Gene Symbol | RRP8 |
Entrez Gene ID | 23378 |
Full Name | ribosomal RNA processing 8 |
Synonyms | KIAA0409,NML |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » RRP8 cDNA ORF clone
Gene Symbol | RRP8 |
Entrez Gene ID | 23378 |
Full Name | ribosomal RNA processing 8 |
Synonyms | KIAA0409,NML |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_015324.3 | NP_056139.1 | ribosomal RNA-processing protein 8 |
XM_011519955.2 | XP_011518257.1 | ribosomal RNA-processing protein 8 isoform X1 |
XM_017017423.1 | XP_016872912.1 | ribosomal RNA-processing protein 8 isoform X2 |
XM_017017423.2 | XP_016872912.1 | ribosomal RNA-processing protein 8 isoform X2 |
NM_015324.4 | NP_056139.1 | ribosomal RNA-processing protein 8 |
Homo sapiens (human) | RRP8 | NP_056139.1 |
Mus musculus (house mouse) | Rrp8 | NP_080173.1 |
Rattus norvegicus (Norway rat) | Rrp8 | NP_001008347.1 |
Gallus gallus (chicken) | RRP8 | XP_423009.3 |
Oryza sativa (rice) | Os02g0593900 | NP_001047303.1 |
Pan troglodytes (chimpanzee) | RRP8 | XP_508260.3 |
RRP8 | XP_001100895.2 | |
Canis lupus familiaris (dog) | RRP8 | XP_534039.3 |
Arabidopsis thaliana (thale cress) | AT5G40530 | NP_198869.2 |
Xenopus tropicalis (tropical clawed frog) | LOC100498652 | XP_002943150.1 |
Bos taurus (cattle) | RRP8 | NP_001179303.1 |
NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner.
Waku T, Nakajima Y, Yokoyama W, Nomura N, Kako K, Kobayashi A, Shimizu T, Fukamizu A
Journal of cell science129(12)2382-93(2016 06)
Novel Autoantigens Associated with Lupus Nephritis.
Onishi S, Adnan E, Ishizaki J, Miyazaki T, Tanaka Y, Matsumoto T, Suemori K, Shudou M, Okura T, Takeda H, Sawasaki T, Yasukawa M, Hasegawa H
PloS one10(6)e0126564(2015)
Nucleolar repression facilitates initiation and maintenance of senescence.
Yang L, Song T, Chen L, Soliman H, Chen J
Cell cycle (Georgetown, Tex.)14(22)3613-23(2015)
Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability.
Yang L, Song T, Chen L, Kabra N, Zheng H, Koomen J, Seto E, Chen J
Molecular and cellular biology33(19)3835-48(2013 Oct)
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
NML depletion increases 60S ribosomal protein L11 (RPL11) levels in the ribosome-free fraction and protein levels of p53 through an RPL11-MDM2 complex, which activates the p53 pathway.
Title: NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner.
Among Systemic lupus erythematosus patients, 63.6% and 45.5% of those with lupus nephritis were positive for anti-RRP8 and anti-TNP1 antibodies, compared with 12.5% and 9.4% of Systemic lupus erythematosus patients without nephritis, respectively.
Title: Novel Autoantigens Associated with Lupus Nephritis.
Breast tumors without detectable nucleolar NML expression had poor survival.
Title: Nucleolar repression facilitates initiation and maintenance of senescence.
Data indicate that the the nucleomethylin (NML)-SirT1 interaction was competitively inhibited by rRNA.
Title: Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability.
These observations suggest that NML may regulate consumption of hepatic triglyceride in liver regeneration after partial hepatectomy due to storage of excess ATP.
Title: The nucleolar protein NML regulates hepatic ATP levels during liver regeneration after partial hepatectomy.
The following RRP8 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RRP8 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu27887 | |
Clone ID Related Accession (Same CDS sequence) | NM_015324.3 , NM_015324.4 | |
Accession Version | NM_015324.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Homo sapiens(human) | |
Product | ribosomal RNA-processing protein 8 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX417992.2, BC001071.2, AB007869.1, R51624.1 and AC009796.6. On Nov 22, 2018 this sequence version replaced NM_015324.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB007869.1, SRR1803612.183196.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000254605.11/ ENSP00000254605.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGTTCGAAG AGCCTGAGTG GGCCGAGGCG GCCCCAGTAG CCGCGGGCCT TGGGCCCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_056139.1 |
CDS | 115..1485 |
Translation |
Target ORF information:
Target ORF information:
|
NM_015324.4 |
1 | ATGTTCGAAG AGCCTGAGTG GGCCGAGGCG GCCCCAGTAG CCGCGGGCCT TGGGCCCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu92071 | |
Clone ID Related Accession (Same CDS sequence) | XM_017017423.1 , XM_017017423.2 | |
Accession Version | XM_017017423.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | ribosomal RNA-processing protein 8 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCACAGC GGCTGGATGG GGCCCGATTT CGCTACCTCA ATGAACAGTT GTACTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016872912.1 |
CDS | 949..1596 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017017423.1 |
1 | ATGGCACAGC GGCTGGATGG GGCCCGATTT CGCTACCTCA ATGAACAGTT GTACTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu92071 | |
Clone ID Related Accession (Same CDS sequence) | XM_017017423.1 , XM_017017423.2 | |
Accession Version | XM_017017423.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 648bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | ribosomal RNA-processing protein 8 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017017423.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGCACAGC GGCTGGATGG GGCCCGATTT CGCTACCTCA ATGAACAGTT GTACTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016872912.1 |
CDS | 949..1596 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017017423.2 |
1 | ATGGCACAGC GGCTGGATGG GGCCCGATTT CGCTACCTCA ATGAACAGTT GTACTCAGGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu27887 | |
Clone ID Related Accession (Same CDS sequence) | NM_015324.3 , NM_015324.4 | |
Accession Version | NM_015324.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1371bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-01 | |
Organism | Homo sapiens(human) | |
Product | ribosomal RNA-processing protein 8 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BX417992.2, BC001071.2, AB007869.1 and R51624.1. On Aug 10, 2011 this sequence version replaced NM_015324.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.263469.1, SRR1803614.14172.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGTTCGAAG AGCCTGAGTG GGCCGAGGCG GCCCCAGTAG CCGCGGGCCT TGGGCCCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_056139.1 |
CDS | 149..1519 |
Translation |
Target ORF information:
Target ORF information:
|
NM_015324.3 |
1 | ATGTTCGAAG AGCCTGAGTG GGCCGAGGCG GCCCCAGTAG CCGCGGGCCT TGGGCCCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu66108 | |
Clone ID Related Accession (Same CDS sequence) | XM_011519955.2 | |
Accession Version | XM_011519955.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1287bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | ribosomal RNA-processing protein 8 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011519955.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTTCGAAG AGCCTGAGTG GGCCGAGGCG GCCCCAGTAG CCGCGGGCCT TGGGCCCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_011518257.1 |
CDS | 177..1463 |
Translation |
Target ORF information:
Target ORF information:
|
XM_011519955.2 |
1 | ATGTTCGAAG AGCCTGAGTG GGCCGAGGCG GCCCCAGTAG CCGCGGGCCT TGGGCCCGTA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
NML-mediated rRNA base methylation links ribosomal subunit formation to cell proliferation in a p53-dependent manner. |
Novel Autoantigens Associated with Lupus Nephritis. |
Nucleolar repression facilitates initiation and maintenance of senescence. |
Regulation of SirT1-nucleomethylin binding by rRNA coordinates ribosome biogenesis with nutrient availability. |
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. |