×

PKD2 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol PKD2
Entrez Gene ID 5311
Full Name polycystin 2, transient receptor potential cation channel
Synonyms APKD2,PC2,PKD4,Pc-2,TRPP2
General protein information
Preferred Names

polycystin 2, transient receptor potential cation channel

Names

polycystin-2
autosomal dominant polycystic kidney disease type II protein
polycystic kidney disease 2 (autosomal dominant)
transient receptor potential cation channel subfamily P member 2

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

4

4q22.1

Summary This gene encodes a member of the polycystin protein family. The encoded protein is a multi-pass membrane protein that functions as a calcium permeable cation channel, and is involved in calcium transport and calcium signaling in renal epithelial cells. This protein interacts with polycystin 1, and they may be partners in a common signaling cascade involved in tubular morphogenesis. Mutations in this gene are associated with autosomal dominant polycystic kidney disease type 2. [provided by RefSeq, Mar 2011].
Disorder MIM:

173910

Disorder Html: Polycystic kidney disease 2, 613095 (3)

mRNA and Protein(s)

mRNA Protein Name
NM_000297.3 NP_000288.1 polycystin-2
XM_011532028.2 XP_011530330.1 polycystin-2 isoform X1
XM_011532029.1 XP_011530331.1 polycystin-2 isoform X2
XM_011532030.2 XP_011530332.1 polycystin-2 isoform X3



Macaca mulatta (rhesus monkey) PKD2 XP_001099242.1
Pan troglodytes (chimpanzee) PKD2 XP_003310458.1
Mus musculus (house mouse) Pkd2 NP_032887.3
Bos taurus (cattle) PKD2 NP_001039777.1
Gallus gallus (chicken) PKD2 NP_001026311.1
Canis lupus familiaris (dog) PKD2 XP_544974.2
Xenopus tropicalis (tropical clawed frog) pkd2 XP_002938673.2
Homo sapiens (human) PKD2 NP_000288.1
Rattus norvegicus (Norway rat) Pkd2 NP_001178863.1
Danio rerio (zebrafish) pkd2 NP_001002310.1
Caenorhabditis elegans (roundworm) pkd-2 NP_502838.3


Related articles in PubMed

Molecular insights into lipid-assisted Ca
Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kühlbrandt W, Witzgall R, Ziegler C
Nature structural & molecular biology24(2)123-130(2017 Feb)

Association of Rare Nonsynonymous Variants in PKD1 and PKD2 with Familial Intracranial Aneurysms in a Japanese Population.
Hirota K, Akagawa H, Onda H, Yoneyama T, Kawamata T, Kasuya H
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association25(12)2900-2906(2016 Dec)

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.
Shen PS, Yang X, DeCaen PG, Liu X, Bulkley D, Clapham DE, Cao E
Cell167(3)763-773.e11(2016 Oct)

TRPP2 Enhances Metastasis by Regulating Epithelial-Mesenchymal Transition in Laryngeal Squamous Cell Carcinoma.
Wu K, Shen B, Jiang F, Xia L, Fan T, Qin M, Yang L, Guo J, Li Y, Zhu M, Du J, Liu Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(6)2203-2215(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

SNPs in and near PKD2 showed significant evidence of association in individual samples of black adults (rs17013735, P-value=0.0009) and white adults (rs11938025; P-value=0.0005; rs2725270, P-value=0.003).
Title: Variants on chromosome 4q21 near PKD2 and SIBLINGs are associated with dental caries.

TRPP2 mutations are associated with autosomal dominant polycystic kidney disease.
Title: Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes.

The structure of human PC2 in a closed conformation, solved by electron cryomicroscopy at 4.2-A resolution.
Title: Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).

Two cryo-EM structures of distinct channel states of full-length human PC2 in complex with lipids and cations.
Title: Molecular insights into lipid-assisted Ca

Data show that in 82 (87.2%) of the patients, pathogenic mutations were detected in PKD1 (79.0%-92.5%), whereas in 12 (12.8%) patients pathogenic mutations were detected in PKD2 (7.5%-21.0%).
Title: Technical Evaluation: Identification of Pathogenic Mutations in PKD1 and PKD2 in Patients with Autosomal Dominant Polycystic Kidney Disease by Next-Generation Sequencing and Use of a Comprehensive New Classification System.

The following PKD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PKD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

