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CLN3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CLN3
Entrez Gene ID 1201
Full Name ceroid-lipofuscinosis, neuronal 3
Synonyms BTS, JNCL
General protein information
Preferred Names
battenin
Names
battenin
batten disease protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p12.1

Summary This gene encodes a protein that is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs). Many alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

607042

Disorder Html: Ceroid-lipofuscinosis, neuronal-3, juvenile, 204200 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_001286104 NP_001273033 battenin isoform b
NM_001286105 NP_001273034 battenin isoform c
NM_001286109 NP_001273038 battenin isoform d
NM_001286110 NP_001273039 battenin isoform e
NM_001042432 NP_001035897 battenin isoform a
NM_000086 NP_000077 battenin isoform a



Homo sapiens (human) CLN3 NP_001035897.1
Canis lupus familiaris (dog) CLN3 NP_001013435.1
Bos taurus (cattle) CLN3 NP_001068642.2
Mus musculus (house mouse) Cln3 NP_034037.3
Rattus norvegicus (Norway rat) Cln3 NP_001006972.1
Danio rerio (zebrafish) cln3 NP_001007307.1
Drosophila melanogaster (fruit fly) cln3 NP_649011.1
Caenorhabditis elegans cln-3.2 NP_491556.1
Caenorhabditis elegans cln-3.1 NP_001256315.1
Caenorhabditis elegans cln-3.3 NP_505237.1
Xenopus (Silurana) tropicalis (western clawed frog) cln3 XP_004919824.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CLN3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CLN3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu27581 NM_001286104 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu16887 NM_001286105 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 4, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu27575 NM_001286109 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 5, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OHu16865 NM_001286110 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 6, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OHu25863 NM_001042432 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00
OHu25863 NM_000086 Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27581
Clone ID Related Accession (Same CDS sequence) NM_001286104
Accession Version NM_001286104.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1245bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform b
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA703317.1 and AK302027.1. Transcript Variant: This variant (3) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302027.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGCTGTGCT CCTGGCGGAC
ATCCTCCCCA CACTCGTCAT CAAATTGTTG GCTCCTCTTG GCCTTCACCT GCTGCCCTAC
AGCCCCCGGG TTCTCGTCAG TGGGATTTGT GCTGCTGGAA GCTTCGTCCT GGTTGCCTTT
TCTCATTCTG TGGGGACCAG CCTGTGTGGT GTGGTCTTCG CTAGCATCTC ATCAGGCCTT
GGGGAGGTCA CCTTCCTCTC CCTCACTGCC TTCTACCCCA GGGCCGTGAT CTCCTGGTGG
TCCTCAGGGA CTGGGGGAGC TGGGCTGCTG GGGGCCCTGT CCTACCTGGG CCTCACCCAG
GCCGGCCTCT CCCCTCAGCA GACCCTGCTG TCCATGCTGG GTATCCCTGC CCTGCTGCTG
GCCAGCTATT TCTTGTTGCT CACATCTCCT GAGGCCCAGG ACCCTGGAGG GGAAGAAGAA
GCAGAGAGCG CAGCCCGGCA GCCCCTCATA AGAACCGAGG CCCCGGAGTC GAAGCCAGGC
TCCAGCTCCA GCCTCTCCCT TCGGGAAAGG TGGACAGTGT TCAAGGGTCT GCTGTGGTAC
ATTGTTCCCT TGGTCGTAGT TTACTTTGCC GAGTATTTCA TTAACCAGGG ACTTTTTGAA
CTCCTCTTTT TCTGGAACAC TTCCCTGAGT CACGCTCAGC AATACCGCTG GTACCAGATG
CTGTACCAGG CTGGCGTCTT TGCCTCCCGC TCTTCTCTCC GCTGCTGTCG CATCCGTTTC
ACCTGGGCCC TGGCCCTGCT GCAGTGCCTC AACCTGGTGT TCCTGCTGGC AGACGTGTGG
TTCGGCTTTC TGCCAAGCAT CTACCTCGTC TTCCTGATCA TTCTGTATGA GGGGCTCCTG
GGAGGCGCAG CCTACGTGAA CACCTTCCAC AACATCGCCC TGGAGACCAG TGATGAGCAC
CGGGAGTTTG CAATGGCGGC CACCTGCATC TCTGACACAC TGGGGATCTC CCTGTCGGGG
CTCCTGGCTT TGCCTCTGCA TGACTTCCTC TGCCAGCTCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001273033.1
CDS360..1604
Misc Feature(1)324..326(+)
Misc Feature(2)468..1601(+)
Exon (1)1..283
Gene:CLN3
Gene Synonym:
Exon (2)284..405
Gene:CLN3
Gene Synonym:
Exon (3)406..484
Gene:CLN3
Gene Synonym:
Exon (4)485..581
Gene:CLN3
Gene Synonym:
Exon (5)582..661
Gene:CLN3
Gene Synonym:
Exon (6)662..747
Gene:CLN3
Gene Synonym:
Exon (7)748..820
Gene:CLN3
Gene Synonym:
Exon (8)821..964
Gene:CLN3
Gene Synonym:
Exon (9)965..1077
Gene:CLN3
Gene Synonym:
Exon (10)1078..1124
Gene:CLN3
Gene Synonym:
Exon (11)1125..1193
Gene:CLN3
Gene Synonym:
Exon (12)1194..1249
Gene:CLN3
Gene Synonym:
Exon (13)1250..1343
Gene:CLN3
Gene Synonym:
Exon (14)1344..1484
Gene:CLN3
Gene Synonym:
Exon (15)1485..1840
Gene:CLN3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001286104
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001286104

