×

CATSPER1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol CATSPER1
Entrez Gene ID 117144
Full Name cation channel sperm associated 1
Synonyms CATSPER,SPGF7
General protein information
Preferred Names

cation channel sperm associated 1

Names

cation channel sperm-associated protein 1
hCatSper
sperm ion channel
sperm-associated cation channel 1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

11

11q13.1

Summary Calcium ions play a primary role in the regulation of sperm motility. This gene belongs to a family of putative cation channels that are specific to spermatozoa and localize to the flagellum. The protein family features a single repeat with six membrane-spanning segments and a predicted calcium-selective pore region. [provided by RefSeq, Jul 2008].
Disorder MIM:

606389

Disorder Html: Male infertility, nonsyndromic, autosomal recessive, 612997 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_053054.3 NP_444282.3 cation channel sperm-associated protein 1



Bos taurus (cattle) CATSPER1 XP_005227286.1
Macaca mulatta (rhesus monkey) CATSPER1 XP_001118063.1
Homo sapiens (human) CATSPER1 NP_444282.3
Pan troglodytes (chimpanzee) CATSPER1 XP_003313190.1
Mus musculus (house mouse) Catsper1 NP_647462.1
Rattus norvegicus (Norway rat) Catsper1 XP_001070492.2
Canis lupus familiaris (dog) CATSPER1 XP_005631803.1


Related articles in PubMed

Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa.
Williams HL, Mansell S, Alasmari W, Brown SG, Wilson SM, Sutton KA, Miller MR, Lishko PV, Barratt CL, Publicover SJ, Martins da Silva S
Human reproduction (Oxford, England)30(12)2737-46(2015 Dec)

Analysis of the correlation of CATSPER single nucleotide polymorphisms (SNPs) with idiopathic asthenospermia.
Shu F, Zhou X, Li F, Lu D, Lei B, Li Q, Yang Y, Yang X, Shi R, Mao X
Journal of assisted reproduction and genetics32(11)1643-9(2015 Nov)

Widespread macromolecular interaction perturbations in human genetic disorders.
Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabási AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M
Cell161(3)647-660(2015 Apr)

The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.
Mata-Rocha M, Hernández-Sánchez J, Guarneros G, de la Chesnaye E, Sánchez-Tusié AA, Treviño CL, Felix R, Oviedo N
FEBS letters588(18)3352-60(2014 Sep)

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Navarini AA, Simpson MA, Weale M, Knight J, Carlavan I, Reiniche P, Burden DA, Layton A, Bataille V, Allen M, Pleass R, Pink A, Creamer D, English J, Munn S, Walton S, , Willis C, Déret S, Voegel JJ, Spector T, Smith CH, Trembath RC, Barker JN
Nature communications54020(2014 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Sperm with a near absence of CatSper current failed to respond to activation of CatSper by progesterone and there was fertilization failure at IVF.
Title: Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa.

The role of CATSPER1 in idiopathic asthenospermia pathogenesis: exonal SNP rs1893316 in CATSPER1 significantly correlated with idiopathic asthenospermia risk
Title: Analysis of the correlation of CATSPER single nucleotide polymorphisms (SNPs) with idiopathic asthenospermia.

Sox5 and Sox9 cause a significant increase in transactivation of the Catsper1 promoter.
Title: The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.

Progesterone via CatSper activates the PI3K-AKT pathway required for motility and hyperactivation but not for acrosome reaction.
Title: Progesterone utilizes the PI3K-AKT pathway in human spermatozoa to regulate motility and hyperactivation but not acrosome reaction.

CatSper is indeed the principal Ca2+ channel of human spermatozoa, and that it is strongly potentiated by progesterone.
Title: Disruption of the principal, progesterone-activated sperm Ca2+ channel in a CatSper2-deficient infertile patient.

