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MDH2 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol MDH2
Entrez Gene ID 4191
Full Name malate dehydrogenase 2
Synonyms EIEE51,M-MDH,MDH,MGC:3559,MOR1
General protein information
Preferred Names

malate dehydrogenase 2

Names

malate dehydrogenase, mitochondrial
malate dehydrogenase 2, NAD (mitochondrial)
testicular tissue protein Li 120
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

7

7q11.23
Summary Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
Disorder MIM:

154100

Disorder Html: Epileptic encephalopathy, early infantile, 51, 617339 (3)

Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
NM_005918.3 NP_005909.2 malate dehydrogenase, mitochondrial isoform 1 precursor
NM_001282403.1 NP_001269332.1 malate dehydrogenase, mitochondrial isoform 2 precursor
NM_001282404.1 NP_001269333.1 malate dehydrogenase, mitochondrial isoform 3
NM_005918.4 NP_005909.2 malate dehydrogenase, mitochondrial isoform 1 precursor
NM_001282404.2 NP_001269333.1 malate dehydrogenase, mitochondrial isoform 3
NM_001282403.2 NP_001269332.1 malate dehydrogenase, mitochondrial isoform 2 precursor

Pathways from BioSystems


Homologies


Homo sapiens (human) MDH2 NP_005909.2
Pan troglodytes (chimpanzee) MDH2 XP_001156205.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP001903 XP_321163.4
Caenorhabditis elegans (roundworm) mdh-2 NP_498457.1
Magnaporthe oryzae (rice blast fungus) MGG_09367 XP_003720254.1
Arabidopsis thaliana (thale cress) mMDH1 NP_564625.1
Oryza sativa (rice) Os01g0649100 NP_001043717.1
Oryza sativa (rice) Os05g0574400 NP_001056389.1
LOC719983 XP_001114888.1
Canis lupus familiaris (dog) LOC102152275 XP_005634130.1
Mus musculus (house mouse) Mdh2 NP_032643.2
Gallus gallus (chicken) MDH2 XP_415765.1
Drosophila melanogaster (fruit fly) Mdh2 NP_650696.1
Kluyveromyces lactis KLLA0F25960g XP_456236.1
Arabidopsis thaliana (thale cress) mMDH2 NP_188120.1
Xenopus tropicalis (tropical clawed frog) mdh2 NP_001011412.1
Danio rerio (zebrafish) mdh2 NP_998296.1
Schizosaccharomyces pombe (fission yeast) SPCC306.08c NP_587816.1
Canis lupus familiaris (dog) MDH2 XP_849944.1
Rattus norvegicus (Norway rat) Mdh2 NP_112413.2
Saccharomyces cerevisiae (baker's yeast) MDH1 NP_012838.1
Eremothecium gossypii AGOS_ADR152C NP_984248.1
Neurospora crassa NCU04899 XP_958408.1

Gene Ontology


Bibliography

Related articles in PubMed

MDH2 is an RNA binding protein involved in downregulation of sodium channel Scn1a expression under seizure condition.
Chen YH, Liu SJ, Gao MM, Zeng T, Lin GW, Tan NN, Tang HL, Lu P, Su T, Sun WW, Xie LC, Yi YH, Long YS
Biochimica et biophysica acta1863(6)1492-1499(2017 Jun)

Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy.
Ait-El-Mkadem S, Dayem-Quere M, Gusic M, Chaussenot A, Bannwarth S, Fran?ois B, Genin EC, Fragaki K, Volker-Touw CLM, Vasnier C, Serre V, van Gassen KLI, Lespinasse F, Richter S, Eisenhofer G, Rouzier C, Mochel F, De Saint-Martin A, Abi Warde MT, de Sain-van der Velde MGM, Jans JJM, Amiel J, Avsec Z, Mertes C, Haack TB, Strom T, Meitinger T, Bonnen PE, Taylor RW, Gagneur J, van Hasselt PM, R?tig A, Delahodde A, Prokisch H, Fuchs SA, Paquis-Flucklinger V
American journal of human genetics100(1)151-159(2017 Jan)

Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer.
Lo YW, Lin ST, Chang SJ, Chan CH, Lyu KW, Chang JF, May EW, Lin DY, Chou HC, Chan HL
Journal of cellular and molecular medicine19(4)744-59(2015 Apr)

Whole-exome sequencing identifies MDH2 as a new familial paraganglioma gene.
Casc?n A, Comino-M?ndez I, Curr?s-Freixes M, de Cubas AA, Contreras L, Richter S, Peitzsch M, Mancikova V, Inglada-P?rez L, P?rez-Barrios A, Calatayud M, Azriel S, Villar-Vicente R, Aller J, Seti?n F, Moran S, Garcia JF, R?o-Mach?n A, Let?n R, G?mez-Gra?a ?, Apell?niz-Ruiz M, Roncador G, Esteller M, Rodr?guez-Antona C, Satr?stegui J, Eisenhofer G, Urioste M, Robledo M
Journal of the National Cancer Institute107(5)(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

loss-of-function mutations in MDH2 are also associated with severe neurological clinical presentations in children
Title: Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy.

