TMEM106B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Gene Symbol	TMEM106B
Entrez Gene ID	54664
Full Name	transmembrane protein 106B
General protein information	Preferred Names transmembrane protein 106B Names transmembrane protein 106B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7p21.3
Disorder MIM:	613413

mRNA and Protein(s)

mRNA	Protein	Name
NM_001134232.1	NP_001127704.1	transmembrane protein 106B
NM_018374.3	NP_060844.2	transmembrane protein 106B
NM_018374.4	NP_060844.2	transmembrane protein 106B
NM_001134232.2	NP_001127704.1	transmembrane protein 106B
XM_005249789.1	XP_005249846.1	transmembrane protein 106B isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	TMEM106B	XP_518973.3
	TMEM106B	XP_001082836.2
Canis lupus familiaris (dog)	TMEM106B	XP_005628619.1
Mus musculus (house mouse)	Tmem106b	NP_082268.2
Danio rerio (zebrafish)	tmem106bb	NP_001038517.1
Gallus gallus (chicken)	TMEM106B	NP_001012576.1
Homo sapiens (human)	TMEM106B	NP_060844.2
Bos taurus (cattle)	TMEM106B	NP_001029509.1
Rattus norvegicus (Norway rat)	Tmem106b	NP_001004267.1
Xenopus tropicalis (tropical clawed frog)	tmem106b	NP_001016812.1

Gene Ontology
Bibliography

Related articles in PubMed

A recurrent de novo mutation in TMEM106B causes hypomyelinating leukodystrophy.
Simons C, Dyment D, Bent SJ, Crawford J, D'Hooghe M, Kohlsch?tter A, Venkateswaran S, Helman G, Poll-The BT, Makowski CC, Ito Y, Kernohan K, Hartley T, Waisfisz Q, Taft RJ, , van der Knaap MS, Wolf NI
Brain : a journal of neurology140(12)3105-3111(2017 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Single-nucleotide polymorphisms in the TMEM106B gene have been identified as a risk factor in frontotemporal dementia (FTD).
Title: TMEM106B and ApoE polymorphisms in CHMP2B-mediated frontotemporal dementia (FTD-3).

A common causal variant underlying both association with disease and association with TMEM106B expression in lymphoblastoid cell lines.
Title: A Dementia-Associated Risk Variant near TMEM106B Alters Chromatin Architecture and Gene Expression.

TMEM106B enhances the benefit of cognitive reserve on brain structure in fronto-temporal dementia.
Title: Cognitive reserve and TMEM106B genotype modulate brain damage in presymptomatic frontotemporal dementia: a GENFI study.

we expanded our understanding of the TMEM106B haplotype that is protective against TDP-43 proteinopathy.
Title: Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.

Study developed a TMEM106B transgenic mouse model that recapitulates the interaction between progranulin and TMEM106B in human patients and supports a regulation of TMEM106B by progranulin in the aged brain and a role of TMEM106B in frontotemporal lobar degeneration-progranulin disease progression.
Title: Elevated TMEM106B levels exaggerate lipofuscin accumulation and lysosomal dysfunction in aged mice with progranulin deficiency.

The following TMEM106B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TMEM106B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17671	NM_018374.4 Latest version!	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu17671	NM_001134232.2 Latest version!	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu17671	XM_005249789.1 Latest version!	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu17671	NM_018374.3	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu17671	NM_001134232.1	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

TMEM106B ( NM_001134232.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001127704.1 Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17671
Clone ID Related Accession (Same CDS sequence)	NM_001134232.1 , NM_018374.3 , NM_018374.4 , NM_001134232.2 , XM_005249789.1
Accession Version	NM_001134232.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-19
Organism	Homo sapiens(human)
Product	transmembrane protein 106B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA452299.1, BC033901.2 and AC007321.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.61970.1, SRR1660809.33761.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001127704.1
CDS	207..1031
Translation	MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ

Target ORF information:

RefSeq Version	NM_001134232.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134232.1

ORF Insert Sequence:

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM106B ( NM_018374.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_060844.2 Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 1, mRNA.

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CloneID	OHu17671
Clone ID Related Accession (Same CDS sequence)	NM_001134232.1 , NM_018374.3 , NM_018374.4 , NM_001134232.2 , XM_005249789.1
Accession Version	NM_018374.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-09
Organism	Homo sapiens(human)
Product	transmembrane protein 106B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA452299.1, BC033901.2 and AC007321.2. On Aug 21, 2008 this sequence version replaced NM_018374.2. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033901.2, SRR1660803.54443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060844.2
CDS	401..1225
Translation	MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ

Target ORF information:

RefSeq Version	NM_018374.3
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018374.3

ORF Insert Sequence:

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM106B ( NM_018374.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060844.2 Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17671
Clone ID Related Accession (Same CDS sequence)	NM_001134232.1 , NM_018374.3 , NM_018374.4 , NM_001134232.2 , XM_005249789.1
Accession Version	NM_018374.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-27
Organism	Homo sapiens(human)
Product	transmembrane protein 106B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA452299.1, BC033901.2 and AC007321.2. On May 31, 2019 this sequence version replaced NM_018374.3. Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033901.2, SRR1660803.54443.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060844.2
CDS	329..1153
Translation	MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ

Target ORF information:

RefSeq Version	NM_018374.4
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018374.4

ORF Insert Sequence:

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM106B ( NM_001134232.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001127704.1 Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17671
Clone ID Related Accession (Same CDS sequence)	NM_001134232.1 , NM_018374.3 , NM_018374.4 , NM_001134232.2 , XM_005249789.1
Accession Version	NM_001134232.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-28
Organism	Homo sapiens(human)
Product	transmembrane protein 106B
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DA452299.1, BC033901.2 and AC007321.2. On Nov 23, 2018 this sequence version replaced NM_001134232.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.10086.1, SRR1660807.156750.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000396668.8/ ENSP00000379902.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001127704.1
CDS	135..959
Translation	MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ

Target ORF information:

RefSeq Version	NM_001134232.2
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001134232.2

ORF Insert Sequence:

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

TMEM106B ( XM_005249789.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_005249846.1 Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant X1, mRNA.

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CloneID	OHu17671
Clone ID Related Accession (Same CDS sequence)	NM_001134232.1 , NM_018374.3 , NM_018374.4 , NM_001134232.2 , XM_005249789.1
Accession Version	XM_005249789.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 825bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	transmembrane protein 106B isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005249846.1
CDS	257..1081
Translation	MGKSLSHLPLHSSKEDAYDGVTSENMRNGLVNSEVHNEDGRNGDVSQFPYVEFTGRDSVTCPTCQGTGRIPRGQENQLVALIPYSDQRLRPRRTKLYVMASVFVCLLLSGLAVFFLFPRSIDVKYIGVKSAYVSYDVQKRTIYLNITNTLNITNNNYYSVEVENITAQVQFSKTVIGKARLNNITIIGPLDMKQIDYTVPTVIAEEMSYMYDFCTLISIKVHNIVLMMQVTVTTTYFGHSEQISQERYQYVDCGRNTTYQLGQSEYLNVLQPQQ

Target ORF information:

RefSeq Version	XM_005249789.1
Organism	Homo sapiens(human)
Definition	Homo sapiens transmembrane protein 106B (TMEM106B), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005249789.1

ORF Insert Sequence:

ATGGGAAAGT CTCTTTCTCA TTTGCCTTTG CATTCAAGCA AAGAAGATGC TTATGATGGA 
GTCACATCTG AAAACATGAG GAATGGACTG GTTAATAGTG AAGTCCATAA TGAAGATGGA 
AGAAATGGAG ATGTCTCTCA GTTTCCATAT GTGGAATTTA CAGGAAGAGA TAGTGTCACC 
TGCCCTACTT GTCAGGGAAC AGGAAGAATT CCTAGGGGGC AAGAAAACCA ACTGGTGGCA 
TTGATTCCAT ATAGTGATCA GAGATTAAGG CCAAGAAGAA CAAAGCTGTA TGTGATGGCT 
TCTGTGTTTG TCTGTCTACT CCTTTCTGGA TTGGCTGTGT TTTTCCTTTT CCCTCGCTCT 
ATCGACGTGA AATACATTGG TGTAAAATCA GCCTATGTCA GTTATGATGT TCAGAAGCGT 
ACAATTTATT TAAATATCAC AAACACACTA AATATAACAA ACAATAACTA TTACTCTGTC 
GAAGTTGAAA ACATCACTGC CCAAGTTCAA TTTTCAAAAA CAGTTATTGG AAAGGCACGC 
TTAAACAACA TAACCATTAT TGGTCCACTT GATATGAAAC AAATTGATTA CACAGTACCT 
ACCGTTATAG CAGAGGAAAT GAGTTATATG TATGATTTCT GTACTCTGAT ATCCATCAAA 
GTGCATAACA TAGTACTCAT GATGCAAGTT ACTGTGACAA CAACATACTT TGGCCACTCT 
GAACAGATAT CCCAGGAGAG GTATCAGTAT GTCGACTGTG GAAGAAACAC AACTTATCAG 
TTGGGGCAGT CTGAATATTT AAATGTACTT CAGCCACAAC AGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A recurrent de novo mutation in TMEM106B causes hypomyelinating leukodystrophy.
Brain : a journal of neurology140(12)3105-3111(2017 Dec)
Simons C,Dyment D,Bent SJ,Crawford J,D'Hooghe M,Kohlsch?tter A,Venkateswaran S,Helman G,Poll-The BT,Makowski CC,Ito Y,Kernohan K,Hartley T,Waisfisz Q,Taft RJ,,van der Knaap MS,Wolf NI

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TMEM106B cDNA ORF clone, Homo sapiens(human)

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Target ORF information:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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