The following CATSPER1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CATSPER1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu22164 NM_053054.3
Latest version!
Homo sapiens cation channel sperm associated 1 (CATSPER1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $391.30
$559.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu22164
Clone ID Related Accession (Same CDS sequence) NM_053054.3
Accession Version NM_053054.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2343bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-22
Organism Homo sapiens(Human)
Product cation channel sperm-associated protein 1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP006287.2, BC032950.2, BC036522.2 and AF407333.1. This sequence is a reference standard in the RefSeqGene project. On Jan 24, 2009 this sequence version replaced NM_053054.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032950.2, AF407333.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGATCAAA ACTCAGTGCC TGAAAAGGCT CAGAATGAGG CAGACACCAA TAACGCAGAT 
AGGTTCTTTC GCTCTCACTC ATCACCCCCA CACCACAGGC CAGGCCACAG CAGAGCTCTC
CACCATTACG AGTTGCACCA TCACGGCGTG CCCCACCAAC GTGGTGAATC TCACCACCCT
CCGGAGTTCC AAGACTTCCA CGACCAAGCC TTGTCCTCCC ATGTCCACCA ATCTCACCAC
CACAGCGAGG CACGGAATCA CGGCAGAGCC CATGGCCCCA CAGGCTTTGG TCTGGCTCCC
TCTCAAGGCG CCGTCCCCTC CCACCGTTCC TACGGTGAGG ACTACCATGA TGAGCTCCAA
CGTGATGGCA GGAGGCATCA TGATGGGTCC CAATACGGTG GGTTCCATCA GCAGAGTGAC
TCCCATTACC ATAGGGGGTC TCACCATGGC AGACCCCAAT ATCTCGGTGA GAATTTATCC
CACTATTCCT CTGGCGTGCC CCACCACGGT GAGGCTTCCC ACCATGGTGG GTCCTACCTC
CCCCATGGAC CCAATCCCTA CAGTGAGTCC TTCCACCACA GCGAGGCTTC CCACCTTAGC
GGGCTCCAAC ACGATGAGTC CCAGCATCAC CAAGTCCCCC ACCGTGGCTG GCCCCACCAT
CACCAAGTCC ACCACCATGG CAGGTCCCGT CATCATGAAG CCCACCAGCA TGGAAAGTCT
CCTCATCACG GAGAGACCAT TTCCCCTCAT TCCTCTGTGG GGTCCTACCA GCGTGGGATA
TCTGACTATC ACAGCGAGTA CCACCAAGGT GATCACCACC CCAGTGAGTA CCACCATGGC
GACCATCCCC ACCACACACA GCACCACTAC CACCAGACCC ACCGGCACCG AGACTACCAT
CAGCACCAAG ACCACCACGG CGCGTATCAT TCCAGTTACC TCCATGGCGA CTACGTCCAG
AGCACTTCCC AACTCTCTAT CCCACACACA TCCCGGAGCC TGATTCACGA TGCCCCCGGC
CCTGCTGCTT CTCGTACAGG AGTCTTCCCC TATCACGTAG CACACCCACG GGGCTCGGCT
CACAGCATGA CTCGGTCCTC CAGCACAATC CGCTCACGTG TCACCCAGAT GTCCAAAAAA
GTCCATACCC AGGATATCTC CACCAAACAT TCAGAAGACT GGGGCAAAGA AGAAGGGCAA
TTTCAGAAAC GCAAAACCGG CCGGCTCCAG CGGACCCGCA AGAAGGGACA CTCTACCAAT
CTCTTCCAGT GGCTGTGGGA AAAGCTAACC TTCCTCATTC AGGGCTTCCG GGAAATGATC
CGGAACCTGA CCCAATCCTT GGCCTTTGAA ACTTTCATCT TCTTCGTTGT CTGCCTCAAC
ACCGTCATGC TGGTGGCCCA GACCTTCGCT GAAGTCGAGA TCCGGGGCGA GTGGTACTTC
ATGGCCTTGG ACTCCATATT CTTCTGCATC TACGTGGTGG AAGCCCTGCT CAAGATCATC
GCCCTGGGCC TCTCGTACTT CTTTGACTTC TGGAACAATT TGGACTTCTT CATTATGGCC
ATGGCCGTGC TGGACTTCTT GCTGATGCAG ACCCACTCCT TCGCCATCTA CCACCAAAGC
CTCTTCCGGA TCCTCAAGGT CTTCAAGAGC CTGCGGGCCC TGAGGGCAAT CCGGGTCCTG
CGGAGGCTCA GCTTCCTGAC CAGCGTCCAG GAAGTGACAG GGACCCTGGG CCAGTCCTTG
CCGTCCATCG CAGCCATCCT CATCCTCATG TTTACCTGCC TCTTCCTCTT CTCCGCGGTC
CTCCGGGCAC TGTTCCGCAA ATCTGACCCC AAGCGCTTCC AGAACATCTT CACCACCATC
TTCACCCTCT TCACCTTGCT CACGCTGGAT GACTGGTCCC TCATCTACAT GGACAGCCGT
GCCCAGGGCG CCTGGTACAT CATTCCCATC CTCGTAATTT ACATCATCAT CCAGTACTTC
ATCTTCCTCA ACCTGGTGAT TACTGTCCTG GTGGATAGCT TCCAGACGGC GCTGTTCAAA
GGCCTTGAGA AAGCGAAGCA GGAGAGGGCC GCCCGGATCC AAGAGAAGCT GCTGGAAGAC
TCACTGACGG AGCTCAGAGC TGCAGAGCCC AAAGAGGTGG CGAGTGAAGG CACCATGCTG
AAGCGGCTCA TCGAGAAAAA GTTTGGGACC ATGACTGAGA AGCAGCAGGA GCTCCTGTTC
CATTACCTGC AGCTGGTGGC AAGCGTGGAG CAGGAGCAGC AGAAGTTCCG CTCCCAGGCA
GCCGTCATCG ATGAGATTGT GGACACCACA TTTGAGGCTG GAGAAGAGGA CTTCAGGAAT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_444282.3
CDS139..2481
Misc Feature(1)1474..1536
Misc Feature(2)1585..2169
Misc Feature(3)1594..2025
Misc Feature(4)1594..1656
Misc Feature(5)1684..1746
Misc Feature(6)1762..1824
Misc Feature(7)1876..1938
Misc Feature(8)2077..2139
Exon (1)1..1354
Exon (2)1355..1567
Exon (3)1568..1681
Exon (4)1682..1829
Exon (5)1830..1921
Exon (6)1922..2065
Exon (7)2066..2129
Exon (8)2130..2202
Exon (9)2203..2263
Exon (10)2264..2339
Exon (11)2340..2454
Exon (12)2455..2619
Translation