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGCTGTGCT CCTGGCGGAC
ATCCTCCCCA CACTCGTCAT CAAATTGTTG GCTCCTCTTG GCCTTCACCT GCTGCCCTAC
AGCCCCCGGG TTCTCGTCAG TGGGATTTGT GCTGCTGGAA GCTTCGTCCT GGTTGCCTTT
TCTCATTCTG TGGGGACCAG CCTGTGTGGT GTGGTCTTCG CTAGCATCTC ATCAGGCCTT
GGGGAGGTCA CCTTCCTCTC CCTCACTGCC TTCTACCCCA GGGCCGTGAT CTCCTGGTGG
TCCTCAGGGA CTGGGGGAGC TGGGCTGCTG GGGGCCCTGT CCTACCTGGG CCTCACCCAG
GCCGGCCTCT CCCCTCAGCA GACCCTGCTG TCCATGCTGG GTATCCCTGC CCTGCTGCTG
GCCAGCTATT TCTTGTTGCT CACATCTCCT GAGGCCCAGG ACCCTGGAGG GGAAGAAGAA
GCAGAGAGCG CAGCCCGGCA GCCCCTCATA AGAACCGAGG CCCCGGAGTC GAAGCCAGGC
TCCAGCTCCA GCCTCTCCCT TCGGGAAAGG TGGACAGTGT TCAAGGGTCT GCTGTGGTAC
ATTGTTCCCT TGGTCGTAGT TTACTTTGCC GAGTATTTCA TTAACCAGGG ACTTTTTGAA
CTCCTCTTTT TCTGGAACAC TTCCCTGAGT CACGCTCAGC AATACCGCTG GTACCAGATG
CTGTACCAGG CTGGCGTCTT TGCCTCCCGC TCTTCTCTCC GCTGCTGTCG CATCCGTTTC
ACCTGGGCCC TGGCCCTGCT GCAGTGCCTC AACCTGGTGT TCCTGCTGGC AGACGTGTGG
TTCGGCTTTC TGCCAAGCAT CTACCTCGTC TTCCTGATCA TTCTGTATGA GGGGCTCCTG
GGAGGCGCAG CCTACGTGAA CACCTTCCAC AACATCGCCC TGGAGACCAG TGATGAGCAC
CGGGAGTTTG CAATGGCGGC CACCTGCATC TCTGACACAC TGGGGATCTC CCTGTCGGGG
CTCCTGGCTT TGCCTCTGCA TGACTTCCTC TGCCAGCTCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16887
Clone ID Related Accession (Same CDS sequence) NM_001286105
Accession Version NM_001286105.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1017bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform c
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP252176.1, AK297690.1 and AK302027.1. Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks two exons compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (c) with a shorter and distinct N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK297690.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGGACCC AGGCCCAACG CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT 
CTGTCTCTAC GGCTCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001273034.1
CDS465..1481
Misc Feature(1)411..413(+)
Misc Feature(2)540..1478(+)
Exon (1)1..369
Gene:CLN3
Gene Synonym:
Exon (2)370..466
Gene:CLN3
Gene Synonym:
Exon (3)467..538
Gene:CLN3
Gene Synonym:
Exon (4)539..624
Gene:CLN3
Gene Synonym:
Exon (5)625..697
Gene:CLN3
Gene Synonym:
Exon (6)698..841
Gene:CLN3
Gene Synonym:
Exon (7)842..954
Gene:CLN3
Gene Synonym:
Exon (8)955..1001
Gene:CLN3
Gene Synonym:
Exon (9)1002..1070
Gene:CLN3
Gene Synonym:
Exon (10)1071..1126
Gene:CLN3
Gene Synonym:
Exon (11)1127..1220
Gene:CLN3
Gene Synonym:
Exon (12)1221..1361
Gene:CLN3
Gene Synonym:
Exon (13)1362..1717
Gene:CLN3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001286105
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 4, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001286105

