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TFAP2E cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol TFAP2E
Entrez Gene ID 339488
Full Name transcription factor AP-2 epsilon
Synonyms AP2E
General protein information
Preferred Names

transcription factor AP-2 epsilon

Names

transcription factor AP-2-epsilon
AP2-epsilon
activating enhancer-binding protein 2-epsilon
adaptor-related protein complex 2, epsilon subunit
transcription factor AP-2 epsilon (activating enhancer binding protein 2 epsilon)
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

1

1p34.3
Disorder MIM:

614428


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_178548.3 NP_848643.2 transcription factor AP-2-epsilon
NM_178548.4 NP_848643.2 transcription factor AP-2-epsilon
XM_017001139.1 XP_016856628.1 transcription factor AP-2-epsilon isoform X1
XM_017001139.2 XP_016856628.1 transcription factor AP-2-epsilon isoform X1

Pathways from BioSystems


Homologies


Homo sapiens (human) TFAP2E NP_848643.2
Pan troglodytes (chimpanzee) TFAP2E XP_524661.3
Bos taurus (cattle) TFAP2E XP_003585964.1
Xenopus tropicalis (tropical clawed frog) tfap2e NP_001123400.1
Gallus gallus (chicken) TFAP2E XP_417778.2
Danio rerio (zebrafish) tfap2e NP_957115.1
Mus musculus (house mouse) Tfap2e NP_945198.2
Rattus norvegicus (Norway rat) Tfap2e NP_001178693.1

Gene Ontology


Bibliography

Related articles in PubMed

Depletion of TFAP2E attenuates adriamycin-mediated apoptosis in human neuroblastoma cells.
Hoshi R, Watanabe Y, Ishizuka Y, Hirano T, Nagasaki-Maeoka E, Yoshizawa S, Uekusa S, Kawashima H, Ohashi K, Sugito K, Fukuda N, Nagase H, Soma M, Ozaki T, Koshinaga T, Fujiwara K
Oncology reports37(4)2459-2464(2017 Apr)

Transcription Factor AP2?: A Potential Predictor of Chemoresistance in Patients With Gastric Cancer.
Sun J, Du N, Li J, Zhou J, Tao G, Sun S, He J
Technology in cancer research & treatment15(2)285-95(2016 Apr)

TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer.
Zhang ZM, Wang Y, Huang R, Liu YP, Li X, Hu FL, Zhu L, Wang F, Cui BB, Dong XS, Zhao YS
Journal of cancer research and clinical oncology140(12)2119-27(2014 Dec)

The transcription factor activating enhancer-binding protein epsilon (AP-2?) regulates the core promoter of type II collagen (COL2A1).
Niebler S, Bosserhoff AK
The FEBS journal280(6)1397-408(2013 Mar)

TFAP2E-DKK4 and chemoresistance in colorectal cancer.
Ebert MP, T?nzer M, Balluff B, Burgermeister E, Kretzschmar AK, Hughes DJ, Tetzner R, Lofton-Day C, Rosenberg R, Reinacher-Schick AC, Schulmann K, Tannapfel A, Hofheinz R, R?cken C, Keller G, Langer R, Specht K, Porschen R, St?hlmacher-Williams J, Schuster T, Str?bel P, Schmid RM
The New England journal of medicine366(1)44-53(2012 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results showed that lower expression levels of TFAP2E are significantly associated with a shorter survival of patients with neuroblastoma indicating that TFAP2E acts as a tumor suppressor of neuroblastoma.
Title: Depletion of TFAP2E attenuates adriamycin-mediated apoptosis in human neuroblastoma cells.

Hypermethylation of TFAP2E was associated with lack of response to fluorouracil-based chemotherapy, indicating that it might be a potential predictor of treatment response in patients with gastric cancer.
Title: Transcription Factor AP2?: A Potential Predictor of Chemoresistance in Patients With Gastric Cancer.

AP-2E was frequently hypermethylated in tumors from patients with colorectal cancer
Title: TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer.

AP-2epsilon indirectly interacts with the core promoter of COL2A1 and subsequently inhibits its transcriptional activity, thus modulating cartilage development.
Title: The transcription factor activating enhancer-binding protein epsilon (AP-2?) regulates the core promoter of type II collagen (COL2A1).

