Gene Symbol | BCL6B |
Entrez Gene ID | 255877 |
Full Name | B cell CLL/lymphoma 6B |
Synonyms | BAZF,ZBTB28,ZNF62 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » BCL6B cDNA ORF clone
gRNAs
Gene Symbol | BCL6B |
Entrez Gene ID | 255877 |
Full Name | B cell CLL/lymphoma 6B |
Synonyms | BAZF,ZBTB28,ZNF62 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_181844.3 | NP_862827.1 | B-cell CLL/lymphoma 6 member B protein |
NM_181844.4 | NP_862827.2 | B-cell CLL/lymphoma 6 member B protein |
BCL6B expression in hepatocellular carcinoma and its efficacy in the inhibition of liver damage and fibrogenesis.
Wang W, Huang P, Wu P, Kong R, Xu J, Zhang L, Yang Q, Xie Q, Zhang L, Zhou X, Chen L, Xie H, Zhou L, Zheng S
Oncotarget6(24)20252-65(2015 Aug)
Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU.
Li X, Yu J, Brock MV, Tao Q, Herman JG, Liang P, Guo M
Oncotarget6(13)11547-60(2015 May)
B cell CLL/lymphoma 6 member B inhibits hepatocellular carcinoma metastases in vitro and in mice.
Wang J, Dong L, Xu L, Chu ES, Chen Y, Shen J, Li X, Wong CC, Sung JJ, Yu J
Cancer letters355(2)192-200(2014 Dec)
The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter.
Deng J, Liang H, Dong Q, Hou Y, Xie X, Yu J, Fan D, Hao X
Open biology4(7)(2014 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
BCL6B plays a pivotal role as a prognostic biomarker for HCC.
Title: BCL6B expression in hepatocellular carcinoma and its efficacy in the inhibition of liver damage and fibrogenesis.
Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cells to become resistant to 5-FU.
Title: Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU.
BCL6B functions as a tumor suppressor that inhibits HCC metastases in vitro and in vivo.
Title: B cell CLL/lymphoma 6 member B inhibits hepatocellular carcinoma metastases in vitro and in mice.
Patients with three or more methylated CpG sites in the BCL6B promoter were significantly associated with poor survival.
Title: The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter.
BCL6B methylation may serve as a novel potential non-invasive plasma biomarker for the detection of gastric cancer
Title: Promoter hypermethylation of BCL6B gene is a potential plasma DNA biomarker for gastric cancer.
The following BCL6B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BCL6B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu07610![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_181844.3 | |
Accession Version | NM_181844.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1443bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-12 | |
Organism | Homo sapiens(human) | |
Product | B-cell CLL/lymphoma 6 member B protein | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC059404.1 and AB076580.1. On Mar 28, 2007 this sequence version replaced NM_181844.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.124867.1, BC059404.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGGTTCCC CCGCCGCCCC GGAGGGAGCG CTGGGCTACG TCCGCGAGTT CACTCGCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_862827.1 |
CDS | 63..1505 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGTTCCC CCGCCGCCCC GGAGGGAGCG CTGGGCTACG TCCGCGAGTT CACTCGCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu107186 | |
Clone ID Related Accession (Same CDS sequence) | NM_181844.4 | |
Accession Version | NM_181844.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1440bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-23 | |
Organism | Homo sapiens(human) | |
Product | B-cell CLL/lymphoma 6 member B protein | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC059404.1, AB076580.1, AC040977.10 and AK122893.1. On Nov 20, 2018 this sequence version replaced NM_181844.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK292878.1, AB076580.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000293805.10/ ENSP00000293805.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## |
1 | ATGGGTTCCC CCGCCGCCCC GGAGGGAGCG CTGGGCTACG TCCGCGAGTT CACTCGCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_862827.2 |
CDS | 63..1502 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGGTTCCC CCGCCGCCCC GGAGGGAGCG CTGGGCTACG TCCGCGAGTT CACTCGCCAC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
BCL6B expression in hepatocellular carcinoma and its efficacy in the inhibition of liver damage and fibrogenesis. |
Epigenetic silencing of BCL6B inactivates p53 signaling and causes human hepatocellular carcinoma cell resist to 5-FU. |
B cell CLL/lymphoma 6 member B inhibits hepatocellular carcinoma metastases in vitro and in mice. |
The survival decrease in gastric cancer is associated with the methylation of B-cell CLL/lymphoma 6 member B promoter. |