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FOXC1 cDNA ORF clone, Homo sapiens (human)

Gene Symbol FOXC1
Entrez Gene ID 2296
Full Name forkhead box C1
Synonyms ARA, FKHL7, FREAC-3, FREAC3, IGDA, IHG1, IRID1, RIEG3
General protein information
Preferred Names
forkhead box protein C1
Names
forkhead box protein C1
myeloid factor-delta
forkhead-related activator 3
forkhead-related protein FKHL7
forkhead, drosophila, homolog-like 7
forkhead-related transcription factor 3
forkhead/winged helix-like transcription factor 7
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p25

Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

601090

Disorder Html: Iridogoniodysgenesis, type 1, 601631 (3); Rieger or Axenfeld

mRNA and Protein(s)

mRNA Protein Name
NM_001453 NP_001444 forkhead box protein C1



Homo sapiens (human) FOXC1 NP_001444.2
Pan troglodytes (chimpanzee) FOXC1 XP_003311061.2
Mus musculus (house mouse) Foxc1 NP_032618.2
Rattus norvegicus (Norway rat) Foxc1 NP_599165.1
Danio rerio (zebrafish) foxc1a NP_571803.1
Xenopus (Silurana) tropicalis (western clawed frog) foxc1 NP_001007864.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following FOXC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19618 NM_001453 Homo sapiens forkhead box C1 (FOXC1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $321.30
$459.00
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19618
Clone ID Related Accession (Same CDS sequence) NM_001453
Accession Version NM_001453.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1662bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Structure linear
Update Date 03-MAY-2014
Organism Homo sapiens (human)
Product forkhead box protein C1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL034344.24. This sequence is a reference standard in the RefSeqGene project. On Dec 14, 2006 this sequence version replaced gi:4503734. Sequence Note: This RefSeq record was created from genomic sequence data because mRNA transcripts were not available for the full length of the gene. The extent of this transcript is supported by orthologous mouse data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGCAGGCGC GCTACTCCGT GTCCAGCCCC AACTCCCTGG GAGTGGTGCC CTACCTCGGC 
GGCGAGCAGA GCTACTACCG CGCGGCGGCC GCGGCGGCCG GGGGCGGCTA CACCGCCATG
CCGGCCCCCA TGAGCGTGTA CTCGCACCCT GCGCACGCCG AGCAGTACCC GGGCGGCATG
GCCCGCGCCT ACGGGCCCTA CACGCCGCAG CCGCAGCCCA AGGACATGGT GAAGCCGCCC
TATAGCTACA TCGCGCTCAT CACCATGGCC ATCCAGAACG CCCCGGACAA GAAGATCACC
CTGAACGGCA TCTACCAGTT CATCATGGAC CGCTTCCCCT TCTACCGGGA CAACAAGCAG
GGCTGGCAGA ACAGCATCCG CCACAACCTC TCGCTCAACG AGTGCTTCGT CAAGGTGCCG
CGCGACGACA AGAAGCCGGG CAAGGGCAGC TACTGGACGC TGGACCCGGA CTCCTACAAC
ATGTTCGAGA ACGGCAGCTT CCTGCGGCGG CGGCGGCGCT TCAAGAAGAA GGACGCGGTG
AAGGACAAGG AGGAGAAGGA CAGGCTGCAC CTCAAGGAGC CGCCCCCGCC CGGCCGCCAG
CCCCCGCCCG CGCCGCCGGA GCAGGCCGAC GGCAACGCGC CCGGTCCGCA GCCGCCGCCC
GTGCGCATCC AGGACATCAA GACCGAGAAC GGTACGTGCC CCTCGCCGCC CCAGCCCCTG
TCCCCGGCCG CCGCCCTGGG CAGCGGCAGC GCCGCCGCGG TGCCCAAGAT CGAGAGCCCC
GACAGCAGCA GCAGCAGCCT GTCCAGCGGG AGCAGCCCCC CGGGCAGCCT GCCGTCGGCG
CGGCCGCTCA GCCTGGACGG TGCGGATTCC GCGCCGCCGC CGCCCGCGCC CTCCGCCCCG
CCGCCGCACC ATAGCCAGGG CTTCAGCGTG GACAACATCA TGACGTCGCT GCGGGGGTCG
CCGCAGAGCG CGGCCGCGGA GCTCAGCTCC GGCCTTCTGG CCTCGGCGGC CGCGTCCTCG
CGCGCGGGGA TCGCACCCCC GCTGGCGCTC GGCGCCTACT CGCCCGGCCA GAGCTCCCTC
TACAGCTCCC CCTGCAGCCA GACCTCCAGC GCGGGCAGCT CGGGCGGCGG CGGCGGCGGC
GCGGGGGCCG CGGGGGGCGC GGGCGGCGCC GGGACCTACC ACTGCAACCT GCAAGCCATG
AGCCTGTACG CGGCCGGCGA GCGCGGGGGC CACTTGCAGG GCGCGCCCGG GGGCGCGGGC
GGCTCGGCCG TGGACGACCC CCTGCCCGAC TACTCTCTGC CTCCGGTCAC CAGCAGCAGC
TCGTCGTCCC TGAGTCACGG CGGCGGCGGC GGCGGCGGCG GGGGAGGCCA GGAGGCCGGC
CACCACCCTG CGGCCCACCA AGGCCGCCTC ACCTCGTGGT ACCTGAACCA GGCGGGCGGA
GACCTGGGCC ACTTGGCGAG CGCGGCGGCG GCGGCGGCGG CCGCAGGCTA CCCGGGCCAG
CAGCAGAACT TCCACTCGGT GCGGGAGATG TTCGAGTCAC AGAGGATCGG CTTGAACAAC
TCTCCAGTGA ACGGGAATAG TAGCTGTCAA ATGGCCTTCC CTTCCAGCCA GTCTCTGTAC
CGCACGTCCG GAGCTTTCGT CTACGACTGT AGCAAGTTTT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001444.2
CDS1..1662
Misc Feature(1)232..465(+)
Misc Feature(2)340..444(+)
Misc Feature(3)703..705(+)
Misc Feature(4)721..723(+)
Misc Feature(5)958..960(+)
Misc Feature(6)1561..1563(+)
Exon (1)1..3452
Gene:FOXC1
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001453
Organism Homo sapiens (human)
Definition Homo sapiens forkhead box C1 (FOXC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001453

