Gene Symbol | GPR12 |
Entrez Gene ID | 2835 |
Full Name | G protein-coupled receptor 12 |
Synonyms | GPCR12,GPCR21,PPP1R84 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » GPR12 cDNA ORF clone
gRNAs
Gene Symbol | GPR12 |
Entrez Gene ID | 2835 |
Full Name | G protein-coupled receptor 12 |
Synonyms | GPCR12,GPCR21,PPP1R84 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_005288.4 | NP_005279.1 | G-protein coupled receptor 12 |
NM_005288.3 | NP_005279.1 | G-protein coupled receptor 12 |
XM_005266360.3 | XP_005266417.1 | G-protein coupled receptor 12 isoform X1 |
Homo sapiens (human) | GPR12 | NP_005279.1 |
Rattus norvegicus (Norway rat) | Gpr12 | NP_001032372.1 |
Gallus gallus (chicken) | GPR12 | XP_004938835.1 |
Xenopus tropicalis (tropical clawed frog) | gpr12 | XP_002941580.1 |
GPR12 | XP_001094268.1 | |
Mus musculus (house mouse) | Gpr12 | NP_032177.1 |
Pan troglodytes (chimpanzee) | GPR12 | XP_001157503.1 |
Canis lupus familiaris (dog) | GPR12 | XP_005635581.1 |
Bos taurus (cattle) | GPR12 | NP_001193259.1 |
Danio rerio (zebrafish) | gpr12 | XP_005162795.1 |
Cannabidiol, a novel inverse agonist for GPR12.
Brown KJ, Laun AS, Song ZH
Biochemical and biophysical research communications493(1)451-454(2017 11)
Involvement of GPR12 in the regulation of cell proliferation and survival.
Lu X, Zhang N, Meng B, Dong S, Hu Y
Molecular and cellular biochemistry366(1-2)101-10(2012 Jul)
Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.
Uhlenbrock K, Huber J, Ardati A, Busch AE, Kostenis E
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology13(2)75-84(2003)
Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors.
Song ZH, Modi W, Bonner TI
Genomics28(2)347-9(1995 Jul)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Since we have demonstrated that CBD is an inverse agonist for GPR12, this provides novel mechanism of action for CBD, and an initial chemical scaffold upon which highly potent and efficacious agents acting on GPR12 may be developed with the ultimate goal of blocking cancer metastasis.
Title: Cannabidiol, a novel inverse agonist for GPR12.
GPR12 may play a role in cell proliferation and survival
Title: Involvement of GPR12 in the regulation of cell proliferation and survival.
control of gene expression in vascular endothelial cells in the presence of fluid shear stress and classifies it as a sphingosine 1-phosphate receptor
Title: Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells.
The following GPR12 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GPR12 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu28061![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_005288.4 , NM_005288.3 | |
Accession Version | NM_005288.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-30 | |
Organism | Homo sapiens(human) | |
Product | G-protein coupled receptor 12 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL159978.14, AK290220.1 and AW015633.1. On Nov 23, 2018 this sequence version replaced NM_005288.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660803.250970.1, SRR1803615.90676.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000405846.5/ ENSP00000384932.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGAATGAAG ACCTGAAGGT CAATTTAAGC GGGCTGCCTC GGGATTATTT AGATGCCGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_005279.1 |
CDS | 224..1228 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAATGAAG ACCTGAAGGT CAATTTAAGC GGGCTGCCTC GGGATTATTT AGATGCCGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu28061![]() |
|
Clone ID Related Accession (Same CDS sequence) | NM_005288.4 , NM_005288.3 | |
Accession Version | NM_005288.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1005bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-26 | |
Organism | Homo sapiens(human) | |
Product | G-protein coupled receptor 12 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AK290220.1, AL159978.14 and AW015633.1. On Apr 8, 2009 this sequence version replaced NM_005288.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.212668.1, SRR1660803.250970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGAATGAAG ACCTGAAGGT CAATTTAAGC GGGCTGCCTC GGGATTATTT AGATGCCGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_005279.1 |
CDS | 223..1227 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGAATGAAG ACCTGAAGGT CAATTTAAGC GGGCTGCCTC GGGATTATTT AGATGCCGCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu47154 | |
Clone ID Related Accession (Same CDS sequence) | XM_005266360.3 | |
Accession Version | XM_005266360.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 528bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | G-protein coupled receptor 12 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000013.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005266360.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTCGTCA TGCTCTGGGG GACCTCCATC TGCCTGGGGC TGCTGCCCGT CATGGGCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005266417.1 |
CDS | 297..824 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGCTCGTCA TGCTCTGGGG GACCTCCATC TGCCTGGGGC TGCTGCCCGT CATGGGCTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Cannabidiol, a novel inverse agonist for GPR12. |
Involvement of GPR12 in the regulation of cell proliferation and survival. |
Fluid shear stress differentially regulates gpr3, gpr6, and gpr12 expression in human umbilical vein endothelial cells. |
Molecular cloning and chromosomal localization of human genes encoding three closely related G protein-coupled receptors. |