CPA1 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | CPA1 |
| Entrez Gene ID | 1357 |
| Full Name | carboxypeptidase A1 |
| Synonyms | CPA |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | This gene encodes a member of the carboxypeptidase A family of zinc metalloproteases. This enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic cancer. [provided by RefSeq, Jan 2015]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_001868.3 | NP_001859.1 | carboxypeptidase A1 preproprotein |
| NM_001868.4 | NP_001859.1 | carboxypeptidase A1 preproprotein |
| Canis lupus familiaris (dog) | CPA1 | XP_005628437.1 |
| Bos taurus (cattle) | CPA1 | NP_777175.1 |
| Mus musculus (house mouse) | Cpa1 | NP_079626.2 |
| CPA1 | XP_001096893.1 | |
| Rattus norvegicus (Norway rat) | Cpa1 | NP_058694.2 |
| Gallus gallus (chicken) | CPA1 | NP_989915.1 |
| Danio rerio (zebrafish) | cpa5 | NP_954965.1 |
| Drosophila melanogaster (fruit fly) | CG17633 | NP_609310.2 |
| Anopheles gambiae (African malaria mosquito) | CBPA1_ANOGA | XP_318615.2 |
| Homo sapiens (human) | CPA1 | NP_001859.1 |
| Danio rerio (zebrafish) | cpa1 | NP_001018318.1 |
| Pan troglodytes (chimpanzee) | CPA1 | XP_003318844.1 |
| Xenopus tropicalis (tropical clawed frog) | cpa1 | NP_001107681.1 |
Related articles in PubMed
No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort.
Wu H, Zhou DZ, Berki D, Geisz A, Zou WB, Sun XT, Hu LH, Zhao ZH, Zhao AJ, He L, Cooper DN, F?rec C, Chen JM, Li ZS, Sahin-T?th M, Liao Z
Human mutation38(8)959-963(2017 Aug)
Genetic Analysis of Japanese Children With Acute Recurrent and Chronic Pancreatitis.
Saito N, Suzuki M, Sakurai Y, Nakano S, Naritaka N, Minowa K, Sai JK, Shimizu T
Journal of pediatric gastroenterology and nutrition63(4)431-6(2016 Oct)
Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.
Szab? A, Pilsak C, Bence M, Witt H, Sahin-T?th M
The Journal of biological chemistry291(34)17706-16(2016 08)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Gene mutations were present in PRSS1 in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations.
Title: Genetic Analysis of Japanese Children With Acute Recurrent and Chronic Pancreatitis.
Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.
Title: Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.
mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity
Title: Variants in CPA1 are strongly associated with early onset chronic pancreatitis.
Serum pro-CPA and CPA levels were increased in either pancreatitis or pancreatic malignancy
Title: Serum procarboxypeptidase A and carboxypeptidase A levels in pancreatic disease.
A description of the ternary complex hCPA1-Zn2+-poly(acrylic acid) is included as a model of the interaction of mucoadhesive polymers with proteases in the gastrointestinal tract.
Title: Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid).
The following CPA1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CPA1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu12811 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001868.3 , NM_001868.4 | |
| Accession Version | NM_001868.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | carboxypeptidase A1 preproprotein | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC378103.1, AK291493.1 and X67318.1. This sequence is a reference standard in the RefSeqGene project. On Jan 15, 2015 this sequence version replaced NM_001868.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCGGGGGT TGCTGGTGTT GAGTGTCCTG TTGGGGGCTG TCTTTGGCAA GGAGGACTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001859.1 |
| CDS | 151..1410 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001868.3 |
ORF Insert Sequence:
1 | ATGCGGGGGT TGCTGGTGTT GAGTGTCCTG TTGGGGGCTG TCTTTGGCAA GGAGGACTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu12811 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001868.3 , NM_001868.4 | |
| Accession Version | NM_001868.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-08-21 | |
| Organism | Homo sapiens(human) | |
| Product | carboxypeptidase A1 preproprotein | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291493.1 and X67318.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_001868.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291493.1, BT007313.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968832 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000011292.8/ ENSP00000011292.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGCGGGGGT TGCTGGTGTT GAGTGTCCTG TTGGGGGCTG TCTTTGGCAA GGAGGACTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001859.1 |
| CDS | 28..1287 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001868.4 |
ORF Insert Sequence:
1 | ATGCGGGGGT TGCTGGTGTT GAGTGTCCTG TTGGGGGCTG TCTTTGGCAA GGAGGACTTT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort. |
|
Genetic Analysis of Japanese Children With Acute Recurrent and Chronic Pancreatitis. |
|
Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2. |