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KRT3 cDNA ORF clone, Homo sapiens (human)

Gene Symbol KRT3
Entrez Gene ID 3850
Full Name keratin 3, type II
Synonyms CK3, K3
General protein information
Preferred Names
keratin, type II cytoskeletal 3
Names
keratin, type II cytoskeletal 3
CK-3
cytokeratin 3
cytokeratin-3
65 kDa cytokeratin
type-II keratin Kb3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12q13.13

Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the corneal epithelium with family member KRT12 and mutations in these genes have been associated with Meesmann's Corneal Dystrophy. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

148043

Disorder Html: Meesmann corneal dystrophy, 122100 (3)

mRNA and Protein(s)

mRNA Protein Name
XM_011538324 XP_011536626 keratin, type II cytoskeletal 3 isoform X1
NM_057088 NP_476429 keratin, type II cytoskeletal 3


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following KRT3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KRT3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu58653 XM_011538324 PREDICTED: Homo sapiens keratin 3, type II (KRT3), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $307.30
$439.00
OHu17842 NM_057088 Homo sapiens keratin 3, type II (KRT3), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $307.30
$439.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu58653
Clone ID Related Accession (Same CDS sequence) XM_011538324
Accession Version XM_011538324.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1527bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 12-MAR-2015
Organism Homo sapiens (human)
Product keratin, type II cytoskeletal 3 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NT_029419.13) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 107 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 6.2 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCAGAATG CACTCTCTGC CTTGGCCACC CTACTGTGCC TCCCACCCTT GACTGCCGCA 
GAGTTCATTC AGACTCCAGT TCCTCCAGCC CTGTGTCCAT GGGGCCTCAT GGTGTGCAGG
CAGAAAGGCA CGTCGTTTGC CCAAGACCAG TCCTTGCCCA TGGGAGTCTC GTGCAGATCC
AAGCCCCTCA ATGTGGAGAT CGACCCCCAG ATTGGGCAAG TAAAGGCCCA GGAGCGGGAA
CAGATCAAGA CCCTCAACAA CAAGTTTGCC TCCTTCATTG ACAAGGTGCG GTTCCTGGAG
CAACAGAACA AAGTCCTGGA GACCAAGTGG AACCTGCTCC AGCAGCAGGG CACAAGTTCC
ATCTCAGGCA CAAACAACCT TGAGCCTCTT TTTGAGAATC ACATCAACTA CCTGCGGAGC
TACCTGGACA ACATCCTCGG GGAGAGAGGG CGCCTGGACT CTGAGCTGAA GAACATGGAG
GACCTGGTGG AAGACTTCAA GAAGAAATAT GAGGATGAAA TCAATAAACG TACAGCTGCT
GAGAATGAAT TTGTGACTCT GAAGAAGGAT GTGGACAGTG CCTATATGAA CAAGGTGGAG
CTTCAGGCCA AAGTGGATGC CTTGATAGAT GAGATCGACT TCTTAAGGAC CCTCTACGAC
GCTGAGCTAT CTCAGATGCA GAGCCACATC AGTGACACAT CTGTGGTGCT GTCCATGGAC
AATAATCGCT CCCTGGACCT GGACAGCATC ATTGCTGAAG TTCGTGCACA GTATGAGGAT
ATCGCTCAGA GAAGCAAGGC CGAAGCTGAG GCCCTGTACC AGACCAAGTT GGGGGAGCTG
CAGACCACGG CTGGCAGGCA TGGGGATGAC CTAAGAAATA CCAAGAGCGA GATCATAGAG
CTCAACAGAA TGATCCAGAG GCTGCGGGCA GAGATCGAGG GTGTCAAGAA GCAGAATGCC
AACCTGCAGA CGGCCATTGC CGAGGCCGAG CAGCATGGAG AGATGGCCCT CAAGGATGCC
AATGCCAAGC TCCAAGAGCT GCAGGCTGCT CTACAGCAGG CGAAGGATGA CCTGGCGCGG
CTGCTACGTG ACTACCAGGA GCTGATGAAT GTCAAGCTGG CCCTGGACGT GGAGATCGCC
ACCTACCGCA AGCTGCTGGA GGGCGAGGAG TACAGGATGT CTGGAGAGTG TCCGAGTGCT
GTCAGCATCT CCGTGGTCAG CAGCAGCACG ACTTCCGCCT CCGCAGGTGG CTATGGAGGA
GGTTACGGCG GAGGCATGGG CGGTGGTTTA GGAGGTGGCT TCAGTGCGGG CGGCGGCTCA
GGCAGTGGCT TTGGCCGGGG AGGCGGCGGT GGAATCGGCG GTGGATTTGG CGGCGGCAGC
AGCGGTTTCA GCGGTGGCAG CGGCTTTGGC TCCATCTCTG GCGCCCGCTA TGGAGTCAGT
GGCGGGGGCT TCAGCTCGGC CAGCAACCGG GGCGGCAGCA TCAAGTTCTC CCAGTCCTCC
CAGTCCTCCC AGCGCTACTC CAGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011536626.1
CDS48..1574
Misc Feature(1)276..1223(+)
Misc Feature(2)831..1115(+)
Translation