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGTGGACCC AGGCCCAACG CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT 
CTGTCTCTAC GGCTCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu27575
Clone ID Related Accession (Same CDS sequence) NM_001286109
Accession Version NM_001286109.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1083bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform d
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP252176.1, DA869025.1 and BC111068.1. Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence, the 3' UTR, and lacks an alternate in-frame exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (d) with a shorter N-terminus and missing an alternate internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## NMD candidate :: translation inferred ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: BC111068.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTGAGTG CCGCCCACGA CATCCTTAGC CACAAGAGGA CATCGGGAAA CCAGAGCCAT 
GCTGTGCTCC TGGCGGACAT CCTCCCCACA CTCGTCATCA AATTGTTGGC TCCTCTTGGC
CTTCACCTGC TGCCCTACAG CCCCCGGGTT CTCGTCAGTG GGATTTGTGC TGCTGGAAGC
TTCGTCCTGG TTGCCTTTTC TCATTCTGTG GGGACCAGCC TGTGTGGTGT GGTCTTCGCT
AGCATCTCAT CAGGCCTTGG GGAGGTCACC TTCCTCTCCC TCACTGCCTT CTACCCCAGG
GCCGTGATCT CCTGGTGGTC CTCAGGGACT GGGGGAGCTG GGCTGCTGGG GGCCCTGTCC
TACCTGGGCC TCACCCAGGC CGGCCTCTCC CCTCAGCAGA CCCTGCTGTC CATGCTGGGT
ATCCCTGCCC TGCTGCTGGC CAGCTATTTC TTGTTGCTCA CATCTCCTGA GGCCCAGGAC
CCTGGAGGGG AAGAAGAAGC AGAGAGCGCA GCCCGGCAGC CCCTCATAAG AACCGAGGCC
CCGGAGTCGA AGCCAGGCTC CAGCTCCAGC CTCTCCCTTC GGGAAAGGTG GACAGTGTTC
AAGGGTCTGC TGTGGTACAT TGTTCCCTTG GTCGTAGTTT ACTTTGCCGA GTATTTCATT
AACCAGGGAC TTTTTGAACT CCTCTTTTTC TGGAACACTT CCCTGAGTCA CGCTCAGCAA
TACCGCTGGT ACCAGATGCT GTACCAGGCT GGCGTCTTTG CCTCCCGCTC TTCTCTCCGC
TGCTGTCGCA TCCGTTTCAC CTGGGCCCTG GCCCTGCTGC AGTGCCTCAA CCTGGTGTTC
CTGCTGGCAG ACGTGTGGTT CGGCTTTCTG CCAAGCATCT ACCTCGTCTT CCTGATCATT
CTGTATGAGG GGCTCCTGGG AGGCGCAGCC TACGTGAACA CCTTCCACAA CATCGCCCTG
GAGACCAGTG ATGAGCACCG GGAGTTTGCA ATGGCGGCCA CCTGCATCTC TGACACACTG
GGGATCTCCC TGTCGGGGCT CCTGGCTTTG CCTCTGCATG ACTTCCTCTG CCAGCTCTCC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001273038.1
CDS407..1489
Misc Feature(1)317..319(+)
Misc Feature(2)407..1486(+)
Exon (1)1..369
Gene:CLN3
Gene Synonym:
Exon (2)370..466
Gene:CLN3
Gene Synonym:
Exon (3)467..546
Gene:CLN3
Gene Synonym:
Exon (4)547..632
Gene:CLN3
Gene Synonym:
Exon (5)633..705
Gene:CLN3
Gene Synonym:
Exon (6)706..849
Gene:CLN3
Gene Synonym:
Exon (7)850..962
Gene:CLN3
Gene Synonym:
Exon (8)963..1009
Gene:CLN3
Gene Synonym:
Exon (9)1010..1078
Gene:CLN3
Gene Synonym:
Exon (10)1079..1134
Gene:CLN3
Gene Synonym:
Exon (11)1135..1228
Gene:CLN3
Gene Synonym:
Exon (12)1229..1369
Gene:CLN3
Gene Synonym:
Exon (13)1370..1541
Gene:CLN3
Gene Synonym:
Exon (14)1542..1791
Gene:CLN3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001286109
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 5, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001286109

