KCNJ14 cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | KCNJ14 |
| Entrez Gene ID | 3770 |
| Full Name | potassium voltage-gated channel subfamily J member 14 |
| Synonyms | IRK4,KIR2.4 |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel, and probably has a role in controlling the excitability of motor neurons. [provided by RefSeq, Feb 2013]. |
| Disorder MIM: |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_013348.3 | NP_037480.1 | ATP-sensitive inward rectifier potassium channel 14 |
| NM_013348.4 | NP_037480.1 | ATP-sensitive inward rectifier potassium channel 14 |
| Pan troglodytes (chimpanzee) | KCNJ14 | XP_003953598.1 |
| Mus musculus (house mouse) | Kcnj14 | NP_666075.1 |
| Xenopus tropicalis (tropical clawed frog) | kcnj14 | XP_002935044.1 |
| Canis lupus familiaris (dog) | KCNJ14 | XP_854874.1 |
| Rattus norvegicus (Norway rat) | Kcnj14 | NP_733836.1 |
| Homo sapiens (human) | KCNJ14 | NP_037480.1 |
| Bos taurus (cattle) | KCNJ14 | NP_001192950.1 |
| Danio rerio (zebrafish) | kcnj14 | XP_005157986.1 |
| KCNJ14 | XP_001113703.1 |
Related articles in PubMed
L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Yokoyama K, Urashima M, Ohkido I, Kono T, Yoshida T, Muramatsu M, Niu T, Hosoya T
Nephron. Clinical practice115(4)c237-43(2010)
Rare independent mutations in renal salt handling genes contribute to blood pressure variation.
Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, Newton-Cheh C, State MW, Levy D, Lifton RP
Nature genetics40(5)592-599(2008 May)
Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits.
Tennant BP, Cui Y, Tinker A, Clapp LH
The Journal of membrane biology213(1)19-29(2006)
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels.
Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA
Pharmacological reviews57(4)509-26(2005 Dec)
Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.
Fang Y, Schram G, Romanenko VG, Shi C, Conti L, Vandenberg CA, Davies PF, Nattel S, Levitan I
American journal of physiology. Cell physiology289(5)C1134-44(2005 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Observational study of gene-disease association. (HuGE Navigator)
Title: L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.
Using patch-clamp techniques, we characterized K(IR) channels in cultured pulmonary artery smooth muscle cells and compared them to cloned Kir2.1 and Kir2.4 channels
Title: Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits.
Kir2.2 and Kir2.1 are primary determinants of endogenous K(+) conductance in HAECs under resting conditions and that Kir2.2 provides the dominant conductance in these cells.
Title: Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2.
The following KCNJ14 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNJ14 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu10911 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_013348.3 , NM_013348.4 | |
| Accession Version | NM_013348.3 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-05-03 | |
| Organism | Homo sapiens(human) | |
| Product | ATP-sensitive inward rectifier potassium channel 14 | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF081466.1 and AC008403.8. On Feb 12, 2013 this sequence version replaced NM_013348.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF081466.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## | |
1 | ATGGGCCTGG CCAGGGCCCT ACGCCGCCTC AGCGGCGCCC TGGATTCGGG AGACAGCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_037480.1 |
| CDS | 208..1518 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_013348.3 |
ORF Insert Sequence:
1 | ATGGGCCTGG CCAGGGCCCT ACGCCGCCTC AGCGGCGCCC TGGATTCGGG AGACAGCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu10911 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_013348.3 , NM_013348.4 | |
| Accession Version | NM_013348.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1311bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2020-01-04 | |
| Organism | Homo sapiens(human) | |
| Product | ATP-sensitive inward rectifier potassium channel 14 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AF081466.1 and AC008403.8. On Jul 17, 2019 this sequence version replaced NM_013348.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AF081466.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## | |
1 | ATGGGCCTGG CCAGGGCCCT ACGCCGCCTC AGCGGCGCCC TGGATTCGGG AGACAGCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_037480.1 |
| CDS | 341..1651 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_013348.4 |
ORF Insert Sequence:
1 | ATGGGCCTGG CCAGGGCCCT ACGCCGCCTC AGCGGCGCCC TGGATTCGGG AGACAGCCGG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
 |
L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms. |
|
Rare independent mutations in renal salt handling genes contribute to blood pressure variation. |
|
Functional expression of inward rectifier potassium channels in cultured human pulmonary smooth muscle cells: evidence for a major role of Kir2.4 subunits. |
|
International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels. |
|
Functional expression of Kir2.x in human aortic endothelial cells: the dominant role of Kir2.2. |