Online Only Promotion

Up to 50% OFF! Starting
from $49/clone

***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu59728 XM_011532029.1
Latest version!
Homo sapiens polycystin 2, transient receptor potential cation channel (PKD2), transcript variant X2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 5-7 $391.30
$559.00
OHu59729 XM_011532030.2
Latest version!
Homo sapiens polycystin 2, transient receptor potential cation channel (PKD2), transcript variant X3, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $391.30
$559.00
OHu26897 NM_000297.3
Latest version!
Homo sapiens polycystin 2, transient receptor potential cation channel (PKD2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $265.30
$379.00
OHu59727 XM_011532028.2
Latest version!
Homo sapiens polycystin 2, transient receptor potential cation channel (PKD2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $475.30
$679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu59728
Clone ID Related Accession (Same CDS sequence) XM_011532029.1
Accession Version XM_011532029.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2187bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product polycystin-2 isoform X2
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
ATGATGAGCT CCAATGTGTA CTACTACACC CGGATGATGT CACAGCTCTT CCTAGACACC 
CCCGTGTCCA AAACGGAGAA AACTAACTTT AAAACTCTGT CTTCCATGGA AGACTTCTGG
AAGTTCACAG AAGGCTCCTT ATTGGATGGG CTGTACTGGA AGATGCAGCC CAGCAACCAG
ACTGAAGCTG ACAACCGAAG TTTCATCTTC TATGAGAACC TGCTGTTAGG GGTTCCACGA
ATACGGCAAC TCCGAGTCAG AAATGGATCC TGCTCTATCC CCCAGGACTT GAGAGATGAA
ATTAAAGAGT GCTATGATGT CTACTCTGTC AGTAGTGAAG ATAGGGCTCC CTTTGGGCCC
CGAAATGGAA CCGCTTGGAT CTACACAAGT GAAAAAGACT TGAATGGTAG TAGCCACTGG
GGAATCATTG CAACTTATAG TGGAGCTGGC TATTATCTGG ATTTGTCAAG AACAAGAGAG
GAAACAGCTG CACAAGTTGC TAGCCTCAAG AAAAATGTCT GGCTGGACCG AGGAACCAGG
GCAACTTTTA TTGACTTCTC AGTGTACAAC GCCAACATTA ACCTGTTCTG TGTGGTCAGG
TTATTGGTTG AATTCCCAGC AACAGGTGGT GTGATTCCAT CTTGGCAATT TCAGCCTTTA
AAGCTGATCC GATATGTCAC AACTTTTGAT TTCTTCCTGG CAGCCTGTGA GATTATCTTT
TGTTTCTTTA TCTTTTACTA TGTGGTGGAA GAGATATTGG AAATTCGCAT TCACAAACTA
CACTATTTCA GGAGTTTCTG GAATTGTCTG GATGTTGTGA TCGTTGTGCT GTCAGTGGTA
GCTATAGGAA TTAACATATA CAGAACATCA AATGTGGAGG TGCTACTACA GTTTCTGGAA
GATCAAAATA CTTTCCCCAA CTTTGAGCAT CTGGCATATT GGCAGATACA GTTCAACAAT
ATAGCTGCTG TCACAGTATT TTTTGTCTGG ATTAAGCTCT TCAAATTCAT CAATTTTAAC
AGGACCATGA GCCAGCTCTC GACAACCATG TCTCGATGTG CCAAAGACCT GTTTGGCTTT
GCTATTATGT TCTTCATTAT TTTCCTAGCG TATGCTCAGT TGGCATACCT TGTCTTTGGC
ACTCAGGTCG ATGACTTCAG TACTTTCCAA GAGTGTATCT TCACTCAATT CCGTATCATT
TTGGGCGATA TCAACTTTGC AGAGATTGAG GAAGCTAATC GAGTTTTGGG ACCAATTTAT
TTCACTACAT TTGTGTTCTT TATGTTCTTC ATTCTTTTGA ATATGTTTTT GGCTATCATC
AATGATACTT ACTCTGAAGT GAAATCTGAC TTGGCACAGC AGAAAGCTGA AATGGAACTC
TCAGATCTTA TCAGAAAGGG CTACCATAAA GCTTTGGTCA AACTAAAACT GAAAAAAAAT
ACCGTGGATG ACATTTCAGA GAGTCTGCGG CAAGGAGGAG GCAAGTTAAA CTTTGACGAA
CTTCGACAAG ATCTCAAAGG GAAGGGCCAT ACTGATGCAG AGATTGAGGC AATATTCACA
AAGTACGACC AAGATGGAGA CCAAGAACTG ACCGAACATG AACATCAGCA GATGAGAGAC
GACTTGGAGA AAGAGAGGGA GGACCTGGAT TTGGATCACA GTTCTTTACC ACGTCCCATG
AGCAGCCGAA GTTTCCCTCG AAGCCTGGAT GACTCTGAGG AGGATGACGA TGAAGATAGC
GGACATAGCT CCAGAAGGAG GGGAAGCATT TCTAGTGGCG TTTCTTACGA AGAGTTTCAA
GTCCTGGTGA GACGAGTGGA CCGGATGGAG CATTCCATCG GCAGCATAGT GTCCAAGATT
GACGCCGTGA TCGTGAAGCT AGAGATTATG GAGCGAGCCA AACTGAAGAG GAGGGAGGTG
CTGGGAAGGC TGTTGGATGG GGTGGCCGAG GATGAAAGGC TGGGTCGTGA CAGTGAAATC
CATAGGGAAC AGATGGAACG GCTAGTACGT GAAGAGTTGG AACGCTGGGA ATCCGATGAT
GCAGCTTCCC AGATCAGTCA TGGTTTAGGC ACGCCAGTGG GACTAAATGG TCAACCTCGC
CCCAGAAGCT CCCGCCCATC TTCCTCCCAA TCTACAGAAG GCATGGAAGG TGCAGGTGGA
AATGGGAGTT CTAATGTCCA CGTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530331.1
CDS98..2284
Misc Feature(1)176..1438
Misc Feature(2)1571..1711
Translation

Target ORF information:

RefSeq Version XM_011532029.1
Organism Homo sapiens(Human)
Definition Homo sapiens polycystin 2, transient receptor potential cation channel (PKD2), transcript variant X2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532029.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
ATGATGAGCT CCAATGTGTA CTACTACACC CGGATGATGT CACAGCTCTT CCTAGACACC 
CCCGTGTCCA AAACGGAGAA AACTAACTTT AAAACTCTGT CTTCCATGGA AGACTTCTGG
AAGTTCACAG AAGGCTCCTT ATTGGATGGG CTGTACTGGA AGATGCAGCC CAGCAACCAG
ACTGAAGCTG ACAACCGAAG TTTCATCTTC TATGAGAACC TGCTGTTAGG GGTTCCACGA
ATACGGCAAC TCCGAGTCAG AAATGGATCC TGCTCTATCC CCCAGGACTT GAGAGATGAA
ATTAAAGAGT GCTATGATGT CTACTCTGTC AGTAGTGAAG ATAGGGCTCC CTTTGGGCCC
CGAAATGGAA CCGCTTGGAT CTACACAAGT GAAAAAGACT TGAATGGTAG TAGCCACTGG
GGAATCATTG CAACTTATAG TGGAGCTGGC TATTATCTGG ATTTGTCAAG AACAAGAGAG
GAAACAGCTG CACAAGTTGC TAGCCTCAAG AAAAATGTCT GGCTGGACCG AGGAACCAGG
GCAACTTTTA TTGACTTCTC AGTGTACAAC GCCAACATTA ACCTGTTCTG TGTGGTCAGG
TTATTGGTTG AATTCCCAGC AACAGGTGGT GTGATTCCAT CTTGGCAATT TCAGCCTTTA
AAGCTGATCC GATATGTCAC AACTTTTGAT TTCTTCCTGG CAGCCTGTGA GATTATCTTT
TGTTTCTTTA TCTTTTACTA TGTGGTGGAA GAGATATTGG AAATTCGCAT TCACAAACTA
CACTATTTCA GGAGTTTCTG GAATTGTCTG GATGTTGTGA TCGTTGTGCT GTCAGTGGTA
GCTATAGGAA TTAACATATA CAGAACATCA AATGTGGAGG TGCTACTACA GTTTCTGGAA
GATCAAAATA CTTTCCCCAA CTTTGAGCAT CTGGCATATT GGCAGATACA GTTCAACAAT
ATAGCTGCTG TCACAGTATT TTTTGTCTGG ATTAAGCTCT TCAAATTCAT CAATTTTAAC
AGGACCATGA GCCAGCTCTC GACAACCATG TCTCGATGTG CCAAAGACCT GTTTGGCTTT
GCTATTATGT TCTTCATTAT TTTCCTAGCG TATGCTCAGT TGGCATACCT TGTCTTTGGC
ACTCAGGTCG ATGACTTCAG TACTTTCCAA GAGTGTATCT TCACTCAATT CCGTATCATT
TTGGGCGATA TCAACTTTGC AGAGATTGAG GAAGCTAATC GAGTTTTGGG ACCAATTTAT
TTCACTACAT TTGTGTTCTT TATGTTCTTC ATTCTTTTGA ATATGTTTTT GGCTATCATC
AATGATACTT ACTCTGAAGT GAAATCTGAC TTGGCACAGC AGAAAGCTGA AATGGAACTC
TCAGATCTTA TCAGAAAGGG CTACCATAAA GCTTTGGTCA AACTAAAACT GAAAAAAAAT
ACCGTGGATG ACATTTCAGA GAGTCTGCGG CAAGGAGGAG GCAAGTTAAA CTTTGACGAA
CTTCGACAAG ATCTCAAAGG GAAGGGCCAT ACTGATGCAG AGATTGAGGC AATATTCACA
AAGTACGACC AAGATGGAGA CCAAGAACTG ACCGAACATG AACATCAGCA GATGAGAGAC
GACTTGGAGA AAGAGAGGGA GGACCTGGAT TTGGATCACA GTTCTTTACC ACGTCCCATG
AGCAGCCGAA GTTTCCCTCG AAGCCTGGAT GACTCTGAGG AGGATGACGA TGAAGATAGC
GGACATAGCT CCAGAAGGAG GGGAAGCATT TCTAGTGGCG TTTCTTACGA AGAGTTTCAA
GTCCTGGTGA GACGAGTGGA CCGGATGGAG CATTCCATCG GCAGCATAGT GTCCAAGATT
GACGCCGTGA TCGTGAAGCT AGAGATTATG GAGCGAGCCA AACTGAAGAG GAGGGAGGTG
CTGGGAAGGC TGTTGGATGG GGTGGCCGAG GATGAAAGGC TGGGTCGTGA CAGTGAAATC
CATAGGGAAC AGATGGAACG GCTAGTACGT GAAGAGTTGG AACGCTGGGA ATCCGATGAT
GCAGCTTCCC AGATCAGTCA TGGTTTAGGC ACGCCAGTGG GACTAAATGG TCAACCTCGC
CCCAGAAGCT CCCGCCCATC TTCCTCCCAA TCTACAGAAG GCATGGAAGG TGCAGGTGGA
AATGGGAGTT CTAATGTCCA CGTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu59729
Clone ID Related Accession (Same CDS sequence) XM_011532030.2
Accession Version XM_011532030.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2067bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product polycystin-2 isoform X3
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532030.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
ATGTTCACAG AAGGCTCCTT ATTGGATGGG CTGTACTGGA AGATGCAGCC CAGCAACCAG 
ACTGAAGCTG ACAACCGAAG TTTCATCTTC TATGAGAACC TGCTGTTAGG GGTTCCACGA
ATACGGCAAC TCCGAGTCAG AAATGGATCC TGCTCTATCC CCCAGGACTT GAGAGATGAA
ATTAAAGAGT GCTATGATGT CTACTCTGTC AGTAGTGAAG ATAGGGCTCC CTTTGGGCCC
CGAAATGGAA CCGCTTGGAT CTACACAAGT GAAAAAGACT TGAATGGTAG TAGCCACTGG
GGAATCATTG CAACTTATAG TGGAGCTGGC TATTATCTGG ATTTGTCAAG AACAAGAGAG
GAAACAGCTG CACAAGTTGC TAGCCTCAAG AAAAATGTCT GGCTGGACCG AGGAACCAGG
GCAACTTTTA TTGACTTCTC AGTGTACAAC GCCAACATTA ACCTGTTCTG TGTGGTCAGG
TTATTGGTTG AATTCCCAGC AACAGGTGGT GTGATTCCAT CTTGGCAATT TCAGCCTTTA
AAGCTGATCC GATATGTCAC AACTTTTGAT TTCTTCCTGG CAGCCTGTGA GATTATCTTT
TGTTTCTTTA TCTTTTACTA TGTGGTGGAA GAGATATTGG AAATTCGCAT TCACAAACTA
CACTATTTCA GGAGTTTCTG GAATTGTCTG GATGTTGTGA TCGTTGTGCT GTCAGTGGTA
GCTATAGGAA TTAACATATA CAGAACATCA AATGTGGAGG TGCTACTACA GTTTCTGGAA
GATCAAAATA CTTTCCCCAA CTTTGAGCAT CTGGCATATT GGCAGATACA GTTCAACAAT
ATAGCTGCTG TCACAGTATT TTTTGTCTGG ATTAAGCTCT TCAAATTCAT CAATTTTAAC
AGGACCATGA GCCAGCTCTC GACAACCATG TCTCGATGTG CCAAAGACCT GTTTGGCTTT
GCTATTATGT TCTTCATTAT TTTCCTAGCG TATGCTCAGT TGGCATACCT TGTCTTTGGC
ACTCAGGTCG ATGACTTCAG TACTTTCCAA GAGTGTATCT TCACTCAATT CCGTATCATT
TTGGGCGATA TCAACTTTGC AGAGATTGAG GAAGCTAATC GAGTTTTGGG ACCAATTTAT
TTCACTACAT TTGTGTTCTT TATGTTCTTC ATTCTTTTGA ATATGTTTTT GGCTATCATC
AATGATACTT ACTCTGAAGT GAAATCTGAC TTGGCACAGC AGAAAGCTGA AATGGAACTC
TCAGATCTTA TCAGAAAGGG CTACCATAAA GCTTTGGTCA AACTAAAACT GAAAAAAAAT
ACCGTGGATG ACATTTCAGA GAGTCTGCGG CAAGGAGGAG GCAAGTTAAA CTTTGACGAA
CTTCGACAAG ATCTCAAAGG GAAGGGCCAT ACTGATGCAG AGATTGAGGC AATATTCACA
AAGTACGACC AAGATGGAGA CCAAGAACTG ACCGAACATG AACATCAGCA GATGAGAGAC
GACTTGGAGA AAGAGAGGGA GGACCTGGAT TTGGATCACA GTTCTTTACC ACGTCCCATG
AGCAGCCGAA GTTTCCCTCG AAGCCTGGAT GACTCTGAGG AGGATGACGA TGAAGATAGC
GGACATAGCT CCAGAAGGAG GGGAAGCATT TCTAGTGGCG TTTCTTACGA AGAGTTTCAA
GTCCTGGTGA GACGAGTGGA CCGGATGGAG CATTCCATCG GCAGCATAGT GTCCAAGATT
GACGCCGTGA TCGTGAAGCT AGAGATTATG GAGCGAGCCA AACTGAAGAG GAGGGAGGTG
CTGGGAAGGC TGTTGGATGG GGTGGCCGAG GATGAAAGGC TGGGTCGTGA CAGTGAAATC
CATAGGGAAC AGATGGAACG GCTAGTACGT GAAGAGTTGG AACGCTGGGA ATCCGATGAT
GCAGCTTCCC AGATCAGTCA TGGTTTAGGC ACGCCAGTGG GACTAAATGG TCAACCTCGC
CCCAGAAGCT CCCGCCCATC TTCCTCCCAA TCTACAGAAG GCATGGAAGG TGCAGGTGGA
AATGGGAGTT CTAATGTCCA CGTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530332.1
CDS259..2325
Misc Feature(1)262..1479
Misc Feature(2)1612..1752
Translation

Target ORF information:

RefSeq Version XM_011532030.2
Organism Homo sapiens(Human)
Definition Homo sapiens polycystin 2, transient receptor potential cation channel (PKD2), transcript variant X3, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532030.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
ATGTTCACAG AAGGCTCCTT ATTGGATGGG CTGTACTGGA AGATGCAGCC CAGCAACCAG 
ACTGAAGCTG ACAACCGAAG TTTCATCTTC TATGAGAACC TGCTGTTAGG GGTTCCACGA
ATACGGCAAC TCCGAGTCAG AAATGGATCC TGCTCTATCC CCCAGGACTT GAGAGATGAA
ATTAAAGAGT GCTATGATGT CTACTCTGTC AGTAGTGAAG ATAGGGCTCC CTTTGGGCCC
CGAAATGGAA CCGCTTGGAT CTACACAAGT GAAAAAGACT TGAATGGTAG TAGCCACTGG
GGAATCATTG CAACTTATAG TGGAGCTGGC TATTATCTGG ATTTGTCAAG AACAAGAGAG
GAAACAGCTG CACAAGTTGC TAGCCTCAAG AAAAATGTCT GGCTGGACCG AGGAACCAGG
GCAACTTTTA TTGACTTCTC AGTGTACAAC GCCAACATTA ACCTGTTCTG TGTGGTCAGG
TTATTGGTTG AATTCCCAGC AACAGGTGGT GTGATTCCAT CTTGGCAATT TCAGCCTTTA
AAGCTGATCC GATATGTCAC AACTTTTGAT TTCTTCCTGG CAGCCTGTGA GATTATCTTT
TGTTTCTTTA TCTTTTACTA TGTGGTGGAA GAGATATTGG AAATTCGCAT TCACAAACTA
CACTATTTCA GGAGTTTCTG GAATTGTCTG GATGTTGTGA TCGTTGTGCT GTCAGTGGTA
GCTATAGGAA TTAACATATA CAGAACATCA AATGTGGAGG TGCTACTACA GTTTCTGGAA
GATCAAAATA CTTTCCCCAA CTTTGAGCAT CTGGCATATT GGCAGATACA GTTCAACAAT
ATAGCTGCTG TCACAGTATT TTTTGTCTGG ATTAAGCTCT TCAAATTCAT CAATTTTAAC
AGGACCATGA GCCAGCTCTC GACAACCATG TCTCGATGTG CCAAAGACCT GTTTGGCTTT
GCTATTATGT TCTTCATTAT TTTCCTAGCG TATGCTCAGT TGGCATACCT TGTCTTTGGC
ACTCAGGTCG ATGACTTCAG TACTTTCCAA GAGTGTATCT TCACTCAATT CCGTATCATT
TTGGGCGATA TCAACTTTGC AGAGATTGAG GAAGCTAATC GAGTTTTGGG ACCAATTTAT
TTCACTACAT TTGTGTTCTT TATGTTCTTC ATTCTTTTGA ATATGTTTTT GGCTATCATC
AATGATACTT ACTCTGAAGT GAAATCTGAC TTGGCACAGC AGAAAGCTGA AATGGAACTC
TCAGATCTTA TCAGAAAGGG CTACCATAAA GCTTTGGTCA AACTAAAACT GAAAAAAAAT
ACCGTGGATG ACATTTCAGA GAGTCTGCGG CAAGGAGGAG GCAAGTTAAA CTTTGACGAA
CTTCGACAAG ATCTCAAAGG GAAGGGCCAT ACTGATGCAG AGATTGAGGC AATATTCACA
AAGTACGACC AAGATGGAGA CCAAGAACTG ACCGAACATG AACATCAGCA GATGAGAGAC
GACTTGGAGA AAGAGAGGGA GGACCTGGAT TTGGATCACA GTTCTTTACC ACGTCCCATG
AGCAGCCGAA GTTTCCCTCG AAGCCTGGAT GACTCTGAGG AGGATGACGA TGAAGATAGC
GGACATAGCT CCAGAAGGAG GGGAAGCATT TCTAGTGGCG TTTCTTACGA AGAGTTTCAA
GTCCTGGTGA GACGAGTGGA CCGGATGGAG CATTCCATCG GCAGCATAGT GTCCAAGATT
GACGCCGTGA TCGTGAAGCT AGAGATTATG GAGCGAGCCA AACTGAAGAG GAGGGAGGTG
CTGGGAAGGC TGTTGGATGG GGTGGCCGAG GATGAAAGGC TGGGTCGTGA CAGTGAAATC
CATAGGGAAC AGATGGAACG GCTAGTACGT GAAGAGTTGG AACGCTGGGA ATCCGATGAT
GCAGCTTCCC AGATCAGTCA TGGTTTAGGC ACGCCAGTGG GACTAAATGG TCAACCTCGC
CCCAGAAGCT CCCGCCCATC TTCCTCCCAA TCTACAGAAG GCATGGAAGG TGCAGGTGGA
AATGGGAGTT CTAATGTCCA CGTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu26897
Clone ID Related Accession (Same CDS sequence) NM_000297.3
Accession Version NM_000297.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2907bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-23
Organism Homo sapiens(Human)
Product polycystin-2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC112263.1, AF054992.1, AF113693.1 and AW600307.1. This sequence is a reference standard in the RefSeqGene project. On Mar 3, 2011 this sequence version replaced NM_000297.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC112261.1, U50928.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
ATGGTGAACT CCAGTCGCGT GCAGCCTCAG CAGCCCGGGG ACGCCAAGCG GCCGCCCGCG 
CCCCGCGCGC CGGACCCGGG CCGGCTGATG GCTGGCTGCG CGGCCGTGGG CGCCAGCCTC
GCCGCCCCGG GCGGCCTCTG CGAGCAGCGG GGCCTGGAGA TCGAGATGCA GCGCATCCGG
CAGGCGGCCG CGCGGGACCC CCCGGCCGGA GCCGCGGCCT CCCCTTCTCC TCCGCTCTCG
TCGTGCTCCC GGCAGGCGTG GAGCCGCGAT AACCCCGGCT TCGAGGCCGA GGAGGAGGAG
GAGGAGGTGG AAGGGGAAGA AGGCGGAATG GTGGTGGAGA TGGACGTAGA GTGGCGCCCG