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGCTGAGTG CCGCCCACGA CATCCTTAGC CACAAGAGGA CATCGGGAAA CCAGAGCCAT 
GCTGTGCTCC TGGCGGACAT CCTCCCCACA CTCGTCATCA AATTGTTGGC TCCTCTTGGC
CTTCACCTGC TGCCCTACAG CCCCCGGGTT CTCGTCAGTG GGATTTGTGC TGCTGGAAGC
TTCGTCCTGG TTGCCTTTTC TCATTCTGTG GGGACCAGCC TGTGTGGTGT GGTCTTCGCT
AGCATCTCAT CAGGCCTTGG GGAGGTCACC TTCCTCTCCC TCACTGCCTT CTACCCCAGG
GCCGTGATCT CCTGGTGGTC CTCAGGGACT GGGGGAGCTG GGCTGCTGGG GGCCCTGTCC
TACCTGGGCC TCACCCAGGC CGGCCTCTCC CCTCAGCAGA CCCTGCTGTC CATGCTGGGT
ATCCCTGCCC TGCTGCTGGC CAGCTATTTC TTGTTGCTCA CATCTCCTGA GGCCCAGGAC
CCTGGAGGGG AAGAAGAAGC AGAGAGCGCA GCCCGGCAGC CCCTCATAAG AACCGAGGCC
CCGGAGTCGA AGCCAGGCTC CAGCTCCAGC CTCTCCCTTC GGGAAAGGTG GACAGTGTTC
AAGGGTCTGC TGTGGTACAT TGTTCCCTTG GTCGTAGTTT ACTTTGCCGA GTATTTCATT
AACCAGGGAC TTTTTGAACT CCTCTTTTTC TGGAACACTT CCCTGAGTCA CGCTCAGCAA
TACCGCTGGT ACCAGATGCT GTACCAGGCT GGCGTCTTTG CCTCCCGCTC TTCTCTCCGC
TGCTGTCGCA TCCGTTTCAC CTGGGCCCTG GCCCTGCTGC AGTGCCTCAA CCTGGTGTTC
CTGCTGGCAG ACGTGTGGTT CGGCTTTCTG CCAAGCATCT ACCTCGTCTT CCTGATCATT
CTGTATGAGG GGCTCCTGGG AGGCGCAGCC TACGTGAACA CCTTCCACAA CATCGCCCTG
GAGACCAGTG ATGAGCACCG GGAGTTTGCA ATGGCGGCCA CCTGCATCTC TGACACACTG
GGGATCTCCC TGTCGGGGCT CCTGGCTTTG CCTCTGCATG ACTTCCTCTG CCAGCTCTCC
TGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16865
Clone ID Related Accession (Same CDS sequence) NM_001286110
Accession Version NM_001286110.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1155bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform e
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP252176.1, DA869025.1 and AK294070.1. Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks an alternate in-frame exon compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (e) with a shorter N-terminus and missing an alternate internal segment compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK294070.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCTGAGTG CCGCCCACGA CATCCTTAGC CACAAGAGGA CATCGGGAAA CCAGAGCCAT 
GTGGACCCAG GCCCAACGCC GATCCCCCAC AACAGCTCAT CACGATTTGA CTGCAACTCT
GTCTCTACGG CTGCTGTGCT CCTGGCGGAC ATCCTCCCCA CACTCGTCAT CAAATTGTTG
GCTCCTCTTG GCCTTCACCT GCTGCCCTAC AGCCCCCGGG TTCTCGTCAG TGGGATTTGT
GCTGCTGGAA GCTTCGTCCT GGTTGCCTTT TCTCATTCTG TGGGGACCAG CCTGTGTGGT
GTGGTCTTCG CTAGCATCTC ATCAGGCCTT GGGGAGGTCA CCTTCCTCTC CCTCACTGCC
TTCTACCCCA GGGCCGTGAT CTCCTGGTGG TCCTCAGGGA CTGGGGGAGC TGGGCTGCTG
GGGGCCCTGT CCTACCTGGG CCTCACCCAG GCCGGCCTCT CCCCTCAGCA GACCCTGCTG
TCCATGCTGG GTATCCCTGC CCTGCTGCTG GCCAGCTATT TCTTGTTGCT CACATCTCCT
GAGGCCCAGG ACCCTGGAGG GGAAGAAGAA GCAGAGAGCG CAGCCCGGCA GCCCCTCATA
AGAACCGAGG CCCCGGAGTC GAAGCCAGGC TCCAGCTCCA GCCTCTCCCT TCGGGAAAGG
TGGACAGTGT TCAAGGGTCT GCTGTGGTAC ATTGTTCCCT TGGTCGTAGT TTACTTTGCC
GAGTATTTCA TTAACCAGGG ACTTTTTGAA CTCCTCTTTT TCTGGAACAC TTCCCTGAGT
CACGCTCAGC AATACCGCTG GTACCAGATG CTGTACCAGG CTGGCGTCTT TGCCTCCCGC
TCTTCTCTCC GCTGCTGTCG CATCCGTTTC ACCTGGGCCC TGGCCCTGCT GCAGTGCCTC
AACCTGGTGT TCCTGCTGGC AGACGTGTGG TTCGGCTTTC TGCCAAGCAT CTACCTCGTC
TTCCTGATCA TTCTGTATGA GGGGCTCCTG GGAGGCGCAG CCTACGTGAA CACCTTCCAC
AACATCGCCC TGGAGACCAG TGATGAGCAC CGGGAGTTTG CAATGGCGGC CACCTGCATC
TCTGACACAC TGGGGATCTC CCTGTCGGGG CTCCTGGCTT TGCCTCTGCA TGACTTCCTC
TGCCAGCTCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001273039.1
CDS407..1561
Misc Feature(1)317..319(+)
Misc Feature(2)407..1558(+)
Exon (1)1..369
Gene:CLN3
Gene Synonym:
Exon (2)370..466
Gene:CLN3
Gene Synonym:
Exon (3)467..538
Gene:CLN3
Gene Synonym:
Exon (4)539..618
Gene:CLN3
Gene Synonym:
Exon (5)619..704
Gene:CLN3
Gene Synonym:
Exon (6)705..777
Gene:CLN3
Gene Synonym:
Exon (7)778..921
Gene:CLN3
Gene Synonym:
Exon (8)922..1034
Gene:CLN3
Gene Synonym:
Exon (9)1035..1081
Gene:CLN3
Gene Synonym:
Exon (10)1082..1150
Gene:CLN3
Gene Synonym:
Exon (11)1151..1206
Gene:CLN3
Gene Synonym:
Exon (12)1207..1300
Gene:CLN3
Gene Synonym:
Exon (13)1301..1441
Gene:CLN3
Gene Synonym:
Exon (14)1442..1797
Gene:CLN3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001286110
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 6, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001286110

