Gene Symbol | DPYSL3 |
Entrez Gene ID | 1809 |
Full Name | dihydropyrimidinase like 3 |
Synonyms | CRMP-4,CRMP4,DRP-3,DRP3,LCRMP,ULIP,ULIP-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » DPYSL3 cDNA ORF clone
Gene Symbol | DPYSL3 |
Entrez Gene ID | 1809 |
Full Name | dihydropyrimidinase like 3 |
Synonyms | CRMP-4,CRMP4,DRP-3,DRP3,LCRMP,ULIP,ULIP-1 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001197294.2 | NP_001184223.1 | dihydropyrimidinase-related protein 3 isoform 1 |
NM_001387.3 | NP_001378.1 | dihydropyrimidinase-related protein 3 isoform 2 |
XM_011537574.2 | XP_011535876.1 | dihydropyrimidinase-related protein 3 isoform X1 |
NM_001387.2 | NP_001378.1 | dihydropyrimidinase-related protein 3 isoform 2 |
XM_011537574.1 | XP_011535876.1 | dihydropyrimidinase-related protein 3 isoform X1 |
NM_001197294.1 | NP_001184223.1 | dihydropyrimidinase-related protein 3 isoform 1 |
Gallus gallus (chicken) | DPYSL3 | NP_989824.1 |
Danio rerio (zebrafish) | dpysl3 | NP_001018348.1 |
Mus musculus (house mouse) | Dpysl3 | NP_033494.1 |
Xenopus tropicalis (tropical clawed frog) | dpysl3 | NP_001005637.1 |
Homo sapiens (human) | DPYSL3 | NP_001184223.1 |
Pan troglodytes (chimpanzee) | DPYSL3 | XP_003310939.1 |
DPYSL3 | XP_001102251.1 | |
Bos taurus (cattle) | DPYSL3 | NP_001094538.1 |
Rattus norvegicus (Norway rat) | Dpysl3 | NP_037066.1 |
Canis lupus familiaris (dog) | DPYSL3 | XP_544332.3 |
Combined analysis of CRMP4 methylation levels and CAPRA-S score predicts metastasis and outcomes in prostate cancer patients.
Huang QX, Xiao CT, Chen Z, Lu MH, Pang J, Di JM, Luo ZH, Gao X
Asian journal of andrology20(1)56-61(2018 Jan-Feb)
Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism.
Tsutiya A, Nakano Y, Hansen-Kiss E, Kelly B, Nishihara M, Goshima Y, Corsmeier D, White P, Herman GE, Ohtani-Kaneko R
Scientific reports7(1)16812(2017 Dec)
Collapsin response mediator protein 4 isoforms (CRMP4a and CRMP4b) have opposite effects on cell proliferation, migration, and invasion in gastric cancer.
Guo H, Xia B
BMC cancer16565(2016 07)
Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling.
Nakamura F, Kumeta K, Hida T, Isono T, Nakayama Y, Kuramata-Matsuoka E, Yamashita N, Uchida Y, Ogura K, Gengyo-Ando K, Mitani S, Ogino T, Goshima Y
Nature communications55325(2014 Oct)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Data indicate that CRMP4a and CRMP4b isoforms have opposite effects on cell proliferation, migration, and invasion in gastric cancer. CRMP4a expression was reduced in gastric carcinoma tissues and cell lines and seems to act as a tumor suppressor in gastric carcinoma. CRMP4b expression was higher in tumor tissue and cell lines.
Title: Collapsin response mediator protein 4 isoforms (CRMP4a and CRMP4b) have opposite effects on cell proliferation, migration, and invasion in gastric cancer.
DPYSL3 expression levels inversely correlated with those of VEGF and FAK. Down-regulation of DPYSL3 expression in HCC tissues may serve as a predictive biomarker for HCC after curative resection.
Title: Dihydropyrimidinase-like 3 is a putative hepatocellular carcinoma tumor suppressor.
Expression status of DPYSL3 in gastric cancer tissues may represent a promising biomarker for the malignant behavior of GC.
Title: Dihydropyrimidinase-like 3 facilitates malignant behavior of gastric cancer.
structures provide further insight into the effects of medically relevant mutations of the DPYSL-3 gene encoding CRMP-4 and the putative enzymatic activities of CRMPs
Title: Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder.
DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex
Title: Quantitative proteomic profiling identifies DPYSL3 as pancreatic ductal adenocarcinoma-associated molecule that regulates cell adhesion and migration by stabilization of focal adhesion complex.