Target ORF information:

RefSeq Version XM_011538324
Organism Homo sapiens (human)
Definition PREDICTED: Homo sapiens keratin 3, type II (KRT3), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011538324

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
ATGCAGAATG CACTCTCTGC CTTGGCCACC CTACTGTGCC TCCCACCCTT GACTGCCGCA 
GAGTTCATTC AGACTCCAGT TCCTCCAGCC CTGTGTCCAT GGGGCCTCAT GGTGTGCAGG
CAGAAAGGCA CGTCGTTTGC CCAAGACCAG TCCTTGCCCA TGGGAGTCTC GTGCAGATCC
AAGCCCCTCA ATGTGGAGAT CGACCCCCAG ATTGGGCAAG TAAAGGCCCA GGAGCGGGAA
CAGATCAAGA CCCTCAACAA CAAGTTTGCC TCCTTCATTG ACAAGGTGCG GTTCCTGGAG
CAACAGAACA AAGTCCTGGA GACCAAGTGG AACCTGCTCC AGCAGCAGGG CACAAGTTCC
ATCTCAGGCA CAAACAACCT TGAGCCTCTT TTTGAGAATC ACATCAACTA CCTGCGGAGC
TACCTGGACA ACATCCTCGG GGAGAGAGGG CGCCTGGACT CTGAGCTGAA GAACATGGAG
GACCTGGTGG AAGACTTCAA GAAGAAATAT GAGGATGAAA TCAATAAACG TACAGCTGCT
GAGAATGAAT TTGTGACTCT GAAGAAGGAT GTGGACAGTG CCTATATGAA CAAGGTGGAG
CTTCAGGCCA AAGTGGATGC CTTGATAGAT GAGATCGACT TCTTAAGGAC CCTCTACGAC
GCTGAGCTAT CTCAGATGCA GAGCCACATC AGTGACACAT CTGTGGTGCT GTCCATGGAC
AATAATCGCT CCCTGGACCT GGACAGCATC ATTGCTGAAG TTCGTGCACA GTATGAGGAT
ATCGCTCAGA GAAGCAAGGC CGAAGCTGAG GCCCTGTACC AGACCAAGTT GGGGGAGCTG
CAGACCACGG CTGGCAGGCA TGGGGATGAC CTAAGAAATA CCAAGAGCGA GATCATAGAG
CTCAACAGAA TGATCCAGAG GCTGCGGGCA GAGATCGAGG GTGTCAAGAA GCAGAATGCC
AACCTGCAGA CGGCCATTGC CGAGGCCGAG CAGCATGGAG AGATGGCCCT CAAGGATGCC
AATGCCAAGC TCCAAGAGCT GCAGGCTGCT CTACAGCAGG CGAAGGATGA CCTGGCGCGG
CTGCTACGTG ACTACCAGGA GCTGATGAAT GTCAAGCTGG CCCTGGACGT GGAGATCGCC
ACCTACCGCA AGCTGCTGGA GGGCGAGGAG TACAGGATGT CTGGAGAGTG TCCGAGTGCT
GTCAGCATCT CCGTGGTCAG CAGCAGCACG ACTTCCGCCT CCGCAGGTGG CTATGGAGGA
GGTTACGGCG GAGGCATGGG CGGTGGTTTA GGAGGTGGCT TCAGTGCGGG CGGCGGCTCA
GGCAGTGGCT TTGGCCGGGG AGGCGGCGGT GGAATCGGCG GTGGATTTGG CGGCGGCAGC
AGCGGTTTCA GCGGTGGCAG CGGCTTTGGC TCCATCTCTG GCGCCCGCTA TGGAGTCAGT
GGCGGGGGCT TCAGCTCGGC CAGCAACCGG GGCGGCAGCA TCAAGTTCTC CCAGTCCTCC