GGCAGCCGGA GGTCGGCCGC CTCCTCGGCC GTGAGCTCCG TGGGCGCGCG GAGCCGGGGG
CTTGGGGGCT ACCACGGCGC GGGCCACCCG AGCGGGAGGC GGCGCCGGCG AGAGGACCAG
GGCCCGCCGT GCCCCAGCCC AGTCGGCGGC GGGGACCCGC TGCATCGCCA CCTCCCCCTG
GAAGGGCAGC CGCCCCGAGT GGCCTGGGCG GAGAGGCTGG TTCGCGGGCT GCGAGGTCTC
TGGGGAACAA GACTCATGGA GGAAAGCAGC ACTAACCGAG AGAAATACCT TAAAAGTGTT
TTACGGGAAC TGGTCACATA CCTCCTTTTT CTCATAGTCT TGTGCATCTT GACCTACGGC
ATGATGAGCT CCAATGTGTA CTACTACACC CGGATGATGT CACAGCTCTT CCTAGACACC
CCCGTGTCCA AAACGGAGAA AACTAACTTT AAAACTCTGT CTTCCATGGA AGACTTCTGG
AAGTTCACAG AAGGCTCCTT ATTGGATGGG CTGTACTGGA AGATGCAGCC CAGCAACCAG
ACTGAAGCTG ACAACCGAAG TTTCATCTTC TATGAGAACC TGCTGTTAGG GGTTCCACGA
ATACGGCAAC TCCGAGTCAG AAATGGATCC TGCTCTATCC CCCAGGACTT GAGAGATGAA
ATTAAAGAGT GCTATGATGT CTACTCTGTC AGTAGTGAAG ATAGGGCTCC CTTTGGGCCC
CGAAATGGAA CCGCTTGGAT CTACACAAGT GAAAAAGACT TGAATGGTAG TAGCCACTGG
GGAATCATTG CAACTTATAG TGGAGCTGGC TATTATCTGG ATTTGTCAAG AACAAGAGAG
GAAACAGCTG CACAAGTTGC TAGCCTCAAG AAAAATGTCT GGCTGGACCG AGGAACCAGG
GCAACTTTTA TTGACTTCTC AGTGTACAAC GCCAACATTA ACCTGTTCTG TGTGGTCAGG
TTATTGGTTG AATTCCCAGC AACAGGTGGT GTGATTCCAT CTTGGCAATT TCAGCCTTTA
AAGCTGATCC GATATGTCAC AACTTTTGAT TTCTTCCTGG CAGCCTGTGA GATTATCTTT
TGTTTCTTTA TCTTTTACTA TGTGGTGGAA GAGATATTGG AAATTCGCAT TCACAAACTA
CACTATTTCA GGAGTTTCTG GAATTGTCTG GATGTTGTGA TCGTTGTGCT GTCAGTGGTA
GCTATAGGAA TTAACATATA CAGAACATCA AATGTGGAGG TGCTACTACA GTTTCTGGAA
GATCAAAATA CTTTCCCCAA CTTTGAGCAT CTGGCATATT GGCAGATACA GTTCAACAAT
ATAGCTGCTG TCACAGTATT TTTTGTCTGG ATTAAGCTCT TCAAATTCAT CAATTTTAAC
AGGACCATGA GCCAGCTCTC GACAACCATG TCTCGATGTG CCAAAGACCT GTTTGGCTTT
GCTATTATGT TCTTCATTAT TTTCCTAGCG TATGCTCAGT TGGCATACCT TGTCTTTGGC
ACTCAGGTCG ATGACTTCAG TACTTTCCAA GAGTGTATCT TCACTCAATT CCGTATCATT
TTGGGCGATA TCAACTTTGC AGAGATTGAG GAAGCTAATC GAGTTTTGGG ACCAATTTAT
TTCACTACAT TTGTGTTCTT TATGTTCTTC ATTCTTTTGA ATATGTTTTT GGCTATCATC
AATGATACTT ACTCTGAAGT GAAATCTGAC TTGGCACAGC AGAAAGCTGA AATGGAACTC
TCAGATCTTA TCAGAAAGGG CTACCATAAA GCTTTGGTCA AACTAAAACT GAAAAAAAAT
ACCGTGGATG ACATTTCAGA GAGTCTGCGG CAAGGAGGAG GCAAGTTAAA CTTTGACGAA
CTTCGACAAG ATCTCAAAGG GAAGGGCCAT ACTGATGCAG AGATTGAGGC AATATTCACA
AAGTACGACC AAGATGGAGA CCAAGAACTG ACCGAACATG AACATCAGCA GATGAGAGAC
GACTTGGAGA AAGAGAGGGA GGACCTGGAT TTGGATCACA GTTCTTTACC ACGTCCCATG
AGCAGCCGAA GTTTCCCTCG AAGCCTGGAT GACTCTGAGG AGGATGACGA TGAAGATAGC
GGACATAGCT CCAGAAGGAG GGGAAGCATT TCTAGTGGCG TTTCTTACGA AGAGTTTCAA
GTCCTGGTGA GACGAGTGGA CCGGATGGAG CATTCCATCG GCAGCATAGT GTCCAAGATT
GACGCCGTGA TCGTGAAGCT AGAGATTATG GAGCGAGCCA AACTGAAGAG GAGGGAGGTG
CTGGGAAGGC TGTTGGATGG GGTGGCCGAG GATGAAAGGC TGGGTCGTGA CAGTGAAATC
CATAGGGAAC AGATGGAACG GCTAGTACGT GAAGAGTTGG AACGCTGGGA ATCCGATGAT
GCAGCTTCCC AGATCAGTCA TGGTTTAGGC ACGCCAGTGG GACTAAATGG TCAACCTCGC
CCCAGAAGCT CCCGCCCATC TTCCTCCCAA TCTACAGAAG GCATGGAAGG TGCAGGTGGA
AATGGGAGTT CTAATGTCCA CGTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_000288.1
CDS88..2994
Misc Feature(1)28..30
Misc Feature(2)496..498
Misc Feature(3)583..585
Misc Feature(4)757..819
Misc Feature(5)886..2148
Misc Feature(6)1033..1071
Misc Feature(7)1492..1554
Misc Feature(8)1603..1665
Misc Feature(9)1738..1800
Misc Feature(10)1882..1944
Misc Feature(11)2062..2124
Misc Feature(12)2197..2469
Misc Feature(13)2281..2421
Misc Feature(14)2494..2553
Misc Feature(15)2509..2511
Misc Feature(16)2521..2523
Misc Feature(17)2569..2991
Misc Feature(18)2572..2574
Exon (1)1..682
Exon (2)683..796
Exon (3)797..930
Exon (4)931..1181
Exon (5)1182..1406
Exon (6)1407..1635
Exon (7)1636..1803
Exon (8)1804..1985
Exon (9)1986..2106
Exon (10)2107..2205
Exon (11)2206..2327
Exon (12)2328..2445
Exon (13)2446..2609
Exon (14)2610..2757
Exon (15)2758..5079
Translation