Target ORF information:

RefSeq Version NM_053054.3
Organism Homo sapiens(Human)
Definition Homo sapiens cation channel sperm associated 1 (CATSPER1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_053054.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
ATGGATCAAA ACTCAGTGCC TGAAAAGGCT CAGAATGAGG CAGACACCAA TAACGCAGAT 
AGGTTCTTTC GCTCTCACTC ATCACCCCCA CACCACAGGC CAGGCCACAG CAGAGCTCTC
CACCATTACG AGTTGCACCA TCACGGCGTG CCCCACCAAC GTGGTGAATC TCACCACCCT
CCGGAGTTCC AAGACTTCCA CGACCAAGCC TTGTCCTCCC ATGTCCACCA ATCTCACCAC
CACAGCGAGG CACGGAATCA CGGCAGAGCC CATGGCCCCA CAGGCTTTGG TCTGGCTCCC
TCTCAAGGCG CCGTCCCCTC CCACCGTTCC TACGGTGAGG ACTACCATGA TGAGCTCCAA
CGTGATGGCA GGAGGCATCA TGATGGGTCC CAATACGGTG GGTTCCATCA GCAGAGTGAC
TCCCATTACC ATAGGGGGTC TCACCATGGC AGACCCCAAT ATCTCGGTGA GAATTTATCC
CACTATTCCT CTGGCGTGCC CCACCACGGT GAGGCTTCCC ACCATGGTGG GTCCTACCTC
CCCCATGGAC CCAATCCCTA CAGTGAGTCC TTCCACCACA GCGAGGCTTC CCACCTTAGC
GGGCTCCAAC ACGATGAGTC CCAGCATCAC CAAGTCCCCC ACCGTGGCTG GCCCCACCAT
CACCAAGTCC ACCACCATGG CAGGTCCCGT CATCATGAAG CCCACCAGCA TGGAAAGTCT
CCTCATCACG GAGAGACCAT TTCCCCTCAT TCCTCTGTGG GGTCCTACCA GCGTGGGATA
TCTGACTATC ACAGCGAGTA CCACCAAGGT GATCACCACC CCAGTGAGTA CCACCATGGC
GACCATCCCC ACCACACACA GCACCACTAC CACCAGACCC ACCGGCACCG AGACTACCAT
CAGCACCAAG ACCACCACGG CGCGTATCAT TCCAGTTACC TCCATGGCGA CTACGTCCAG
AGCACTTCCC AACTCTCTAT CCCACACACA TCCCGGAGCC TGATTCACGA TGCCCCCGGC
CCTGCTGCTT CTCGTACAGG AGTCTTCCCC TATCACGTAG CACACCCACG GGGCTCGGCT
CACAGCATGA CTCGGTCCTC CAGCACAATC CGCTCACGTG TCACCCAGAT GTCCAAAAAA
GTCCATACCC AGGATATCTC CACCAAACAT TCAGAAGACT GGGGCAAAGA AGAAGGGCAA
TTTCAGAAAC GCAAAACCGG CCGGCTCCAG CGGACCCGCA AGAAGGGACA CTCTACCAAT
CTCTTCCAGT GGCTGTGGGA AAAGCTAACC TTCCTCATTC AGGGCTTCCG GGAAATGATC
CGGAACCTGA CCCAATCCTT GGCCTTTGAA ACTTTCATCT TCTTCGTTGT CTGCCTCAAC
ACCGTCATGC TGGTGGCCCA GACCTTCGCT GAAGTCGAGA TCCGGGGCGA GTGGTACTTC
ATGGCCTTGG ACTCCATATT CTTCTGCATC TACGTGGTGG AAGCCCTGCT CAAGATCATC
GCCCTGGGCC TCTCGTACTT CTTTGACTTC TGGAACAATT TGGACTTCTT CATTATGGCC
ATGGCCGTGC TGGACTTCTT GCTGATGCAG ACCCACTCCT TCGCCATCTA CCACCAAAGC
CTCTTCCGGA TCCTCAAGGT CTTCAAGAGC CTGCGGGCCC TGAGGGCAAT CCGGGTCCTG
CGGAGGCTCA GCTTCCTGAC CAGCGTCCAG GAAGTGACAG GGACCCTGGG CCAGTCCTTG
CCGTCCATCG CAGCCATCCT CATCCTCATG TTTACCTGCC TCTTCCTCTT CTCCGCGGTC
CTCCGGGCAC TGTTCCGCAA ATCTGACCCC AAGCGCTTCC AGAACATCTT CACCACCATC
TTCACCCTCT TCACCTTGCT CACGCTGGAT GACTGGTCCC TCATCTACAT GGACAGCCGT
GCCCAGGGCG CCTGGTACAT CATTCCCATC CTCGTAATTT ACATCATCAT CCAGTACTTC
ATCTTCCTCA ACCTGGTGAT TACTGTCCTG GTGGATAGCT TCCAGACGGC GCTGTTCAAA
GGCCTTGAGA AAGCGAAGCA GGAGAGGGCC GCCCGGATCC AAGAGAAGCT GCTGGAAGAC
TCACTGACGG AGCTCAGAGC TGCAGAGCCC AAAGAGGTGG CGAGTGAAGG CACCATGCTG
AAGCGGCTCA TCGAGAAAAA GTTTGGGACC ATGACTGAGA AGCAGCAGGA GCTCCTGTTC
CATTACCTGC AGCTGGTGGC AAGCGTGGAG CAGGAGCAGC AGAAGTTCCG CTCCCAGGCA
GCCGTCATCG ATGAGATTGT GGACACCACA TTTGAGGCTG GAGAAGAGGA CTTCAGGAAT
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Specific loss of CatSper function is sufficient to compromise fertilizing capacity of human spermatozoa.
Human reproduction (Oxford, England)30(12)2737-46(2015 Dec)
Williams HL,Mansell S,Alasmari W,Brown SG,Wilson SM,Sutton KA,Miller MR,Lishko PV,Barratt CL,Publicover SJ,Martins da Silva S


