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PADI6 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol PADI6
Entrez Gene ID 353238
Full Name peptidyl arginine deiminase 6
Synonyms PREMBL2,hPADVI
General protein information
Preferred Names

peptidyl arginine deiminase 6

Names

protein-arginine deiminase type-6
peptidyl arginine deiminase, type VI
peptidyl arginine deiminase-like protein
peptidylarginine deiminase type 6

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1p36.13

Summary This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012].
Disorder MIM:

610363


mRNA and Protein(s)

mRNA Protein Name
NM_207421.4 NP_997304.3 protein-arginine deiminase type-6



Pan troglodytes (chimpanzee) PADI6 XP_524564.2
Canis lupus familiaris (dog) PADI6 NP_001091016.1
Mus musculus (house mouse) Padi6 NP_694746.2
Rattus norvegicus (Norway rat) Padi6 NP_001178695.1
Macaca mulatta (rhesus monkey) PADI6 XP_001089244.1
Homo sapiens (human) PADI6 NP_997304.3
Bos taurus (cattle) PADI6 XP_002685843.1


Related articles in PubMed

Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.
Xu Y, Shi Y, Fu J, Yu M, Feng R, Sang Q, Liang B, Chen B, Qu R, Li B, Yan Z, Mao X, Kuang Y, Jin L, He L, Sun X, Wang L
American journal of human genetics99(3)744-752(2016 Sep)

Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
Stacey SN, Sulem P, Gudbjartsson DF, Jonasdottir A, Thorleifsson G, Gudjonsson SA, Masson G, Gudmundsson J, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K, Ragnarsson R, Fuentelsaz V, Corredera C, Grasa M, Planelles D, Sanmartin O, Rudnai P, Gurzau E, Koppova K, Hemminki K, Nexø BA, Tjønneland A, Overvad K, Johannsdottir H, Helgadottir HT, Thorsteinsdottir U, Kong A, Vogel U, Kumar R, Nagore E, Mayordomo JI, Rafnar T, Olafsson JH, Stefansson K
Human molecular genetics23(11)3045-53(2014 Jun)

Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.
Too CL, Murad S, Dhaliwal JS, Larsson P, Jiang X, Ding B, Alfredsson L, Klareskog L, Padyukov L
Arthritis research & therapy14(6)R250(2012 Nov)

Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI.
Rose R, Rose M, Ottmann C
Journal of structural biology180(1)65-72(2012 Oct)

Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study.
Giles JT, Fert-Bober J, Park JK, Bingham CO 3rd, Andrade F, Fox-Talbot K, Pappas D, Rosen A, van Eyk J, Bathon JM, Halushka MK
Arthritis research & therapy14(1)R39(2012 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest
Title: Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.

Crystallographic determination of 14-3-3-sigma binding sites in the human peptidylarginine deiminase type VI.
Title: Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI.

Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
Title: Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.

This study is the first description of the human PADI6 gene and encoded protein, and the first step towards a better understanding of the coordinated regulation of PADI gene expression.
Title: Comparative analysis of the mouse and human peptidylarginine deiminase gene clusters reveals highly conserved non-coding segments and a new human gene, PADI6.

Cloning, gene organization and expression of peptidylarginine deiminase type 6.
Title: cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI.

