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GATA6 cDNA ORF clone, Homo sapiens (human)

Gene Symbol GATA6
Entrez Gene ID 2627
Full Name GATA binding protein 6
General protein information
Preferred Names
transcription factor GATA-6
Names
transcription factor GATA-6
GATA-binding factor 6
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

18

18q11.1-q11.2

Summary This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012]. lac of sum
Disorder MIM:

601656


mRNA and Protein(s)

mRNA Protein Name
NM_005257 NP_005248 transcription factor GATA-6



Homo sapiens (human) GATA6 NP_005248.2
Pan troglodytes (chimpanzee) GATA6 XP_003954430.1
Macaca mulatta (Rhesus monkey) GATA6 XP_002800933.1
Canis lupus familiaris (dog) GATA6 XP_005623196.1
Mus musculus (house mouse) Gata6 NP_034388.2
Rattus norvegicus (Norway rat) Gata6 NP_062058.1
Danio rerio (zebrafish) gata6 NP_571632.1
Xenopus (Silurana) tropicalis (western clawed frog) gata6 NP_989422.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following GATA6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GATA6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu27933
NM_005257 Homo sapiens GATA binding protein 6 (GATA6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$249.50-$349.30
$499.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu27933
Clone ID Related Accession (Same CDS sequence) NM_005257
Accession Version NM_005257.5 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1788bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product transcription factor GATA-6
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY052912.1, X95701.1, U66075.1 and AU309820.1. This sequence is a reference standard in the RefSeqGene project. On Apr 30, 2014 this sequence version replaced gi:386268026. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## regulatory uORF :: PMID: 15173203 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: X95701.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCCTTGA CTGACGGCGG CTGGTGCTTG CCGAAGCGCT TCGGGGCCGC GGGTGCGGAC 
GCCAGCGACT CCAGAGCCTT TCCAGCGCGG GAGCCCTCCA CGCCGCCTTC CCCCATCTCT
TCCTCGTCCT CCTCCTGCTC CCGGGGCGGA GAGCGGGGCC CCGGCGGCGC CAGCAACTGC
GGGACGCCTC AGCTCGACAC GGAGGCGGCG GCCGGACCCC CGGCCCGCTC GCTGCTGCTC
AGTTCCTACG CTTCGCATCC CTTCGGGGCT CCCCACGGAC CTTCGGCGCC TGGGGTCGCG
GGCCCCGGGG GCAACCTGTC GAGCTGGGAG GACTTGCTGC TGTTCACTGA CCTCGACCAA
GCCGCGACCG CCAGCAAGCT GCTGTGGTCC AGCCGCGGCG CCAAGCTGAG CCCCTTCGCA
CCCGAGCAGC CGGAGGAGAT GTACCAGACC CTCGCCGCTC TCTCCAGCCA GGGTCCGGCC
GCCTACGACG GCGCGCCCGG CGGCTTCGTG CACTCTGCGG CCGCGGCGGC AGCAGCCGCG
GCGGCGGCCA GCTCCCCGGT CTACGTGCCC ACCACCCGCG TGGGTTCCAT GCTGCCCGGC
CTACCGTACC ACCTGCAGGG GTCGGGCAGT GGGCCAGCCA ACCACGCGGG CGGCGCGGGC
GCGCACCCCG GCTGGCCTCA GGCCTCGGCC GACAGCCCTC CATACGGCAG CGGAGGCGGC
GCGGCTGGCG GCGGGGCCGC GGGGCCTGGC GGCGCTGGCT CAGCCGCGGC GCACGTCTCG
GCGCGCTTCC CCTACTCTCC CAGCCCGCCC ATGGCCAACG GCGCCGCGCG GGAGCCGGGA
GGCTACGCGG CGGCGGGCAG TGGGGGCGCG GGAGGCGTGA GCGGCGGCGG CAGTAGCCTG
GCGGCCATGG GCGGCCGCGA GCCCCAGTAC AGCTCGCTGT CGGCCGCGCG GCCGCTGAAC
GGGACGTACC ACCACCACCA CCACCACCAC CACCACCATC CGAGCCCCTA CTCGCCCTAC
GTGGGGGCGC CACTGACGCC TGCCTGGCCC GCCGGACCCT TCGAGACCCC GGTGCTGCAC
AGCCTGCAGA GCCGCGCCGG AGCCCCGCTC CCGGTGCCCC GGGGTCCCAG TGCAGACCTG
CTGGAGGACC TGTCCGAGAG CCGCGAGTGC GTGAACTGCG GCTCCATCCA GACGCCGCTG
TGGCGGCGGG ACGGCACCGG CCACTACCTG TGCAACGCCT GCGGGCTCTA CAGCAAGATG
AACGGCCTCA GCCGGCCCCT CATCAAGCCG CAGAAGCGCG TGCCTTCATC ACGGCGGCTT
GGATTGTCCT GTGCCAACTG TCACACCACA ACTACCACCT TATGGCGCAG AAACGCCGAG
GGTGAACCCG TGTGCAATGC TTGTGGACTC TACATGAAAC TCCATGGGGT GCCCAGACCA
CTTGCTATGA AAAAAGAGGG AATTCAAACC AGGAAACGAA AACCTAAGAA CATAAATAAA
TCAAAGACTT GCTCTGGTAA TAGCAATAAT TCCATTCCCA TGACTCCAAC TTCCACCTCT
TCTAACTCAG ATGATTGCAG CAAAAATACT TCCCCCACAA CACAACCTAC AGCCTCAGGG
GCGGGTGCCC CGGTGATGAC TGGTGCGGGA GAGAGCACCA ATCCCGAGAA CAGCGAGCTC
AAGTATTCGG GTCAAGATGG GCTCTACATA GGCGTCAGTC TCGCCTCGCC GGCCGAAGTC
ACGTCCTCCG TGCGACCGGA TTCCTGGTGC GCCCTGGCCC TGGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005248.2
CDS284..2071
Misc Feature(1)227..253(+)
Misc Feature(2)251..253(+)
Misc Feature(3)722..1426(+)
Misc Feature(4)1085..1087(+)
Misc Feature(5)1445..1588(+)
Misc Feature(6)1448..1585(+)
Misc Feature(7)1451..1525(+)
Misc Feature(8)1478..1546(+)
Misc Feature(9)1604..1747(+)
Misc Feature(10)1610..1765(+)
Misc Feature(11)1613..1687(+)
Misc Feature(12)1640..1765(+)
Exon (1)1..246
Gene:GATA6
Gene Synonym:
Exon (2)247..1418
Gene:GATA6
Gene Synonym:
Exon (3)1419..1585
Gene:GATA6
Gene Synonym:
Exon (4)1586..1711
Gene:GATA6
Gene Synonym:
Exon (5)1712..1799
Gene:GATA6
Gene Synonym:
Exon (6)1800..1903
Gene:GATA6
Gene Synonym:
Exon (7)1904..3776
Gene:GATA6
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005257
Organism Homo sapiens (human)
Definition Homo sapiens GATA binding protein 6 (GATA6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005257