book

Analysis of the correlation of CATSPER single nucleotide polymorphisms (SNPs) with idiopathic asthenospermia.
Journal of assisted reproduction and genetics32(11)1643-9(2015 Nov)
Shu F,Zhou X,Li F,Lu D,Lei B,Li Q,Yang Y,Yang X,Shi R,Mao X


book

Widespread macromolecular interaction perturbations in human genetic disorders.
Cell161(3)647-660(2015 Apr)
Sahni N,Yi S,Taipale M,Fuxman Bass JI,Coulombe-Huntington J,Yang F,Peng J,Weile J,Karras GI,Wang Y,Kovács IA,Kamburov A,Krykbaeva I,Lam MH,Tucker G,Khurana V,Sharma A,Liu YY,Yachie N,Zhong Q,Shen Y,Palagi A,San-Miguel A,Fan C,Balcha D,Dricot A,Jordan DM,Walsh JM,Shah AA,Yang X,Stoyanova AK,Leighton A,Calderwood MA,Jacob Y,Cusick ME,Salehi-Ashtiani K,Whitesell LJ,Sunyaev S,Berger B,Barabási AL,Charloteaux B,Hill DE,Hao T,Roth FP,Xia Y,Walhout AJM,Lindquist S,Vidal M


book

The transcription factors Sox5 and Sox9 regulate Catsper1 gene expression.
FEBS letters588(18)3352-60(2014 Sep)
Mata-Rocha M,Hernández-Sánchez J,Guarneros G,de la Chesnaye E,Sánchez-Tusié AA,Treviño CL,Felix R,Oviedo N


book

Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
Nature communications54020(2014 Jun)
Navarini AA,Simpson MA,Weale M,Knight J,Carlavan I,Reiniche P,Burden DA,Layton A,Bataille V,Allen M,Pleass R,Pink A,Creamer D,English J,Munn S,Walton S,,Willis C,Déret S,Voegel JJ,Spector T,Smith CH,Trembath RC,Barker JN


 
*
*
*
*