Gene Symbol | OSTN |
Entrez Gene ID | 344901 |
Full Name | osteocrin |
Synonyms | MUSCLIN |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » OSTN cDNA ORF clone
Gene Symbol | OSTN |
Entrez Gene ID | 344901 |
Full Name | osteocrin |
Synonyms | MUSCLIN |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_017006303.1 | XP_016861792.1 | osteocrin isoform X1 |
XM_005247428.3 | XP_005247485.1 | osteocrin isoform X1 |
NM_198184.1 | NP_937827.1 | osteocrin precursor |
XM_017006303.2 | XP_016861792.1 | osteocrin isoform X1 |
NM_198184.2 | NP_937827.1 | osteocrin precursor |
OSTN | XP_001094278.1 | |
Pan troglodytes (chimpanzee) | OSTN | XP_001144666.2 |
Bos taurus (cattle) | OSTN | NP_001092405.1 |
Homo sapiens (human) | OSTN | NP_937827.1 |
Mus musculus (house mouse) | Ostn | NP_932780.1 |
Gallus gallus (chicken) | OSTN | NP_001092078.1 |
Canis lupus familiaris (dog) | OSTN | XP_850347.2 |
Danio rerio (zebrafish) | LOC100333936 | XP_002664707.1 |
Xenopus tropicalis (tropical clawed frog) | ostn | XP_002934095.2 |
Rattus norvegicus (Norway rat) | Ostn | NP_997495.1 |
Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients.
Chen WJ, Liu Y, Sui YB, Zhang B, Zhang XH, Yin XH
Diabetes & vascular disease research14(2)116-121(2017 03)
Evolution of Osteocrin as an activity-regulated factor in the primate brain.
Ataman B, Boulting GL, Harmin DA, Yang MG, Baker-Salisbury M, Yap EL, Malik AN, Mei K, Rubin AA, Spiegel I, Durresi E, Sharma N, Hu LS, Pletikos M, Griffith EC, Partlow JN, Stevens CR, Adli M, Chahrour M, Sestan N, Walsh CA, Berezovskii VK, Livingstone MS, Greenberg ME
Nature539(7628)242-247(2016 11)
Musclin is an activity-stimulated myokine that enhances physical endurance.
Subbotina E, Sierra A, Zhu Z, Gao Z, Koganti SR, Reyes S, Stepniak E, Walsh SA, Acevedo MR, Perez-Terzic CM, Hodgson-Zingman DM, Zingman LV
Proceedings of the National Academy of Sciences of the United States of America112(52)16042-7(2015 Dec)
Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
Moffatt P, Thomas G, Sellin K, Bessette MC, Lafreni?re F, Akhouayri O, St-Arnaud R, Lanct?t C
The Journal of biological chemistry282(50)36454-62(2007 Dec)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
The circulating concentration of musclin was significantly increased in type 2 diabetes mellitus patients. Results suggest that musclin has a strong relationship with insulin resistance in type 2 diabetes mellitus.
Title: Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients.
findings suggest that, in response to sensory input, OSTN regulates features of neuronal structure and function that are unique to primates
Title: Evolution of Osteocrin as an activity-regulated factor in the primate brain.
Observational study of gene-disease association. (HuGE Navigator)
Title: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.
Foxo1 downregulates musclin mRNA expression both in vitro and in vivo, which should explain insulin-mediated upregulation of this gene in muscle cells.
Title: Foxo1 represses expression of musclin, a skeletal muscle-derived secretory factor.
Ostn is a naturally occurring ligand of the NPR-C clearance receptor and may act to locally modulate the actions of the natriuretic system in bone by blocking the clearance action of NPR-C, thus locally elevating levels of C-type natriuretic peptide.
Title: Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.
The following OSTN gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OSTN cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu31299 | |
Clone ID Related Accession (Same CDS sequence) | XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2 | |
Accession Version | NM_198184.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-14 | |
Organism | Homo sapiens(Human) | |
Product | osteocrin precursor | |
Comment |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_937827.1 |
Translation |
Target ORF information:
Target ORF information:
|
NM_198184.1 |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu31299 | |
Clone ID Related Accession (Same CDS sequence) | XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2 | |
Accession Version | NM_198184.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-28 | |
Organism | Homo sapiens(human) | |
Product | osteocrin precursor | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC126567.8 and AY398681.1. On or before Aug 24, 2016 this sequence version replaced XM_005247428.4, NM_198184.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.16739.1, SRR1660805.110908.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2154665 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_937827.1 |
CDS | 68..469 |
Translation |
Target ORF information:
Target ORF information:
|
NM_198184.2 |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu31299 | |
Clone ID Related Accession (Same CDS sequence) | XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2 | |
Accession Version | XM_017006303.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | osteocrin isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016861792.1 |
CDS | 160..561 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017006303.1 |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu31299 | |
Clone ID Related Accession (Same CDS sequence) | XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2 | |
Accession Version | XM_005247428.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2015-03-11 | |
Organism | Homo sapiens(Human) | |
Product | osteocrin isoform X1 | |
Comment |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005247485.1 |
Translation |
Target ORF information:
Target ORF information:
|
XM_005247428.3 |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu31299 | |
Clone ID Related Accession (Same CDS sequence) | XM_017006303.1 , XM_005247428.3 , NM_198184.1 , XM_017006303.2 , NM_198184.2 | |
Accession Version | XM_017006303.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 402bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | osteocrin isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000003.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017006303.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016861792.1 |
CDS | 160..561 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017006303.2 |
1 | ATGCTGGACT GGAGATTGGC AAGTGCACAT TTCATCCTGG CTGTGACACT GACACTGTGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Increased circulating levels of musclin in newly diagnosed type 2 diabetic patients. |
Evolution of Osteocrin as an activity-regulated factor in the primate brain. |
Musclin is an activity-stimulated myokine that enhances physical endurance. |
Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth. |