CAGTCCTCCC AGCGCTACTC CAGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu17842
Clone ID Related Accession (Same CDS sequence) NM_057088
Accession Version NM_057088.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1887bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product keratin, type II cytoskeletal 3
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff in collaboration with Michael Rogers. The reference sequence was derived from CV571376.1, AJ628418.1, AC107016.20 and BM672628.1. This sequence is a reference standard in the RefSeqGene project. On Jun 15, 2006 this sequence version replaced gi:17318571. ##Evidence-Data-START## Transcript exon combination :: AJ628418.1, AK314987.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2156670 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGAGCAGAC AAGCCAGCAA GACATCTGGT GGCGGGAGCC AGGGTTTCTC CGGCCGCTCT 
GCTGTGGTCT CCGGCAGCAG CAGGATGAGC TGTGTGGCCC ACTCTGGGGG AGCTGGCGGA
GGGGCCTATG GCTTCCGGAG CGGAGCAGGT GGCTTTGGCA GTCGCAGCCT CTACAACCTG
GGCGGCAACA AGAGCATCTC CATCAGCGTG GCAGCTGGCG GCTCCCGGGC TGGAGGCTTT
GGGGGAGGGC GGAGCAGCTG TGCCTTTGCA GGTGGCTATG GAGGTGGCTT TGGGAGCGGC
TATGGAGGTG GCTTTGGTGG TGGCTTTGGT GGTGGCAGAG GAATGGGAGG TGGCTTTGGT
GGAGCTGGTG GCTTTGGAGG GGCTGGTGGC TTTGGAGGGG CTGGTGGCTT TGGTGGTCCT
GGTGGCTTTG GTGGGTCTGG TGGCTTTGGT GGGCCTGGCA GCTTGGGCAG TCCTGGTGGC
TTTGGCCCTG GGGGCTTTCC TGGGGGAATT CAGGAAGTGA CTATCAACCA GAGTCTCCTG
CAGCCCCTCA ATGTGGAGAT CGACCCCCAG ATTGGGCAAG TAAAGGCCCA GGAGCGGGAA
CAGATCAAGA CCCTCAACAA CAAGTTTGCC TCCTTCATTG ACAAGGTGCG GTTCCTGGAG
CAACAGAACA AAGTCCTGGA GACCAAGTGG AACCTGCTCC AGCAGCAGGG CACAAGTTCC
ATCTCAGGCA CAAACAACCT TGAGCCTCTT TTTGAGAATC ACATCAACTA CCTGCGGAGC
TACCTGGACA ACATCCTCGG GGAGAGAGGG CGCCTGGACT CTGAGCTGAA GAACATGGAG
GACCTGGTGG AAGACTTCAA GAAGAAATAT GAGGATGAAA TCAATAAACG TACAGCTGCT
GAGAATGAAT TTGTGACTCT GAAGAAGGAT GTGGACAGTG CCTATATGAA CAAGGTGGAG
