | NM_001281503.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2091bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-06-01 | |
| Organism | Homo sapiens(human) | |
| Product | SLIT and NTRK-like protein 1 precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL355481.12, HY157227.1, DC334447.1, AB067497.1 and AI500170.1. On Jun 2, 2019 this sequence version replaced NM_001281503.1. Transcript Variant: This variant (2) lacks an internal segment compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.133080.1, SRR1660809.112857.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145743, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001268432.1 |
| CDS | 525..2615 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001281503.2 |
ORF Insert Sequence:
1 | ATGCTGCTTT GGATTCTGTT GCTGGAGACG TCTCTTTGTT TTGCCGCTGG AAACGTTACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
Slitrk1 is localized to excitatory synapses and promotes their development. |
|
Analysis of SLITRK1 in Japanese patients with Tourette syndrome using a next-generation sequencer. |
|
A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus. |
|
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations. |