BECN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	BECN2
Entrez Gene ID	441925
Full Name	beclin 2
Synonyms	BECN1L1,BECN1P1
General protein information	Preferred Names beclin 2 Names beclin-2 Beclin-1-like protein 1 beclin-1 autophagy-related pseudogene 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q43
Disorder MIM:	615687

mRNA and Protein(s)

mRNA Protein Name

NM_001290693.1 NP_001277622.1 beclin-2
Pathways from BioSystems
Gene Ontology
Bibliography

Related articles in PubMed

Reactive Oxygen Species-Mediated c-Jun NH
Zhong L, Shu W, Dai W, Gao B, Xiong S
Journal of virology91(15)(2017 Aug)

BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.
Su M, Li Y, Wyborny S, Neau D, Chakravarthy S, Levine B, Colbert CL, Sinha SC
Protein science : a publication of the Protein Society26(5)972-984(2017 May)

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
Dong X, Cheng A, Zou Z, Yang YS, Sumpter RM Jr, Huang CL, Bhagat G, Virgin HW, Lira SA, Levine B
Proceedings of the National Academy of Sciences of the United States of America113(11)2994-9(2016 Mar)

Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer.
Liu JL, Chen FF, Chang SF, Chen CN, Lung J, Lo CH, Lee FH, Lu YC, Hung CH
PloS one10(10)e0141308(2015)

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
He C, Wei Y, Sun K, Li B, Dong X, Zou Z, Liu Y, Kinch LN, Khan S, Sinha S, Xavier RJ, Grishin NV, Xiao G, Eskelinen EL, Scherer PE, Whistler JL, Levine B
Cell154(5)1085-99(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Further data showed that reactive oxygen species-c-Jun activation by HBx resulted in the release of beclin-1 from its association with beclin-2 to form a complex with VPS34, thus enhancing autophagosome formation.
Title: Reactive Oxygen Species-Mediated c-Jun NH

polar BECN2 CCD interface residues result in a metastable homodimer, facilitating dissociation, but enable better interactions with polar ATG14 residues stabilizing the BECN2:ATG14 heterodimer.
Title: BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.

Both transfected and endogenous beclin 2 coimmunoprecipitated with vGPCR. Beclin 2 overexpression decreased HA-vGPCR steady-state levels. It regulates vGPCR levels by a lysosomal degradation pathway.
Title: Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.

distinct patterns of Beclin 1 and Beclin 2 were associated with aggressive clinical outcomes. Beclin 1 overexpression, as well as Beclin 2 overexpression and depletion, contributed to tumor growth.
Title: Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer.

Study identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components.[Beclin 2]
Title: Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.

mRNA	Protein	Name
NM_001290693.1	NP_001277622.1	beclin-2

The following BECN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BECN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu15247	NM_001290693.1 Latest version!	Homo sapiens beclin 2 (BECN2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BECN2 ( NM_001290693.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001277622.1 Homo sapiens beclin 2 (BECN2), mRNA.

