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BTBD2 cDNA ORF clone, Homo sapiens(human)

Summary

Gene Symbol BTBD2
Entrez Gene ID 55643
Full Name BTB domain containing 2
General protein information
Preferred Names

BTB domain containing 2

Names

BTB/POZ domain-containing protein 2
BTB (POZ) domain containing 2
Gene Type protein-coding
Organism Homo sapiens(human)
Genome

19

19p13.3
Summary The C-terminus of the protein encoded by this gene binds topoisomerase I. The N-terminus contains a proline-rich region and a BTB/POZ domain (broad-complex, Tramtrack and bric a brac/Pox virus and Zinc finger), both of which are typically involved in protein-protein interactions. Subcellularly, the protein localizes to cytoplasmic bodies. [provided by RefSeq, Jul 2008].
Disorder MIM:

608531


Reference Sequences (RefSeq)

mRNA and Protein(s)

mRNA Protein Name
XM_005259593.1 XP_005259650.1 BTB/POZ domain-containing protein 2 isoform X1
NM_017797.3 NP_060267.2 BTB/POZ domain-containing protein 2
XM_011528127.1 XP_011526429.1 BTB/POZ domain-containing protein 2 isoform X1
NM_017797.4 NP_060267.2 BTB/POZ domain-containing protein 2

Pathways from BioSystems


Homologies


Rattus norvegicus (Norway rat) Btbd2 XP_006241099.1
Danio rerio (zebrafish) btbd2a NP_001038557.1
Danio rerio (zebrafish) LOC555499 XP_005168501.1
Pan troglodytes (chimpanzee) BTBD2 XP_001172950.2
Bos taurus (cattle) BTBD2 XP_003586345.2
Mus musculus (house mouse) Btbd2 NP_663336.2
Caenorhabditis elegans (roundworm) tag-30 NP_502244.1
Homo sapiens (human) BTBD2 NP_060267.2
LOC721419 XP_001117560.2
Xenopus tropicalis (tropical clawed frog) btbd2 XP_002937976.1

Gene Ontology


Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection.
Khurana B, Zhuang L, Moitra PK, Stantchev TS, Broder CC, Cutler ML, D'Arpa P
Virology journal7332(2010 Nov)

Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.
Liu Y, Shete S, Wang LE, El-Zein R, Etzel CJ, Liang FW, Armstrong G, Tsavachidis S, Gilbert MR, Aldape KD, Xing J, Wu X, Wei Q, Bondy ML
Carcinogenesis31(10)1762-9(2010 Oct)

Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.
Liu Y, Shete S, Etzel CJ, Scheurer M, Alexiou G, Armstrong G, Tsavachidis S, Liang FW, Gilbert M, Aldape K, Armstrong T, Houlston R, Hosking F, Robertson L, Xiao Y, Wiencke J, Wrensch M, Andersson U, Melin BS, Bondy M
Journal of clinical oncology : official journal of the American Society of Clinical Oncology28(14)2467-74(2010 May)

Defining the human deubiquitinating enzyme interaction landscape.
Sowa ME, Bennett EJ, Gygi SP, Harper JW
Cell138(2)389-403(2009 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interaction of BTBD1 and BTBD2 with TOP1 requires TOP1 residues 236 and 237, the same residues required to enhance the infectivity of progeny virions when TOP1 is expressed in African Green Monkey producer cells.
Title: Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.

Polymorphisms in the LIG4, BTBD2, HMGA2, and RTEL1 genes, which are involved in the double-strand break repair pathway, are associated with glioblastoma multiforme survival.
Title: Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.

subcellular colocalization of BTBD1 and BTBD2 to cytoplasmic bodies; TRIM5delta colocalized with BTBD1/2 and appeared to serve as a scaffold for the assembly of endogenous BTBD1/2 proteins
Title: BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.