CTTCAGGCCA AAGTGGATGC CTTGATAGAT GAGATCGACT TCTTAAGGAC CCTCTACGAC
GCTGAGCTAT CTCAGATGCA GAGCCACATC AGTGACACAT CTGTGGTGCT GTCCATGGAC
AATAATCGCT CCCTGGACCT GGACAGCATC ATTGCTGAAG TTCGTGCACA GTATGAGGAT
ATCGCTCAGA GAAGCAAGGC CGAAGCTGAG GCCCTGTACC AGACCAAGTT GGGGGAGCTG
CAGACCACGG CTGGCAGGCA TGGGGATGAC CTAAGAAATA CCAAGAGCGA GATCATAGAG
CTCAACAGAA TGATCCAGAG GCTGCGGGCA GAGATCGAGG GTGTCAAGAA GCAGAATGCC
AACCTGCAGA CGGCCATTGC CGAGGCCGAG CAGCATGGAG AGATGGCCCT CAAGGATGCC
AATGCCAAGC TCCAAGAGCT GCAGGCTGCT CTACAGCAGG CGAAGGATGA CCTGGCGCGG
CTGCTACGTG ACTACCAGGA GCTGATGAAT GTCAAGCTGG CCCTGGACGT GGAGATCGCC
ACCTACCGCA AGCTGCTGGA GGGCGAGGAG TACAGGATGT CTGGAGAGTG TCCGAGTGCT
GTCAGCATCT CCGTGGTCAG CAGCAGCACG ACTTCCGCCT CCGCAGGTGG CTATGGAGGA
GGTTACGGCG GAGGCATGGG CGGTGGTTTA GGAGGTGGCT TCAGTGCGGG CGGCGGCTCA
GGCAGTGGCT TTGGCCGGGG AGGCGGCGGT GGAATCGGCG GTGGATTTGG CGGCGGCAGC
AGCGGTTTCA GCGGTGGCAG CGGCTTTGGC TCCATCTCTG GCGCCCGCTA TGGAGTCAGT
GGCGGGGGCT TCAGCTCGGC CAGCAACCGG GGCGGCAGCA TCAAGTTCTC CCAGTCCTCC
CAGTCCTCCC AGCGCTACTC CAGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_476429.2
CDS67..1953
Misc Feature(1)67..657(+)
Misc Feature(2)655..1602(+)
Misc Feature(3)658..1593(+)
Misc Feature(4)658..765(+)
Misc Feature(5)766..828(+)
Misc Feature(6)829..1104(+)
Misc Feature(7)1105..1176(+)
Misc Feature(8)1177..1593(+)
Misc Feature(9)1210..1494(+)
Misc Feature(10)1594..1950(+)
Exon (1)1..711
Gene:KRT3
Gene Synonym:
Exon (2)712..932
Gene:KRT3
Gene Synonym:
Exon (3)933..993
Gene:KRT3
Gene Synonym:
Exon (4)994..1089
Gene:KRT3
Gene Synonym:
Exon (5)1090..1254
Gene:KRT3
Gene Synonym:
Exon (6)1255..1380
Gene:KRT3
Gene Synonym:
Exon (7)1381..1601
Gene:KRT3
Gene Synonym:
Exon (8)1602..1636
Gene:KRT3
Gene Synonym:
Exon (9)1637..2310
Gene:KRT3
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_057088
Organism Homo sapiens (human)
Definition Homo sapiens keratin 3, type II (KRT3), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_057088

