Gene Symbol | HRNR |
Entrez Gene ID | 388697 |
Full Name | hornerin |
Synonyms | FLG3,S100A16,S100a18 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » HRNR cDNA ORF clone
Gene Symbol | HRNR |
Entrez Gene ID | 388697 |
Full Name | hornerin |
Synonyms | FLG3,S100A16,S100a18 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_001009931.2 | NP_001009931.1 | hornerin |
NM_001009931.3 | NP_001009931.1 | hornerin |
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O'Dwyer ME, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM
Leukemia31(11)2426-2434(2017 Nov)
Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity.
Gutknecht MF, Seaman ME, Ning B, Cornejo DA, Mugler E, Antkowiak PF, Moskaluk CA, Hu S, Epstein FH, Kelly KA
Nature communications8(1)552(2017 09)
Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases.
Hsu CY, Gasc G, Raymond AA, Burlet-Schiltz O, Takahara H, Serre G, M?chin MC, Simon M
The Journal of investigative dermatology137(2)422-429(2017 Feb)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
These results indicate that hornerin is highly expressed in pancreatic tumor endothelium and alters tumor vessel parameters through a VEGF-independent mechanism. Angiogenesis is essential for solid tumor progression.
Title: Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity.
HRNR deimination improves its cross-linking by TGases and its proteolytic processing by calpain-1.
Title: Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases.
HRNR gene function is a target of FLG adaptive sweep, and the functional FLG variants that involve susceptibility to atopic dermatitis, seem to hitchhike the selective sweep on HRNR.
Title: Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.
Human hornerin is a protein whose expression is changed by UVB irradiation.
Title: Ultraviolet B irradiation induces the expression of hornerin in xenotransplanted human skin.
Analysis of the rs877776 single nucleotide polymorphism in HRNR revealed neither a significant difference in genotype distribution between patients and controls nor a significant association of the variant with any atopic dermatitis-related phenotype.
Title: Association of the chromosome 11q13.5 variant with atopic dermatitis in Austrian patients.
The following HRNR gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the HRNR cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu01122 | |
Clone ID Related Accession (Same CDS sequence) | NM_001009931.2 , NM_001009931.3 | |
Accession Version | NM_001009931.2 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 8553bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-04-30 | |
Organism | Homo sapiens(human) | |
Product | hornerin | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AY396741.1 and BR000036.1. On Feb 5, 2013 this sequence version replaced NM_001009931.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY396741.1, BR000036.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## |
1 | ATGCCTAAAC TCCTACAAGG CGTCATCACT GTCATCGATG TTTTCTACCA ATATGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001009931.1 |
CDS | 80..8632 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001009931.2 |
1 | ATGCCTAAAC TCCTACAAGG CGTCATCACT GTCATCGATG TTTTCTACCA ATATGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu01122 | |
Clone ID Related Accession (Same CDS sequence) | NM_001009931.2 , NM_001009931.3 | |
Accession Version | NM_001009931.3 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 8553bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-19 | |
Organism | Homo sapiens(human) | |
Product | hornerin | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL589986.15. On Nov 27, 2019 this sequence version replaced NM_001009931.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY396741.1, BR000036.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## |
1 | ATGCCTAAAC TCCTACAAGG CGTCATCACT GTCATCGATG TTTTCTACCA ATATGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001009931.1 |
CDS | 77..8629 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001009931.3 |
1 | ATGCCTAAAC TCCTACAAGG CGTCATCACT GTCATCGATG TTTTCTACCA ATATGCCACC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Proteomic characterization of human multiple myeloma bone marrow extracellular matrix. |
Identification of the S100 fused-type protein hornerin as a regulator of tumor vascularity. |
Deimination of Human Hornerin Enhances its Processing by Calpain-1 and its Cross-Linking by Transglutaminases. |