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
ATGCTGAGTG CCGCCCACGA CATCCTTAGC CACAAGAGGA CATCGGGAAA CCAGAGCCAT 
GTGGACCCAG GCCCAACGCC GATCCCCCAC AACAGCTCAT CACGATTTGA CTGCAACTCT
GTCTCTACGG CTGCTGTGCT CCTGGCGGAC ATCCTCCCCA CACTCGTCAT CAAATTGTTG
GCTCCTCTTG GCCTTCACCT GCTGCCCTAC AGCCCCCGGG TTCTCGTCAG TGGGATTTGT
GCTGCTGGAA GCTTCGTCCT GGTTGCCTTT TCTCATTCTG TGGGGACCAG CCTGTGTGGT
GTGGTCTTCG CTAGCATCTC ATCAGGCCTT GGGGAGGTCA CCTTCCTCTC CCTCACTGCC
TTCTACCCCA GGGCCGTGAT CTCCTGGTGG TCCTCAGGGA CTGGGGGAGC TGGGCTGCTG
GGGGCCCTGT CCTACCTGGG CCTCACCCAG GCCGGCCTCT CCCCTCAGCA GACCCTGCTG
TCCATGCTGG GTATCCCTGC CCTGCTGCTG GCCAGCTATT TCTTGTTGCT CACATCTCCT
GAGGCCCAGG ACCCTGGAGG GGAAGAAGAA GCAGAGAGCG CAGCCCGGCA GCCCCTCATA
AGAACCGAGG CCCCGGAGTC GAAGCCAGGC TCCAGCTCCA GCCTCTCCCT TCGGGAAAGG
TGGACAGTGT TCAAGGGTCT GCTGTGGTAC ATTGTTCCCT TGGTCGTAGT TTACTTTGCC
GAGTATTTCA TTAACCAGGG ACTTTTTGAA CTCCTCTTTT TCTGGAACAC TTCCCTGAGT
CACGCTCAGC AATACCGCTG GTACCAGATG CTGTACCAGG CTGGCGTCTT TGCCTCCCGC
TCTTCTCTCC GCTGCTGTCG CATCCGTTTC ACCTGGGCCC TGGCCCTGCT GCAGTGCCTC
AACCTGGTGT TCCTGCTGGC AGACGTGTGG TTCGGCTTTC TGCCAAGCAT CTACCTCGTC
TTCCTGATCA TTCTGTATGA GGGGCTCCTG GGAGGCGCAG CCTACGTGAA CACCTTCCAC
AACATCGCCC TGGAGACCAG TGATGAGCAC CGGGAGTTTG CAATGGCGGC CACCTGCATC
TCTGACACAC TGGGGATCTC CCTGTCGGGG CTCCTGGCTT TGCCTCTGCA TGACTTCCTC
TGCCAGCTCT CCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25863
Clone ID Related Accession (Same CDS sequence) NM_000086 , NM_001042432
Accession Version NM_001042432.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1317bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA552461.1, DB101039.1, AF077957.1 and AI138575.1. This sequence is a reference standard in the RefSeqGene project. Transcript Variant: This variant (1) represents the longest transcript. Both variants 1 and 2 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC002394.2, AK313002.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGTGGACCC AGGCCCAACG
CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT CTGTCTCTAC GGCTGCTGTG
CTCCTGGCGG ACATCCTCCC CACACTCGTC ATCAAATTGT TGGCTCCTCT TGGCCTTCAC
CTGCTGCCCT ACAGCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001035897.1
CDS360..1676
Misc Feature(1)324..326(+)
Misc Feature(2)393..395(+)
Misc Feature(3)393..395(+)
Misc Feature(4)399..401(+)
Misc Feature(5)399..401(+)
Misc Feature(6)468..1673(+)
Misc Feature(7)471..533(+)
Misc Feature(8)654..716(+)
Misc Feature(9)741..803(+)
Misc Feature(10)897..959(+)
Misc Feature(11)993..1055(+)
Misc Feature(12)1191..1253(+)
Misc Feature(13)1431..1493(+)
Misc Feature(14)1578..1640(+)
Exon (1)1..283
Gene:CLN3
Gene Synonym:
Exon (2)284..405
Gene:CLN3
Gene Synonym:
Exon (3)406..484
Gene:CLN3
Gene Synonym:
Exon (4)485..581
Gene:CLN3
Gene Synonym:
Exon (5)582..653
Gene:CLN3
Gene Synonym:
Exon (6)654..733
Gene:CLN3
Gene Synonym:
Exon (7)734..819
Gene:CLN3
Gene Synonym:
Exon (8)820..892
Gene:CLN3
Gene Synonym:
Exon (9)893..1036
Gene:CLN3
Gene Synonym:
Exon (10)1037..1149
Gene:CLN3
Gene Synonym:
Exon (11)1150..1196
Gene:CLN3
Gene Synonym:
Exon (12)1197..1265
Gene:CLN3
Gene Synonym:
Exon (13)1266..1321
Gene:CLN3
Gene Synonym:
Exon (14)1322..1415
Gene:CLN3
Gene Synonym:
Exon (15)1416..1556
Gene:CLN3
Gene Synonym:
Exon (16)1557..1913
Gene:CLN3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001042432
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001042432