Price & Availability↑

CloneID	OHu15247
Clone ID Related Accession (Same CDS sequence)	NM_001290693.1
Accession Version	NM_001290693.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1296bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-29
Organism	Homo sapiens(human)
Product	beclin-2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from HM031116.1. ##Evidence-Data-START## Transcript is intronless :: HM031116.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000419583.2/ ENSP00000488361.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTCTTCCA TCCGCTTCCT GTGCCAGCGC TGCCACCAGG CCCTGAAGCT GAGCGGCTCC 
TCGGAGTCTA GGAGCCTCCC TGCAGCCCCG GCGCCCACCT CTGGGCAGGC TGAGCCCGGA 
GACACCCGGG AGCCCGGCGT CACCACCAGG GAGGTGACAG ACGCTGAGGA GCAACAGGAC 
GGTGCCTCTA GCAGATCCCC TCCAGGCGAT GGCAGTGTGT CCAAGGGCCA TGCCAACATC 
TTCACCCTGC TGGGGGAGCT TGGCGCCATG CACATGCTCA GTAGCATCCA GAAGGCAGCT 
GGTGACATTT TTGACATAGT CTCTGGCCAA GCAGTTGTGG ACCATCCCCT GTGTGAAGAA 
TGCACCGACA GTCTTTTAGA GCAGCTGGAC ATCCAGCTCG CTCTCACAGA AGCTGACAGT 
CAGAACTACC AACGCTGCCT GGAGACCGGG GAGCTGGCGA CCAGCGAGGA CGAGGCGGCG 
GCGCTGCGGG CGGAGCTGCG GGACCTGGAG CTGGAGGAGG CCAGGCTGGT GCAGGAGCTG 
GAGGATGTGG ACAGGAACAA TGCAAGAGCA GCGGCGGATC TCCAGGCAGC CCAGGCAGAG 
GCTGCGGAGC TGGACCAGCA GGAGAGGCAG CACTACAGGG ACTACAGTGC CTTGAAGCGG 
CAGCAGCTGG AACTGCTTGA TCAGCTGGGG AACGTGGAGA ACCAGCTGCA GTATGCCAGG 
GTCCAGAGGG ACCGGCTGAA GGAAATCAAC TGTTTCACCG CCACGTTTGA GATCTGGGTG 
GAGGGCCCCT TGGGCGTCAT CAATAACTTC AGGTTGGGCC GCCTCCCCAC TGTCCGTGTG 
GGCTGGAATG AGATTAACAC TGCCTGGGGA CAGGCGGCCT TGCTGCTCCT TACCCTGGCC 
AATACAATTG GACTGCAGTT TCAGAGGTAT CGACTCATCC CCTGCGGAAA CCATTCGTAT 
CTGAAGTCTT TAACAGATGA CCGCACTGAG CTGCCGTTGT TCTGTTATGG GGGGCAGGAT 
GTTTTCCTCA ATAACAAGTA TGACCGCGCG ATGGTGGCCT TCCTGGACTG CATGCAGCAG 
TTCAAGGAAG AGGCTGAGAA GGGTGAGCTG GGCCTCTCTC TGCCCTACGG GATCCAGGTG 
GAGACAGGCC TGATGGAGGA CGTTGGCGGC CGAGGGGAAT GCTATTCCAT CAGAACCCAT 
CTGAACACGC AGGAGCTGTG GACAAAGGCA CTCAAGTTCA TGCTTATAAA TTTCAAGTGG 
AGTCTCATCT GGGTTGCCTC AAGGTATCAA AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001277622.1
CDS	1..1296
Translation	MSSIRFLCQRCHQALKLSGSSESRSLPAAPAPTSGQAEPGDTREPGVTTREVTDAEEQQDGASSRSPPGDGSVSKGHANIFTLLGELGAMHMLSSIQKAAGDIFDIVSGQAVVDHPLCEECTDSLLEQLDIQLALTEADSQNYQRCLETGELATSEDEAAALRAELRDLELEEARLVQELEDVDRNNARAAADLQAAQAEAAELDQQERQHYRDYSALKRQQLELLDQLGNVENQLQYARVQRDRLKEINCFTATFEIWVEGPLGVINNFRLGRLPTVRVGWNEINTAWGQAALLLLTLANTIGLQFQRYRLIPCGNHSYLKSLTDDRTELPLFCYGGQDVFLNNKYDRAMVAFLDCMQQFKEEAEKGELGLSLPYGIQVETGLMEDVGGRGECYSIRTHLNTQELWTKALKFMLINFKWSLIWVASRYQK

Target ORF information:

RefSeq Version	NM_001290693.1
Organism	Homo sapiens(human)
Definition	Homo sapiens beclin 2 (BECN2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001290693.1

ORF Insert Sequence:

ATGTCTTCCA TCCGCTTCCT GTGCCAGCGC TGCCACCAGG CCCTGAAGCT GAGCGGCTCC 
TCGGAGTCTA GGAGCCTCCC TGCAGCCCCG GCGCCCACCT CTGGGCAGGC TGAGCCCGGA 
GACACCCGGG AGCCCGGCGT CACCACCAGG GAGGTGACAG ACGCTGAGGA GCAACAGGAC 
GGTGCCTCTA GCAGATCCCC TCCAGGCGAT GGCAGTGTGT CCAAGGGCCA TGCCAACATC 
TTCACCCTGC TGGGGGAGCT TGGCGCCATG CACATGCTCA GTAGCATCCA GAAGGCAGCT 
GGTGACATTT TTGACATAGT CTCTGGCCAA GCAGTTGTGG ACCATCCCCT GTGTGAAGAA 
TGCACCGACA GTCTTTTAGA GCAGCTGGAC ATCCAGCTCG CTCTCACAGA AGCTGACAGT 
CAGAACTACC AACGCTGCCT GGAGACCGGG GAGCTGGCGA CCAGCGAGGA CGAGGCGGCG 
GCGCTGCGGG CGGAGCTGCG GGACCTGGAG CTGGAGGAGG CCAGGCTGGT GCAGGAGCTG 
GAGGATGTGG ACAGGAACAA TGCAAGAGCA GCGGCGGATC TCCAGGCAGC CCAGGCAGAG 
GCTGCGGAGC TGGACCAGCA GGAGAGGCAG CACTACAGGG ACTACAGTGC CTTGAAGCGG 
CAGCAGCTGG AACTGCTTGA TCAGCTGGGG AACGTGGAGA ACCAGCTGCA GTATGCCAGG 
GTCCAGAGGG ACCGGCTGAA GGAAATCAAC TGTTTCACCG CCACGTTTGA GATCTGGGTG 
GAGGGCCCCT TGGGCGTCAT CAATAACTTC AGGTTGGGCC GCCTCCCCAC TGTCCGTGTG 
GGCTGGAATG AGATTAACAC TGCCTGGGGA CAGGCGGCCT TGCTGCTCCT TACCCTGGCC 
AATACAATTG GACTGCAGTT TCAGAGGTAT CGACTCATCC CCTGCGGAAA CCATTCGTAT 
CTGAAGTCTT TAACAGATGA CCGCACTGAG CTGCCGTTGT TCTGTTATGG GGGGCAGGAT 
GTTTTCCTCA ATAACAAGTA TGACCGCGCG ATGGTGGCCT TCCTGGACTG CATGCAGCAG 
TTCAAGGAAG AGGCTGAGAA GGGTGAGCTG GGCCTCTCTC TGCCCTACGG GATCCAGGTG 
GAGACAGGCC TGATGGAGGA CGTTGGCGGC CGAGGGGAAT GCTATTCCAT CAGAACCCAT 
CTGAACACGC AGGAGCTGTG GACAAAGGCA CTCAAGTTCA TGCTTATAAA TTTCAAGTGG 
AGTCTCATCT GGGTTGCCTC AAGGTATCAA AAGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Reactive Oxygen Species-Mediated c-Jun NH
Journal of virology91(15)(2017 Aug)
Zhong L,Shu W,Dai W,Gao B,Xiong S

BECN2 interacts with ATG14 through a metastable coiled-coil to mediate autophagy.
Protein science : a publication of the Protein Society26(5)972-984(2017 May)
Su M,Li Y,Wyborny S,Neau D,Chakravarthy S,Levine B,Colbert CL,Sinha SC

Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis.
Proceedings of the National Academy of Sciences of the United States of America113(11)2994-9(2016 Mar)
Dong X,Cheng A,Zou Z,Yang YS,Sumpter RM Jr,Huang CL,Bhagat G,Virgin HW,Lira SA,Levine B

Expression of Beclin Family Proteins Is Associated with Tumor Progression in Oral Cancer.
PloS one10(10)e0141308(2015)
Liu JL,Chen FF,Chang SF,Chen CN,Lung J,Lo CH,Lee FH,Lu YC,Hung CH

Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism.
Cell154(5)1085-99(2013 Aug)
He C,Wei Y,Sun K,Li B,Dong X,Zou Z,Liu Y,Kinch LN,Khan S,Sinha S,Xavier RJ,Grishin NV,Xiao G,Eskelinen EL,Scherer PE,Whistler JL,Levine B

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BECN2 cDNA ORF clone, Homo sapiens(human)

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Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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