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FOXC1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol FOXC1
Entrez Gene ID 2296
Full Name forkhead box C1
Synonyms ARA,ASGD3,FKHL7,FREAC-3,FREAC3,IGDA,IHG1,IRID1,RIEG3
General protein information
Preferred Names

forkhead box C1

Names

forkhead box protein C1
forkhead box C1 protein
forkhead, drosophila, homolog-like 7
forkhead-related activator 3
forkhead-related protein FKHL7
forkhead-related transcription factor 3
forkhead/winged helix-like transcription factor 7
myeloid factor-delta

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

6

6p25.3

Summary This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it has been shown to play a role in the regulation of embryonic and ocular development. Mutations in this gene cause various glaucoma phenotypes including primary congenital glaucoma, autosomal dominant iridogoniodysgenesis anomaly, and Axenfeld-Rieger anomaly. [provided by RefSeq, Jul 2008].
Disorder MIM:

601090

Disorder Html: Iridogoniodysgenesis, type 1, 601631 (3); Rieger or Axenfeld

mRNA and Protein(s)

mRNA Protein Name
NM_001453.2 NP_001444.2 forkhead box protein C1



Mus musculus (house mouse) Foxc1 NP_032618.2
Danio rerio (zebrafish) foxc1a NP_571803.1
Pan troglodytes (chimpanzee) FOXC1 XP_003311061.2
Xenopus tropicalis (tropical clawed frog) foxc1 NP_001007864.1
Homo sapiens (human) FOXC1 NP_001444.2
Rattus norvegicus (Norway rat) Foxc1 NP_599165.1


Related articles in PubMed

Brachydactyly type E in an Italian family with 6p25 trisomy.
Fontana P, Tortora C, Petillo R, Malacarne M, Cavani S, Miniero M, D'Ambrosio P, De Brasi D, Pisanti MA
European journal of medical genetics60(3)195-199(2017 Mar)

Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome.
Seifi M, Footz T, Taylor SA, Walter MA
Human mutation38(2)169-179(2017 Feb)

Phenotype of a Belgian Family With 6p25 Deletion Syndrome.
Weegerink NJ, Swinnen FK, Vanakker OM, Casselman JW, Dhooge IJ
The Annals of otology, rhinology, and laryngology125(9)734-45(2016 Sep)

The role and the potential regulatory pathways of high expression of forkhead box C1 in promoting tumor growth and metastasis of basal-like breast cancer.
Zuo HD, Wu Yao W
Journal of B.U.ON. : official journal of the Balkan Union of Oncology21(4)818-825(2016 Jul-Aug)

Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation.
Bin L, Deng L, Yang H, Zhu L, Wang X, Edwards MG, Richers B, Leung DY
PloS one11(12)e0167392(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our findings suggested that FOXCUT expression contributed to the development and progression of nasopharyngeal carcinoma by targeting FOXC1 and that FOXCUT might be useful as a potential nasopharyngeal carcinoma biomarker and therapeutic target.
Title: The long noncoding RNA FOXCUT promotes proliferation and migration by targeting FOXC1 in nasopharyngeal carcinoma.

FOXC1 is correlated with chemosensitivity to anthracycline and could be used as an indicator of chemosensitivity in sporadic triple-negative breast cancer
Title: FOXC1 overexpression is a marker of poor response to anthracycline-based adjuvant chemotherapy in sporadic triple-negative breast cancer.

this report describes an Italian family in which four subjects share brachydactyly type E and a 3 Mb microduplication in region 6p25. The duplication involves the gene FOXC1, expressed during the osteoblast differentiation, which appears a potential candidate gene for brachydactyly.
Title: Brachydactyly type E in an Italian family with 6p25 trisomy.

Elevated expression of FOXC1 enhanced the invasion ability of BLCB cells in vitro.
Title: The role and the potential regulatory pathways of high expression of forkhead box C1 in promoting tumor growth and metastasis of basal-like breast cancer.

this study defines FOXC1 as a regulator specific for KC terminal differentiation and establishes its potential position in the genetic regulatory network.
Title: Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation.