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGTGGACCC AGGCCCAACG
CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT CTGTCTCTAC GGCTGCTGTG
CTCCTGGCGG ACATCCTCCC CACACTCGTC ATCAAATTGT TGGCTCCTCT TGGCCTTCAC
CTGCTGCCCT ACAGCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu25863
Clone ID Related Accession (Same CDS sequence) NM_000086 , NM_001042432
Accession Version NM_000086.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1317bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product battenin isoform a
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AU105965.1, DA869025.1, U32680.1, AF077962.1 and AI138575.1. This sequence is a reference standard in the RefSeqGene project. On Jun 28, 2006 this sequence version replaced gi:4502888. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U32680.1, AF015593.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGTGGACCC AGGCCCAACG
CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT CTGTCTCTAC GGCTGCTGTG
CTCCTGGCGG ACATCCTCCC CACACTCGTC ATCAAATTGT TGGCTCCTCT TGGCCTTCAC
CTGCTGCCCT ACAGCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000077.1
CDS324..1640
Misc Feature(1)288..290(+)
Misc Feature(2)357..359(+)
Misc Feature(3)357..359(+)
Misc Feature(4)363..365(+)
Misc Feature(5)363..365(+)
Misc Feature(6)432..1637(+)
Misc Feature(7)435..497(+)
Misc Feature(8)618..680(+)
Misc Feature(9)705..767(+)
Misc Feature(10)861..923(+)
Misc Feature(11)957..1019(+)
Misc Feature(12)1155..1217(+)
Misc Feature(13)1395..1457(+)
Misc Feature(14)1542..1604(+)
Exon (1)1..369
Gene:CLN3
Gene Synonym:
Exon (2)370..448
Gene:CLN3
Gene Synonym:
Exon (3)449..545
Gene:CLN3
Gene Synonym:
Exon (4)546..617
Gene:CLN3
Gene Synonym:
Exon (5)618..697
Gene:CLN3
Gene Synonym:
Exon (6)698..783
Gene:CLN3
Gene Synonym:
Exon (7)784..856
Gene:CLN3
Gene Synonym:
Exon (8)857..1000
Gene:CLN3
Gene Synonym:
Exon (9)1001..1113
Gene:CLN3
Gene Synonym:
Exon (10)1114..1160
Gene:CLN3
Gene Synonym:
Exon (11)1161..1229
Gene:CLN3
Gene Synonym:
Exon (12)1230..1285
Gene:CLN3
Gene Synonym:
Exon (13)1286..1379
Gene:CLN3
Gene Synonym:
Exon (14)1380..1520
Gene:CLN3
Gene Synonym:
Exon (15)1521..1877
Gene:CLN3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_000086
Organism Homo sapiens (human)
Definition Homo sapiens ceroid-lipofuscinosis, neuronal 3 (CLN3), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000086