The following PADI6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PADI6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu28454 NM_207421.4
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Homo sapiens peptidyl arginine deiminase 6 (PADI6), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $391.30
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu28454
Clone ID Related Accession (Same CDS sequence) NM_207421.4
Accession Version NM_207421.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2085bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-05-07
Organism Homo sapiens(Human)
Product protein-arginine deiminase type-6
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY443100.1 and AY422079.1. This sequence is a reference standard in the RefSeqGene project. On Feb 20, 2014 this sequence version replaced NM_207421.3. ##Evidence-Data-START## Transcript exon combination :: AY443100.1, AY422079.1 [ECO:0000332] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
ATGGTCAGCG TGGAGGGCCG AGCCATGTCC TTCCAGAGTA TCATCCACCT GTCCCTGGAC 
AGCCCTGTCC ATGCCGTTTG TGTGTTGGGC ACAGAAATCT GCTTGGATCT CAGCGGGTGT
GCCCCCCAGA AGTGCCAGTG CTTCACCATC CATGGCTCTG GGAGGGTCTT GATCGATGTG
GCCAACACGG TGATTTCTGA GAAGGAGGAC GCCACCATCT GGTGGCCCCT GTCTGATCCC
ACGTACGCCA CAGTGAAGAT GACATCGCCC AGCCCTTCCG TGGATGCGGA TAAGGTCTCG
GTCACATACT ATGGGCCCAA CGAGGATGCC CCCGTGGGCA CAGCTGTGCT GTACCTCACT
GGCATTGAGG TCTCTCTAGA GGTAGACATC TACCGCAATG GGCAAGTTGA GATGTCAAGT
GACAAACAGG CTAAGAAAAA ATGGATCTGG GGTCCCAGCG GTTGGGGTGC CATCCTGCTT
GTGAATTGCA ACCCTGCTGA TGTGGGCCAG CAACTTGAGG ACAAGAAAAC CAAGAAAGTG
ATCTTTTCAG AGGAAATAAC GAATCTGTCC CAGATGACTC TGAATGTCCA AGGCCCCAGC
TGTATCTTAA AGAAATATCG GCTAGTCCTC CATACCTCCA AGGAAGAGTC GAAGAAGGCG
AGAGTCTACT GGCCCCAAAA AGACAACTCC AGTACCTTTG AGTTGGTGCT GGGGCCCGAC
CAGCACGCCT ATACCTTGGC CCTCCTCGGG AACCACTTGA AGGAGACTTT CTACGTTGAA
GCTATAGCAT TCCCATCTGC CGAATTCTCA GGCCTCATCT CCTACTCTGT GTCCCTGGTG
GAGGAGTCTC AAGACCCGTC AATTCCAGAG ACTGTGCTGT ACAAAGACAC GGTGGTGTTC
CGGGTGGCTC CCTGTGTCTT CATTCCCTGT ACCCAGGTGC CTCTGGAGGT TTACCTGTGC
AGGGAGCTGC AGCTGCAGGG TTTTGTGGAC ACAGTGACGA AGCTGAGTGA GAAGAGCAAC
AGCCAGGTGG CATCTGTCTA TGAGGACCCC AACCGCCTGG GCAGGTGGCT CCAGGATGAG
ATGGCCTTCT GCTACACCCA GGCTCCCCAC AAGACAACGT CCTTGATCCT CGACACACCT
CAGGCCGCCG ATCTCGATGA GTTCCCCATG AAGTACTCAC TGAGCCCTGG TATTGGCTAC
ATGATCCAGG ACACTGAGGA CCATAAAGTG GCCAGCATGG ATTCCATTGG GAACCTGATG
GTGTCCCCAC CTGTCAAGGT CCAAGGGAAA GAGTACCCGC TGGGCAGAGT CCTCATTGGC
AGCAGCTTTT ACCCCAGCGC AGAGGGCCGG GCCATGAGTA AGACCCTCCG AGACTTCCTC
TATGCCCAGC AGGTCCAAGC GCCGGTGGAG CTCTACTCAG ATTGGCTAAT GACTGGCCAC
GTGGATGAGT TCATGTGCTT CATCCCCACA GATGACAAGA ATGAGGGCAA AAAGGGCTTC
CTGCTGCTCC TGGCCAGCCC CAGTGCCTGC TATAAACTGT TCCGAGAGAA ACAGAAGGAA
GGCTATGGCG ACGCTCTTCT GTTTGATGAG CTTAGAGCAG ATCAGCTCCT GTCTAATGGA
AGGGAAGCCA AAACCATCGA CCAACTTCTG GCTGATGAAA GCCTGAAGAA GCAGAATGAA
TACGTGGAGA AGTGCATTCA CCTGAACCGT GACATCCTGA AGACGGAGCT GGGCCTGGTG
GAACAGGACA TCATCGAGAT TCCCCAGCTG TTCTGCTTGG AGAAGCTGAC TAACATCCCC
TCTGACCAGC AGCCCAAGAG GTCCTTTGCG AGGCCATACT TCCCTGACCT GTTGCGGATG
ATTGTGATGG GCAAGAACCT GGGGATCCCC AAGCCTTTTG GGCCCCAAAT CAAGGGGACC
TGCTGCCTGG AAGAAAAGAT TTGCTGCTTG CTGGAGCCCC TGGGCTTCAA GTGCACCTTC
ATCAATGACT TTGACTGTTA CCTGACAGAG GTCGGAGACA TCTGTGCCTG TGCCAACATC
CGCCGGGTGC CCTTTGCCTT CAAATGGTGG AAGATGGTAC CTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_997304.3
CDS51..2135
Misc Feature(1)75..410
Misc Feature(2)78..80
Misc Feature(3)414..890
Misc Feature(4)933..2123
Misc Feature(5)1386..1388
Exon (1)1..166
Exon (2)167..344
Exon (3)345..417
Exon (4)418..485
Exon (5)486..603
Exon (6)604..729
Exon (7)730..908
Exon (8)909..1012
Exon (9)1013..1124
Exon (10)1125..1232
Exon (11)1233..1387
Exon (12)1388..1544
Exon (13)1545..1668
Exon (14)1669..1739
Exon (15)1740..1901
Exon (16)1902..2396
Translation