The following FOXC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FOXC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu19618 NM_001453.2
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Homo sapiens forkhead box C1 (FOXC1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $321.30
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu19618
Clone ID Related Accession (Same CDS sequence) NM_001453.2
Accession Version NM_001453.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1662bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-15
Organism Homo sapiens(Human)
Product forkhead box protein C1
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL034344.24. This sequence is a reference standard in the RefSeqGene project. On Dec 14, 2006 this sequence version replaced NM_001453.1. Sequence Note: This RefSeq record was created from genomic sequence data because mRNA transcripts were not available for the full length of the gene. The extent of this transcript is supported by orthologous mouse data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGCAGGCGC GCTACTCCGT GTCCAGCCCC AACTCCCTGG GAGTGGTGCC CTACCTCGGC 
GGCGAGCAGA GCTACTACCG CGCGGCGGCC GCGGCGGCCG GGGGCGGCTA CACCGCCATG
CCGGCCCCCA TGAGCGTGTA CTCGCACCCT GCGCACGCCG AGCAGTACCC GGGCGGCATG
GCCCGCGCCT ACGGGCCCTA CACGCCGCAG CCGCAGCCCA AGGACATGGT GAAGCCGCCC
TATAGCTACA TCGCGCTCAT CACCATGGCC ATCCAGAACG CCCCGGACAA GAAGATCACC
CTGAACGGCA TCTACCAGTT CATCATGGAC CGCTTCCCCT TCTACCGGGA CAACAAGCAG
GGCTGGCAGA ACAGCATCCG CCACAACCTC TCGCTCAACG AGTGCTTCGT CAAGGTGCCG
CGCGACGACA AGAAGCCGGG CAAGGGCAGC TACTGGACGC TGGACCCGGA CTCCTACAAC
ATGTTCGAGA ACGGCAGCTT CCTGCGGCGG CGGCGGCGCT TCAAGAAGAA GGACGCGGTG
AAGGACAAGG AGGAGAAGGA CAGGCTGCAC CTCAAGGAGC CGCCCCCGCC CGGCCGCCAG
CCCCCGCCCG CGCCGCCGGA GCAGGCCGAC GGCAACGCGC CCGGTCCGCA GCCGCCGCCC
GTGCGCATCC AGGACATCAA GACCGAGAAC GGTACGTGCC CCTCGCCGCC CCAGCCCCTG
TCCCCGGCCG CCGCCCTGGG CAGCGGCAGC GCCGCCGCGG TGCCCAAGAT CGAGAGCCCC
GACAGCAGCA GCAGCAGCCT GTCCAGCGGG AGCAGCCCCC CGGGCAGCCT GCCGTCGGCG
CGGCCGCTCA GCCTGGACGG TGCGGATTCC GCGCCGCCGC CGCCCGCGCC CTCCGCCCCG
CCGCCGCACC ATAGCCAGGG CTTCAGCGTG GACAACATCA TGACGTCGCT GCGGGGGTCG
CCGCAGAGCG CGGCCGCGGA GCTCAGCTCC GGCCTTCTGG CCTCGGCGGC CGCGTCCTCG
CGCGCGGGGA TCGCACCCCC GCTGGCGCTC GGCGCCTACT CGCCCGGCCA GAGCTCCCTC
TACAGCTCCC CCTGCAGCCA GACCTCCAGC GCGGGCAGCT CGGGCGGCGG CGGCGGCGGC
GCGGGGGCCG CGGGGGGCGC GGGCGGCGCC GGGACCTACC ACTGCAACCT GCAAGCCATG
AGCCTGTACG CGGCCGGCGA GCGCGGGGGC CACTTGCAGG GCGCGCCCGG GGGCGCGGGC
GGCTCGGCCG TGGACGACCC CCTGCCCGAC TACTCTCTGC CTCCGGTCAC CAGCAGCAGC
TCGTCGTCCC TGAGTCACGG CGGCGGCGGC GGCGGCGGCG GGGGAGGCCA GGAGGCCGGC
CACCACCCTG CGGCCCACCA AGGCCGCCTC ACCTCGTGGT ACCTGAACCA GGCGGGCGGA
GACCTGGGCC ACTTGGCGAG CGCGGCGGCG GCGGCGGCGG CCGCAGGCTA CCCGGGCCAG
CAGCAGAACT TCCACTCGGT GCGGGAGATG TTCGAGTCAC AGAGGATCGG CTTGAACAAC
TCTCCAGTGA ACGGGAATAG TAGCTGTCAA ATGGCCTTCC CTTCCAGCCA GTCTCTGTAC
CGCACGTCCG GAGCTTTCGT CTACGACTGT AGCAAGTTTT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001444.2
CDS1..1662
Misc Feature(1)232..498
Misc Feature(2)order(340..345,370..372,379..384,442..444)
Misc Feature(3)703..705
Misc Feature(4)721..723
Misc Feature(5)958..960
Misc Feature(6)1561..1563
Exon (1)1..3452
Translation

Target ORF information:

RefSeq Version NM_001453.2
Organism Homo sapiens(Human)
Definition Homo sapiens forkhead box C1 (FOXC1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001453.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
ATGCAGGCGC GCTACTCCGT GTCCAGCCCC AACTCCCTGG GAGTGGTGCC CTACCTCGGC 
GGCGAGCAGA GCTACTACCG CGCGGCGGCC GCGGCGGCCG GGGGCGGCTA CACCGCCATG
CCGGCCCCCA TGAGCGTGTA CTCGCACCCT GCGCACGCCG AGCAGTACCC GGGCGGCATG
GCCCGCGCCT ACGGGCCCTA CACGCCGCAG CCGCAGCCCA AGGACATGGT GAAGCCGCCC
TATAGCTACA TCGCGCTCAT CACCATGGCC ATCCAGAACG CCCCGGACAA GAAGATCACC
CTGAACGGCA TCTACCAGTT CATCATGGAC CGCTTCCCCT TCTACCGGGA CAACAAGCAG
GGCTGGCAGA ACAGCATCCG CCACAACCTC TCGCTCAACG AGTGCTTCGT CAAGGTGCCG
CGCGACGACA AGAAGCCGGG CAAGGGCAGC TACTGGACGC TGGACCCGGA CTCCTACAAC
ATGTTCGAGA ACGGCAGCTT CCTGCGGCGG CGGCGGCGCT TCAAGAAGAA GGACGCGGTG
AAGGACAAGG AGGAGAAGGA CAGGCTGCAC CTCAAGGAGC CGCCCCCGCC CGGCCGCCAG
CCCCCGCCCG CGCCGCCGGA GCAGGCCGAC GGCAACGCGC CCGGTCCGCA GCCGCCGCCC
GTGCGCATCC AGGACATCAA GACCGAGAAC GGTACGTGCC CCTCGCCGCC CCAGCCCCTG
TCCCCGGCCG CCGCCCTGGG CAGCGGCAGC GCCGCCGCGG TGCCCAAGAT CGAGAGCCCC
GACAGCAGCA GCAGCAGCCT GTCCAGCGGG AGCAGCCCCC CGGGCAGCCT GCCGTCGGCG
CGGCCGCTCA GCCTGGACGG TGCGGATTCC GCGCCGCCGC CGCCCGCGCC CTCCGCCCCG
CCGCCGCACC ATAGCCAGGG CTTCAGCGTG GACAACATCA TGACGTCGCT GCGGGGGTCG
CCGCAGAGCG CGGCCGCGGA GCTCAGCTCC GGCCTTCTGG CCTCGGCGGC CGCGTCCTCG
CGCGCGGGGA TCGCACCCCC GCTGGCGCTC GGCGCCTACT CGCCCGGCCA GAGCTCCCTC
TACAGCTCCC CCTGCAGCCA GACCTCCAGC GCGGGCAGCT CGGGCGGCGG CGGCGGCGGC
GCGGGGGCCG CGGGGGGCGC GGGCGGCGCC GGGACCTACC ACTGCAACCT GCAAGCCATG
AGCCTGTACG CGGCCGGCGA GCGCGGGGGC CACTTGCAGG GCGCGCCCGG GGGCGCGGGC
GGCTCGGCCG TGGACGACCC CCTGCCCGAC TACTCTCTGC CTCCGGTCAC CAGCAGCAGC
TCGTCGTCCC TGAGTCACGG CGGCGGCGGC GGCGGCGGCG GGGGAGGCCA GGAGGCCGGC
CACCACCCTG CGGCCCACCA AGGCCGCCTC ACCTCGTGGT ACCTGAACCA GGCGGGCGGA
GACCTGGGCC ACTTGGCGAG CGCGGCGGCG GCGGCGGCGG CCGCAGGCTA CCCGGGCCAG
CAGCAGAACT TCCACTCGGT GCGGGAGATG TTCGAGTCAC AGAGGATCGG CTTGAACAAC
TCTCCAGTGA ACGGGAATAG TAGCTGTCAA ATGGCCTTCC CTTCCAGCCA GTCTCTGTAC
CGCACGTCCG GAGCTTTCGT CTACGACTGT AGCAAGTTTT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Brachydactyly type E in an Italian family with 6p25 trisomy.
European journal of medical genetics60(3)195-199(2017 Mar)
Fontana P,Tortora C,Petillo R,Malacarne M,Cavani S,Miniero M,D'Ambrosio P,De Brasi D,Pisanti MA


book

Comparison of Bioinformatics Prediction, Molecular Modeling, and Functional Analyses of FOXC1 Mutations in Patients with Axenfeld-Rieger Syndrome.
Human mutation38(2)169-179(2017 Feb)
Seifi M,Footz T,Taylor SA,Walter MA


book

Phenotype of a Belgian Family With 6p25 Deletion Syndrome.
The Annals of otology, rhinology, and laryngology125(9)734-45(2016 Sep)
Weegerink NJ,Swinnen FK,Vanakker OM,Casselman JW,Dhooge IJ


book

The role and the potential regulatory pathways of high expression of forkhead box C1 in promoting tumor growth and metastasis of basal-like breast cancer.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology21(4)818-825(2016 Jul-Aug)
Zuo HD,Wu Yao W


book

Forkhead Box C1 Regulates Human Primary Keratinocyte Terminal Differentiation.
PloS one11(12)e0167392(2016)
Bin L,Deng L,Yang H,Zhu L,Wang X,Edwards MG,Richers B,Leung DY


 
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