| Gene Symbol | DTL |
| Entrez Gene ID | 51514 |
| Full Name | denticleless E3 ubiquitin protein ligase homolog |
| Synonyms | CDT2,DCAF2,L2DTL,RAMP |
| General protein information |
|
| Gene Type | protein-coding |
| Organism | Homo sapiens(human) |
| Genome | |
| Disorder MIM: |
The following DTL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DTL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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| CloneID | OHu12908 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_001286229.1 | |
| Accession Version | NM_001286229.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 1380bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector |  User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Homo sapiens(human) | |
| Product | denticleless protein homolog isoform 2 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB070033.1, AC092814.2, AK027651.1, AL606468.8 and AI800751.1. Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the coding region compared to variant 1. These differences result in the use of a alternate AUG, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK027651.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2149004, SAMEA2154529 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGGGATATT CAAGTCTGAT TTTGGATTCC ACTGGCTCTA CTTTATTTGC TAATTGCACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001273158.1 |
| CDS | 922..2301 |
| Translation |
Target ORF information:
Target ORF information:
|
 NM_001286229.1 |
1 | ATGGGATATT CAAGTCTGAT TTTGGATTCC ACTGGCTCTA CTTTATTTGC TAATTGCACA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu14692 |
|
| Clone ID Related Accession (Same CDS sequence) | NM_016448.3 | |
| Accession Version | NM_016448.3 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2193bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2017-10-02 | |
| Organism | Homo sapiens(human) | |
| Product | denticleless protein homolog isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB070033.1, BC033540.1, AL606468.8 and AI800751.1. On Nov 1, 2013 this sequence version replaced NM_016448.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF195765.1, AK000742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. | |
1 | ATGCTCTTCA ATTCGGTGCT CCGCCAGCCC CAGCTTGGCG TCCTGAGAAA TGGATGGTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_057532.3 |
| CDS | 339..2531 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_016448.3 |
1 | ATGCTCTTCA ATTCGGTGCT CCGCCAGCCC CAGCTTGGCG TCCTGAGAAA TGGATGGTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu12896 | |
| Clone ID Related Accession (Same CDS sequence) | NM_001286230.1 | |
| Accession Version | NM_001286230.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2067bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-27 | |
| Organism | Homo sapiens(human) | |
| Product | denticleless protein homolog isoform 3 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092814.2, AK303346.1, AL606468.8 and AI800751.1. On Nov 1, 2013 this sequence version replaced XM_005273159.1. Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK303346.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## | |
1 | ATGCTCTTCA ATTCGGTGCT CCGCCAGCCC CAGCTTGGCG TCCTGAGAAA TGCTCCCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_001273159.1 |
| CDS | 339..2405 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_001286230.1 |
1 | ATGCTCTTCA ATTCGGTGCT CCGCCAGCCC CAGCTTGGCG TCCTGAGAAA TGCTCCCAAT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu67986 | |
| Clone ID Related Accession (Same CDS sequence) | XM_011509614.1 | |
| Accession Version | XM_011509614.1 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2007bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-05 | |
| Organism | Homo sapiens(human) | |
| Product | denticleless protein homolog isoform X1 | |
| Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## | |
1 | ATGGAACATG TACTAGCAGT TGCCAATGAA GAAGGCTTTG TTCGATTGTA TAACACAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | XP_011507916.1 |
| CDS | 229..2235 |
| Translation |
Target ORF information:
Target ORF information:
|
XM_011509614.1 |
1 | ATGGAACATG TACTAGCAGT TGCCAATGAA GAAGGCTTTG TTCGATTGTA TAACACAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| CloneID | OHu107324 | |
| Clone ID Related Accession (Same CDS sequence) | NM_016448.4 | |
| Accession Version | NM_016448.4 Latest version! | Documents for ORF clone product in default vector |
| Sequence Information | ORF Nucleotide Sequence (Length: 2193bp) Protein sequence SNP |
|
| Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
| Clone information | Clone Map | MSDS |
| Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
| ORF Insert Method | CloneEZ™ Seamless cloning technology | |
| Insert Structure | linear | |
| Update Date | 2019-12-30 | |
| Organism | Homo sapiens(human) | |
| Product | denticleless protein homolog isoform 1 | |
| Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092814.2, AL592297.5 and AL606468.8. On Nov 23, 2018 this sequence version replaced NM_016448.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF195765.1, AK000742.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000366991.5/ ENSP00000355958.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. | |
1 | ATGCTCTTCA ATTCGGTGCT CCGCCAGCCC CAGCTTGGCG TCCTGAGAAA TGGATGGTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
| RefSeq | NP_057532.4 |
| CDS | 144..2336 |
| Translation |
Target ORF information:
Target ORF information:
|
NM_016448.4 |
1 | ATGCTCTTCA ATTCGGTGCT CCGCCAGCCC CAGCTTGGCG TCCTGAGAAA TGGATGGTCT |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
PCNA-Dependent Cleavage and Degradation of SDE2 Regulates Response to Replication Stress. |
Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma. |
