This gene encodes a member of a highly conserved family of integral membrane proteins. The encoded protein localizes to the cell membrane of red blood cells and other cell types, where it may regulate ion channels and transporters. Loss of localization of the encoded protein is associated with hereditary stomatocytosis, a form of hemolytic anemia. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].
The following STOM gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the STOM cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
erythrocyte band 7 integral membrane protein isoform a
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368197.1, X60067.1, AL161784.13 and AI224884.1. On May 17, 2019 this sequence version replaced NM_004099.5.
Transcript Variant: This variant (1) encodes the longest isoform (a).
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803616.88435.1, SRR1803616.243471.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2158569, SAMEA2159080 [ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
MANE Ensembl match :: ENST00000286713.7/ ENSP00000286713.2
RefSeq Select criteria :: based on conservation, expression, longest protein
##RefSeq-Attributes-END##
COMPLETENESS: complete on the 3' end.
erythrocyte band 7 integral membrane protein isoform a
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368197.1, X60067.1, AL161784.13 and AI224884.1. On Jul 20, 2012 this sequence version replaced NM_004099.4.
Transcript Variant: This variant (1) encodes the longest isoform (a).
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: SRR1803617.41658.1, SRR1660803.95342.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns SAMEA2158569, SAMEA2159080 [ECO:0000348]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
erythrocyte band 7 integral membrane protein isoform c
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368197.1, BI553227.1, AL161784.13 and AI224884.1.
Transcript Variant: This variant (3) uses two alternate splice sites in the 3' coding region, which result in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BI553227.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
erythrocyte band 7 integral membrane protein isoform c
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368197.1, BI553227.1, AL161784.13 and AI224884.1. On Jun 1, 2019 this sequence version replaced NM_001270526.1.
Transcript Variant: This variant (3) uses two alternate splice sites in the 3' coding region, which result in a frameshift, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BI553227.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
erythrocyte band 7 integral membrane protein isoform b
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368197.1, BG701899.1, AL161784.13 and AI224884.1. On May 31, 2019 this sequence version replaced NM_198194.2.
Transcript Variant: This variant (2) lacks several alternate exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BI603242.1, BI550327.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
erythrocyte band 7 integral membrane protein isoform b
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368197.1, BG701899.1, AL161784.13 and AI224884.1. On Jul 20, 2012 this sequence version replaced NM_198194.1.
Transcript Variant: This variant (2) lacks several alternate exons in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BI603242.1, BI552936.1 [ECO:0000332]
##Evidence-Data-END##
COMPLETENESS: complete on the 3' end.
erythrocyte band 7 integral membrane protein isoform d
Comment
Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC368197.1, BP208523.1, AL161784.13 and AI224884.1.
Transcript Variant: This variant (4) has multiple differences, compared to variant 1. These differences include use of alternate splice sites and lack of a 3' coding exon, which result in a frameshift. The encoded isoform (d) has a shorter and distinct C-terminus, compared to isoform 1.
Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.
Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.
User Manual
NM_004099.6