TFAP2E hypermethylation is associated with clinical nonresponsiveness to chemotherapy in colorectal cancer.
Title: TFAP2E-DKK4 and chemoresistance in colorectal cancer.

The following TFAP2E gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TFAP2E cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu24380 NM_178548.4
Latest version!		 Homo sapiens transcription factor AP-2 epsilon (TFAP2E), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $189.50-$265.30
$379.00
OHu87306 XM_017001139.2
Latest version!		 Homo sapiens transcription factor AP-2 epsilon (TFAP2E), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00
View Old Accession Versions >>
OHu24380 NM_178548.3 Homo sapiens transcription factor AP-2 epsilon (TFAP2E), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK		 $189.50-$265.30
$379.00
OHu87306 XM_017001139.1 Homo sapiens transcription factor AP-2 epsilon (TFAP2E), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $223.30
$319.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu24380
Clone ID Related Accession (Same CDS sequence) NM_178548.3 , NM_178548.4
Accession Version NM_178548.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1329bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-11-26
Organism Homo sapiens(human)
Product transcription factor AP-2-epsilon
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC004865.1 and AL157951.5. On Jul 22, 2008 this sequence version replaced NM_178548.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC041175.1, AY326454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTGGTGC ACACCTACTC CGCCATGGAG CGCCCCGACG GGCTGGGAGC AGCTGCCGGC 
GGGGCCCGCC TGTCGTCTCT GCCCCAGGCG GCCTACGGGC CGGCGCCCCC GCTCTGCCAC 
ACGCCGGCCG CCACAGCTGC CGCCGAATTC CAGCCGCCCT ACTTCCCGCC GCCCTACCCG 
CAGCCACCGC TGCCCTACGG TCAGGCGCCC GACGCCGCCG CAGCCTTTCC CCACCTGGCA 
GGGGACCCAT ATGGCGGCCT GGCGCCCCTG GCGCAGCCGC AGCCTCCTCA GGCCGCCTGG 
GCCGCGCCCC GCGCAGCCGC CCGCGCCCAC GAGGAGCCTC CCGGCCTGCT GGCACCGCCC 
GCCCGCGCCC TGGGCCTTGA CCCGCGCCGT GACTATGCCA CTGCCGTGCC CCGGCTCCTG 
CACGGCCTGG CCGACGGCGC GCACGGCCTG GCAGACGCAC CTCTCGGCCT TCCGGGGCTG 
GCGGCGGCCC CCGGTCTGGA GGACCTGCAG GCAATGGACG AGCCGGGAAT GAGCCTCCTA 
GACCAGTCCG TGATCAAGAA AGTGCCCATC CCCTCCAAAG CCAGCAGCCT CTCAGCCCTC 
TCCTTGGCCA AAGACAGCCT GGTGGGCGGC ATCACAAATC CTGGTGAGGT CTTCTGCTCC 
GTGCCCGGCC GGCTTTCACT GCTCAGCTCA ACGTCCAAGT ACAAGGTGAC GGTGGGGGAG 
GTGCAGCGGC GACTCTCGCC TCCCGAGTGC CTCAACGCCT CCCTCCTGGG GGGTGTCCTC 
CGCAGGGCCA AGTCCAAAAA TGGGGGCCGG TGTTTGCGGG AACGGTTAGA GAAGATTGGG 
CTCAACCTGC CAGCTGGCCG TCGCAAGGCC GCCAATGTGA CGCTGCTGAC TTCGCTAGTG 
GAAGGAGAGG CCGTGCACCT GGCCCGAGAC TTCGGTTACG TCTGTGAGAC GGAGTTCCCA 
GCCAAGGCAG CTGCCGAGTA CCTGTGCCGA CAGCACGCTG ACCCGGGGGA GCTGCACAGC 
CGCAAGAGCA TGCTGCTGGC TGCCAAGCAG ATCTGCAAGG AGTTTGCAGA CTTGATGGCT 
CAGGACCGCT CACCGCTGGG CAACAGCCGC CCAGCACTCA TCCTGGAGCC CGGAGTACAG 
AGCTGCTTGA CACACTTTAG CCTCATCACC CATGGCTTCG GTGGGCCTGC CATCTGTGCT 
GCCCTCACTG CCTTCCAGAA CTATTTGCTG GAGTCACTCA AGGGGCTGGA CAAGATGTTT 
CTAAGCAGTG TGGGCAGTGG GCATGGTGAA ACCAAGGCTT CGGAGAAGGA TGCCAAGCAT 
CGGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_848643.2
CDS209..1537
Translation