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
ATGGGAGGCT GTGCAGGCTC GCGGCGGCGC TTTTCGGATT CCGAGGGGGA GGAGACCGTC 
CCGGAGCCCC GGCTCCCTCT GTTGGACCAT CAGGGCGCGC ATTGGAAGAA CGCGGTGGGC
TTCTGGCTGC TGGGCCTTTG CAACAACTTC TCTTATGTGG TGATGCTGAG TGCCGCCCAC
GACATCCTTA GCCACAAGAG GACATCGGGA AACCAGAGCC ATGTGGACCC AGGCCCAACG
CCGATCCCCC ACAACAGCTC ATCACGATTT GACTGCAACT CTGTCTCTAC GGCTGCTGTG
CTCCTGGCGG ACATCCTCCC CACACTCGTC ATCAAATTGT TGGCTCCTCT TGGCCTTCAC
CTGCTGCCCT ACAGCCCCCG GGTTCTCGTC AGTGGGATTT GTGCTGCTGG AAGCTTCGTC
CTGGTTGCCT TTTCTCATTC TGTGGGGACC AGCCTGTGTG GTGTGGTCTT CGCTAGCATC
TCATCAGGCC TTGGGGAGGT CACCTTCCTC TCCCTCACTG CCTTCTACCC CAGGGCCGTG
ATCTCCTGGT GGTCCTCAGG GACTGGGGGA GCTGGGCTGC TGGGGGCCCT GTCCTACCTG
GGCCTCACCC AGGCCGGCCT CTCCCCTCAG CAGACCCTGC TGTCCATGCT GGGTATCCCT
GCCCTGCTGC TGGCCAGCTA TTTCTTGTTG CTCACATCTC CTGAGGCCCA GGACCCTGGA
GGGGAAGAAG AAGCAGAGAG CGCAGCCCGG CAGCCCCTCA TAAGAACCGA GGCCCCGGAG
TCGAAGCCAG GCTCCAGCTC CAGCCTCTCC CTTCGGGAAA GGTGGACAGT GTTCAAGGGT
CTGCTGTGGT ACATTGTTCC CTTGGTCGTA GTTTACTTTG CCGAGTATTT CATTAACCAG
GGACTTTTTG AACTCCTCTT TTTCTGGAAC ACTTCCCTGA GTCACGCTCA GCAATACCGC
TGGTACCAGA TGCTGTACCA GGCTGGCGTC TTTGCCTCCC GCTCTTCTCT CCGCTGCTGT
CGCATCCGTT TCACCTGGGC CCTGGCCCTG CTGCAGTGCC TCAACCTGGT GTTCCTGCTG
GCAGACGTGT GGTTCGGCTT TCTGCCAAGC ATCTACCTCG TCTTCCTGAT CATTCTGTAT
GAGGGGCTCC TGGGAGGCGC AGCCTACGTG AACACCTTCC ACAACATCGC CCTGGAGACC
AGTGATGAGC ACCGGGAGTT TGCAATGGCG GCCACCTGCA TCTCTGACAC ACTGGGGATC
TCCCTGTCGG GGCTCCTGGC TTTGCCTCTG CATGACTTCC TCTGCCAGCT CTCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Next generation sequencing-based molecular diagnosis of retinitis pigmentosa: identification of a novel genotype-phenotype correlation and clinical refinements
Hum. Genet. 133 (3), 331-345 (2014)
Wang F, Wang H, Tuan HF, Nguyen DH, Sun V, Keser V, Bowne SJ, Sullivan LS, Luo H, Zhao L, Wang X, Zaneveld JE, Salvo JS, Siddiqui S, Mao L, Wheaton DK, Birch DG, Branham KE, Heckenlively JR, Wen C, Flagg K, Ferreyra H, Pei J, Khan A, Ren H, Wang K, Lopez I, Qamar R, Zenteno JC, Ayala-Ramirez R, Buentello-Volante B, Fu Q, Simpson DA, Li Y, Sui R, Silvestri G, Daiger SP, Koenekoop RK, Zhang K and Chen R.