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
ATGGCCTTGA CTGACGGCGG CTGGTGCTTG CCGAAGCGCT TCGGGGCCGC GGGTGCGGAC 
GCCAGCGACT CCAGAGCCTT TCCAGCGCGG GAGCCCTCCA CGCCGCCTTC CCCCATCTCT
TCCTCGTCCT CCTCCTGCTC CCGGGGCGGA GAGCGGGGCC CCGGCGGCGC CAGCAACTGC
GGGACGCCTC AGCTCGACAC GGAGGCGGCG GCCGGACCCC CGGCCCGCTC GCTGCTGCTC
AGTTCCTACG CTTCGCATCC CTTCGGGGCT CCCCACGGAC CTTCGGCGCC TGGGGTCGCG
GGCCCCGGGG GCAACCTGTC GAGCTGGGAG GACTTGCTGC TGTTCACTGA CCTCGACCAA
GCCGCGACCG CCAGCAAGCT GCTGTGGTCC AGCCGCGGCG CCAAGCTGAG CCCCTTCGCA
CCCGAGCAGC CGGAGGAGAT GTACCAGACC CTCGCCGCTC TCTCCAGCCA GGGTCCGGCC
GCCTACGACG GCGCGCCCGG CGGCTTCGTG CACTCTGCGG CCGCGGCGGC AGCAGCCGCG
GCGGCGGCCA GCTCCCCGGT CTACGTGCCC ACCACCCGCG TGGGTTCCAT GCTGCCCGGC
CTACCGTACC ACCTGCAGGG GTCGGGCAGT GGGCCAGCCA ACCACGCGGG CGGCGCGGGC
GCGCACCCCG GCTGGCCTCA GGCCTCGGCC GACAGCCCTC CATACGGCAG CGGAGGCGGC
GCGGCTGGCG GCGGGGCCGC GGGGCCTGGC GGCGCTGGCT CAGCCGCGGC GCACGTCTCG
GCGCGCTTCC CCTACTCTCC CAGCCCGCCC ATGGCCAACG GCGCCGCGCG GGAGCCGGGA
GGCTACGCGG CGGCGGGCAG TGGGGGCGCG GGAGGCGTGA GCGGCGGCGG CAGTAGCCTG
GCGGCCATGG GCGGCCGCGA GCCCCAGTAC AGCTCGCTGT CGGCCGCGCG GCCGCTGAAC
GGGACGTACC ACCACCACCA CCACCACCAC CACCACCATC CGAGCCCCTA CTCGCCCTAC
GTGGGGGCGC CACTGACGCC TGCCTGGCCC GCCGGACCCT TCGAGACCCC GGTGCTGCAC
AGCCTGCAGA GCCGCGCCGG AGCCCCGCTC CCGGTGCCCC GGGGTCCCAG TGCAGACCTG
CTGGAGGACC TGTCCGAGAG CCGCGAGTGC GTGAACTGCG GCTCCATCCA GACGCCGCTG
TGGCGGCGGG ACGGCACCGG CCACTACCTG TGCAACGCCT GCGGGCTCTA CAGCAAGATG
AACGGCCTCA GCCGGCCCCT CATCAAGCCG CAGAAGCGCG TGCCTTCATC ACGGCGGCTT
GGATTGTCCT GTGCCAACTG TCACACCACA ACTACCACCT TATGGCGCAG AAACGCCGAG
GGTGAACCCG TGTGCAATGC TTGTGGACTC TACATGAAAC TCCATGGGGT GCCCAGACCA
CTTGCTATGA AAAAAGAGGG AATTCAAACC AGGAAACGAA AACCTAAGAA CATAAATAAA
TCAAAGACTT GCTCTGGTAA TAGCAATAAT TCCATTCCCA TGACTCCAAC TTCCACCTCT
TCTAACTCAG ATGATTGCAG CAAAAATACT TCCCCCACAA CACAACCTAC AGCCTCAGGG
GCGGGTGCCC CGGTGATGAC TGGTGCGGGA GAGAGCACCA ATCCCGAGAA CAGCGAGCTC
AAGTATTCGG GTCAAGATGG GCTCTACATA GGCGTCAGTC TCGCCTCGCC GGCCGAAGTC
ACGTCCTCCG TGCGACCGGA TTCCTGGTGC GCCCTGGCCC TGGCCTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Nicotine induces the up-regulation of the alpha7-nicotinic receptor (alpha7-nAChR) in human squamous cell lung cancer cells via the Sp1/GATA protein pathway
J. Biol. Chem. 288 (46), 33049-33059 (2013)
Brown KC, Perry HE, Lau JK, Jones DV, Pulliam JF, Thornhill BA, Crabtree CM, Luo H, Chen YC and Dasgupta P.


