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POU5F1B cDNA ORF clone, Homo sapiens (human)

Gene Symbol POU5F1B
Entrez Gene ID 5462
Full Name POU class 5 homeobox 1B
Synonyms OCT4-PG1, OCT4PG1, OTF3C, OTF3P1, POU5F1P1, POU5F1P4, POU5FLC20, POU5FLC8
General protein information
Preferred Names
putative POU domain, class 5, transcription factor 1B
Names
putative POU domain, class 5, transcription factor 1B
POU 5 domain protein
POU class 5 homeobox 1 pseudogene 1
POU domain transcription factor Oct-4
octamer binding protein 3_like sequence
POU domain transcription factor OCT4-pg1
POU domain, class 5, transcription factor 1 pseudogene 1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8q24.21

Summary This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]. lac of sum
Disorder MIM:

615739


mRNA and Protein(s)

mRNA Protein Name
NM_001159542 NP_001153014 putative POU domain, class 5, transcription factor 1B



Homo sapiens (human) POU5F1B NP_001153014.1
Pan troglodytes (chimpanzee) POU5F1B XP_528230.1


Related articles in PubMed

The following POU5F1B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the POU5F1B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu26333
NM_001159542 Homo sapiens POU class 5 homeobox 1B (POU5F1B), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$159.50-$223.30
$319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu26333
Clone ID Related Accession (Same CDS sequence) NM_001159542
Accession Version NM_001159542.1 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1080bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 25-MAY-2014
Organism Homo sapiens (human)
Product putative POU domain, class 5, transcription factor 1B
Comment VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DQ486513.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: DQ486513.1 [ECO:0000345] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCGGGAC ACCTGGCTTC GGATTTCGCC TTCTCGCCCC CTCCAGGCGG TGGGGGTGAT 
GGGCCATGGG GGGCGGAGCC GGGCTGGGTT GATCCTCTGA CCTGGCTAAG CTTCCAAGGC
CCTCCTGGAG GGCCAGGAAT CGGGCCGGGG GTTGGGCCAG GCTCTGAGGT GTGGGGGATT
CCCCCTTGCC CCCCGCCGTA TGAGTTATGT GGGGGGATGG CGTACTGTGG GCCTCAGGTT
GGAGTGGGGC TAGTGCCCCA AGGCGGCTTG GAGACCTCTC AGCCTGAGAG CGAAGCAGGA
GTCGGGGTGG AGAGCAACTC CAATGGGGCC TCCCCGGAAC CCTGCACCGT CCCCCCTGGT
GCCGTGAAGC TGGAGAAGGA GAAGCTAGAG CAAAACCCGG AGAAGTCCCA GGACATCAAA
GCTCTGCAGA AAGAACTCGA GCAATTTGCC AAGCTCCTGA AGCAGAAGAG GATCACCCTG
GGATATACAC AGGCCGATGT GGGGCTCATC CTGGGGGTTC TATTTGGGAA GGTGTTCAGC
CAAAAGACCA TCTGCCGCTT TGAGGCTCTG CAGCTTAGCT TCAAGAACAT GTGTAAGCTG
CGGCCCTTGC TGCAGAAGTG GGTGGAGGAA GCTGACAACA ATGAAAATCT TCAGGAGATA
TGCAAAGCAG AAACCCTCAT GCAGGCCCGA AAGAGAAAGC GAACCAGTAT CGAGAACCGA
GTGAGAGGCA ACCTGGAGAA TTTGTTCCTG CAGTGCCCGA AACCCACACT GCAGATCAGC
CACATCGCCC AGCAGCTTGG GCTCGAGAAG GATGTGGTCC GAGTGTGGTT CTGTAACCGG
CGCCAGAAGG GCAAGCGATC AAGCAGCGAC TATGCACAAC GAGAGGATTT TGAGGCTGCT
GGGTCTCCTT TCTCAGGGGG ACCAGTGTCC TTTCCTCCGG CCCCAGGGCC CCATTTTGGT
ACCCCAGGCT ATGGGAGCCC TCACTTCACT GCACTGTACT CCTCAGTCCC TTTCCCTGAG
GGGGAAGTCT TTCCCCCAGT CTCCGTCATC ACTCTGGGCT CTCCCATGCA TTCAAACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001153014.1
CDS256..1335
Misc Feature(1)208..210(+)
Misc Feature(2)667..891(+)
Misc Feature(3)946..1119(+)
Misc Feature(4)946..1113(+)
Misc Feature(5)952..1101(+)
Exon (1)1..1599
Gene:POU5F1B
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_001159542
Organism Homo sapiens (human)
Definition Homo sapiens POU class 5 homeobox 1B (POU5F1B), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001159542

