NLRP5 cDNA ORF clone, Homo sapiens(human)
Gene Symbol | NLRP5 |
Entrez Gene ID | 126206 |
Full Name | NLR family pyrin domain containing 5 |
Synonyms | CLR19.8,MATER,NALP5,PAN11,PYPAF8 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). Expression of this gene is restricted to the oocyte. A mouse gene that encodes a maternal oocyte protein, similar to this encoded protein, is required for normal early embryogenesis. [provided by RefSeq, Jul 2008]. |
Disorder MIM: |
mRNA and Protein(s)
mRNA | Protein | Name |
---|---|---|
NM_153447.4 | NP_703148.4 | NACHT, LRR and PYD domains-containing protein 5 |

Pan troglodytes (chimpanzee) | NLRP5 | XP_001139299.2 |
NLRP5 | NP_001121103.1 | |
Canis lupus familiaris (dog) | NLRP5 | XP_005616898.1 |
Bos taurus (cattle) | NLRP5 | NP_001007815.1 |
Rattus norvegicus (Norway rat) | Nlrp5 | NP_001100944.1 |
Homo sapiens (human) | NLRP5 | NP_703148.4 |
Mus musculus (house mouse) | Nlrp5 | NP_035990.1 |

Related articles in PubMed
Genetic modifiers of multiple sclerosis progression, severity and onset.
Sadovnick AD, Traboulsee AL, Zhao Y, Bernales CQ, Encarnacion M, Ross JP, Yee IM, Criscuoli MG, Vilari?o-G?ell C
Clinical immunology (Orlando, Fla.)180100-105(2017 Jul)
NADPH oxidase-4 and MATER expressions in granulosa cells: Relationships with ovarian aging.
Maraldi T, Resca E, Nicoli A, Beretti F, Zavatti M, Capodanno F, Morini D, Palomba S, La Sala GB, De Pol A
Life sciences162108-14(2016 Oct)
Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans.
Docherty LE, Rezwan FI, Poole RL, Turner CL, Kivuva E, Maher ER, Smithson SF, Hamilton-Shield JP, Patalan M, Gizewska M, Peregud-Pogorzelski J, Beygo J, Buiting K, Horsthemke B, Soellner L, Begemann M, Eggermann T, Baple E, Mansour S, Temple IK, Mackay DJ
Nature communications68086(2015 Sep)
A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease.
Rovelet-Lecrux A, Legallic S, Wallon D, Flaman JM, Martinaud O, Bombois S, Rollin-Sillaire A, Michon A, Le Ber I, Pariente J, Puel M, Paquet C, Croisile B, Thomas-Ant?rion C, Vercelletto M, L?vy R, Fr?bourg T, Hannequin D, Campion D,
European journal of human genetics : EJHG20(6)613-7(2012 Jun)
The genetics of NOD-like receptors in Crohn's disease.
Cummings JR, Cooney RM, Clarke G, Beckly J, Geremia A, Pathan S, Hancock L, Guo C, Cardon LR, Jewell DP
Tissue antigens76(1)48-56(2010 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
PSMG4 and NLRP5 appear of particular interest as they were found to be associated with more than one clinical phenotype and are implicated in biological processes considered relevant to the pathophysiology of MS. Also, PSMG4 p.W99R and NLRP5 p.R761L were found to correlate with an earlier age of MS clinical onset. Our data suggests PSMG4 and NLPR5 as potential targets for the development of modifying therapies for MS.
Title: Genetic modifiers of multiple sclerosis progression, severity and onset.
expression of MATER and NOX4 proteins are closely related to the follicular development and ovulation with particular regard for ovarian aging
Title: NADPH oxidase-4 and MATER expressions in granulosa cells: Relationships with ovarian aging.
NLRP5 mutation is associated with multilocus imprinting disorders and reproductive wastage.
Title: Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans.
Observational study of gene-disease association. (HuGE Navigator)
Title: A large-scale candidate gene association study of age at menarche and age at natural menopause.
Observational study of gene-disease association. (HuGE Navigator)
Title: The genetics of NOD-like receptors in Crohn's disease.
The following NLRP5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NLRP5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
CloneID | OHu31436![]() |
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Clone ID Related Accession (Same CDS sequence) | NM_153447.4 | |
Accession Version | NM_153447.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 3603bp) Protein sequence SNP |
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Vector | pcDNA3.1+/C-(K)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-25 | |
Organism | Homo sapiens(human) | |
Product | NACHT, LRR and PYD domains-containing protein 5 | |
Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY154460.1 and AC024580.6. This sequence is a reference standard in the RefSeqGene project. On Oct 16, 2007 this sequence version replaced NM_153447.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY054986.1, AY154460.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000390649.8/ ENSP00000375063.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAAGGTTG CAGGAGGACT TGAACTTGGA GCTGCTGCTC TGCTCTCAGC ATCACCACGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_703148.4 |
CDS | 1..3603 |
Translation |

Target ORF information:
Target ORF information:
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ORF Insert Sequence:
1 | ATGAAGGTTG CAGGAGGACT TGAACTTGGA GCTGCTGCTC TGCTCTCAGC ATCACCACGT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
![]() |
Genetic modifiers of multiple sclerosis progression, severity and onset. |
![]() |
NADPH oxidase-4 and MATER expressions in granulosa cells: Relationships with ovarian aging. |
![]() |
Mutations in NLRP5 are associated with reproductive wastage and multilocus imprinting disorders in humans. |
![]() |
A genome-wide study reveals rare CNVs exclusive to extreme phenotypes of Alzheimer disease. |
![]() |
The genetics of NOD-like receptors in Crohn's disease. |