Gene Symbol | SV2C |
Entrez Gene ID | 22987 |
Full Name | synaptic vesicle glycoprotein 2C |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » SV2C cDNA ORF clone
Gene Symbol | SV2C |
Entrez Gene ID | 22987 |
Full Name | synaptic vesicle glycoprotein 2C |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_011543282.2 | XP_011541584.2 | synaptic vesicle glycoprotein 2C isoform X1 |
NM_001297716.1 | NP_001284645.1 | synaptic vesicle glycoprotein 2C isoform 2 |
XM_017009244.1 | XP_016864733.1 | synaptic vesicle glycoprotein 2C isoform X2 |
XM_017009244.2 | XP_016864733.1 | synaptic vesicle glycoprotein 2C isoform X2 |
NM_014979.4 | NP_055794.3 | synaptic vesicle glycoprotein 2C isoform 1 |
XM_011543281.2 | XP_011541583.1 | synaptic vesicle glycoprotein 2C isoform X1 |
NM_001297716.2 | NP_001284645.1 | synaptic vesicle glycoprotein 2C isoform 2 |
NM_014979.3 | NP_055794.3 | synaptic vesicle glycoprotein 2C isoform 1 |
XM_011543281.3 | XP_011541583.1 | synaptic vesicle glycoprotein 2C isoform X1 |
XM_011543282.3 | XP_011541584.2 | synaptic vesicle glycoprotein 2C isoform X1 |
Pan troglodytes (chimpanzee) | SV2C | XP_526889.2 |
SV2C | XP_001105846.1 | |
Canis lupus familiaris (dog) | LOC488943 | XP_546060.2 |
Mus musculus (house mouse) | Sv2c | NP_083486.1 |
Danio rerio (zebrafish) | sv2c | NP_001121811.1 |
Rattus norvegicus (Norway rat) | Sv2c | NP_113781.1 |
Homo sapiens (human) | SV2C | NP_055794.1 |
Bos taurus (cattle) | SV2C | NP_001178948.1 |
Gallus gallus (chicken) | SV2C | XP_004937396.1 |
Xenopus tropicalis (tropical clawed frog) | sv2c | XP_002934873.1 |
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease.
Dunn AR, Stout KA, Ozawa M, Lohr KM, Hoffman CA, Bernstein AI, Li Y, Wang M, Sgobio C, Sastry N, Cai H, Caudle WM, Miller GW
Proceedings of the National Academy of Sciences of the United States of America114(11)E2253-E2262(2017 Mar)
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R
Nature structural & molecular biology23(7)656-62(2016 07)
Botulinum neurotoxins: new questions arising from structural biology.
Kammerer RA, Benoit RM
Trends in biochemical sciences39(11)517-26(2014 Nov)
Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.
Schneider BP, Li L, Shen F, Miller KD, Radovich M, O'Neill A, Gray RJ, Lane D, Flockhart DA, Jiang G, Wang Z, Lai D, Koller D, Pratt JH, Dang CT, Northfelt D, Perez EA, Shenkier T, Cobleigh M, Smith ML, Railey E, Partridge A, Gralow J, Sparano J, Davidson NE, Foroud T, Sledge GW
British journal of cancer111(6)1241-8(2014 Sep)
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
Deng X, Sabino EC, Cunha-Neto E, Ribeiro AL, Ianni B, Mady C, Busch MP, Seielstad M,
PloS one8(11)e79629(2013)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
N-linked glycosylation of SV2C is required for binding and uptake of botulinum neurotoxin A.
Title: N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
Studies indicate that botulinum neurotoxins (BoNTs) in complex with its protein receptor, synaptic vesicle glycoprotein 2 (SV2) family member C represented a major advance for the detailed molecular understanding of BoNT-host cell receptor interactions.
Title: Botulinum neurotoxins: new questions arising from structural biology.
A genetic variant in SV2C predicted clinically relevant bevacizumab-induced hypertension in two independent, randomised phase III trials.
Title: Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100.
high-resolution crystal structure of the BoNT/A receptor-binding domain in complex with the SV2C luminal domain
Title: Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A.
The fact that multiple SNPs in SV2C may impact response to atypical antipsychotics suggests that further evaluation of SNPs in this gene
Title: Genotypic variation in the SV2C gene impacts response to atypical antipsychotics the CATIE study.