Data indicate that acetyl-CoA acetyltransferase (ACAT1) and malate dehydrogenase (MDH2) are involved in various drug-resistance-forming mechanisms.
Title: Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer.

Segregation of the mutation with disease and absence of MDH2 in mutated tumors revealed MDH2 as a novel pheochromocytoma/paraganglioma susceptibility gene.
Title: Whole-exome sequencing identifies MDH2 as a new familial paraganglioma gene.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following MDH2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MDH2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu09726 NM_001282404.2
Latest version!		 Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$99.50-$139.30
$199.00
OHu10150 NM_001282403.2
Latest version!		 Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $139.30
$199.00
OHu14773 NM_005918.4
Latest version!		 Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $265.30
$379.00
View Old Accession Versions >>
OHu14773 NM_005918.3 Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $265.30
$379.00
OHu09726 NM_001282404.1 Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK or customized vector
in pcDNA3.1-C-(k)DYK 		$99.50-$139.30
$199.00
OHu10150 NM_001282403.1 Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK or customized vector 7-9 $139.30
$199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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2-4 Clone 40% OFF
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*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu09726
Clone ID Related Accession (Same CDS sequence) NM_001282404.1 , NM_001282404.2
Accession Version NM_001282404.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 696bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-23
Organism Homo sapiens(human)
Product malate dehydrogenase, mitochondrial isoform 3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP382246.1, DC354622.1, AK095803.1, AK290779.1 and AA214555.1. Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1, that causes translation to begin at a downstream AUG. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK095803.1, SRR1660807.59786.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGACCCGGG ACGACCTGTT CAACACCAAT GCCACGATTG TGGCCACCCT GACCGCTGCC 
TGTGCCCAGC ACTGCCCGGA AGCCATGATC TGCGTCATTG CCAATCCGGT TAATTCCACC 
ATCCCCATCA CAGCAGAAGT TTTCAAGAAG CATGGAGTGT ACAACCCCAA CAAAATCTTC 
GGCGTGACGA CCCTGGACAT CGTCAGAGCC AACACCTTTG TTGCAGAGCT GAAGGGTTTG 
GATCCAGCTC GAGTCAACGT CCCTGTCATT GGTGGCCATG CTGGGAAGAC CATCATCCCC 
CTGATCTCTC AGTGCACCCC CAAGGTGGAC TTTCCCCAGG ACCAGCTGAC AGCACTCACT 
GGGCGGATCC AGGAGGCCGG CACGGAGGTG GTCAAGGCTA AAGCCGGAGC AGGCTCTGCC 
ACCCTCTCCA TGGCGTATGC CGGCGCCCGC TTTGTCTTCT CCCTTGTGGA TGCAATGAAT 
GGAAAGGAAG GTGTTGTGGA ATGTTCCTTC GTTAAGTCAC AGGAAACGGA ATGTACCTAC 
TTCTCCACAC CGCTGCTGCT TGGGAAAAAG GGCATCGAGA AGAACCTGGG CATCGGCAAA 
GTCTCCTCTT TTGAGGAGAA GATGATCTCG GATGCCATCC CCGAGCTGAA GGCCTCCATC 
AAGAAGGGGG AAGATTTCGT GAAGACCCTG AAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001269333.1
CDS295..990
Translation

Target ORF information:

RefSeq Version NM_001282404.1
Organism Homo sapiens(human)
Definition Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001282404.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGACCCGGG ACGACCTGTT CAACACCAAT GCCACGATTG TGGCCACCCT GACCGCTGCC 
TGTGCCCAGC ACTGCCCGGA AGCCATGATC TGCGTCATTG CCAATCCGGT TAATTCCACC 
ATCCCCATCA CAGCAGAAGT TTTCAAGAAG CATGGAGTGT ACAACCCCAA CAAAATCTTC 
GGCGTGACGA CCCTGGACAT CGTCAGAGCC AACACCTTTG TTGCAGAGCT GAAGGGTTTG 
GATCCAGCTC GAGTCAACGT CCCTGTCATT GGTGGCCATG CTGGGAAGAC CATCATCCCC 
CTGATCTCTC AGTGCACCCC CAAGGTGGAC TTTCCCCAGG ACCAGCTGAC AGCACTCACT 
GGGCGGATCC AGGAGGCCGG CACGGAGGTG GTCAAGGCTA AAGCCGGAGC AGGCTCTGCC 
ACCCTCTCCA TGGCGTATGC CGGCGCCCGC TTTGTCTTCT CCCTTGTGGA TGCAATGAAT 
GGAAAGGAAG GTGTTGTGGA ATGTTCCTTC GTTAAGTCAC AGGAAACGGA ATGTACCTAC 
TTCTCCACAC CGCTGCTGCT TGGGAAAAAG GGCATCGAGA AGAACCTGGG CATCGGCAAA 
GTCTCCTCTT TTGAGGAGAA GATGATCTCG GATGCCATCC CCGAGCTGAA GGCCTCCATC 
AAGAAGGGGG AAGATTTCGT GAAGACCCTG AAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu09726
Clone ID Related Accession (Same CDS sequence) NM_001282404.1 , NM_001282404.2
Accession Version NM_001282404.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 696bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-27
Organism Homo sapiens(human)
Product malate dehydrogenase, mitochondrial isoform 3
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006330.5 and AC005077.5. On Jun 1, 2019 this sequence version replaced NM_001282404.1. Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1, that causes translation to begin at a downstream AUG. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.256334.1, SRR1803612.61949.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
ATGACCCGGG ACGACCTGTT CAACACCAAT GCCACGATTG TGGCCACCCT GACCGCTGCC 
TGTGCCCAGC ACTGCCCGGA AGCCATGATC TGCGTCATTG CCAATCCGGT TAATTCCACC 
ATCCCCATCA CAGCAGAAGT TTTCAAGAAG CATGGAGTGT ACAACCCCAA CAAAATCTTC 
GGCGTGACGA CCCTGGACAT CGTCAGAGCC AACACCTTTG TTGCAGAGCT GAAGGGTTTG 
GATCCAGCTC GAGTCAACGT CCCTGTCATT GGTGGCCATG CTGGGAAGAC CATCATCCCC 
CTGATCTCTC AGTGCACCCC CAAGGTGGAC TTTCCCCAGG ACCAGCTGAC AGCACTCACT 
GGGCGGATCC AGGAGGCCGG CACGGAGGTG GTCAAGGCTA AAGCCGGAGC AGGCTCTGCC 
ACCCTCTCCA TGGCGTATGC CGGCGCCCGC TTTGTCTTCT CCCTTGTGGA TGCAATGAAT 
GGAAAGGAAG GTGTTGTGGA ATGTTCCTTC GTTAAGTCAC AGGAAACGGA ATGTACCTAC 
TTCTCCACAC CGCTGCTGCT TGGGAAAAAG GGCATCGAGA AGAACCTGGG CATCGGCAAA 
GTCTCCTCTT TTGAGGAGAA GATGATCTCG GATGCCATCC CCGAGCTGAA GGCCTCCATC 
AAGAAGGGGG AAGATTTCGT GAAGACCCTG AAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001269333.1
CDS208..903
Translation

Target ORF information:

RefSeq Version NM_001282404.2
Organism Homo sapiens(human)
Definition Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001282404.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
ATGACCCGGG ACGACCTGTT CAACACCAAT GCCACGATTG TGGCCACCCT GACCGCTGCC 
TGTGCCCAGC ACTGCCCGGA AGCCATGATC TGCGTCATTG CCAATCCGGT TAATTCCACC 
ATCCCCATCA CAGCAGAAGT TTTCAAGAAG CATGGAGTGT ACAACCCCAA CAAAATCTTC 
GGCGTGACGA CCCTGGACAT CGTCAGAGCC AACACCTTTG TTGCAGAGCT GAAGGGTTTG 
GATCCAGCTC GAGTCAACGT CCCTGTCATT GGTGGCCATG CTGGGAAGAC CATCATCCCC 
CTGATCTCTC AGTGCACCCC CAAGGTGGAC TTTCCCCAGG ACCAGCTGAC AGCACTCACT 
GGGCGGATCC AGGAGGCCGG CACGGAGGTG GTCAAGGCTA AAGCCGGAGC AGGCTCTGCC 
ACCCTCTCCA TGGCGTATGC CGGCGCCCGC TTTGTCTTCT CCCTTGTGGA TGCAATGAAT 
GGAAAGGAAG GTGTTGTGGA ATGTTCCTTC GTTAAGTCAC AGGAAACGGA ATGTACCTAC 
TTCTCCACAC CGCTGCTGCT TGGGAAAAAG GGCATCGAGA AGAACCTGGG CATCGGCAAA 
GTCTCCTCTT TTGAGGAGAA GATGATCTCG GATGCCATCC CCGAGCTGAA GGCCTCCATC 
AAGAAGGGGG AAGATTTCGT GAAGACCCTG AAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu10150
Clone ID Related Accession (Same CDS sequence) NM_001282403.1 , NM_001282403.2
Accession Version NM_001282403.1 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 891bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-02-23
Organism Homo sapiens(human)
Product malate dehydrogenase, mitochondrial isoform 2 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP382246.1, DC354622.1, AK293460.1, AK290779.1, AK095803.1 and AA214555.1. On or before Sep 5, 2013 this sequence version replaced XM_005250351.1, XM_005277583.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.14514.1, SRR1803614.128182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGCTCTCCG CCCTCGCCCG GCCTGCCAGC GCTGCTCTCC GCCGCAGCTT CAGCACCTCG 
GCCCAGAACA ATGCTAAAGT AGCTGTGCTA GGGGCCTCTG GAGGCATCGG GCAGCCACTT 
TCACTTCTCC TGAAGAACAG CCCCTTGGTG AGCCGCCTGA CCCTCTATGA TATCGCGCAC 
ACACCCGGAG TGGCCGCAGA TCTGAGCCAC ATCGAGACCA AAGCCGCTGT GAAAGGCTAC 
CTCGGACCTG AACAGCTGCC TGACTGCCTG AAAGGTTGTG ATGTGGTAGT TATTCCGGCT 
GGAGTCCCCA GAAAGCCAGG CATGACCCGG GACGACCTGT TCAACACCAA TGCCACGATT 
GTGGCCACCC TGACCGCTGC CTGTGCCCAG CACTGCCCGG AAGCCATGAT CTGCGTCATT 
GCCAATCCGG GTTTGGATCC AGCTCGAGTC AACGTCCCTG TCATTGGTGG CCATGCTGGG 
AAGACCATCA TCCCCCTGAT CTCTCAGTGC ACCCCCAAGG TGGACTTTCC CCAGGACCAG 
CTGACAGCAC TCACTGGGCG GATCCAGGAG GCCGGCACGG AGGTGGTCAA GGCTAAAGCC 
GGAGCAGGCT CTGCCACCCT CTCCATGGCG TATGCCGGCG CCCGCTTTGT CTTCTCCCTT 
GTGGATGCAA TGAATGGAAA GGAAGGTGTT GTGGAATGTT CCTTCGTTAA GTCACAGGAA 
ACGGAATGTA CCTACTTCTC CACACCGCTG CTGCTTGGGA AAAAGGGCAT CGAGAAGAAC 
CTGGGCATCG GCAAAGTCTC CTCTTTTGAG GAGAAGATGA TCTCGGATGC CATCCCCGAG 
CTGAAGGCCT CCATCAAGAA GGGGGAAGAT TTCGTGAAGA CCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001269332.1
CDS143..1033
Translation

Target ORF information:

RefSeq Version NM_001282403.1
Organism Homo sapiens(human)
Definition Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001282403.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGCTCTCCG CCCTCGCCCG GCCTGCCAGC GCTGCTCTCC GCCGCAGCTT CAGCACCTCG 
GCCCAGAACA ATGCTAAAGT AGCTGTGCTA GGGGCCTCTG GAGGCATCGG GCAGCCACTT 
TCACTTCTCC TGAAGAACAG CCCCTTGGTG AGCCGCCTGA CCCTCTATGA TATCGCGCAC 
ACACCCGGAG TGGCCGCAGA TCTGAGCCAC ATCGAGACCA AAGCCGCTGT GAAAGGCTAC 
CTCGGACCTG AACAGCTGCC TGACTGCCTG AAAGGTTGTG ATGTGGTAGT TATTCCGGCT 
GGAGTCCCCA GAAAGCCAGG CATGACCCGG GACGACCTGT TCAACACCAA TGCCACGATT 
GTGGCCACCC TGACCGCTGC CTGTGCCCAG CACTGCCCGG AAGCCATGAT CTGCGTCATT 
GCCAATCCGG GTTTGGATCC AGCTCGAGTC AACGTCCCTG TCATTGGTGG CCATGCTGGG 
AAGACCATCA TCCCCCTGAT CTCTCAGTGC ACCCCCAAGG TGGACTTTCC CCAGGACCAG 
CTGACAGCAC TCACTGGGCG GATCCAGGAG GCCGGCACGG AGGTGGTCAA GGCTAAAGCC 
GGAGCAGGCT CTGCCACCCT CTCCATGGCG TATGCCGGCG CCCGCTTTGT CTTCTCCCTT 
GTGGATGCAA TGAATGGAAA GGAAGGTGTT GTGGAATGTT CCTTCGTTAA GTCACAGGAA 
ACGGAATGTA CCTACTTCTC CACACCGCTG CTGCTTGGGA AAAAGGGCAT CGAGAAGAAC 
CTGGGCATCG GCAAAGTCTC CTCTTTTGAG GAGAAGATGA TCTCGGATGC CATCCCCGAG 
CTGAAGGCCT CCATCAAGAA GGGGGAAGAT TTCGTGAAGA CCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu10150
Clone ID Related Accession (Same CDS sequence) NM_001282403.1 , NM_001282403.2
Accession Version NM_001282403.2 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 891bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-28
Organism Homo sapiens(human)
Product malate dehydrogenase, mitochondrial isoform 2 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006330.5 and AC005077.5. On Jun 1, 2019 this sequence version replaced NM_001282403.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803614.14514.1, SRR1803614.128182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGCTCTCCG CCCTCGCCCG GCCTGCCAGC GCTGCTCTCC GCCGCAGCTT CAGCACCTCG 
GCCCAGAACA ATGCTAAAGT AGCTGTGCTA GGGGCCTCTG GAGGCATCGG GCAGCCACTT 
TCACTTCTCC TGAAGAACAG CCCCTTGGTG AGCCGCCTGA CCCTCTATGA TATCGCGCAC 
ACACCCGGAG TGGCCGCAGA TCTGAGCCAC ATCGAGACCA AAGCCGCTGT GAAAGGCTAC 
CTCGGACCTG AACAGCTGCC TGACTGCCTG AAAGGTTGTG ATGTGGTAGT TATTCCGGCT 
GGAGTCCCCA GAAAGCCAGG CATGACCCGG GACGACCTGT TCAACACCAA TGCCACGATT 
GTGGCCACCC TGACCGCTGC CTGTGCCCAG CACTGCCCGG AAGCCATGAT CTGCGTCATT 
GCCAATCCGG GTTTGGATCC AGCTCGAGTC AACGTCCCTG TCATTGGTGG CCATGCTGGG 
AAGACCATCA TCCCCCTGAT CTCTCAGTGC ACCCCCAAGG TGGACTTTCC CCAGGACCAG 
CTGACAGCAC TCACTGGGCG GATCCAGGAG GCCGGCACGG AGGTGGTCAA GGCTAAAGCC 
GGAGCAGGCT CTGCCACCCT CTCCATGGCG TATGCCGGCG CCCGCTTTGT CTTCTCCCTT 
GTGGATGCAA TGAATGGAAA GGAAGGTGTT GTGGAATGTT CCTTCGTTAA GTCACAGGAA 
ACGGAATGTA CCTACTTCTC CACACCGCTG CTGCTTGGGA AAAAGGGCAT CGAGAAGAAC 
CTGGGCATCG GCAAAGTCTC CTCTTTTGAG GAGAAGATGA TCTCGGATGC CATCCCCGAG 
CTGAAGGCCT CCATCAAGAA GGGGGAAGAT TTCGTGAAGA CCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001269332.1
CDS56..946
Translation

Target ORF information:

RefSeq Version NM_001282403.2
Organism Homo sapiens(human)
Definition Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_001282403.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
ATGCTCTCCG CCCTCGCCCG GCCTGCCAGC GCTGCTCTCC GCCGCAGCTT CAGCACCTCG 
GCCCAGAACA ATGCTAAAGT AGCTGTGCTA GGGGCCTCTG GAGGCATCGG GCAGCCACTT 
TCACTTCTCC TGAAGAACAG CCCCTTGGTG AGCCGCCTGA CCCTCTATGA TATCGCGCAC 
ACACCCGGAG TGGCCGCAGA TCTGAGCCAC ATCGAGACCA AAGCCGCTGT GAAAGGCTAC 
CTCGGACCTG AACAGCTGCC TGACTGCCTG AAAGGTTGTG ATGTGGTAGT TATTCCGGCT 
GGAGTCCCCA GAAAGCCAGG CATGACCCGG GACGACCTGT TCAACACCAA TGCCACGATT 
GTGGCCACCC TGACCGCTGC CTGTGCCCAG CACTGCCCGG AAGCCATGAT CTGCGTCATT 
GCCAATCCGG GTTTGGATCC AGCTCGAGTC AACGTCCCTG TCATTGGTGG CCATGCTGGG 
AAGACCATCA TCCCCCTGAT CTCTCAGTGC ACCCCCAAGG TGGACTTTCC CCAGGACCAG 
CTGACAGCAC TCACTGGGCG GATCCAGGAG GCCGGCACGG AGGTGGTCAA GGCTAAAGCC 
GGAGCAGGCT CTGCCACCCT CTCCATGGCG TATGCCGGCG CCCGCTTTGT CTTCTCCCTT 
GTGGATGCAA TGAATGGAAA GGAAGGTGTT GTGGAATGTT CCTTCGTTAA GTCACAGGAA 
ACGGAATGTA CCTACTTCTC CACACCGCTG CTGCTTGGGA AAAAGGGCAT CGAGAAGAAC 
CTGGGCATCG GCAAAGTCTC CTCTTTTGAG GAGAAGATGA TCTCGGATGC CATCCCCGAG 
CTGAAGGCCT CCATCAAGAA GGGGGAAGAT TTCGTGAAGA CCCTGAAGTG A