Target ORF information:

RefSeq Version NM_207421.4
Organism Homo sapiens(Human)
Definition Homo sapiens peptidyl arginine deiminase 6 (PADI6), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_207421.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
ATGGTCAGCG TGGAGGGCCG AGCCATGTCC TTCCAGAGTA TCATCCACCT GTCCCTGGAC 
AGCCCTGTCC ATGCCGTTTG TGTGTTGGGC ACAGAAATCT GCTTGGATCT CAGCGGGTGT
GCCCCCCAGA AGTGCCAGTG CTTCACCATC CATGGCTCTG GGAGGGTCTT GATCGATGTG
GCCAACACGG TGATTTCTGA GAAGGAGGAC GCCACCATCT GGTGGCCCCT GTCTGATCCC
ACGTACGCCA CAGTGAAGAT GACATCGCCC AGCCCTTCCG TGGATGCGGA TAAGGTCTCG
GTCACATACT ATGGGCCCAA CGAGGATGCC CCCGTGGGCA CAGCTGTGCT GTACCTCACT
GGCATTGAGG TCTCTCTAGA GGTAGACATC TACCGCAATG GGCAAGTTGA GATGTCAAGT
GACAAACAGG CTAAGAAAAA ATGGATCTGG GGTCCCAGCG GTTGGGGTGC CATCCTGCTT
GTGAATTGCA ACCCTGCTGA TGTGGGCCAG CAACTTGAGG ACAAGAAAAC CAAGAAAGTG
ATCTTTTCAG AGGAAATAAC GAATCTGTCC CAGATGACTC TGAATGTCCA AGGCCCCAGC
TGTATCTTAA AGAAATATCG GCTAGTCCTC CATACCTCCA AGGAAGAGTC GAAGAAGGCG
AGAGTCTACT GGCCCCAAAA AGACAACTCC AGTACCTTTG AGTTGGTGCT GGGGCCCGAC
CAGCACGCCT ATACCTTGGC CCTCCTCGGG AACCACTTGA AGGAGACTTT CTACGTTGAA
GCTATAGCAT TCCCATCTGC CGAATTCTCA GGCCTCATCT CCTACTCTGT GTCCCTGGTG
GAGGAGTCTC AAGACCCGTC AATTCCAGAG ACTGTGCTGT ACAAAGACAC GGTGGTGTTC
CGGGTGGCTC CCTGTGTCTT CATTCCCTGT ACCCAGGTGC CTCTGGAGGT TTACCTGTGC
AGGGAGCTGC AGCTGCAGGG TTTTGTGGAC ACAGTGACGA AGCTGAGTGA GAAGAGCAAC
AGCCAGGTGG CATCTGTCTA TGAGGACCCC AACCGCCTGG GCAGGTGGCT CCAGGATGAG
ATGGCCTTCT GCTACACCCA GGCTCCCCAC AAGACAACGT CCTTGATCCT CGACACACCT
CAGGCCGCCG ATCTCGATGA GTTCCCCATG AAGTACTCAC TGAGCCCTGG TATTGGCTAC
ATGATCCAGG ACACTGAGGA CCATAAAGTG GCCAGCATGG ATTCCATTGG GAACCTGATG
GTGTCCCCAC CTGTCAAGGT CCAAGGGAAA GAGTACCCGC TGGGCAGAGT CCTCATTGGC
AGCAGCTTTT ACCCCAGCGC AGAGGGCCGG GCCATGAGTA AGACCCTCCG AGACTTCCTC
TATGCCCAGC AGGTCCAAGC GCCGGTGGAG CTCTACTCAG ATTGGCTAAT GACTGGCCAC
GTGGATGAGT TCATGTGCTT CATCCCCACA GATGACAAGA ATGAGGGCAA AAAGGGCTTC
CTGCTGCTCC TGGCCAGCCC CAGTGCCTGC TATAAACTGT TCCGAGAGAA ACAGAAGGAA
GGCTATGGCG ACGCTCTTCT GTTTGATGAG CTTAGAGCAG ATCAGCTCCT GTCTAATGGA
AGGGAAGCCA AAACCATCGA CCAACTTCTG GCTGATGAAA GCCTGAAGAA GCAGAATGAA
TACGTGGAGA AGTGCATTCA CCTGAACCGT GACATCCTGA AGACGGAGCT GGGCCTGGTG
GAACAGGACA TCATCGAGAT TCCCCAGCTG TTCTGCTTGG AGAAGCTGAC TAACATCCCC
TCTGACCAGC AGCCCAAGAG GTCCTTTGCG AGGCCATACT TCCCTGACCT GTTGCGGATG
ATTGTGATGG GCAAGAACCT GGGGATCCCC AAGCCTTTTG GGCCCCAAAT CAAGGGGACC
TGCTGCCTGG AAGAAAAGAT TTGCTGCTTG CTGGAGCCCC TGGGCTTCAA GTGCACCTTC
ATCAATGACT TTGACTGTTA CCTGACAGAG GTCGGAGACA TCTGTGCCTG TGCCAACATC
CGCCGGGTGC CCTTTGCCTT CAAATGGTGG AAGATGGTAC CTTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Mutations in PADI6 Cause Female Infertility Characterized by Early Embryonic Arrest.
American journal of human genetics99(3)744-752(2016 Sep)
Xu Y,Shi Y,Fu J,Yu M,Feng R,Sang Q,Liang B,Chen B,Qu R,Li B,Yan Z,Mao X,Kuang Y,Jin L,He L,Sun X,Wang L


