ARC cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | ARC |
| Entrez Gene ID | 23237 |
| Full Name | activity regulated cytoskeleton associated protein |
| Synonyms | Arg3.1 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_015193.4 | NP_056008.1 | activity-regulated cytoskeleton-associated protein |
| NM_015193.5 | NP_056008.1 | activity-regulated cytoskeleton-associated protein |
| Homo sapiens (human) | ARC | NP_056008.1 |
| Rattus norvegicus (Norway rat) | Arc | NP_062234.1 |
| Gallus gallus (chicken) | ARC | NP_989763.1 |
| Bos taurus (cattle) | ARC | NP_001193336.1 |
| Xenopus tropicalis (tropical clawed frog) | arc | XP_004918984.1 |
| Pan troglodytes (chimpanzee) | ARC | XP_528245.2 |
| Mus musculus (house mouse) | Arc | NP_061260.1 |
| LOC702690 | XP_001090976.1 |
Related articles in PubMed
TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation.
Husain N, Yuan Q, Yen YC, Pletnikova O, Sally DQ, Worley P, Bichler Z, Shawn Je H
Aging cell16(2)281-292(2017 Apr)
Implication of the APP Gene in Intellectual Abilities.
Myrum C, Nikolaienko O, Bramham CR, Haavik J, Zayats T
Journal of Alzheimer's disease : JAD59(2)723-735(2017)
The Arc Gene Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese.
Bi R, Kong LL, Xu M, Li GD, Zhang DF, , Li T, Fang Y, Zhang C, Zhang B, Yao YG
Molecular neurobiology(2017 Jan)
Rare mutations and hypermethylation of the ARC gene associated with schizophrenia.
Chuang YA, Hu TM, Chen CH, Hsu SH, Tsai HY, Cheng MC
Schizophrenia research176(2-3)106-113(2016 10)
Decreased apoptosis repressor with caspase recruitment domain confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways.
Gobe GC, Ng KL, Small DM, Vesey DA, Johnson DW, Samaratunga H, Oliver K, Wood S, Barclay JL, Rajandram R, Li L, Morais C
Biochemical and biophysical research communications473(1)47-53(2016 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
missense mutations in TRIAD3 abolished the interaction of TRIAD3A with Arc, disrupting Arc ubiquitination, and consequently Arc degradation.
Title: TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation.
Study identified several rare mutations that reduced ARC expression in schizophrenia patients. Furthermore, DNA methylation of ARC in schizophrenia patients may be associated with a downregulation of ARC mRNA expression. These findings suggest that multiple rare ARC variants and DNA methylation of ARC might contribute to the pathogenesis of schizophrenia.
Title: Rare mutations and hypermethylation of the ARC gene associated with schizophrenia.
ARC confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways
Title: Decreased apoptosis repressor with caspase recruitment domain confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways.
We tested whether ARC variants are associated with six measures of cognitive functioning in 670 healthy subjects in the Norwegian Cognitive NeuroGenetics (NCNG) by extracting data from its Genome-Wide Association Study (GWAS).
Title: Common variants in the ARC gene are not associated with?cognitive abilities.
this is the first report associating an ARC SNP with schizophrenia and supports recent large-scale GWAS findings implicating the ARC complex in schizophrenia risk
Title: Association of SNPs in EGR3 and ARC with Schizophrenia Supports a Biological Pathway for Schizophrenia Risk.
The following ARC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ARC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu01629 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_015193.4 , NM_015193.5 | |
| Accession Version | NM_015193.4 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-28 | |
| Organism | Homo sapiens(human) | |
| Product | activity-regulated cytoskeleton-associated protein | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP006547.1, BC012321.1 and AI096899.1. On Aug 8, 2012 this sequence version replaced NM_015193.3. CCDS Note: This CCDS ID represents the protein described in PMIDs: 10970730 and 17466953. This transcript is supported by BC075802.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously PMID: 17466953. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012321.1, AF193421.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## NMD candidate :: PMID: 17466953 ##RefSeq-Attributes-END## | |
1 | ATGGAGCTGG ACCACCGGAC CAGCGGCGGG CTCCACGCCT ACCCCGGGCC GCGGGGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_056008.1 |
| CDS | 202..1392 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_015193.4 |
ORF Insert Sequence:
1 | ATGGAGCTGG ACCACCGGAC CAGCGGCGGG CTCCACGCCT ACCCCGGGCC GCGGGGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu01629 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_015193.4 , NM_015193.5 | |
| Accession Version | NM_015193.5 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1191bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-01 | |
| Organism | Homo sapiens(human) | |
| Product | activity-regulated cytoskeleton-associated protein | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AP006547.1 and BC012321.1. On Nov 22, 2018 this sequence version replaced NM_015193.4. CCDS Note: This CCDS ID represents the protein described in PMIDs: 10970730 and 17466953. This transcript is supported by BC075802.1. It should be noted this transcript is predicted to undergo nonsense-mediated mRNA decay (NMD). However, the protein is represented because it was detected endogenously PMID: 17466953. It is likely that the majority of transcripts representing this variant will undergo NMD, while some low level of NMD escape may allow for the expression of this protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012321.1, SRR1660807.232290.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145544 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000356613.4/ ENSP00000349022.2 NMD candidate :: PMID: 17466953 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGGAGCTGG ACCACCGGAC CAGCGGCGGG CTCCACGCCT ACCCCGGGCC GCGGGGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_056008.1 |
| CDS | 209..1399 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_015193.5 |
ORF Insert Sequence:
1 | ATGGAGCTGG ACCACCGGAC CAGCGGCGGG CTCCACGCCT ACCCCGGGCC GCGGGGCGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
TRIAD3/RNF216 mutations associated with Gordon Holmes syndrome lead to synaptic and cognitive impairments via Arc misregulation. |
|
Implication of the APP Gene in Intellectual Abilities. |
|
The Arc Gene Confers Genetic Susceptibility to Alzheimer's Disease in Han Chinese. |
|
Rare mutations and hypermethylation of the ARC gene associated with schizophrenia. |
|
Decreased apoptosis repressor with caspase recruitment domain confers resistance to sunitinib in renal cell carcinoma through alternate angiogenesis pathways. |