The following SV2C gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SV2C cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
Online Only Promotion
Up to 50% OFF! Starting
from $49/clone
CloneID | OHu65218 | |
Clone ID Related Accession (Same CDS sequence) | XM_011543282.2 , NM_014979.4 , XM_011543281.2 , NM_014979.3 , XM_011543281.3 , XM_011543282.3 | |
Accession Version | NM_014979.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-23 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC026774.7, AK094917.1, DA725900.1, BC100825.1, AC108091.3, AB028977.1, AC113404.3 and R44558.1. On Nov 22, 2018 this sequence version replaced NM_014979.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.223336.1, SRR1660807.7929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145245, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000502798.7/ ENSP00000423541.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055794.3 |
CDS | 232..2415 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014979.4 |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu95757 | |
Clone ID Related Accession (Same CDS sequence) | XM_017009244.1 , XM_017009244.2 | |
Accession Version | XM_017009244.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTACCT TTCTTCCAGG TGCTGTTTGG ATCCATATAC TTATGGCAGT GGTCTCATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016864733.1 |
CDS | 154..1302 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017009244.1 |
1 | ATGGCTACCT TTCTTCCAGG TGCTGTTTGG ATCCATATAC TTATGGCAGT GGTCTCATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu95757 | |
Clone ID Related Accession (Same CDS sequence) | XM_017009244.1 , XM_017009244.2 | |
Accession Version | XM_017009244.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1149bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017009244.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCTACCT TTCTTCCAGG TGCTGTTTGG ATCCATATAC TTATGGCAGT GGTCTCATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016864733.1 |
CDS | 154..1302 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017009244.2 |
1 | ATGGCTACCT TTCTTCCAGG TGCTGTTTGG ATCCATATAC TTATGGCAGT GGTCTCATAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39511 | |
Clone ID Related Accession (Same CDS sequence) | NM_001297716.1 , NM_001297716.2 | |
Accession Version | NM_001297716.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2031bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-23 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK094917.1, AC108091.3 and AC026783.5. On Jul 10, 2014 this sequence version replaced XM_005248470.1. Transcript Variant: This variant (2) has an alternate 3' terminal exon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK094917.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145245, SAMEA2145743 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001284645.1 |
CDS | 201..2231 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001297716.1 |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu39511 | |
Clone ID Related Accession (Same CDS sequence) | NM_001297716.1 , NM_001297716.2 | |
Accession Version | NM_001297716.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2031bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-25 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC026774.7, AK094917.1, AC108091.3 and AC026783.5. On May 31, 2019 this sequence version replaced NM_001297716.1. Transcript Variant: This variant (2) has an alternate 3' terminal exon, compared to variant 1. The resulting isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK094917.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2145245, SAMEA2145743 [ECO:0000350] ##Evidence-Data-END## |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001284645.1 |
CDS | 232..2262 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001297716.2 |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu65218 | |
Clone ID Related Accession (Same CDS sequence) | XM_011543282.2 , NM_014979.4 , XM_011543281.2 , NM_014979.3 , XM_011543281.3 , XM_011543282.3 | |
Accession Version | NM_014979.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK094917.1, DA725900.1, BC100825.1, AC108091.3, AB028977.1, AC113404.3 and R44558.1. On Sep 23, 2014 this sequence version replaced NM_014979.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.223336.1, SRR1660807.7929.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145245, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_055794.3 |
CDS | 201..2384 |
Translation |
Target ORF information:
Target ORF information:
|
NM_014979.3 |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu65218 | |
Clone ID Related Accession (Same CDS sequence) | XM_011543282.2 , NM_014979.4 , XM_011543281.2 , NM_014979.3 , XM_011543281.3 , XM_011543282.3 | |
Accession Version | XM_011543282.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011543282.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011541584.2 |
CDS | 1128..3311 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011543282.2 |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu65218 | |
Clone ID Related Accession (Same CDS sequence) | XM_011543282.2 , NM_014979.4 , XM_011543281.2 , NM_014979.3 , XM_011543281.3 , XM_011543282.3 | |
Accession Version | XM_011543281.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011543281.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011541583.1 |
CDS | 568..2751 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011543281.2 |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu65218 | |
Clone ID Related Accession (Same CDS sequence) | XM_011543282.2 , NM_014979.4 , XM_011543281.2 , NM_014979.3 , XM_011543281.3 , XM_011543282.3 | |
Accession Version | XM_011543281.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011543281.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011541583.1 |
CDS | 568..2751 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011543281.3 |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu65218 | |
Clone ID Related Accession (Same CDS sequence) | XM_011543282.2 , NM_014979.4 , XM_011543281.2 , NM_014979.3 , XM_011543281.3 , XM_011543282.3 | |
Accession Version | XM_011543282.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2184bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | synaptic vesicle glycoprotein 2C isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011543282.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011541584.2 |
CDS | 1128..3311 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011543282.3 |
1 | ATGGAAGACT CTTACAAGGA TAGGACTTCA CTGATGAAGG GTGCCAAGGA CATTGCCAGA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Synaptic vesicle glycoprotein 2C (SV2C) modulates dopamine release and is disrupted in Parkinson disease. |
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A. |
Botulinum neurotoxins: new questions arising from structural biology. |
Genetic variant predicts bevacizumab-induced hypertension in ECOG-5103 and ECOG-2100. |
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. |