Target ORF information:

RefSeq Version NM_178548.3
Organism Homo sapiens(human)
Definition Homo sapiens transcription factor AP-2 epsilon (TFAP2E), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_178548.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTGGTGC ACACCTACTC CGCCATGGAG CGCCCCGACG GGCTGGGAGC AGCTGCCGGC 
GGGGCCCGCC TGTCGTCTCT GCCCCAGGCG GCCTACGGGC CGGCGCCCCC GCTCTGCCAC 
ACGCCGGCCG CCACAGCTGC CGCCGAATTC CAGCCGCCCT ACTTCCCGCC GCCCTACCCG 
CAGCCACCGC TGCCCTACGG TCAGGCGCCC GACGCCGCCG CAGCCTTTCC CCACCTGGCA 
GGGGACCCAT ATGGCGGCCT GGCGCCCCTG GCGCAGCCGC AGCCTCCTCA GGCCGCCTGG 
GCCGCGCCCC GCGCAGCCGC CCGCGCCCAC GAGGAGCCTC CCGGCCTGCT GGCACCGCCC 
GCCCGCGCCC TGGGCCTTGA CCCGCGCCGT GACTATGCCA CTGCCGTGCC CCGGCTCCTG 
CACGGCCTGG CCGACGGCGC GCACGGCCTG GCAGACGCAC CTCTCGGCCT TCCGGGGCTG 
GCGGCGGCCC CCGGTCTGGA GGACCTGCAG GCAATGGACG AGCCGGGAAT GAGCCTCCTA 
GACCAGTCCG TGATCAAGAA AGTGCCCATC CCCTCCAAAG CCAGCAGCCT CTCAGCCCTC 
TCCTTGGCCA AAGACAGCCT GGTGGGCGGC ATCACAAATC CTGGTGAGGT CTTCTGCTCC 
GTGCCCGGCC GGCTTTCACT GCTCAGCTCA ACGTCCAAGT ACAAGGTGAC GGTGGGGGAG 
GTGCAGCGGC GACTCTCGCC TCCCGAGTGC CTCAACGCCT CCCTCCTGGG GGGTGTCCTC 
CGCAGGGCCA AGTCCAAAAA TGGGGGCCGG TGTTTGCGGG AACGGTTAGA GAAGATTGGG 
CTCAACCTGC CAGCTGGCCG TCGCAAGGCC GCCAATGTGA CGCTGCTGAC TTCGCTAGTG 
GAAGGAGAGG CCGTGCACCT GGCCCGAGAC TTCGGTTACG TCTGTGAGAC GGAGTTCCCA 
GCCAAGGCAG CTGCCGAGTA CCTGTGCCGA CAGCACGCTG ACCCGGGGGA GCTGCACAGC 
CGCAAGAGCA TGCTGCTGGC TGCCAAGCAG ATCTGCAAGG AGTTTGCAGA CTTGATGGCT 
CAGGACCGCT CACCGCTGGG CAACAGCCGC CCAGCACTCA TCCTGGAGCC CGGAGTACAG 
AGCTGCTTGA CACACTTTAG CCTCATCACC CATGGCTTCG GTGGGCCTGC CATCTGTGCT 
GCCCTCACTG CCTTCCAGAA CTATTTGCTG GAGTCACTCA AGGGGCTGGA CAAGATGTTT 
CTAAGCAGTG TGGGCAGTGG GCATGGTGAA ACCAAGGCTT CGGAGAAGGA TGCCAAGCAT 
CGGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu24380
Clone ID Related Accession (Same CDS sequence) NM_178548.3 , NM_178548.4
Accession Version NM_178548.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1329bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-05-01
Organism Homo sapiens(human)
Product transcription factor AP-2-epsilon
