Gene Symbol | PGP |
Entrez Gene ID | 283871 |
Full Name | phosphoglycolate phosphatase |
Synonyms | AUM,G3PP,PGPase |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » PGP cDNA ORF clone
Gene Symbol | PGP |
Entrez Gene ID | 283871 |
Full Name | phosphoglycolate phosphatase |
Synonyms | AUM,G3PP,PGPase |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001042371.3 | NP_001035830.1 | glycerol-3-phosphate phosphatase |
NM_001042371.2 | NP_001035830.1 | glycerol-3-phosphate phosphatase |
Pan troglodytes (chimpanzee) | PGP | XP_001162359.2 |
LOC695591 | XP_001084229.2 | |
Canis lupus familiaris (dog) | PGP | XP_005622146.1 |
Rattus norvegicus (Norway rat) | Pgp | NP_001162623.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP011350 | XP_309300.4 |
Caenorhabditis elegans (roundworm) | C53A3.2 | NP_504511.1 |
Caenorhabditis elegans (roundworm) | CELE_K09H11.7 | NP_504509.1 |
Caenorhabditis elegans (roundworm) | C45E5.1 | NP_500857.2 |
Saccharomyces cerevisiae (baker's yeast) | PHO13 | NP_010045.1 |
Kluyveromyces lactis | KLLA0D19382g | XP_453922.1 |
Schizosaccharomyces pombe (fission yeast) | pho2 | NP_596255.1 |
Neurospora crassa | NCU00088 | XP_957212.1 |
Bos taurus (cattle) | PGP | NP_001033261.1 |
Caenorhabditis elegans (roundworm) | F44E7.2 | NP_504512.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_10149 | XP_003713787.1 |
Arabidopsis thaliana (thale cress) | PGLP2 | NP_199587.1 |
Gallus gallus (chicken) | PGP | NP_001025809.1 |
Caenorhabditis elegans (roundworm) | K02D10.1 | NP_001122707.1 |
Oryza sativa (rice) | Os09g0261300 | NP_001062708.2 |
Xenopus tropicalis (tropical clawed frog) | pgp | XP_002932481.1 |
Homo sapiens (human) | PGP | NP_001035830.1 |
Mus musculus (house mouse) | Pgp | NP_080230.2 |
Danio rerio (zebrafish) | pgp | NP_997891.2 |
Drosophila melanogaster (fruit fly) | CG5567 | NP_649015.2 |
Eremothecium gossypii | AGOS_ABL184W | NP_982763.1 |
A Guardian Angel Phosphatase for Mainline Carbon Metabolism.
Beaudoin GA, Hanson AD
Trends in biochemical sciences41(11)893-894(2016 Nov)
Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes.
Mugabo Y, Zhao S, Seifried A, Gezzar S, Al-Mass A, Zhang D, Lamontagne J, Attane C, Poursharifi P, Iglesias J, Joly E, Peyot ML, Gohla A, Madiraju SR, Prentki M
Proceedings of the National Academy of Sciences of the United States of America113(4)E430-9(2016 Jan)
Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).
Jansson PJ, Yamagishi T, Arvind A, Seebacher N, Gutierrez E, Stacy A, Maleki S, Sharp D, Sahni S, Richardson DR
The Journal of biological chemistry290(15)9588-603(2015 Apr)
Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results.
Machaczka M, Wahlin BE, Piatkowska-Jakubas B, Rucinska M, Jurczak W, Balana-Nowak A, Klimkowska M, H?gglund H, Skotnicki AB
Medical oncology (Northwood, London, England)29(3)2070-6(2012 Sep)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Phosphoglycolate phosphatase rescues central carbon metabolism from toxic secondary metabolites in humans and yeast.
Title: A Guardian Angel Phosphatase for Mainline Carbon Metabolism.
Data indicate that Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance (MDR) via utilization of lysosomal P-glycoprotein (Pgp) transport activity.
Title: Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp).
acute myeloid leukemia patients with co-expression of PGP and Ly showed better overall survival compared with PGP(+) patients without Ly expression
Title: Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results.
expressed in skin lesions from groins and axilla in patients with hidradenitis suppurativa
Title: Cutaneous PGP 9.5 distribution patterns in hidradenitis suppurativa.
the PI3K/Akt pathway is involved in MDR in lymphoma cell lines and PI3K/Akt inhibition correlates down-regulation of NF-kappaB activity and inhibition Pgp function.
Title: PI3K/Akt inhibition modulates multidrug resistance and activates NF-kappaB in murine lymphoma cell lines.
The following PGP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PGP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu14417 | |
Clone ID Related Accession (Same CDS sequence) | NM_001042371.3 , NM_001042371.2 | |
Accession Version | NM_001042371.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-25 | |
Organism | Homo sapiens(human) | |
Product | glycerol-3-phosphate phosphatase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009065.8, AW161386.1, BC035985.1, DA336356.1 and AK026146.1. On May 17, 2019 this sequence version replaced NM_001042371.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.10732.1, SRR1803616.239423.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000333503.8/ ENSP00000330918.7 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## |
1 | ATGGCGGCGG CGGAGGCCGG TGGCGACGAC GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001035830.1 |
CDS | 64..1029 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001042371.3 |
1 | ATGGCGGCGG CGGAGGCCGG TGGCGACGAC GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu14417 | |
Clone ID Related Accession (Same CDS sequence) | NM_001042371.3 , NM_001042371.2 | |
Accession Version | NM_001042371.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-16 | |
Organism | Homo sapiens(human) | |
Product | glycerol-3-phosphate phosphatase | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AW161386.1, BC035985.1, DA336356.1, AK026146.1 and AC009065.8. On or before Jul 31, 2014 this sequence version replaced NM_024118.1, NM_001042371.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803616.239423.1, SRR1660809.10732.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGCGGCGG CGGAGGCCGG TGGCGACGAC GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001035830.1 |
CDS | 45..1010 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001042371.2 |
1 | ATGGCGGCGG CGGAGGCCGG TGGCGACGAC GCCCGCTGCG TGCGGCTGAG CGCCGAGCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
A Guardian Angel Phosphatase for Mainline Carbon Metabolism. |
Identification of a mammalian glycerol-3-phosphate phosphatase: Role in metabolism and signaling in pancreatic ?-cells and hepatocytes. |
Di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT) overcomes multidrug resistance by a novel mechanism involving the hijacking of lysosomal P-glycoprotein (Pgp). |
Association between P-glycoprotein and lymphoid antigen expression on myeloblasts versus therapy response and survival in de novo acute myeloid leukemia: long-term follow-up results. |