Target ORF information:

RefSeq Version NM_000297.3
Organism Homo sapiens(Human)
Definition Homo sapiens polycystin 2, transient receptor potential cation channel (PKD2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_000297.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
ATGGTGAACT CCAGTCGCGT GCAGCCTCAG CAGCCCGGGG ACGCCAAGCG GCCGCCCGCG 
CCCCGCGCGC CGGACCCGGG CCGGCTGATG GCTGGCTGCG CGGCCGTGGG CGCCAGCCTC
GCCGCCCCGG GCGGCCTCTG CGAGCAGCGG GGCCTGGAGA TCGAGATGCA GCGCATCCGG
CAGGCGGCCG CGCGGGACCC CCCGGCCGGA GCCGCGGCCT CCCCTTCTCC TCCGCTCTCG
TCGTGCTCCC GGCAGGCGTG GAGCCGCGAT AACCCCGGCT TCGAGGCCGA GGAGGAGGAG
GAGGAGGTGG AAGGGGAAGA AGGCGGAATG GTGGTGGAGA TGGACGTAGA GTGGCGCCCG
GGCAGCCGGA GGTCGGCCGC CTCCTCGGCC GTGAGCTCCG TGGGCGCGCG GAGCCGGGGG
CTTGGGGGCT ACCACGGCGC GGGCCACCCG AGCGGGAGGC GGCGCCGGCG AGAGGACCAG
GGCCCGCCGT GCCCCAGCCC AGTCGGCGGC GGGGACCCGC TGCATCGCCA CCTCCCCCTG
GAAGGGCAGC CGCCCCGAGT GGCCTGGGCG GAGAGGCTGG TTCGCGGGCT GCGAGGTCTC
TGGGGAACAA GACTCATGGA GGAAAGCAGC ACTAACCGAG AGAAATACCT TAAAAGTGTT
TTACGGGAAC TGGTCACATA CCTCCTTTTT CTCATAGTCT TGTGCATCTT GACCTACGGC
ATGATGAGCT CCAATGTGTA CTACTACACC CGGATGATGT CACAGCTCTT CCTAGACACC
CCCGTGTCCA AAACGGAGAA AACTAACTTT AAAACTCTGT CTTCCATGGA AGACTTCTGG
AAGTTCACAG AAGGCTCCTT ATTGGATGGG CTGTACTGGA AGATGCAGCC CAGCAACCAG
ACTGAAGCTG ACAACCGAAG TTTCATCTTC TATGAGAACC TGCTGTTAGG GGTTCCACGA
ATACGGCAAC TCCGAGTCAG AAATGGATCC TGCTCTATCC CCCAGGACTT GAGAGATGAA
ATTAAAGAGT GCTATGATGT CTACTCTGTC AGTAGTGAAG ATAGGGCTCC CTTTGGGCCC
CGAAATGGAA CCGCTTGGAT CTACACAAGT GAAAAAGACT TGAATGGTAG TAGCCACTGG
GGAATCATTG CAACTTATAG TGGAGCTGGC TATTATCTGG ATTTGTCAAG AACAAGAGAG
GAAACAGCTG CACAAGTTGC TAGCCTCAAG AAAAATGTCT GGCTGGACCG AGGAACCAGG
GCAACTTTTA TTGACTTCTC AGTGTACAAC GCCAACATTA ACCTGTTCTG TGTGGTCAGG
TTATTGGTTG AATTCCCAGC AACAGGTGGT GTGATTCCAT CTTGGCAATT TCAGCCTTTA
AAGCTGATCC GATATGTCAC AACTTTTGAT TTCTTCCTGG CAGCCTGTGA GATTATCTTT
TGTTTCTTTA TCTTTTACTA TGTGGTGGAA GAGATATTGG AAATTCGCAT TCACAAACTA
CACTATTTCA GGAGTTTCTG GAATTGTCTG GATGTTGTGA TCGTTGTGCT GTCAGTGGTA
GCTATAGGAA TTAACATATA CAGAACATCA AATGTGGAGG TGCTACTACA GTTTCTGGAA
GATCAAAATA CTTTCCCCAA CTTTGAGCAT CTGGCATATT GGCAGATACA GTTCAACAAT
ATAGCTGCTG TCACAGTATT TTTTGTCTGG ATTAAGCTCT TCAAATTCAT CAATTTTAAC
AGGACCATGA GCCAGCTCTC GACAACCATG TCTCGATGTG CCAAAGACCT GTTTGGCTTT
GCTATTATGT TCTTCATTAT TTTCCTAGCG TATGCTCAGT TGGCATACCT TGTCTTTGGC
ACTCAGGTCG ATGACTTCAG TACTTTCCAA GAGTGTATCT TCACTCAATT CCGTATCATT
TTGGGCGATA TCAACTTTGC AGAGATTGAG GAAGCTAATC GAGTTTTGGG ACCAATTTAT
TTCACTACAT TTGTGTTCTT TATGTTCTTC ATTCTTTTGA ATATGTTTTT GGCTATCATC
AATGATACTT ACTCTGAAGT GAAATCTGAC TTGGCACAGC AGAAAGCTGA AATGGAACTC
TCAGATCTTA TCAGAAAGGG CTACCATAAA GCTTTGGTCA AACTAAAACT GAAAAAAAAT
ACCGTGGATG ACATTTCAGA GAGTCTGCGG CAAGGAGGAG GCAAGTTAAA CTTTGACGAA
CTTCGACAAG ATCTCAAAGG GAAGGGCCAT ACTGATGCAG AGATTGAGGC AATATTCACA
AAGTACGACC AAGATGGAGA CCAAGAACTG ACCGAACATG AACATCAGCA GATGAGAGAC
GACTTGGAGA AAGAGAGGGA GGACCTGGAT TTGGATCACA GTTCTTTACC ACGTCCCATG
AGCAGCCGAA GTTTCCCTCG AAGCCTGGAT GACTCTGAGG AGGATGACGA TGAAGATAGC
GGACATAGCT CCAGAAGGAG GGGAAGCATT TCTAGTGGCG TTTCTTACGA AGAGTTTCAA
GTCCTGGTGA GACGAGTGGA CCGGATGGAG CATTCCATCG GCAGCATAGT GTCCAAGATT
GACGCCGTGA TCGTGAAGCT AGAGATTATG GAGCGAGCCA AACTGAAGAG GAGGGAGGTG
CTGGGAAGGC TGTTGGATGG GGTGGCCGAG GATGAAAGGC TGGGTCGTGA CAGTGAAATC
CATAGGGAAC AGATGGAACG GCTAGTACGT GAAGAGTTGG AACGCTGGGA ATCCGATGAT
GCAGCTTCCC AGATCAGTCA TGGTTTAGGC ACGCCAGTGG GACTAAATGG TCAACCTCGC
CCCAGAAGCT CCCGCCCATC TTCCTCCCAA TCTACAGAAG GCATGGAAGG TGCAGGTGGA
AATGGGAGTT CTAATGTCCA CGTATGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu59727