book

Osmotic stress changes the expression and subcellular localization of the Batten disease protein CLN3
PLoS ONE 8 (6), E66203 (2013)
Getty A, Kovacs AD, Lengyel-Nelson T, Cardillo A, Hof C, Chan CH and Pearce DA.


book

Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach
J. Proteome Res. 12 (5), 2101-2115 (2013)
Scifo E, Szwajda A, Debski J, Uusi-Rauva K, Kesti T, Dadlez M, Gingras AC, Tyynela J, Baumann MH, Jalanko A and Lalowski M.


book

Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments
Cell. Mol. Life Sci. 69 (12), 2075-2089 (2012)
Uusi-Rauva K, Kyttala A, van der Kant R, Vesa J, Tanhuanpaa K, Neefjes J, Olkkonen VM and Jalanko A.


book

A model for Batten disease protein CLN3: functional implications from homology and mutations
FEBS Lett. 399 (1-2), 75-77 (1996)
Janes RW, Munroe PB, Mitchison HM, Gardiner RM, Mole SE and Wallace BA.


book

Rapid diagnostic test for the major mutation underlying Batten disease
J. Med. Genet. 33 (12), 1041-1042 (1996)
Jarvela I, Mitchison HM, Munroe PB, O'Rawe AM, Mole SE and Syvanen AC.


book

Chromosome 16 microdeletion in a patient with juvenile neuronal ceroid lipofuscinosis (Batten disease)
Am. J. Hum. Genet. 56 (3), 663-668 (1995)
Taschner PE, de Vos N, Thompson AD, Callen DF, Doggett N, Mole SE, Dooley TP, Barth PG and Breuning MH.


book

Neuronal Ceroid-Lipofuscinoses
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Mole,S.E. and Williams,R.E.


book

Dystonia Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Klein,C., Marras,C. and Munchau,A.


book

Characterization of two new members of the pregnancy-specific beta 1-glycoprotein family from the myeloid cell line KG-1 and suggestion of two distinct classes of transcription unit
Biochemistry 29 (44), 10213-10218 (1990)
Barnett TR, Pickle W 2nd and Elting JJ.


 
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