The following DPYSL3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DPYSL3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu12334 | |
Clone ID Related Accession (Same CDS sequence) | NM_001387.3 , NM_001387.2 | |
Accession Version | NM_001387.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-18 | |
Organism | Homo sapiens(human) | |
Product | dihydropyrimidinase-related protein 3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI570709.1, D78014.1, BC039006.1 and CA424493.1. On May 31, 2019 this sequence version replaced NM_001387.2. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.128517.1, SRR1803614.253045.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCCTACC AAGGCAAGAA GAACATCCCG CGGATCACGA GTGACCGTCT CCTTATCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001378.1 |
CDS | 106..1818 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001387.3 |
1 | ATGTCCTACC AAGGCAAGAA GAACATCCCG CGGATCACGA GTGACCGTCT CCTTATCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu12334 | |
Clone ID Related Accession (Same CDS sequence) | NM_001387.3 , NM_001387.2 | |
Accession Version | NM_001387.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1713bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-16 | |
Organism | Homo sapiens(human) | |
Product | dihydropyrimidinase-related protein 3 isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AI570709.1, D78014.1, BC039006.1 and CA424493.1. On Mar 17, 2004 this sequence version replaced NM_001387.1. Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus compared to isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: D78014.1, SRR1660805.156572.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCCTACC AAGGCAAGAA GAACATCCCG CGGATCACGA GTGACCGTCT CCTTATCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001378.1 |
CDS | 111..1823 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001387.2 |
1 | ATGTCCTACC AAGGCAAGAA GAACATCCCG CGGATCACGA GTGACCGTCT CCTTATCAAG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu57372 | |
Clone ID Related Accession (Same CDS sequence) | XM_011537574.2 , XM_011537574.1 | |
Accession Version | XM_011537574.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1701bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | dihydropyrimidinase-related protein 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011537574.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTATTT CAATATACGA AACACAGAGT GACCGTCTCC TTATCAAGGG AGGCAGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011535876.1 |
CDS | 507..2207 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011537574.2 |
1 | ATGCCTATTT CAATATACGA AACACAGAGT GACCGTCTCC TTATCAAGGG AGGCAGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu57372 | |
Clone ID Related Accession (Same CDS sequence) | XM_011537574.2 , XM_011537574.1 | |
Accession Version | XM_011537574.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1701bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | dihydropyrimidinase-related protein 3 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCCTATTT CAATATACGA AACACAGAGT GACCGTCTCC TTATCAAGGG AGGCAGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011535876.1 |
CDS | 507..2207 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011537574.1 |
1 | ATGCCTATTT CAATATACGA AACACAGAGT GACCGTCTCC TTATCAAGGG AGGCAGAATC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10411 | |
Clone ID Related Accession (Same CDS sequence) | NM_001197294.2 , NM_001197294.1 | |
Accession Version | NM_001197294.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2055bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-11-16 | |
Organism | Homo sapiens(human) | |
Product | dihydropyrimidinase-related protein 3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC011373.4, BC077077.1, D78014.1 and CA424493.1. On Nov 22, 2018 this sequence version replaced NM_001197294.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC077077.1, SRR1803612.105721.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000343218.10/ ENSP00000343690.5 RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGCCTCGG GCCGGAGGGG CTGGGACAGC TCCCACGAAG ACGATCTGCC CGTGTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001184223.1 |
CDS | 211..2265 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001197294.2 |
1 | ATGGCCTCGG GCCGGAGGGG CTGGGACAGC TCCCACGAAG ACGATCTGCC CGTGTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10411 | |
Clone ID Related Accession (Same CDS sequence) | NM_001197294.2 , NM_001197294.1 | |
Accession Version | NM_001197294.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2055bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | dihydropyrimidinase-related protein 3 isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC077077.1, D78014.1 and CA424493.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC077077.1, SRR1803612.105721.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGCCTCGG GCCGGAGGGG CTGGGACAGC TCCCACGAAG ACGATCTGCC CGTGTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001184223.1 |
CDS | 199..2253 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001197294.1 |
1 | ATGGCCTCGG GCCGGAGGGG CTGGGACAGC TCCCACGAAG ACGATCTGCC CGTGTACCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Combined analysis of CRMP4 methylation levels and CAPRA-S score predicts metastasis and outcomes in prostate cancer patients. |
Human CRMP4 mutation and disrupted Crmp4 expression in mice are associated with ASD characteristics and sexual dimorphism. |
Collapsin response mediator protein 4 isoforms (CRMP4a and CRMP4b) have opposite effects on cell proliferation, migration, and invasion in gastric cancer. |
Amino- and carboxyl-terminal domains of Filamin-A interact with CRMP1 to mediate Sema3A signalling. |