Gene Symbol | CXorf57 |
Entrez Gene ID | 55086 |
Full Name | chromosome X open reading frame 57 |
Synonyms | RADX |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
ORF » Species Summary » Homo sapiens » CXorf57 cDNA ORF clone
Gene Symbol | CXorf57 |
Entrez Gene ID | 55086 |
Full Name | chromosome X open reading frame 57 |
Synonyms | RADX |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome |
mRNA | Protein | Name |
---|---|---|
NM_018015.6 | NP_060485.4 | RPA-related protein RADX isoform 1 |
NM_001184782.1 | NP_001171711.1 | RPA-related protein RADX isoform 2 |
NM_018015.5 | NP_060485.4 | RPA-related protein RADX isoform 1 |
Bos taurus (cattle) | CXHXorf57 | XP_005227896.1 |
Gallus gallus (chicken) | C4HXORF57 | XP_420350.4 |
CXHXorf57 | XP_001093394.1 | |
Rattus norvegicus (Norway rat) | LOC680663 | NP_001120849.1 |
Homo sapiens (human) | CXorf57 | NP_060485.4 |
Canis lupus familiaris (dog) | CXHXorf57 | XP_852816.1 |
Xenopus tropicalis (tropical clawed frog) | LOC100498514 | XP_002934581.2 |
Pan troglodytes (chimpanzee) | CXHXorf57 | XP_003317656.1 |
Mus musculus (house mouse) | D330045A20Rik | NP_780535.1 |
Danio rerio (zebrafish) | si:ch211-26b3.2 | XP_001343120.5 |
RADX interacts with single-stranded DNA to promote replication fork stability.
Schubert L, Ho T, Hoffmann S, Haahr P, Gu?rillon C, Mailand N
EMBO reports18(11)1991-2003(2017 Nov)
RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.
Dungrawala H, Bhat KP, Le Meur R, Chazin WJ, Ding X, Sharan SK, Wessel SR, Sathe AA, Zhao R, Cortez D
Molecular cell67(3)374-386.e5(2017 Aug)
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
Taipale M, Tucker G, Peng J, Krykbaeva I, Lin ZY, Larsen B, Choi H, Berger B, Gingras AC, Lindquist S
Cell158(2)434-448(2014 Jul)
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Baltz AG, Munschauer M, Schwanh?usser B, Vasile A, Murakawa Y, Schueler M, Youngs N, Penfold-Brown D, Drew K, Milek M, Wyler E, Bonneau R, Selbach M, Dieterich C, Landthaler M
Molecular cell46(5)674-90(2012 Jun)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
By antagonizing RAD51 at forks, RADX allows cells to maintain a high capacity for homology-directed repair while ensuring that replication functions of RAD51 are properly regulated. Thus, RADX is essential to achieve the proper balance of RAD51 activity to maintain genome stability.
Title: RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks.
The following CXorf57 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CXorf57 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu19440 | |
Clone ID Related Accession (Same CDS sequence) | NM_018015.6 , NM_018015.5 | |
Accession Version | NM_018015.6 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2568bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-09 | |
Organism | Homo sapiens(human) | |
Product | RPA-related protein RADX isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC047503.1, BC011483.1 and BC070110.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_018015.5. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC047503.1, BC070110.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000372548.9/ ENSP00000361628.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGTCTGGTG AGTCAGGACA GCCTGAGGCT GGTCCCTCAC ATGCAGGGCT AGATTGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_060485.4 |
CDS | 104..2671 |
Translation |
Target ORF information:
Target ORF information:
|
NM_018015.6 |
1 | ATGTCTGGTG AGTCAGGACA GCCTGAGGCT GGTCCCTCAC ATGCAGGGCT AGATTGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu10932 | |
Clone ID Related Accession (Same CDS sequence) | NM_001184782.1 | |
Accession Version | NM_001184782.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2277bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-09 | |
Organism | Homo sapiens(human) | |
Product | RPA-related protein RADX isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB065928.1, BC047503.1, AK024253.1, AL606833.8 and BC070110.1. Transcript Variant: This variant (2) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. This variant encodes isoform 2, which is shorter than isoform 1. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.158307.1, SRR1803614.118626.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTGGTG AGTCAGGACA GCCTGAGGCT GGTCCCTCAC ATGCAGGGCT AGATTGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001171711.1 |
CDS | 152..2428 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001184782.1 |
1 | ATGTCTGGTG AGTCAGGACA GCCTGAGGCT GGTCCCTCAC ATGCAGGGCT AGATTGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu19440 | |
Clone ID Related Accession (Same CDS sequence) | NM_018015.6 , NM_018015.5 | |
Accession Version | NM_018015.5 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 2568bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-12-09 | |
Organism | Homo sapiens(human) | |
Product | RPA-related protein RADX isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB065928.1, BC047503.1, BC011483.1 and BC070110.1. This sequence is a reference standard in the RefSeqGene project. On Jul 3, 2008 this sequence version replaced NM_018015.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). ##Evidence-Data-START## Transcript exon combination :: BC070110.1, BC047503.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTGGTG AGTCAGGACA GCCTGAGGCT GGTCCCTCAC ATGCAGGGCT AGATTGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_060485.4 |
CDS | 152..2719 |
Translation |
Target ORF information:
Target ORF information:
|
NM_018015.5 |
1 | ATGTCTGGTG AGTCAGGACA GCCTGAGGCT GGTCCCTCAC ATGCAGGGCT AGATTGGCCG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RADX interacts with single-stranded DNA to promote replication fork stability. |
RADX Promotes Genome Stability and Modulates Chemosensitivity by Regulating RAD51 at Replication Forks. |
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. |
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. |