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POU3F1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol POU3F1
Entrez Gene ID 5453
Full Name POU class 3 homeobox 1
Synonyms OCT6,OTF6,SCIP
General protein information
Preferred Names

POU class 3 homeobox 1

Names

POU domain, class 3, transcription factor 1
OTF-6
POU domain transcription factor SCIP
octamer-binding protein 6
octamer-binding transcription factor 6

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1p34.3

Disorder MIM:

602479


mRNA and Protein(s)

mRNA Protein Name
NM_002699.3 NP_002690.3 POU domain, class 3, transcription factor 1



Rattus norvegicus (Norway rat) Pou3f1 NP_620193.1
Homo sapiens (human) POU3F1 NP_002690.3
Bos taurus (cattle) POU3F1 NP_001098921.1


Related articles in PubMed

Expression of organic anion-transporting polypeptide 1A2 and organic cation transporter 6 as a predictor of pathologic response to neoadjuvant chemotherapy in triple negative breast cancer.
Hashimoto Y, Tatsumi S, Takeda R, Naka A, Ogane N, Kameda Y, Kawachi K, Shimizu S, Sakai M, Kamoshida S
Breast cancer research and treatment145(1)101-11(2014 May)

Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
Velez Edwards DR, Naj AC, Monda K, North KE, Neuhouser M, Magvanjav O, Kusimo I, Vitolins MZ, Manson JE, O'Sullivan MJ, Rampersaud E, Edwards TL
Human genetics132(3)323-36(2013 Mar)

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, , , , Johnson AD, Foster MC, Greenawalt DM, Griffin P, Ding J, Newman AB, Tylavsky F, Miljkovic I, Kritchevsky SB, Launer L, Garcia M, Eiriksdottir G, Carr JJ, Gudnason V, Harris TB, Cupples LA, Borecki IB
PLoS genetics8(5)e1002695(2012)

Aberrant CpG island hypermethylation and down-regulation of Oct-6 mRNA expression in human hepatocellular carcinoma.
Sun JZ, Yang XX, Li XH, Xu WW, Wang Y, Zhu W, Li M
Digestive diseases and sciences56(10)3072-7(2011 Oct)

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Stahl EA, Raychaudhuri S, Remmers EF, Xie G, Eyre S, Thomson BP, Li Y, Kurreeman FA, Zhernakova A, Hinks A, Guiducci C, Chen R, Alfredsson L, Amos CI, Ardlie KG, , Barton A, Bowes J, Brouwer E, Burtt NP, Catanese JJ, Coblyn J, Coenen MJ, Costenbader KH, Criswell LA, Crusius JB, Cui J, de Bakker PI, De Jager PL, Ding B, Emery P, Flynn E, Harrison P, Hocking LJ, Huizinga TW, Kastner DL, Ke X, Lee AT, Liu X, Martin P, Morgan AW, Padyukov L, Posthumus MD, Radstake TR, Reid DM, Seielstad M, Seldin MF, Shadick NA, Steer S, Tak PP, Thomson W, van der Helm-van Mil AH, van der Horst-Bruinsma IE, van der Schoot CE, van Riel PL, Weinblatt ME, Wilson AG, Wolbink GJ, Wordsworth BP, , Wijmenga C, Karlson EW, Toes RE, de Vries N, Begovich AB, Worthington J, Siminovitch KA, Gregersen PK, Klareskog L, Plenge RM
Nature genetics42(6)508-14(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Combined high OATP1A2/high OCT6 may be a potential predictor of response to anthracycline/taxane-based chemotherapy in breast cancer
Title: Expression of organic anion-transporting polypeptide 1A2 and organic cation transporter 6 as a predictor of pathologic response to neoadjuvant chemotherapy in triple negative breast cancer.

CpG island hypermethylation contributes to down-regulation of Oct-6 mRNA expression in hepatocellular carcinoma.
Title: Aberrant CpG island hypermethylation and down-regulation of Oct-6 mRNA expression in human hepatocellular carcinoma.

Strict control of Pou3f1 transgene expression is critical to proper myelination, and factors responsible for Pouf31 downregulation during myelination may play important roles in the development of peripheral neuropathies.
Title: Misexpression of Pou3f1 results in peripheral nerve hypomyelination and axonal loss.

Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes.
Title: Matrix metalloproteinase-19 expression in keratinocytes is repressed by transcription factors Tst-1 and Skn-1a: implications for keratinocyte differentiation.

