KCTD12 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | KCTD12 |
| Entrez Gene ID | 115207 |
| Full Name | potassium channel tetramerization domain containing 12 |
| Synonyms | C13orf2,PFET1,PFETIN |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_138444.3 | NP_612453.1 | BTB/POZ domain-containing protein KCTD12 |
| NM_138444.4 | NP_612453.1 | BTB/POZ domain-containing protein KCTD12 |
| Homo sapiens (human) | KCTD12 | NP_612453.1 |
| Pan troglodytes (chimpanzee) | KCTD12 | XP_001137708.2 |
| Bos taurus (cattle) | KCTD12 | XP_005213929.1 |
| Rattus norvegicus (Norway rat) | Kctd12 | XP_006252482.1 |
| Danio rerio (zebrafish) | kctd12.1 | NP_919386.1 |
| Canis lupus familiaris (dog) | KCTD12 | XP_542614.3 |
| KCTD12 | XP_001085454.1 | |
| Danio rerio (zebrafish) | kctd12.2 | NP_001029191.1 |
| Mus musculus (house mouse) | Kctd12 | NP_808383.3 |
| Xenopus tropicalis (tropical clawed frog) | kctd12 | NP_001096456.1 |
Related articles in PubMed
KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Zhong Y, Yang J, Xu WW, Wang Y, Zheng CC, Li B, He QY
Oncogene36(44)6177-6189(2017 Nov)
Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells.
Luo L, Cui J, Feng Z, Li Y, Wang M, Cai Y, Wu Y, Jin J
Oncology reports37(2)871-878(2017 Feb)
The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states.
Smaldone G, Pirone L, Pedone E, Marlovits T, Vitagliano L, Ciccarelli L
FEBS letters590(11)1663-71(2016 Jun)
KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.
Li L, Duan T, Wang X, Zhang RH, Zhang M, Wang S, Wang F, Wu Y, Huang H, Kang T
Scientific reports620460(2016 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
our study demonstrate that KCTD12 binds to CDC25B and activates CDK1 and Aurora A to facilitate the G2/M transition and promote tumorigenesis and that Aurora A phosphorylates KCTD12 at serine 243 to trigger a positive feedback loop, thereby potentiating the effects of KCTD12. Thus, the KCTD12-CDC25B-CDK1-Aurora A axis has important implications for cancer diagnoses and prognoses.
Title: KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition.
Low KCTD12 expression is associated with uveal melanoma.
Title: Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells.
Studies determined that KCTD12 plays an important role in the tumorigenesis of colorectal cancer progression via activation of the ERK signaling pathway.
Title: KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway.
N-terminal domain of KCTD12 assumes an alpha/beta structure, whereas the C-terminal domain is predominantly characterized by a beta-structure.
Title: A biophysical characterization of the folded domains of KCTD12: insights into interaction with the GABAB2 receptor.
KCTD12 is a useful and reliable biomarker for both the diagnosis and prognosis of gastrointestinal stromal tumor.
Title: Use of potassium channel tetramerization domain-containing 12 as a biomarker for diagnosis and prognosis of gastrointestinal stromal tumor.
The following KCTD12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCTD12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu10914 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_138444.3 , NM_138444.4 | |
| Accession Version | NM_138444.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-02-16 | |
| Organism | Homo sapiens(human) | |
| Product | BTB/POZ domain-containing protein KCTD12 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB153209.1, AF359381.1, AC000403.1 and BU742274.1. On May 1, 2007 this sequence version replaced NM_138444.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF359381.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCTCTGG CGGACAGCAC ACGTGGATTA CCCAACGGGG GCGGCGGCGG GGGCGGCAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_612453.1 |
| CDS | 258..1235 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_138444.3 |
ORF Insert Sequence:
1 | ATGGCTCTGG CGGACAGCAC ACGTGGATTA CCCAACGGGG GCGGCGGCGG GGGCGGCAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu10914 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_138444.3 , NM_138444.4 | |
| Accession Version | NM_138444.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 978bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-10-25 | |
| Organism | Homo sapiens(human) | |
| Product | BTB/POZ domain-containing protein KCTD12 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB153209.1, AF359381.1, AC000403.1 and BU742274.1. On May 17, 2019 this sequence version replaced NM_138444.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AF359381.1, BC013764.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000377474.4/ ENSP00000366694.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGGCTCTGG CGGACAGCAC ACGTGGATTA CCCAACGGGG GCGGCGGCGG GGGCGGCAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_612453.1 |
| CDS | 258..1235 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_138444.4 |
ORF Insert Sequence:
1 | ATGGCTCTGG CGGACAGCAC ACGTGGATTA CCCAACGGGG GCGGCGGCGG GGGCGGCAGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
KCTD12 promotes tumorigenesis by facilitating CDC25B/CDK1/Aurora A-dependent G2/M transition. |
|
Lentiviral-mediated overexpression of KCTD12 inhibits the proliferation of human uveal melanoma OCM-1 cells. |
|
The BTB domains of the potassium channel tetramerization domain proteins prevalently assume pentameric states. |
|
KCTD12 Regulates Colorectal Cancer Cell Stemness through the ERK Pathway. |