MYOC cDNA ORF clone, Homo sapiens(human)
| Gene Symbol | MYOC |
| Entrez Gene ID | 4653 |
| Full Name | myocilin |
| Synonyms | GLC1A,GPOA,JOAG,JOAG1,TIGR |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Summary | MYOC encodes the protein myocilin, which is believed to have a role in cytoskeletal function. MYOC is expressed in many occular tissues, including the trabecular meshwork, and was revealed to be the trabecular meshwork glucocorticoid-inducible response protein (TIGR). The trabecular meshwork is a specialized eye tissue essential in regulating intraocular pressure, and mutations in MYOC have been identified as the cause of hereditary juvenile-onset open-angle glaucoma. [provided by RefSeq, Jul 2008]. |
| Disorder MIM: | |
| Disorder Html: | Glaucoma 1A, primary open angle, 137750 (3) |
mRNA and Protein(s)
| mRNA | Protein | Name |
|---|---|---|
| NM_000261.2 | NP_000252.1 | myocilin precursor |
| NM_000261.1 | NP_000252.1 | myocilin precursor |
| Homo sapiens (human) | MYOC | NP_000252.1 |
| MYOC | XP_001099905.1 | |
| Danio rerio (zebrafish) | myoc | NP_001015062.1 |
| Mus musculus (house mouse) | Myoc | NP_034995.3 |
| Gallus gallus (chicken) | MYOC | XP_422235.4 |
| Xenopus tropicalis (tropical clawed frog) | myoc | XP_002934195.2 |
| Pan troglodytes (chimpanzee) | MYOC | XP_513995.2 |
| Canis lupus familiaris (dog) | MYOC | NP_001041495.2 |
| Bos taurus (cattle) | MYOC | NP_776543.2 |
| Rattus norvegicus (Norway rat) | Myoc | NP_110492.1 |
The following MYOC gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MYOC cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
| CloneID | OHu24937 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_000261.2 , NM_000261.1 | |
| Accession Version | NM_000261.2 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-30 | |
| Organism | Homo sapiens(human) | |
| Product | myocilin precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from Z98750.1 and AF001620.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_000261.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189667.323867.1, U85257.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153980, SAMEA2154125 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000037502.11/ ENSP00000037502.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGAGGTTCT TCTGTGCACG TTGCTGCAGC TTTGGGCCTG AGATGCCAGC TGTCCAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000252.1 |
| CDS | 78..1592 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_000261.2 |
ORF Insert Sequence:
1 | ATGAGGTTCT TCTGTGCACG TTGCTGCAGC TTTGGGCCTG AGATGCCAGC TGTCCAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu24937 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_000261.2 , NM_000261.1 | |
| Accession Version | NM_000261.1 | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1515bp) Protein sequence SNP |
|
| Vector | pcDNA3.1+/C-(K)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-12-26 | |
| Organism | Homo sapiens(human) | |
| Product | myocilin precursor | |
| Comment | Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF001620.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF001620.1, FJ237046.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2153980, SAMEA2154125 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length. | |
1 | ATGAGGTTCT TCTGTGCACG TTGCTGCAGC TTTGGGCCTG AGATGCCAGC TGTCCAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_000252.1 |
| CDS | 23..1537 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_000261.1 |
ORF Insert Sequence:
1 | ATGAGGTTCT TCTGTGCACG TTGCTGCAGC TTTGGGCCTG AGATGCCAGC TGTCCAGCTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.