Comment Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC004865.1 and AL157951.5. On Nov 22, 2018 this sequence version replaced NM_178548.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. ##Evidence-Data-START## Transcript exon combination :: BC041175.1, AY326454.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMN01820691 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373235.4/ ENSP00000362332.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTGGTGC ACACCTACTC CGCCATGGAG CGCCCCGACG GGCTGGGAGC AGCTGCCGGC 
GGGGCCCGCC TGTCGTCTCT GCCCCAGGCG GCCTACGGGC CGGCGCCCCC GCTCTGCCAC 
ACGCCGGCCG CCACAGCTGC CGCCGAATTC CAGCCGCCCT ACTTCCCGCC GCCCTACCCG 
CAGCCACCGC TGCCCTACGG TCAGGCGCCC GACGCCGCCG CAGCCTTTCC CCACCTGGCA 
GGGGACCCAT ATGGCGGCCT GGCGCCCCTG GCGCAGCCGC AGCCTCCTCA GGCCGCCTGG 
GCCGCGCCCC GCGCAGCCGC CCGCGCCCAC GAGGAGCCTC CCGGCCTGCT GGCACCGCCC 
GCCCGCGCCC TGGGCCTTGA CCCGCGCCGT GACTATGCCA CTGCCGTGCC CCGGCTCCTG 
CACGGCCTGG CCGACGGCGC GCACGGCCTG GCAGACGCAC CTCTCGGCCT TCCGGGGCTG 
GCGGCGGCCC CCGGTCTGGA GGACCTGCAG GCAATGGACG AGCCGGGAAT GAGCCTCCTA 
GACCAGTCCG TGATCAAGAA AGTGCCCATC CCCTCCAAAG CCAGCAGCCT CTCAGCCCTC 
TCCTTGGCCA AAGACAGCCT GGTGGGCGGC ATCACAAATC CTGGTGAGGT CTTCTGCTCC 
GTGCCCGGCC GGCTTTCACT GCTCAGCTCA ACGTCCAAGT ACAAGGTGAC GGTGGGGGAG 
GTGCAGCGGC GACTCTCGCC TCCCGAGTGC CTCAACGCCT CCCTCCTGGG GGGTGTCCTC 
CGCAGGGCCA AGTCCAAAAA TGGGGGCCGG TGTTTGCGGG AACGGTTAGA GAAGATTGGG 
CTCAACCTGC CAGCTGGCCG TCGCAAGGCC GCCAATGTGA CGCTGCTGAC TTCGCTAGTG 
GAAGGAGAGG CCGTGCACCT GGCCCGAGAC TTCGGTTACG TCTGTGAGAC GGAGTTCCCA 
GCCAAGGCAG CTGCCGAGTA CCTGTGCCGA CAGCACGCTG ACCCGGGGGA GCTGCACAGC 
CGCAAGAGCA TGCTGCTGGC TGCCAAGCAG ATCTGCAAGG AGTTTGCAGA CTTGATGGCT 
CAGGACCGCT CACCGCTGGG CAACAGCCGC CCAGCACTCA TCCTGGAGCC CGGAGTACAG 
AGCTGCTTGA CACACTTTAG CCTCATCACC CATGGCTTCG GTGGGCCTGC CATCTGTGCT 
GCCCTCACTG CCTTCCAGAA CTATTTGCTG GAGTCACTCA AGGGGCTGGA CAAGATGTTT 
CTAAGCAGTG TGGGCAGTGG GCATGGTGAA ACCAAGGCTT CGGAGAAGGA TGCCAAGCAT 
CGGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_848643.2
CDS265..1593
Translation

Target ORF information:

RefSeq Version NM_178548.4
Organism Homo sapiens(human)
Definition Homo sapiens transcription factor AP-2 epsilon (TFAP2E), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_178548.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGCTGGTGC ACACCTACTC CGCCATGGAG CGCCCCGACG GGCTGGGAGC AGCTGCCGGC 
GGGGCCCGCC TGTCGTCTCT GCCCCAGGCG GCCTACGGGC CGGCGCCCCC GCTCTGCCAC 
ACGCCGGCCG CCACAGCTGC CGCCGAATTC CAGCCGCCCT ACTTCCCGCC GCCCTACCCG 
CAGCCACCGC TGCCCTACGG TCAGGCGCCC GACGCCGCCG CAGCCTTTCC CCACCTGGCA 
GGGGACCCAT ATGGCGGCCT GGCGCCCCTG GCGCAGCCGC AGCCTCCTCA GGCCGCCTGG 
GCCGCGCCCC GCGCAGCCGC CCGCGCCCAC GAGGAGCCTC CCGGCCTGCT GGCACCGCCC 
GCCCGCGCCC TGGGCCTTGA CCCGCGCCGT GACTATGCCA CTGCCGTGCC CCGGCTCCTG 
CACGGCCTGG CCGACGGCGC GCACGGCCTG GCAGACGCAC CTCTCGGCCT TCCGGGGCTG 
GCGGCGGCCC CCGGTCTGGA GGACCTGCAG GCAATGGACG AGCCGGGAAT GAGCCTCCTA 
GACCAGTCCG TGATCAAGAA AGTGCCCATC CCCTCCAAAG CCAGCAGCCT CTCAGCCCTC 
TCCTTGGCCA AAGACAGCCT GGTGGGCGGC ATCACAAATC CTGGTGAGGT CTTCTGCTCC 
GTGCCCGGCC GGCTTTCACT GCTCAGCTCA ACGTCCAAGT ACAAGGTGAC GGTGGGGGAG 
GTGCAGCGGC GACTCTCGCC TCCCGAGTGC CTCAACGCCT CCCTCCTGGG GGGTGTCCTC 
CGCAGGGCCA AGTCCAAAAA TGGGGGCCGG TGTTTGCGGG AACGGTTAGA GAAGATTGGG 
CTCAACCTGC CAGCTGGCCG TCGCAAGGCC GCCAATGTGA CGCTGCTGAC TTCGCTAGTG 
GAAGGAGAGG CCGTGCACCT GGCCCGAGAC TTCGGTTACG TCTGTGAGAC GGAGTTCCCA 
GCCAAGGCAG CTGCCGAGTA CCTGTGCCGA CAGCACGCTG ACCCGGGGGA GCTGCACAGC 
CGCAAGAGCA TGCTGCTGGC TGCCAAGCAG ATCTGCAAGG AGTTTGCAGA CTTGATGGCT 
CAGGACCGCT CACCGCTGGG CAACAGCCGC CCAGCACTCA TCCTGGAGCC CGGAGTACAG 
AGCTGCTTGA CACACTTTAG CCTCATCACC CATGGCTTCG GTGGGCCTGC CATCTGTGCT 
GCCCTCACTG CCTTCCAGAA CTATTTGCTG GAGTCACTCA AGGGGCTGGA CAAGATGTTT 
CTAAGCAGTG TGGGCAGTGG GCATGGTGAA ACCAAGGCTT CGGAGAAGGA TGCCAAGCAT 
CGGAAATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu87306
Clone ID Related Accession (Same CDS sequence) XM_017001139.1 , XM_017001139.2
Accession Version XM_017001139.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1071bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product transcription factor AP-2-epsilon isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGCTGGTGC ACACCTACTC CGCCATGGAG CGCCCCGACG GGCTGGGAGC AGCTGCCGGC 
GGGGCCCGCC TGTCGTCTCT GCCCCAGGCG GCCTACGGGC CGGCGCCCCC GCTCTGCCAC 
ACGCCGGCCG CCACAGCTGC CGCCGAATTC CAGCCGCCCT ACTTCCCGCC GCCCTACCCG 
CAGCCACCGC TGCCCTACGG TCAGGCGCCC GACGCCGCCG CAGCCTTTCC CCACCTGGCA 
GGGGACCCAT ATGGCGGCCT GGCGCCCCTG GCGCAGCCGC AGCCTCCTCA GGCCGCCTGG 
GCCGCGCCCC GCGCAGCCGC CCGCGCCCAC GAGGAGCCTC CCGGCCTGCT GGCACCGCCC 
GCCCGCGCCC TGGGCCTTGA CCCGCGCCGT GACTATGCCA CTGCCGTGCC CCGGCTCCTG 
CACGGCCTGG CCGACGGCGC GCACGGCCTG GCAGACGCAC CTCTCGGCCT TCCGGGGCTG 
GCGGCGGCCC CCGGTCTGGA GGACCTGCAG GCAATGGACG AGCCGGGAAT GAGCCTCCTA 
GACCAGTCCG TGATCAAGAA AGTGCCCATC CCCTCCAAAG CCAGCAGCCT CTCAGCCCTC 
TCCTTGGCCA AAGACAGCCT GGTGGGCGGC ATCACAAATC CTGGTGAGGT CTTCTGCTCC 
GTGCCCGGCC GGCTTTCACT GCTCAGCTCA ACGTCCAAGT ACAAGGTGAC GGTGGGGGAG 
GTGCAGCGGC GACTCTCGCC TCCCGAGTGC CTCAACGCCT CCCTCCTGGG GGGTGTCCTC 
CGCAGGGCCA AGTCCAAAAA TGGGGGCCGG TGTTTGCGGG AACGGTTAGA GAAGATTGGG 
CTCAACCTGC CAGCTGGCCG TCGCAAGGCC GCCAATGTGA CGCTGCTGAC TTCGCTAGTG 
GAAGGAGAGG CCGTGCACCT GGCCCGAGAC TTCGGTTACG TCTGTGAGAC GGAGTTCCCA 
GCCAAGGCAG CTGCCGAGTA CCTGTGCCGA CAGCACGCTG ACCCGGGGGA GCTGCACAGC 
CGCAAGAGCA TGCTGCTGGC TGCCAAATCT GCAAGGAGTT TGCAGACTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016856628.1
CDS2512..3582
Translation