The following POU3F1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POU3F1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu30114 NM_002699.3
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Homo sapiens POU class 3 homeobox 1 (POU3F1), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $265.30
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu30114
Clone ID Related Accession (Same CDS sequence) NM_002699.3
Accession Version NM_002699.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1356bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-06
Organism Homo sapiens(Human)
Product POU domain, class 3, transcription factor 1
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL139158.11. On Jul 22, 2006 this sequence version replaced NM_002699.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCCACCA CCGCGCAGTA CCTGCCGCGG GGCCCCGGTG GCGGAGCCGG GGGCACCGGG 
CCGCTTATGC ACCCGGACGC CGCGGCGGCG GCGGCGGCGG CGGCGGCCGC GGAGCGATTG
CATGCAGGGG CCGCGTACCG CGAAGTGCAG AAGCTGATGC ACCACGAGTG GCTGGGCGCG
GGCGCGGGCC ACCCCGTGGG CCTAGCGCAC CCCCAGTGGC TACCCACGGG AGGAGGCGGC
GGCGGCGATT GGGCCGGCGG CCCGCACCTA GAACACGGCA AGGCAGGCGG CGGCGGCACC
GGCCGAGCCG ACGACGGCGG CGGCGGCGGA GGTTTCCACG CGCGCCTGGT GCACCAGGGG
GCGGCCCACG CGGGCGCGGC ATGGGCGCAG GGCAGCACAG CGCACCACTT GGGCCCGGCC
ATGTCGCCCT CGCCCGGGGC CAGCGGGGGC CACCAGCCCC AGCCGCTCGG GCTGTACGCG
CAGGCGGCCT ACCCGGGGGG CGGCGGCGGC GGCCTGGCCG GGATGCTGGC GGCGGGCGGT
GGCGGCGCGG GGCCGGGCCT GCACCACGCG CTGCACGAGG ATGGCCACGA GGCGCAGCTG
GAGCCGTCGC CGCCGCCGCA TCTGGGCGCC CACGGACACG CACACGGACA TGCACACGCG
GGCGGCCTGC ACGCGGCGGC GGCGCACCTG CACCCGGGCG CGGGCGGCGG CGGCTCATCG
GTGGGCGAGC ACTCGGACGA GGATGCGCCC AGCTCGGACG ACCTGGAGCA GTTCGCCAAG
CAGTTCAAGC AGCGGCGCAT CAAGCTGGGC TTTACGCAGG CCGACGTGGG GCTGGCGCTG
GGCACGCTCT ACGGTAACGT GTTCTCGCAG ACCACCATCT GCCGCTTCGA GGCCCTGCAG
CTGAGCTTCA AGAACATGTG CAAGCTCAAG CCGCTGCTCA ACAAGTGGCT GGAGGAGACC
GACTCGTCCA GCGGCAGCCC CACCAACCTG GACAAGATCG CGGCGCAGGG CCGCAAGCGC
AAGAAGCGCA CGTCCATCGA GGTGGGGGTC AAAGGCGCGC TCGAGAGCCA CTTTCTCAAG
TGCCCCAAGC CCTCGGCGCA CGAGATCACC GGCTTGGCAG ACAGCCTGCA GCTGGAGAAG
GAGGTGGTGC GCGTCTGGTT CTGCAACCGG CGGCAGAAGG AGAAGCGCAT GACCCCTGCG
GCCGGCGCGG GCCACCCGCC CATGGACGAT GTATACGCGC CTGGGGAGCT AGGGCCTGGC
GGGGGCGGCG CATCGCCACC CTCCGCGCCC CCACCGCCCC CGCCGGCGGC GCTGCACCAC
CACCACCACC ACACACTGCC CGGCTCAGTG CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002690.3
CDS36..1391
Misc Feature(1)774..998
Misc Feature(2)order(1053..1067,1071..1073,1122..1124,1140..1142,1179..1181,1185..1190,1197..1202,1206..1214,1218..1223)
Misc Feature(3)1059..1220
Misc Feature(4)order(1059..1061,1068..1070,1188..1190,1197..1202,1209..1211)
Exon (1)1..2928
Translation

Target ORF information:

RefSeq Version NM_002699.3
Organism Homo sapiens(Human)
Definition Homo sapiens POU class 3 homeobox 1 (POU3F1), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002699.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
ATGGCCACCA CCGCGCAGTA CCTGCCGCGG GGCCCCGGTG GCGGAGCCGG GGGCACCGGG 
CCGCTTATGC ACCCGGACGC CGCGGCGGCG GCGGCGGCGG CGGCGGCCGC GGAGCGATTG
CATGCAGGGG CCGCGTACCG CGAAGTGCAG AAGCTGATGC ACCACGAGTG GCTGGGCGCG
GGCGCGGGCC ACCCCGTGGG CCTAGCGCAC CCCCAGTGGC TACCCACGGG AGGAGGCGGC
GGCGGCGATT GGGCCGGCGG CCCGCACCTA GAACACGGCA AGGCAGGCGG CGGCGGCACC
GGCCGAGCCG ACGACGGCGG CGGCGGCGGA GGTTTCCACG CGCGCCTGGT GCACCAGGGG
GCGGCCCACG CGGGCGCGGC ATGGGCGCAG GGCAGCACAG CGCACCACTT GGGCCCGGCC
ATGTCGCCCT CGCCCGGGGC CAGCGGGGGC CACCAGCCCC AGCCGCTCGG GCTGTACGCG
CAGGCGGCCT ACCCGGGGGG CGGCGGCGGC GGCCTGGCCG GGATGCTGGC GGCGGGCGGT
GGCGGCGCGG GGCCGGGCCT GCACCACGCG CTGCACGAGG ATGGCCACGA GGCGCAGCTG
GAGCCGTCGC CGCCGCCGCA TCTGGGCGCC CACGGACACG CACACGGACA TGCACACGCG
GGCGGCCTGC ACGCGGCGGC GGCGCACCTG CACCCGGGCG CGGGCGGCGG CGGCTCATCG
GTGGGCGAGC ACTCGGACGA GGATGCGCCC AGCTCGGACG ACCTGGAGCA GTTCGCCAAG
CAGTTCAAGC AGCGGCGCAT CAAGCTGGGC TTTACGCAGG CCGACGTGGG GCTGGCGCTG
GGCACGCTCT ACGGTAACGT GTTCTCGCAG ACCACCATCT GCCGCTTCGA GGCCCTGCAG
CTGAGCTTCA AGAACATGTG CAAGCTCAAG CCGCTGCTCA ACAAGTGGCT GGAGGAGACC
GACTCGTCCA GCGGCAGCCC CACCAACCTG GACAAGATCG CGGCGCAGGG CCGCAAGCGC
AAGAAGCGCA CGTCCATCGA GGTGGGGGTC AAAGGCGCGC TCGAGAGCCA CTTTCTCAAG
TGCCCCAAGC CCTCGGCGCA CGAGATCACC GGCTTGGCAG ACAGCCTGCA GCTGGAGAAG
GAGGTGGTGC GCGTCTGGTT CTGCAACCGG CGGCAGAAGG AGAAGCGCAT GACCCCTGCG
GCCGGCGCGG GCCACCCGCC CATGGACGAT GTATACGCGC CTGGGGAGCT AGGGCCTGGC
GGGGGCGGCG CATCGCCACC CTCCGCGCCC CCACCGCCCC CGCCGGCGGC GCTGCACCAC
CACCACCACC ACACACTGCC CGGCTCAGTG CAGTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Expression of organic anion-transporting polypeptide 1A2 and organic cation transporter 6 as a predictor of pathologic response to neoadjuvant chemotherapy in triple negative breast cancer.
Breast cancer research and treatment145(1)101-11(2014 May)
Hashimoto Y,Tatsumi S,Takeda R,Naka A,Ogane N,Kameda Y,Kawachi K,Shimizu S,Sakai M,Kamoshida S


book

Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
Human genetics132(3)323-36(2013 Mar)
Velez Edwards DR,Naj AC,Monda K,North KE,Neuhouser M,Magvanjav O,Kusimo I,Vitolins MZ,Manson JE,O'Sullivan MJ,Rampersaud E,Edwards TL


book

Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
PLoS genetics8(5)e1002695(2012)
Fox CS,Liu Y,White CC,Feitosa M,Smith AV,Heard-Costa N,Lohman K,,,,Johnson AD,Foster MC,Greenawalt DM,Griffin P,Ding J,Newman AB,Tylavsky F,Miljkovic I,Kritchevsky SB,Launer L,Garcia M,Eiriksdottir G,Carr JJ,Gudnason V,Harris TB,Cupples LA,Borecki IB


book

Aberrant CpG island hypermethylation and down-regulation of Oct-6 mRNA expression in human hepatocellular carcinoma.
Digestive diseases and sciences56(10)3072-7(2011 Oct)
Sun JZ,Yang XX,Li XH,Xu WW,Wang Y,Zhu W,Li M


book

Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
Nature genetics42(6)508-14(2010 Jun)
Stahl EA,Raychaudhuri S,Remmers EF,Xie G,Eyre S,Thomson BP,Li Y,Kurreeman FA,Zhernakova A,Hinks A,Guiducci C,Chen R,Alfredsson L,Amos CI,Ardlie KG,,Barton A,Bowes J,Brouwer E,Burtt NP,Catanese JJ,Coblyn J,Coenen MJ,Costenbader KH,Criswell LA,Crusius JB,Cui J,de Bakker PI,De Jager PL,Ding B,Emery P,Flynn E,Harrison P,Hocking LJ,Huizinga TW,Kastner DL,Ke X,Lee AT,Liu X,Martin P,Morgan AW,Padyukov L,Posthumus MD,Radstake TR,Reid DM,Seielstad M,Seldin MF,Shadick NA,Steer S,Tak PP,Thomson W,van der Helm-van Mil AH,van der Horst-Bruinsma IE,van der Schoot CE,van Riel PL,Weinblatt ME,Wilson AG,Wolbink GJ,Wordsworth BP,,Wijmenga C,Karlson EW,Toes RE,de Vries N,Begovich AB,Worthington J,Siminovitch KA,Gregersen PK,Klareskog L,Plenge RM


 
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