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
ATGGCGGGAC ACCTGGCTTC GGATTTCGCC TTCTCGCCCC CTCCAGGCGG TGGGGGTGAT 
GGGCCATGGG GGGCGGAGCC GGGCTGGGTT GATCCTCTGA CCTGGCTAAG CTTCCAAGGC
CCTCCTGGAG GGCCAGGAAT CGGGCCGGGG GTTGGGCCAG GCTCTGAGGT GTGGGGGATT
CCCCCTTGCC CCCCGCCGTA TGAGTTATGT GGGGGGATGG CGTACTGTGG GCCTCAGGTT
GGAGTGGGGC TAGTGCCCCA AGGCGGCTTG GAGACCTCTC AGCCTGAGAG CGAAGCAGGA
GTCGGGGTGG AGAGCAACTC CAATGGGGCC TCCCCGGAAC CCTGCACCGT CCCCCCTGGT
GCCGTGAAGC TGGAGAAGGA GAAGCTAGAG CAAAACCCGG AGAAGTCCCA GGACATCAAA
GCTCTGCAGA AAGAACTCGA GCAATTTGCC AAGCTCCTGA AGCAGAAGAG GATCACCCTG
GGATATACAC AGGCCGATGT GGGGCTCATC CTGGGGGTTC TATTTGGGAA GGTGTTCAGC
CAAAAGACCA TCTGCCGCTT TGAGGCTCTG CAGCTTAGCT TCAAGAACAT GTGTAAGCTG
CGGCCCTTGC TGCAGAAGTG GGTGGAGGAA GCTGACAACA ATGAAAATCT TCAGGAGATA
TGCAAAGCAG AAACCCTCAT GCAGGCCCGA AAGAGAAAGC GAACCAGTAT CGAGAACCGA
GTGAGAGGCA ACCTGGAGAA TTTGTTCCTG CAGTGCCCGA AACCCACACT GCAGATCAGC
CACATCGCCC AGCAGCTTGG GCTCGAGAAG GATGTGGTCC GAGTGTGGTT CTGTAACCGG
CGCCAGAAGG GCAAGCGATC AAGCAGCGAC TATGCACAAC GAGAGGATTT TGAGGCTGCT
GGGTCTCCTT TCTCAGGGGG ACCAGTGTCC TTTCCTCCGG CCCCAGGGCC CCATTTTGGT
ACCCCAGGCT ATGGGAGCCC TCACTTCACT GCACTGTACT CCTCAGTCCC TTTCCCTGAG
GGGGAAGTCT TTCCCCCAGT CTCCGTCATC ACTCTGGGCT CTCCCATGCA TTCAAACTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Differential expression of Oct4 variants and pseudogenes in normal urothelium and urothelial cancer
Am. J. Pathol. 183 (4), 1128-1136 (2013)
Wezel F, Pearson J, Kirkwood LA and Southgate J.


book

A diabetic milieu promotes OCT4 and NANOG production in human visceral-derived adipose stem cells
Diabetologia 56 (1), 173-184 (2013)
Dentelli P, Barale C, Togliatto G, Trombetta A, Olgasi C, Gili M, Riganti C, Toppino M and Brizzi MF.


book

Colorectal cancer susceptibility variants alter risk of breast cancer in a Chinese Han population
Genet. Mol. Res. 12 (4), 6268-6274 (2013)
Wei W, Jiang M, Luo L, Li Z, Wang P and Dong WQ.


book

Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D
Psychol Med 42 (6), 1151-1162 (2012)
Clark SL, Adkins DE, Aberg K, Hettema JM, McClay JL, Souza RP and van den Oord EJ.


book

The POU5F1P1 pseudogene encodes a putative protein similar to POU5F1 isoform 1
Oncol. Rep. 20 (5), 1029-1033 (2008)
Panagopoulos I, Moller E, Collin A and Mertens F.


book

[Identification of the OCT4-pg1 retrogene and NANOG gene expression in the human embryonic eye]
Izv. Akad. Nauk. Ser. Biol. 2, 134-138 (2008)
Firsova,N.V., Markintantova,Iu.V., Smirnova,Iu.A., Panova,I.G., Sukhikh,G.T., Zinov'eva,R.D. and Mitashov,V.I.


book

Genome-wide association study of prostate cancer identifies a second risk locus at 8q24
Nat. Genet. 39 (5), 645-649 (2007)
Yeager M, Orr N, Hayes RB, Jacobs KB, Kraft P, Wacholder S, Minichiello MJ, Fearnhead P, Yu K, Chatterjee N, Wang Z, Welch R, Staats BJ, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Gelmann EP, Tucker M, Gerhard DS, Fraumeni JF Jr, Hoover R, Hunter DJ, Chanock SJ and Thomas G.


book

Oct4 pseudogenes are transcribed in cancers
Biochem. Biophys. Res. Commun. 337 (4), 1047-1051 (2005)
Suo G, Han J, Wang X, Zhang J, Zhao Y, Zhao Y and Dai J.


book

Emergence of young human genes after a burst of retroposition in primates
PLoS Biol. 3 (11), E357 (2005)
Marques AC, Dupanloup I, Vinckenbosch N, Reymond A and Kaessmann H.


book

Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues
Nucleic Acids Res. 20 (17), 4613-4620 (1992)
Takeda J, Seino S and Bell GI.


 
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