Target ORF information:

RefSeq Version XM_017001139.1
Organism Homo sapiens(human)
Definition Homo sapiens transcription factor AP-2 epsilon (TFAP2E), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017001139.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGCTGGTGC ACACCTACTC CGCCATGGAG CGCCCCGACG GGCTGGGAGC AGCTGCCGGC 
GGGGCCCGCC TGTCGTCTCT GCCCCAGGCG GCCTACGGGC CGGCGCCCCC GCTCTGCCAC 
ACGCCGGCCG CCACAGCTGC CGCCGAATTC CAGCCGCCCT ACTTCCCGCC GCCCTACCCG 
CAGCCACCGC TGCCCTACGG TCAGGCGCCC GACGCCGCCG CAGCCTTTCC CCACCTGGCA 
GGGGACCCAT ATGGCGGCCT GGCGCCCCTG GCGCAGCCGC AGCCTCCTCA GGCCGCCTGG 
GCCGCGCCCC GCGCAGCCGC CCGCGCCCAC GAGGAGCCTC CCGGCCTGCT GGCACCGCCC 
GCCCGCGCCC TGGGCCTTGA CCCGCGCCGT GACTATGCCA CTGCCGTGCC CCGGCTCCTG 
CACGGCCTGG CCGACGGCGC GCACGGCCTG GCAGACGCAC CTCTCGGCCT TCCGGGGCTG 
GCGGCGGCCC CCGGTCTGGA GGACCTGCAG GCAATGGACG AGCCGGGAAT GAGCCTCCTA 
GACCAGTCCG TGATCAAGAA AGTGCCCATC CCCTCCAAAG CCAGCAGCCT CTCAGCCCTC 
TCCTTGGCCA AAGACAGCCT GGTGGGCGGC ATCACAAATC CTGGTGAGGT CTTCTGCTCC 
GTGCCCGGCC GGCTTTCACT GCTCAGCTCA ACGTCCAAGT ACAAGGTGAC GGTGGGGGAG 
GTGCAGCGGC GACTCTCGCC TCCCGAGTGC CTCAACGCCT CCCTCCTGGG GGGTGTCCTC 
CGCAGGGCCA AGTCCAAAAA TGGGGGCCGG TGTTTGCGGG AACGGTTAGA GAAGATTGGG 
CTCAACCTGC CAGCTGGCCG TCGCAAGGCC GCCAATGTGA CGCTGCTGAC TTCGCTAGTG 
GAAGGAGAGG CCGTGCACCT GGCCCGAGAC TTCGGTTACG TCTGTGAGAC GGAGTTCCCA 
GCCAAGGCAG CTGCCGAGTA CCTGTGCCGA CAGCACGCTG ACCCGGGGGA GCTGCACAGC 
CGCAAGAGCA TGCTGCTGGC TGCCAAATCT GCAAGGAGTT TGCAGACTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu87306
Clone ID Related Accession (Same CDS sequence) XM_017001139.1 , XM_017001139.2
Accession Version XM_017001139.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1071bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-06-12
Organism Homo sapiens(human)
Product transcription factor AP-2-epsilon isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017001139.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END## 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGCTGGTGC ACACCTACTC CGCCATGGAG CGCCCCGACG GGCTGGGAGC AGCTGCCGGC 
GGGGCCCGCC TGTCGTCTCT GCCCCAGGCG GCCTACGGGC CGGCGCCCCC GCTCTGCCAC 
ACGCCGGCCG CCACAGCTGC CGCCGAATTC CAGCCGCCCT ACTTCCCGCC GCCCTACCCG 
CAGCCACCGC TGCCCTACGG TCAGGCGCCC GACGCCGCCG CAGCCTTTCC CCACCTGGCA 
GGGGACCCAT ATGGCGGCCT GGCGCCCCTG GCGCAGCCGC AGCCTCCTCA GGCCGCCTGG 
GCCGCGCCCC GCGCAGCCGC CCGCGCCCAC GAGGAGCCTC CCGGCCTGCT GGCACCGCCC 
GCCCGCGCCC TGGGCCTTGA CCCGCGCCGT GACTATGCCA CTGCCGTGCC CCGGCTCCTG 
CACGGCCTGG CCGACGGCGC GCACGGCCTG GCAGACGCAC CTCTCGGCCT TCCGGGGCTG 
GCGGCGGCCC CCGGTCTGGA GGACCTGCAG GCAATGGACG AGCCGGGAAT GAGCCTCCTA 
GACCAGTCCG TGATCAAGAA AGTGCCCATC CCCTCCAAAG CCAGCAGCCT CTCAGCCCTC 
TCCTTGGCCA AAGACAGCCT GGTGGGCGGC ATCACAAATC CTGGTGAGGT CTTCTGCTCC 
GTGCCCGGCC GGCTTTCACT GCTCAGCTCA ACGTCCAAGT ACAAGGTGAC GGTGGGGGAG 
GTGCAGCGGC GACTCTCGCC TCCCGAGTGC CTCAACGCCT CCCTCCTGGG GGGTGTCCTC 
CGCAGGGCCA AGTCCAAAAA TGGGGGCCGG TGTTTGCGGG AACGGTTAGA GAAGATTGGG 
CTCAACCTGC CAGCTGGCCG TCGCAAGGCC GCCAATGTGA CGCTGCTGAC TTCGCTAGTG 
GAAGGAGAGG CCGTGCACCT GGCCCGAGAC TTCGGTTACG TCTGTGAGAC GGAGTTCCCA 
GCCAAGGCAG CTGCCGAGTA CCTGTGCCGA CAGCACGCTG ACCCGGGGGA GCTGCACAGC 
CGCAAGAGCA TGCTGCTGGC TGCCAAATCT GCAAGGAGTT TGCAGACTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_016856628.1
CDS4840..5910
Translation

Target ORF information:

RefSeq Version XM_017001139.2
Organism Homo sapiens(human)
Definition Homo sapiens transcription factor AP-2 epsilon (TFAP2E), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_017001139.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGCTGGTGC ACACCTACTC CGCCATGGAG CGCCCCGACG GGCTGGGAGC AGCTGCCGGC 
GGGGCCCGCC TGTCGTCTCT GCCCCAGGCG GCCTACGGGC CGGCGCCCCC GCTCTGCCAC 
ACGCCGGCCG CCACAGCTGC CGCCGAATTC CAGCCGCCCT ACTTCCCGCC GCCCTACCCG 
CAGCCACCGC TGCCCTACGG TCAGGCGCCC GACGCCGCCG CAGCCTTTCC CCACCTGGCA 
GGGGACCCAT ATGGCGGCCT GGCGCCCCTG GCGCAGCCGC AGCCTCCTCA GGCCGCCTGG 
GCCGCGCCCC GCGCAGCCGC CCGCGCCCAC GAGGAGCCTC CCGGCCTGCT GGCACCGCCC 
GCCCGCGCCC TGGGCCTTGA CCCGCGCCGT GACTATGCCA CTGCCGTGCC CCGGCTCCTG 
CACGGCCTGG CCGACGGCGC GCACGGCCTG GCAGACGCAC CTCTCGGCCT TCCGGGGCTG 
GCGGCGGCCC CCGGTCTGGA GGACCTGCAG GCAATGGACG AGCCGGGAAT GAGCCTCCTA 
GACCAGTCCG TGATCAAGAA AGTGCCCATC CCCTCCAAAG CCAGCAGCCT CTCAGCCCTC 
TCCTTGGCCA AAGACAGCCT GGTGGGCGGC ATCACAAATC CTGGTGAGGT CTTCTGCTCC 
GTGCCCGGCC GGCTTTCACT GCTCAGCTCA ACGTCCAAGT ACAAGGTGAC GGTGGGGGAG 
GTGCAGCGGC GACTCTCGCC TCCCGAGTGC CTCAACGCCT CCCTCCTGGG GGGTGTCCTC 
CGCAGGGCCA AGTCCAAAAA TGGGGGCCGG TGTTTGCGGG AACGGTTAGA GAAGATTGGG 
CTCAACCTGC CAGCTGGCCG TCGCAAGGCC GCCAATGTGA CGCTGCTGAC TTCGCTAGTG 
GAAGGAGAGG CCGTGCACCT GGCCCGAGAC TTCGGTTACG TCTGTGAGAC GGAGTTCCCA 
GCCAAGGCAG CTGCCGAGTA CCTGTGCCGA CAGCACGCTG ACCCGGGGGA GCTGCACAGC 
CGCAAGAGCA TGCTGCTGGC TGCCAAATCT GCAAGGAGTT TGCAGACTTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Depletion of TFAP2E attenuates adriamycin-mediated apoptosis in human neuroblastoma cells.
Oncology reports37(4)2459-2464(2017 Apr)
Hoshi R,Watanabe Y,Ishizuka Y,Hirano T,Nagasaki-Maeoka E,Yoshizawa S,Uekusa S,Kawashima H,Ohashi K,Sugito K,Fukuda N,Nagase H,Soma M,Ozaki T,Koshinaga T,Fujiwara K


book

Transcription Factor AP2?: A Potential Predictor of Chemoresistance in Patients With Gastric Cancer.
Technology in cancer research & treatment15(2)285-95(2016 Apr)
Sun J,Du N,Li J,Zhou J,Tao G,Sun S,He J


book

TFAP2E hypermethylation was associated with survival advantage in patients with colorectal cancer.
Journal of cancer research and clinical oncology140(12)2119-27(2014 Dec)
Zhang ZM,Wang Y,Huang R,Liu YP,Li X,Hu FL,Zhu L,Wang F,Cui BB,Dong XS,Zhao YS


book

The transcription factor activating enhancer-binding protein epsilon (AP-2?) regulates the core promoter of type II collagen (COL2A1).
The FEBS journal280(6)1397-408(2013 Mar)
Niebler S,Bosserhoff AK


book

TFAP2E-DKK4 and chemoresistance in colorectal cancer.
The New England journal of medicine366(1)44-53(2012 Jan)
Ebert MP,T?nzer M,Balluff B,Burgermeister E,Kretzschmar AK,Hughes DJ,Tetzner R,Lofton-Day C,Rosenberg R,Reinacher-Schick AC,Schulmann K,Tannapfel A,Hofheinz R,R?cken C,Keller G,Langer R,Specht K,Porschen R,St?hlmacher-Williams J,Schuster T,Str?bel P,Schmid RM