Clone ID Related Accession (Same CDS sequence) XM_011532028.2
Accession Version XM_011532028.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2682bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-06-06
Organism Homo sapiens(Human)
Product polycystin-2 isoform X1
Comment MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000004.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011532028.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGGTGAACT CCAGTCGCGT GCAGCCTCAG CAGCCCGGGG ACGCCAAGCG GCCGCCCGCG 
CCCCGCGCGC CGGACCCGGG CCGGCTGATG GCTGGCTGCG CGGCCGTGGG CGCCAGCCTC
GCCGCCCCGG GCGGCCTCTG CGAGCAGCGG GGCCTGGAGA TCGAGATGCA GCGCATCCGG
CAGGCGGCCG CGCGGGACCC CCCGGCCGGA GCCGCGGCCT CCCCTTCTCC TCCGCTCTCG
TCGTGCTCCC GGCAGGCGTG GAGCCGCGAT AACCCCGGCT TCGAGGCCGA GGAGGAGGAG
GAGGAGGTGG AAGGGGAAGA AGGCGGAATG GTGGTGGAGA TGGACGTAGA GTGGCGCCCG
GGCAGCCGGA GGTCGGCCGC CTCCTCGGCC GTGAGCTCCG TGGGCGCGCG GAGCCGGGGG
CTTGGGGGCT ACCACGGCGC GGGCCACCCG AGCGGGAGGC GGCGCCGGCG AGAGGACCAG
GGCCCGCCGT GCCCCAGCCC AGTCGGCGGC GGGGACCCGC TGCATCGCCA CCTCCCCCTG
GAAGGGCAGC CGCCCCGAGT GGCCTGGGCG GAGAGGCTGG TTCGCGGGCT GCGAGGTCTC
TGGGGAACAA GACTCATGGA GGAAAGCAGC ACTAACCGAG AGAAATACCT TAAAAGTGTT
TTACGGGAAC TGGTCACATA CCTCCTTTTT CTCATAGTCT TGTGCATCTT GACCTACGGC
ATGATGAGCT CCAATGTGTA CTACTACACC CGGATGATGT CACAGCTCTT CCTAGACACC
CCCGTGTCCA AAACGGAGAA AACTAACTTT AAAACTCTGT CTTCCATGGA AGACTTCTGG
AAGTTCACAG AAGGCTCCTT ATTGGATGGG CTGTACTGGA AGATGCAGCC CAGCAACCAG
ACTGAAGCTG ACAACCGAAG TTTCATCTTC TATGAGAACC TGCTGTTAGG GGTTCCACGA
ATACGGCAAC TCCGAGTCAG AAATGGATCC TGCTCTATCC CCCAGGACTT GAGAGATGAA
ATTAAAGAGT GCTATGATGT CTACTCTGTC AGTAGTGAAG ATAGGGCTCC CTTTGGGCCC
CGAAATGGAA CCGCGTTATT GGTTGAATTC CCAGCAACAG GTGGTGTGAT TCCATCTTGG
CAATTTCAGC CTTTAAAGCT GATCCGATAT GTCACAACTT TTGATTTCTT CCTGGCAGCC
TGTGAGATTA TCTTTTGTTT CTTTATCTTT TACTATGTGG TGGAAGAGAT ATTGGAAATT
CGCATTCACA AACTACACTA TTTCAGGAGT TTCTGGAATT GTCTGGATGT TGTGATCGTT
GTGCTGTCAG TGGTAGCTAT AGGAATTAAC ATATACAGAA CATCAAATGT GGAGGTGCTA
CTACAGTTTC TGGAAGATCA AAATACTTTC CCCAACTTTG AGCATCTGGC ATATTGGCAG
ATACAGTTCA ACAATATAGC TGCTGTCACA GTATTTTTTG TCTGGATTAA GCTCTTCAAA
TTCATCAATT TTAACAGGAC CATGAGCCAG CTCTCGACAA CCATGTCTCG ATGTGCCAAA
GACCTGTTTG GCTTTGCTAT TATGTTCTTC ATTATTTTCC TAGCGTATGC TCAGTTGGCA
TACCTTGTCT TTGGCACTCA GGTCGATGAC TTCAGTACTT TCCAAGAGTG TATCTTCACT
CAATTCCGTA TCATTTTGGG CGATATCAAC TTTGCAGAGA TTGAGGAAGC TAATCGAGTT
TTGGGACCAA TTTATTTCAC TACATTTGTG TTCTTTATGT TCTTCATTCT TTTGAATATG
TTTTTGGCTA TCATCAATGA TACTTACTCT GAAGTGAAAT CTGACTTGGC ACAGCAGAAA
GCTGAAATGG AACTCTCAGA TCTTATCAGA AAGGGCTACC ATAAAGCTTT GGTCAAACTA
AAACTGAAAA AAAATACCGT GGATGACATT TCAGAGAGTC TGCGGCAAGG AGGAGGCAAG
TTAAACTTTG ACGAACTTCG ACAAGATCTC AAAGGGAAGG GCCATACTGA TGCAGAGATT
GAGGCAATAT TCACAAAGTA CGACCAAGAT GGAGACCAAG AACTGACCGA ACATGAACAT
CAGCAGATGA GAGACGACTT GGAGAAAGAG AGGGAGGACC TGGATTTGGA TCACAGTTCT
TTACCACGTC CCATGAGCAG CCGAAGTTTC CCTCGAAGCC TGGATGACTC TGAGGAGGAT
GACGATGAAG ATAGCGGACA TAGCTCCAGA AGGAGGGGAA GCATTTCTAG TGGCGTTTCT
TACGAAGAGT TTCAAGTCCT GGTGAGACGA GTGGACCGGA TGGAGCATTC CATCGGCAGC
ATAGTGTCCA AGATTGACGC CGTGATCGTG AAGCTAGAGA TTATGGAGCG AGCCAAACTG
AAGAGGAGGG AGGTGCTGGG AAGGCTGTTG GATGGGGTGG CCGAGGATGA AAGGCTGGGT
CGTGACAGTG AAATCCATAG GGAACAGATG GAACGGCTAG TACGTGAAGA GTTGGAACGC
TGGGAATCCG ATGATGCAGC TTCCCAGATC AGTCATGGTT TAGGCACGCC AGTGGGACTA
AATGGTCAAC CTCGCCCCAG AAGCTCCCGC CCATCTTCCT CCCAATCTAC AGAAGGCATG
GAAGGTGCAG GTGGAAATGG GAGTTCTAAT GTCCACGTAT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011530330.1
CDS81..2762
Misc Feature(1)879..1916
Misc Feature(2)2049..2189
Translation