book

Germline sequence variants in TGM3 and RGS22 confer risk of basal cell carcinoma.
Human molecular genetics23(11)3045-53(2014 Jun)
Stacey SN,Sulem P,Gudbjartsson DF,Jonasdottir A,Thorleifsson G,Gudjonsson SA,Masson G,Gudmundsson J,Sigurgeirsson B,Benediktsdottir KR,Thorisdottir K,Ragnarsson R,Fuentelsaz V,Corredera C,Grasa M,Planelles D,Sanmartin O,Rudnai P,Gurzau E,Koppova K,Hemminki K,Nexø BA,Tjønneland A,Overvad K,Johannsdottir H,Helgadottir HT,Thorsteinsdottir U,Kong A,Vogel U,Kumar R,Nagore E,Mayordomo JI,Rafnar T,Olafsson JH,Stefansson K


book

Polymorphisms in peptidylarginine deiminase associate with rheumatoid arthritis in diverse Asian populations: evidence from MyEIRA study and meta-analysis.
Arthritis research & therapy14(6)R250(2012 Nov)
Too CL,Murad S,Dhaliwal JS,Larsson P,Jiang X,Ding B,Alfredsson L,Klareskog L,Padyukov L


book

Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI.
Journal of structural biology180(1)65-72(2012 Oct)
Rose R,Rose M,Ottmann C


book

Myocardial citrullination in rheumatoid arthritis: a correlative histopathologic study.
Arthritis research & therapy14(1)R39(2012 Feb)
Giles JT,Fert-Bober J,Park JK,Bingham CO 3rd,Andrade F,Fox-Talbot K,Pappas D,Rosen A,van Eyk J,Bathon JM,Halushka MK


 
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