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGCAGGCGC GCTACTCCGT GTCCAGCCCC AACTCCCTGG GAGTGGTGCC CTACCTCGGC 
GGCGAGCAGA GCTACTACCG CGCGGCGGCC GCGGCGGCCG GGGGCGGCTA CACCGCCATG
CCGGCCCCCA TGAGCGTGTA CTCGCACCCT GCGCACGCCG AGCAGTACCC GGGCGGCATG
GCCCGCGCCT ACGGGCCCTA CACGCCGCAG CCGCAGCCCA AGGACATGGT GAAGCCGCCC
TATAGCTACA TCGCGCTCAT CACCATGGCC ATCCAGAACG CCCCGGACAA GAAGATCACC
CTGAACGGCA TCTACCAGTT CATCATGGAC CGCTTCCCCT TCTACCGGGA CAACAAGCAG
GGCTGGCAGA ACAGCATCCG CCACAACCTC TCGCTCAACG AGTGCTTCGT CAAGGTGCCG
CGCGACGACA AGAAGCCGGG CAAGGGCAGC TACTGGACGC TGGACCCGGA CTCCTACAAC
ATGTTCGAGA ACGGCAGCTT CCTGCGGCGG CGGCGGCGCT TCAAGAAGAA GGACGCGGTG
AAGGACAAGG AGGAGAAGGA CAGGCTGCAC CTCAAGGAGC CGCCCCCGCC CGGCCGCCAG
CCCCCGCCCG CGCCGCCGGA GCAGGCCGAC GGCAACGCGC CCGGTCCGCA GCCGCCGCCC
GTGCGCATCC AGGACATCAA GACCGAGAAC GGTACGTGCC CCTCGCCGCC CCAGCCCCTG
TCCCCGGCCG CCGCCCTGGG CAGCGGCAGC GCCGCCGCGG TGCCCAAGAT CGAGAGCCCC
GACAGCAGCA GCAGCAGCCT GTCCAGCGGG AGCAGCCCCC CGGGCAGCCT GCCGTCGGCG
CGGCCGCTCA GCCTGGACGG TGCGGATTCC GCGCCGCCGC CGCCCGCGCC CTCCGCCCCG
CCGCCGCACC ATAGCCAGGG CTTCAGCGTG GACAACATCA TGACGTCGCT GCGGGGGTCG
CCGCAGAGCG CGGCCGCGGA GCTCAGCTCC GGCCTTCTGG CCTCGGCGGC CGCGTCCTCG
CGCGCGGGGA TCGCACCCCC GCTGGCGCTC GGCGCCTACT CGCCCGGCCA GAGCTCCCTC
TACAGCTCCC CCTGCAGCCA GACCTCCAGC GCGGGCAGCT CGGGCGGCGG CGGCGGCGGC
GCGGGGGCCG CGGGGGGCGC GGGCGGCGCC GGGACCTACC ACTGCAACCT GCAAGCCATG
AGCCTGTACG CGGCCGGCGA GCGCGGGGGC CACTTGCAGG GCGCGCCCGG GGGCGCGGGC
GGCTCGGCCG TGGACGACCC CCTGCCCGAC TACTCTCTGC CTCCGGTCAC CAGCAGCAGC
TCGTCGTCCC TGAGTCACGG CGGCGGCGGC GGCGGCGGCG GGGGAGGCCA GGAGGCCGGC
CACCACCCTG CGGCCCACCA AGGCCGCCTC ACCTCGTGGT ACCTGAACCA GGCGGGCGGA
GACCTGGGCC ACTTGGCGAG CGCGGCGGCG GCGGCGGCGG CCGCAGGCTA CCCGGGCCAG
CAGCAGAACT TCCACTCGGT GCGGGAGATG TTCGAGTCAC AGAGGATCGG CTTGAACAAC
TCTCCAGTGA ACGGGAATAG TAGCTGTCAA ATGGCCTTCC CTTCCAGCCA GTCTCTGTAC
CGCACGTCCG GAGCTTTCGT CTACGACTGT AGCAAGTTTT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