Target ORF information:

RefSeq Version XM_011532028.2
Organism Homo sapiens(Human)
Definition Homo sapiens polycystin 2, transient receptor potential cation channel (PKD2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
XM_011532028.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
ATGGTGAACT CCAGTCGCGT GCAGCCTCAG CAGCCCGGGG ACGCCAAGCG GCCGCCCGCG 
CCCCGCGCGC CGGACCCGGG CCGGCTGATG GCTGGCTGCG CGGCCGTGGG CGCCAGCCTC
GCCGCCCCGG GCGGCCTCTG CGAGCAGCGG GGCCTGGAGA TCGAGATGCA GCGCATCCGG
CAGGCGGCCG CGCGGGACCC CCCGGCCGGA GCCGCGGCCT CCCCTTCTCC TCCGCTCTCG
TCGTGCTCCC GGCAGGCGTG GAGCCGCGAT AACCCCGGCT TCGAGGCCGA GGAGGAGGAG
GAGGAGGTGG AAGGGGAAGA AGGCGGAATG GTGGTGGAGA TGGACGTAGA GTGGCGCCCG
GGCAGCCGGA GGTCGGCCGC CTCCTCGGCC GTGAGCTCCG TGGGCGCGCG GAGCCGGGGG
CTTGGGGGCT ACCACGGCGC GGGCCACCCG AGCGGGAGGC GGCGCCGGCG AGAGGACCAG
GGCCCGCCGT GCCCCAGCCC AGTCGGCGGC GGGGACCCGC TGCATCGCCA CCTCCCCCTG
GAAGGGCAGC CGCCCCGAGT GGCCTGGGCG GAGAGGCTGG TTCGCGGGCT GCGAGGTCTC
TGGGGAACAA GACTCATGGA GGAAAGCAGC ACTAACCGAG AGAAATACCT TAAAAGTGTT
TTACGGGAAC TGGTCACATA CCTCCTTTTT CTCATAGTCT TGTGCATCTT GACCTACGGC
ATGATGAGCT CCAATGTGTA CTACTACACC CGGATGATGT CACAGCTCTT CCTAGACACC
CCCGTGTCCA AAACGGAGAA AACTAACTTT AAAACTCTGT CTTCCATGGA AGACTTCTGG
AAGTTCACAG AAGGCTCCTT ATTGGATGGG CTGTACTGGA AGATGCAGCC CAGCAACCAG
ACTGAAGCTG ACAACCGAAG TTTCATCTTC TATGAGAACC TGCTGTTAGG GGTTCCACGA
ATACGGCAAC TCCGAGTCAG AAATGGATCC TGCTCTATCC CCCAGGACTT GAGAGATGAA
ATTAAAGAGT GCTATGATGT CTACTCTGTC AGTAGTGAAG ATAGGGCTCC CTTTGGGCCC
CGAAATGGAA CCGCGTTATT GGTTGAATTC CCAGCAACAG GTGGTGTGAT TCCATCTTGG
CAATTTCAGC CTTTAAAGCT GATCCGATAT GTCACAACTT TTGATTTCTT CCTGGCAGCC
TGTGAGATTA TCTTTTGTTT CTTTATCTTT TACTATGTGG TGGAAGAGAT ATTGGAAATT
CGCATTCACA AACTACACTA TTTCAGGAGT TTCTGGAATT GTCTGGATGT TGTGATCGTT
GTGCTGTCAG TGGTAGCTAT AGGAATTAAC ATATACAGAA CATCAAATGT GGAGGTGCTA
CTACAGTTTC TGGAAGATCA AAATACTTTC CCCAACTTTG AGCATCTGGC ATATTGGCAG
ATACAGTTCA ACAATATAGC TGCTGTCACA GTATTTTTTG TCTGGATTAA GCTCTTCAAA
TTCATCAATT TTAACAGGAC CATGAGCCAG CTCTCGACAA CCATGTCTCG ATGTGCCAAA
GACCTGTTTG GCTTTGCTAT TATGTTCTTC ATTATTTTCC TAGCGTATGC TCAGTTGGCA
TACCTTGTCT TTGGCACTCA GGTCGATGAC TTCAGTACTT TCCAAGAGTG TATCTTCACT
CAATTCCGTA TCATTTTGGG CGATATCAAC TTTGCAGAGA TTGAGGAAGC TAATCGAGTT
TTGGGACCAA TTTATTTCAC TACATTTGTG TTCTTTATGT TCTTCATTCT TTTGAATATG
TTTTTGGCTA TCATCAATGA TACTTACTCT GAAGTGAAAT CTGACTTGGC ACAGCAGAAA
GCTGAAATGG AACTCTCAGA TCTTATCAGA AAGGGCTACC ATAAAGCTTT GGTCAAACTA
AAACTGAAAA AAAATACCGT GGATGACATT TCAGAGAGTC TGCGGCAAGG AGGAGGCAAG
TTAAACTTTG ACGAACTTCG ACAAGATCTC AAAGGGAAGG GCCATACTGA TGCAGAGATT
GAGGCAATAT TCACAAAGTA CGACCAAGAT GGAGACCAAG AACTGACCGA ACATGAACAT
CAGCAGATGA GAGACGACTT GGAGAAAGAG AGGGAGGACC TGGATTTGGA TCACAGTTCT
TTACCACGTC CCATGAGCAG CCGAAGTTTC CCTCGAAGCC TGGATGACTC TGAGGAGGAT
GACGATGAAG ATAGCGGACA TAGCTCCAGA AGGAGGGGAA GCATTTCTAG TGGCGTTTCT
TACGAAGAGT TTCAAGTCCT GGTGAGACGA GTGGACCGGA TGGAGCATTC CATCGGCAGC
ATAGTGTCCA AGATTGACGC CGTGATCGTG AAGCTAGAGA TTATGGAGCG AGCCAAACTG
AAGAGGAGGG AGGTGCTGGG AAGGCTGTTG GATGGGGTGG CCGAGGATGA AAGGCTGGGT
CGTGACAGTG AAATCCATAG GGAACAGATG GAACGGCTAG TACGTGAAGA GTTGGAACGC
TGGGAATCCG ATGATGCAGC TTCCCAGATC AGTCATGGTT TAGGCACGCC AGTGGGACTA
AATGGTCAAC CTCGCCCCAG AAGCTCCCGC CCATCTTCCT CCCAATCTAC AGAAGGCATG
GAAGGTGCAG GTGGAAATGG GAGTTCTAAT GTCCACGTAT GA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Molecular insights into lipid-assisted Ca
Nature structural & molecular biology24(2)123-130(2017 Feb)
Wilkes M,Madej MG,Kreuter L,Rhinow D,Heinz V,De Sanctis S,Ruppel S,Richter RM,Joos F,Grieben M,Pike AC,Huiskonen JT,Carpenter EP,Kühlbrandt W,Witzgall R,Ziegler C


book

Association of Rare Nonsynonymous Variants in PKD1 and PKD2 with Familial Intracranial Aneurysms in a Japanese Population.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association25(12)2900-2906(2016 Dec)
Hirota K,Akagawa H,Onda H,Yoneyama T,Kawamata T,Kasuya H


book

The Structure of the Polycystic Kidney Disease Channel PKD2 in Lipid Nanodiscs.
Cell167(3)763-773.e11(2016 Oct)
Shen PS,Yang X,DeCaen PG,Liu X,Bulkley D,Clapham DE,Cao E


book

TRPP2 Enhances Metastasis by Regulating Epithelial-Mesenchymal Transition in Laryngeal Squamous Cell Carcinoma.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology39(6)2203-2215(2016)
Wu K,Shen B,Jiang F,Xia L,Fan T,Qin M,Yang L,Guo J,Li Y,Zhu M,Du J,Liu Y


 
*
*
*
*