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
ATGAGCAGAC AAGCCAGCAA GACATCTGGT GGCGGGAGCC AGGGTTTCTC CGGCCGCTCT 
GCTGTGGTCT CCGGCAGCAG CAGGATGAGC TGTGTGGCCC ACTCTGGGGG AGCTGGCGGA
GGGGCCTATG GCTTCCGGAG CGGAGCAGGT GGCTTTGGCA GTCGCAGCCT CTACAACCTG
GGCGGCAACA AGAGCATCTC CATCAGCGTG GCAGCTGGCG GCTCCCGGGC TGGAGGCTTT
GGGGGAGGGC GGAGCAGCTG TGCCTTTGCA GGTGGCTATG GAGGTGGCTT TGGGAGCGGC
TATGGAGGTG GCTTTGGTGG TGGCTTTGGT GGTGGCAGAG GAATGGGAGG TGGCTTTGGT
GGAGCTGGTG GCTTTGGAGG GGCTGGTGGC TTTGGAGGGG CTGGTGGCTT TGGTGGTCCT
GGTGGCTTTG GTGGGTCTGG TGGCTTTGGT GGGCCTGGCA GCTTGGGCAG TCCTGGTGGC
TTTGGCCCTG GGGGCTTTCC TGGGGGAATT CAGGAAGTGA CTATCAACCA GAGTCTCCTG
CAGCCCCTCA ATGTGGAGAT CGACCCCCAG ATTGGGCAAG TAAAGGCCCA GGAGCGGGAA
CAGATCAAGA CCCTCAACAA CAAGTTTGCC TCCTTCATTG ACAAGGTGCG GTTCCTGGAG
CAACAGAACA AAGTCCTGGA GACCAAGTGG AACCTGCTCC AGCAGCAGGG CACAAGTTCC
ATCTCAGGCA CAAACAACCT TGAGCCTCTT TTTGAGAATC ACATCAACTA CCTGCGGAGC
TACCTGGACA ACATCCTCGG GGAGAGAGGG CGCCTGGACT CTGAGCTGAA GAACATGGAG
GACCTGGTGG AAGACTTCAA GAAGAAATAT GAGGATGAAA TCAATAAACG TACAGCTGCT
GAGAATGAAT TTGTGACTCT GAAGAAGGAT GTGGACAGTG CCTATATGAA CAAGGTGGAG
CTTCAGGCCA AAGTGGATGC CTTGATAGAT GAGATCGACT TCTTAAGGAC CCTCTACGAC
GCTGAGCTAT CTCAGATGCA GAGCCACATC AGTGACACAT CTGTGGTGCT GTCCATGGAC
AATAATCGCT CCCTGGACCT GGACAGCATC ATTGCTGAAG TTCGTGCACA GTATGAGGAT
ATCGCTCAGA GAAGCAAGGC CGAAGCTGAG GCCCTGTACC AGACCAAGTT GGGGGAGCTG
CAGACCACGG CTGGCAGGCA TGGGGATGAC CTAAGAAATA CCAAGAGCGA GATCATAGAG
CTCAACAGAA TGATCCAGAG GCTGCGGGCA GAGATCGAGG GTGTCAAGAA GCAGAATGCC
AACCTGCAGA CGGCCATTGC CGAGGCCGAG CAGCATGGAG AGATGGCCCT CAAGGATGCC
AATGCCAAGC TCCAAGAGCT GCAGGCTGCT CTACAGCAGG CGAAGGATGA CCTGGCGCGG
CTGCTACGTG ACTACCAGGA GCTGATGAAT GTCAAGCTGG CCCTGGACGT GGAGATCGCC
ACCTACCGCA AGCTGCTGGA GGGCGAGGAG TACAGGATGT CTGGAGAGTG TCCGAGTGCT
GTCAGCATCT CCGTGGTCAG CAGCAGCACG ACTTCCGCCT CCGCAGGTGG CTATGGAGGA
GGTTACGGCG GAGGCATGGG CGGTGGTTTA GGAGGTGGCT TCAGTGCGGG CGGCGGCTCA
GGCAGTGGCT TTGGCCGGGG AGGCGGCGGT GGAATCGGCG GTGGATTTGG CGGCGGCAGC
AGCGGTTTCA GCGGTGGCAG CGGCTTTGGC TCCATCTCTG GCGCCCGCTA TGGAGTCAGT
GGCGGGGGCT TCAGCTCGGC CAGCAACCGG GGCGGCAGCA TCAAGTTCTC CCAGTCCTCC
CAGTCCTCCC AGCGCTACTC CAGATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

 
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