book

Spontaneously differentiated GATA6-positive human embryonic stem cells represent an important cellular step in human embryonic development; they are not just an artifact of in vitro culture
Stem Cells Dev. 22 (20), 2706-2713 (2013)
Lee JH, Hong KS, Mantel C, Broxmeyer HE, Lee MR and Kim KS.


book

Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis
Cancer Cell 23 (6), 725-738 (2013)
Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF and Nguyen DX.


book

Endothelial GATA-6 deficiency promotes pulmonary arterial hypertension
Am. J. Pathol. 182 (6), 2391-2406 (2013)
Ghatnekar A, Chrobak I, Reese C, Stawski L, Seta F, Wirrig E, Paez-Cortez J, Markiewicz M, Asano Y, Harley R, Silver R, Feghali-Bostwick C and Trojanowska M.


book

Two novel GATA6 mutations cause childhood-onset diabetes mellitus, pancreas malformation and congenital heart disease
Horm Res Paediatr 79 (4), 250-256 (2013)
Gong M, Simaite D, Kuhnen P, Heldmann M, Spagnoli F, Blankenstein O, Hubner N, Hussain K and Raile K.


book

A unique role of an amino terminal 16-residue region of long-type GATA-6
J. Biochem. 135 (5), 639-650 (2004)
Takeda M, Obayashi K, Kobayashi A and Maeda M.


book

Distinct functions are implicated for the GATA-4, -5, and -6 transcription factors in the regulation of intestine epithelial cell differentiation
Mol. Cell. Biol. 18 (5), 2901-2911 (1998)
Gao X, Sedgwick T, Shi YB and Evans T.


book

GATA-6 DNA binding protein expressed in human gastric adenocarcinoma MKN45 cells
FEBS Lett. 414 (2), 333-337 (1997)
Yoshida T, Sato R, Mahmood S, Kawasaki S, Futai M and Maeda M.


book

Molecular cloning of human GATA-6 DNA binding protein: high levels of expression in heart and gut
Biochim. Biophys. Acta 1353 (2), 98-102 (1997)
Huggon IC, Davies A, Gove C, Moscoso G, Moniz C, Foss Y, Farzaneh F and Towner P.


book

The human GATA-6 gene: structure, chromosomal location, and regulation of expression by tissue-specific and mitogen-responsive signals
Genomics 38 (3), 283-290 (1996)
Suzuki E, Evans T, Lowry J, Truong L, Bell DW, Testa JR and Walsh K.


 
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