FOXC1 in human trabecular meshwork cells is involved in regulatory pathway that includes miR-204, MEIS2, and ITGbeta1
Exp. Eye Res. 111, 112-121 (2013)
Paylakhi SH, Moazzeni H, Yazdani S, Rassouli P, Arefian E, Jaberi E, Arash EH, Gilani AS, Fan JB, April C, Amin S, Suri F and Elahi E.


book

A novel forkhead box C1 gene mutation in a Korean family with Axenfeld-Rieger syndrome
Mol. Vis. 19, 935-943 (2013)
Kim GN, Ki CS, Seo SW, Yoo JM, Han YS, Chung IY, Park JM and Kim SJ.


book

Copy number aberrations of genes regulating normal thymus development in thymic epithelial tumors
Clin. Cancer Res. 19 (8), 1960-1971 (2013)
Petrini I, Wang Y, Zucali PA, Lee HS, Pham T, Voeller D, Meltzer PS and Giaccone G.


book

High expression of FOXC1 is associated with poor clinical outcome in non-small cell lung cancer patients
Tumour Biol. 34 (2), 941-946 (2013)
Wei LX, Zhou RS, Xu HF, Wang JY and Yuan MH.


book

High level of FOXC1 expression is associated with poor prognosis in pancreatic ductal adenocarcinoma
Tumour Biol. 34 (2), 853-858 (2013)
Wang L, Gu F, Liu CY, Wang RJ, Li J and Xu JY.


book

Autosomal dominant Axenfeld-Rieger anomaly maps to 6p25
Am. J. Hum. Genet. 61 (3), 765-768 (1997)
Gould,D.B., Mears,A.J., Pearce,W.G. and Walter,M.A.


book

Autosomal dominant iridogoniodysgenesis anomaly maps to 6p25
Am. J. Hum. Genet. 59 (6), 1321-1327 (1996)
Mears AJ, Mirzayans F, Gould DB, Pearce WG and Walter MA.


book

Chromosomal localization of six human forkhead genes, freac-1 (FKHL5), -3 (FKHL7), -4 (FKHL8), -5 (FKHL9), -6 (FKHL10), and -8 (FKHL12)
Genomics 30 (3), 464-469 (1995)
Larsson C, Hellqvist M, Pierrou S, White I, Enerback S and Carlsson P.


book

Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending
EMBO J. 13 (20), 5002-5012 (1994)
Pierrou S, Hellqvist M, Samuelsson L, Enerback S and Carlsson P.


book

Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells
Blood 81 (11), 2854-2859 (1993)
Hromas R, Moore J, Johnston T, Socha C and Klemsz M.


 
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