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu14773
Clone ID Related Accession (Same CDS sequence) NM_005918.3 , NM_005918.4
Accession Version NM_005918.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1017bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2017-10-02
Organism Homo sapiens(human)
Product malate dehydrogenase, mitochondrial isoform 1 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BP382246.1, DC354622.1, AF047470.1, AK095803.1 and AA214555.1. This sequence is a reference standard in the RefSeqGene project. On Sep 5, 2013 this sequence version replaced NM_005918.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.11568.1, SRR1660809.253659.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCTCTCCG CCCTCGCCCG GCCTGCCAGC GCTGCTCTCC GCCGCAGCTT CAGCACCTCG 
GCCCAGAACA ATGCTAAAGT AGCTGTGCTA GGGGCCTCTG GAGGCATCGG GCAGCCACTT 
TCACTTCTCC TGAAGAACAG CCCCTTGGTG AGCCGCCTGA CCCTCTATGA TATCGCGCAC 
ACACCCGGAG TGGCCGCAGA TCTGAGCCAC ATCGAGACCA AAGCCGCTGT GAAAGGCTAC 
CTCGGACCTG AACAGCTGCC TGACTGCCTG AAAGGTTGTG ATGTGGTAGT TATTCCGGCT 
GGAGTCCCCA GAAAGCCAGG CATGACCCGG GACGACCTGT TCAACACCAA TGCCACGATT 
GTGGCCACCC TGACCGCTGC CTGTGCCCAG CACTGCCCGG AAGCCATGAT CTGCGTCATT 
GCCAATCCGG TTAATTCCAC CATCCCCATC ACAGCAGAAG TTTTCAAGAA GCATGGAGTG 
TACAACCCCA ACAAAATCTT CGGCGTGACG ACCCTGGACA TCGTCAGAGC CAACACCTTT 
GTTGCAGAGC TGAAGGGTTT GGATCCAGCT CGAGTCAACG TCCCTGTCAT TGGTGGCCAT 
GCTGGGAAGA CCATCATCCC CCTGATCTCT CAGTGCACCC CCAAGGTGGA CTTTCCCCAG 
GACCAGCTGA CAGCACTCAC TGGGCGGATC CAGGAGGCCG GCACGGAGGT GGTCAAGGCT 
AAAGCCGGAG CAGGCTCTGC CACCCTCTCC ATGGCGTATG CCGGCGCCCG CTTTGTCTTC 
TCCCTTGTGG ATGCAATGAA TGGAAAGGAA GGTGTTGTGG AATGTTCCTT CGTTAAGTCA 
CAGGAAACGG AATGTACCTA CTTCTCCACA CCGCTGCTGC TTGGGAAAAA GGGCATCGAG 
AAGAACCTGG GCATCGGCAA AGTCTCCTCT TTTGAGGAGA AGATGATCTC GGATGCCATC 
CCCGAGCTGA AGGCCTCCAT CAAGAAGGGG GAAGATTTCG TGAAGACCCT GAAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005909.2
CDS143..1159
Translation

Target ORF information:

RefSeq Version NM_005918.3
Organism Homo sapiens(human)
Definition Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_005918.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCTCTCCG CCCTCGCCCG GCCTGCCAGC GCTGCTCTCC GCCGCAGCTT CAGCACCTCG 
GCCCAGAACA ATGCTAAAGT AGCTGTGCTA GGGGCCTCTG GAGGCATCGG GCAGCCACTT 
TCACTTCTCC TGAAGAACAG CCCCTTGGTG AGCCGCCTGA CCCTCTATGA TATCGCGCAC 
ACACCCGGAG TGGCCGCAGA TCTGAGCCAC ATCGAGACCA AAGCCGCTGT GAAAGGCTAC 
CTCGGACCTG AACAGCTGCC TGACTGCCTG AAAGGTTGTG ATGTGGTAGT TATTCCGGCT 
GGAGTCCCCA GAAAGCCAGG CATGACCCGG GACGACCTGT TCAACACCAA TGCCACGATT 
GTGGCCACCC TGACCGCTGC CTGTGCCCAG CACTGCCCGG AAGCCATGAT CTGCGTCATT 
GCCAATCCGG TTAATTCCAC CATCCCCATC ACAGCAGAAG TTTTCAAGAA GCATGGAGTG 
TACAACCCCA ACAAAATCTT CGGCGTGACG ACCCTGGACA TCGTCAGAGC CAACACCTTT 
GTTGCAGAGC TGAAGGGTTT GGATCCAGCT CGAGTCAACG TCCCTGTCAT TGGTGGCCAT 
GCTGGGAAGA CCATCATCCC CCTGATCTCT CAGTGCACCC CCAAGGTGGA CTTTCCCCAG 
GACCAGCTGA CAGCACTCAC TGGGCGGATC CAGGAGGCCG GCACGGAGGT GGTCAAGGCT 
AAAGCCGGAG CAGGCTCTGC CACCCTCTCC ATGGCGTATG CCGGCGCCCG CTTTGTCTTC 
TCCCTTGTGG ATGCAATGAA TGGAAAGGAA GGTGTTGTGG AATGTTCCTT CGTTAAGTCA 
CAGGAAACGG AATGTACCTA CTTCTCCACA CCGCTGCTGC TTGGGAAAAA GGGCATCGAG 
AAGAACCTGG GCATCGGCAA AGTCTCCTCT TTTGAGGAGA AGATGATCTC GGATGCCATC 
CCCGAGCTGA AGGCCTCCAT CAAGAAGGGG GAAGATTTCG TGAAGACCCT GAAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu14773
Clone ID Related Accession (Same CDS sequence) NM_005918.3 , NM_005918.4
Accession Version NM_005918.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1017bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-09-26
Organism Homo sapiens(human)
Product malate dehydrogenase, mitochondrial isoform 1 precursor
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC006330.5 and AC005077.5. On Nov 23, 2018 this sequence version replaced NM_005918.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.11568.1, SRR3476690.978959.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000315758.10/ ENSP00000327070.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCTCTCCG CCCTCGCCCG GCCTGCCAGC GCTGCTCTCC GCCGCAGCTT CAGCACCTCG 
GCCCAGAACA ATGCTAAAGT AGCTGTGCTA GGGGCCTCTG GAGGCATCGG GCAGCCACTT 
TCACTTCTCC TGAAGAACAG CCCCTTGGTG AGCCGCCTGA CCCTCTATGA TATCGCGCAC 
ACACCCGGAG TGGCCGCAGA TCTGAGCCAC ATCGAGACCA AAGCCGCTGT GAAAGGCTAC 
CTCGGACCTG AACAGCTGCC TGACTGCCTG AAAGGTTGTG ATGTGGTAGT TATTCCGGCT 
GGAGTCCCCA GAAAGCCAGG CATGACCCGG GACGACCTGT TCAACACCAA TGCCACGATT 
GTGGCCACCC TGACCGCTGC CTGTGCCCAG CACTGCCCGG AAGCCATGAT CTGCGTCATT 
GCCAATCCGG TTAATTCCAC CATCCCCATC ACAGCAGAAG TTTTCAAGAA GCATGGAGTG 
TACAACCCCA ACAAAATCTT CGGCGTGACG ACCCTGGACA TCGTCAGAGC CAACACCTTT 
GTTGCAGAGC TGAAGGGTTT GGATCCAGCT CGAGTCAACG TCCCTGTCAT TGGTGGCCAT 
GCTGGGAAGA CCATCATCCC CCTGATCTCT CAGTGCACCC CCAAGGTGGA CTTTCCCCAG 
GACCAGCTGA CAGCACTCAC TGGGCGGATC CAGGAGGCCG GCACGGAGGT GGTCAAGGCT 
AAAGCCGGAG CAGGCTCTGC CACCCTCTCC ATGGCGTATG CCGGCGCCCG CTTTGTCTTC 
TCCCTTGTGG ATGCAATGAA TGGAAAGGAA GGTGTTGTGG AATGTTCCTT CGTTAAGTCA 
CAGGAAACGG AATGTACCTA CTTCTCCACA CCGCTGCTGC TTGGGAAAAA GGGCATCGAG 
AAGAACCTGG GCATCGGCAA AGTCTCCTCT TTTGAGGAGA AGATGATCTC GGATGCCATC 
CCCGAGCTGA AGGCCTCCAT CAAGAAGGGG GAAGATTTCG TGAAGACCCT GAAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005909.2
CDS56..1072
Translation

Target ORF information:

RefSeq Version NM_005918.4
Organism Homo sapiens(human)
Definition Homo sapiens malate dehydrogenase 2 (MDH2), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_005918.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
ATGCTCTCCG CCCTCGCCCG GCCTGCCAGC GCTGCTCTCC GCCGCAGCTT CAGCACCTCG 
GCCCAGAACA ATGCTAAAGT AGCTGTGCTA GGGGCCTCTG GAGGCATCGG GCAGCCACTT 
TCACTTCTCC TGAAGAACAG CCCCTTGGTG AGCCGCCTGA CCCTCTATGA TATCGCGCAC 
ACACCCGGAG TGGCCGCAGA TCTGAGCCAC ATCGAGACCA AAGCCGCTGT GAAAGGCTAC 
CTCGGACCTG AACAGCTGCC TGACTGCCTG AAAGGTTGTG ATGTGGTAGT TATTCCGGCT 
GGAGTCCCCA GAAAGCCAGG CATGACCCGG GACGACCTGT TCAACACCAA TGCCACGATT 
GTGGCCACCC TGACCGCTGC CTGTGCCCAG CACTGCCCGG AAGCCATGAT CTGCGTCATT 
GCCAATCCGG TTAATTCCAC CATCCCCATC ACAGCAGAAG TTTTCAAGAA GCATGGAGTG 
TACAACCCCA ACAAAATCTT CGGCGTGACG ACCCTGGACA TCGTCAGAGC CAACACCTTT 
GTTGCAGAGC TGAAGGGTTT GGATCCAGCT CGAGTCAACG TCCCTGTCAT TGGTGGCCAT 
GCTGGGAAGA CCATCATCCC CCTGATCTCT CAGTGCACCC CCAAGGTGGA CTTTCCCCAG 
GACCAGCTGA CAGCACTCAC TGGGCGGATC CAGGAGGCCG GCACGGAGGT GGTCAAGGCT 
AAAGCCGGAG CAGGCTCTGC CACCCTCTCC ATGGCGTATG CCGGCGCCCG CTTTGTCTTC 
TCCCTTGTGG ATGCAATGAA TGGAAAGGAA GGTGTTGTGG AATGTTCCTT CGTTAAGTCA 
CAGGAAACGG AATGTACCTA CTTCTCCACA CCGCTGCTGC TTGGGAAAAA GGGCATCGAG 
AAGAACCTGG GCATCGGCAA AGTCTCCTCT TTTGAGGAGA AGATGATCTC GGATGCCATC 
CCCGAGCTGA AGGCCTCCAT CAAGAAGGGG GAAGATTTCG TGAAGACCCT GAAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

MDH2 is an RNA binding protein involved in downregulation of sodium channel Scn1a expression under seizure condition.
Biochimica et biophysica acta1863(6)1492-1499(2017 Jun)
Chen YH,Liu SJ,Gao MM,Zeng T,Lin GW,Tan NN,Tang HL,Lu P,Su T,Sun WW,Xie LC,Yi YH,Long YS


book

Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy.
American journal of human genetics100(1)151-159(2017 Jan)
Ait-El-Mkadem S,Dayem-Quere M,Gusic M,Chaussenot A,Bannwarth S,Fran?ois B,Genin EC,Fragaki K,Volker-Touw CLM,Vasnier C,Serre V,van Gassen KLI,Lespinasse F,Richter S,Eisenhofer G,Rouzier C,Mochel F,De Saint-Martin A,Abi Warde MT,de Sain-van der Velde MGM,Jans JJM,Amiel J,Avsec Z,Mertes C,Haack TB,Strom T,Meitinger T,Bonnen PE,Taylor RW,Gagneur J,van Hasselt PM,R?tig A,Delahodde A,Prokisch H,Fuchs SA,Paquis-Flucklinger V


book

Mitochondrial proteomics with siRNA knockdown to reveal ACAT1 and MDH2 in the development of doxorubicin-resistant uterine cancer.
Journal of cellular and molecular medicine19(4)744-59(2015 Apr)
Lo YW,Lin ST,Chang SJ,Chan CH,Lyu KW,Chang JF,May EW,Lin DY,Chou HC,Chan HL


book

Whole-exome sequencing identifies MDH2 as a new familial paraganglioma gene.
Journal of the National Cancer Institute107(5)(2015 Mar)
Casc?n A,Comino-M?ndez I,Curr?s-Freixes M,de Cubas AA,Contreras L,Richter S,Peitzsch M,Mancikova V,Inglada-P?rez L,P?rez-Barrios A,Calatayud M,Azriel S,Villar-Vicente R,Aller J,Seti?n F,Moran S,Garcia JF,R?o-Mach?n A,Let?n R,G?mez-Gra?a ?,Apell?niz-Ruiz M,Roncador G,Esteller M,Rodr?guez-Antona C,Satr?stegui J,Eisenhofer G,Urioste M,Robledo M