The following BTBD2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BTBD2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID Accession No. Definition **Vector *Turnaround time Price (USD) Select
OHu51695 XM_005259593.1
Latest version!		 Homo sapiens BTB domain containing 2 (BTBD2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $223.30
$319.00
OHu69570 XM_011528127.1
Latest version!		 Homo sapiens BTB domain containing 2 (BTBD2), transcript variant X1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $139.30
$199.00
OHu02912 NM_017797.4
Latest version!		 Homo sapiens BTB domain containing 2 (BTBD2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $307.30
$439.00
View Old Accession Versions >>
OHu02912 NM_017797.3 Homo sapiens BTB domain containing 2 (BTBD2), mRNA. pcDNA3.1+/C-(K)DYK or customized vector TBD $307.30
$439.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)


CloneID OHu51695
Clone ID Related Accession (Same CDS sequence) XM_005259593.1
Accession Version XM_005259593.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1134bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2016-06-05
Organism Homo sapiens(human)
Product BTB/POZ domain-containing protein 2 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
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481
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601
661
721
781
841
901
961
1021
1081
ATGTTCAACG GGGGAATGGC CACAACATCC ACGGAGATTG AGCTGCCCGA CGTGGAACCC 
GCTGCCTTCC TCGCACTGCT CAAGTTTCTC TACTCGGACG AGGTGCAGAT TGGCCCGGAG 
ACGGTGATGA CCACGCTATA CACCGCCAAG AAGTACGCGG TGCCAGCGCT CGAGGCCCAT 
TGCGTGGAGT TCCTGAAGAA GAACCTGCGA GCCGACAACG CCTTCATGCT GCTCACGCAG 
GCGCGACTCT TCGATGAACC GCAGCTGGCC AGCCTGTGCC TGGAGAACAT CGACAAAAAC 
ACTGCAGACG CCATCACCGC GGAGGGCTTC ACCGACATTG ACCTGGACAC GCTGGTGGCT 
GTCCTGGAGC GCGACACACT GGGCATCCGT GAGGTGCGGC TGTTCAATGC CGTTGTCCGC 
TGGTCCGAGG CCGAGTGTCA GCGGCAGCAG CTGCAGGTGA CGCCAGAGAA CAGGCGGAAG 
GTTCTGGGCA AGGCCCTGGG CCTCATTCGC TTCCCGCTCA TGACCATCGA GGAGTTCGCT 
GCAGGTCCCG CACAGTCGGG CATCCTGGTG GACCGCGAGG TGGTCAGCCT CTTCCTGCAC 
TTCACCGTCA ACCCCAAGCC ACGAGTGGAG TTCATTGACC GGCCCCGCTG CTGCCTGCGT 
GGGAAGGAGT GCAGCATCAA CCGCTTCCAG CAGGTGGAGA GTCGCTGGGG CTACAGCGGG 
ACCAGTGACC GCATCAGGTT CTCAGTCAAC AAGCGCATCT TCGTGGTGGG ATTTGGGCTG 
TATGGATCCA TCCACGGGCC CACCGACTAC CAAGTGAACA TCCAGATTAT TCACACCGAT 
AGCAACACCG TCTTGGGCCA GAACGACACG GGCTTCAGCT GCGACGGCTC AGCCAGCACC 
TTCCGCGTCA TGTTCAAGGA GCCGGTGGAG GTGCTGCCCA ACGTCAACTA CACGGCCTGT 
GCCACGCTCA AGGGCCCAGA CTCCCACTAC GGCACCAAAG GCCTGCGCAA GGTGACACAC 
GAGTCGCCCA CCACGGGCGC CAAGACCTGC TTCACCTTTT GCTACGCGGC CGGGAACAAC 
AATGGCACAT CCGTGGAGGA CGGCCAGATC CCCGAGGTCA TCTTCTACAC CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_005259650.1
CDS210..1343
Translation

Target ORF information:

RefSeq Version XM_005259593.1
Organism Homo sapiens(human)
Definition Homo sapiens BTB domain containing 2 (BTBD2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_005259593.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
ATGTTCAACG GGGGAATGGC CACAACATCC ACGGAGATTG AGCTGCCCGA CGTGGAACCC 
GCTGCCTTCC TCGCACTGCT CAAGTTTCTC TACTCGGACG AGGTGCAGAT TGGCCCGGAG 
ACGGTGATGA CCACGCTATA CACCGCCAAG AAGTACGCGG TGCCAGCGCT CGAGGCCCAT 
TGCGTGGAGT TCCTGAAGAA GAACCTGCGA GCCGACAACG CCTTCATGCT GCTCACGCAG 
GCGCGACTCT TCGATGAACC GCAGCTGGCC AGCCTGTGCC TGGAGAACAT CGACAAAAAC 
ACTGCAGACG CCATCACCGC GGAGGGCTTC ACCGACATTG ACCTGGACAC GCTGGTGGCT 
GTCCTGGAGC GCGACACACT GGGCATCCGT GAGGTGCGGC TGTTCAATGC CGTTGTCCGC 
TGGTCCGAGG CCGAGTGTCA GCGGCAGCAG CTGCAGGTGA CGCCAGAGAA CAGGCGGAAG 
GTTCTGGGCA AGGCCCTGGG CCTCATTCGC TTCCCGCTCA TGACCATCGA GGAGTTCGCT 
GCAGGTCCCG CACAGTCGGG CATCCTGGTG GACCGCGAGG TGGTCAGCCT CTTCCTGCAC 
TTCACCGTCA ACCCCAAGCC ACGAGTGGAG TTCATTGACC GGCCCCGCTG CTGCCTGCGT 
GGGAAGGAGT GCAGCATCAA CCGCTTCCAG CAGGTGGAGA GTCGCTGGGG CTACAGCGGG 
ACCAGTGACC GCATCAGGTT CTCAGTCAAC AAGCGCATCT TCGTGGTGGG ATTTGGGCTG 
TATGGATCCA TCCACGGGCC CACCGACTAC CAAGTGAACA TCCAGATTAT TCACACCGAT 
AGCAACACCG TCTTGGGCCA GAACGACACG GGCTTCAGCT GCGACGGCTC AGCCAGCACC 
TTCCGCGTCA TGTTCAAGGA GCCGGTGGAG GTGCTGCCCA ACGTCAACTA CACGGCCTGT 
GCCACGCTCA AGGGCCCAGA CTCCCACTAC GGCACCAAAG GCCTGCGCAA GGTGACACAC 
GAGTCGCCCA CCACGGGCGC CAAGACCTGC TTCACCTTTT GCTACGCGGC CGGGAACAAC 
AATGGCACAT CCGTGGAGGA CGGCCAGATC CCCGAGGTCA TCTTCTACAC CTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu69570
Clone ID Related Accession (Same CDS sequence) XM_011528127.1
Accession Version XM_011528127.1 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 615bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-05
Organism Homo sapiens(human)
Product BTB/POZ domain-containing protein 2 isoform X1
Comment Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## 

1
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361
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481
541
601
ATGACCATCG AGGAGTTCGC TGCAGGTCCC GCACAGTCGG GCATCCTGGT GGACCGCGAG 
GTGGTCAGCC TCTTCCTGCA CTTCACCGTC AACCCCAAGC CACGAGTGGA GTTCATTGAC 
CGGCCCCGCT GCTGCCTGCG TGGGAAGGAG TGCAGCATCA ACCGCTTCCA GCAGGTGGAG 
AGTCGCTGGG GCTACAGCGG GACCAGTGAC CGCATCAGGT TCTCAGTCAA CAAGCGCATC 
TTCGTGGTGG GATTTGGGCT GTATGGATCC ATCCACGGGC CCACCGACTA CCAAGTGAAC 
ATCCAGATTA TTCACACCGA TAGCAACACC GTCTTGGGCC AGAACGACAC GGGCTTCAGC 
TGCGACGGCT CAGCCAGCAC CTTCCGCGTC ATGTTCAAGG AGCCGGTGGA GGTGCTGCCC 
AACGTCAACT ACACGGCCTG TGCCACGCTC AAGGGCCCAG ACTCCCACTA CGGCACCAAA 
GGCCTGCGCA AGGTGACACA CGAGTCGCCC ACCACGGGCG CCAAGACCTG CTTCACCTTT 
TGCTACGCGG CCGGGAACAA CAATGGCACA TCCGTGGAGG ACGGCCAGAT CCCCGAGGTC 
ATCTTCTACA CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq XP_011526429.1
CDS330..944
Translation

Target ORF information:

RefSeq Version XM_011528127.1
Organism Homo sapiens(human)
Definition Homo sapiens BTB domain containing 2 (BTBD2), transcript variant X1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 XM_011528127.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
ATGACCATCG AGGAGTTCGC TGCAGGTCCC GCACAGTCGG GCATCCTGGT GGACCGCGAG 
GTGGTCAGCC TCTTCCTGCA CTTCACCGTC AACCCCAAGC CACGAGTGGA GTTCATTGAC 
CGGCCCCGCT GCTGCCTGCG TGGGAAGGAG TGCAGCATCA ACCGCTTCCA GCAGGTGGAG 
AGTCGCTGGG GCTACAGCGG GACCAGTGAC CGCATCAGGT TCTCAGTCAA CAAGCGCATC 
TTCGTGGTGG GATTTGGGCT GTATGGATCC ATCCACGGGC CCACCGACTA CCAAGTGAAC 
ATCCAGATTA TTCACACCGA TAGCAACACC GTCTTGGGCC AGAACGACAC GGGCTTCAGC 
TGCGACGGCT CAGCCAGCAC CTTCCGCGTC ATGTTCAAGG AGCCGGTGGA GGTGCTGCCC 
AACGTCAACT ACACGGCCTG TGCCACGCTC AAGGGCCCAG ACTCCCACTA CGGCACCAAA 
GGCCTGCGCA AGGTGACACA CGAGTCGCCC ACCACGGGCG CCAAGACCTG CTTCACCTTT 
TGCTACGCGG CCGGGAACAA CAATGGCACA TCCGTGGAGG ACGGCCAGAT CCCCGAGGTC 
ATCTTCTACA CCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu02912
Clone ID Related Accession (Same CDS sequence) NM_017797.3 , NM_017797.4
Accession Version NM_017797.3 Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1578bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2018-06-22
Organism Homo sapiens(human)
Product BTB/POZ domain-containing protein 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF355797.1, BU849231.1, BC000564.2 and BC008035.2. On Feb 15, 2005 this sequence version replaced NM_017797.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF355797.1, SRR1163657.450417.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGGCGG GTGGGAGCGG CGGGCGTGCG TCGTGCCCGC CGGGGGTCGG GGTCGGCCCG 
GGCACGGGGG GCAGTCCCGG GCCCAGCGCC AACGCCGCCG CCACCCCGGC CCCCGGCAAC 
GCGGCCGCCG CCGCCGCCGC CGCCGCCGCC GCCGCCGCCG CCCCTGGGCC GACGCCGCCC 
GCCCCGCCGG GCCCCGGGAC AGACGCGCAG GCCGCGGGCG CGGAGCGGGC GGAGGAGGCG 
GCGGGCCCGG GGGCGGCGGC GCTGCAGCGC GAGGCCGCGT ACAACTGGCA GGCCAGCAAG 
CCCACCGTGC AGGAGCGCTT CGCCTTCCTC TTCAACAACG AGGTGCTGTG CGACGTGCAC 
TTCCTGGTGG GCAAGGGGCT CAGCTCGCAG CGCATCCCCG CGCACAGGTT CGTGCTGGCC 
GTGGGCAGCG CCGTCTTTGA TGCCATGTTC AACGGGGGAA TGGCCACAAC ATCCACGGAG 
ATTGAGCTGC CCGACGTGGA ACCCGCTGCC TTCCTCGCAC TGCTCAAGTT TCTCTACTCG 
GACGAGGTGC AGATTGGCCC GGAGACGGTG ATGACCACGC TATACACCGC CAAGAAGTAC 
GCGGTGCCAG CGCTCGAGGC CCATTGCGTG GAGTTCCTGA AGAAGAACCT GCGAGCCGAC 
AACGCCTTCA TGCTGCTCAC GCAGGCGCGA CTCTTCGATG AACCGCAGCT GGCCAGCCTG 
TGCCTGGAGA ACATCGACAA AAACACTGCA GACGCCATCA CCGCGGAGGG CTTCACCGAC 
ATTGACCTGG ACACGCTGGT GGCTGTCCTG GAGCGCGACA CACTGGGCAT CCGTGAGGTG 
CGGCTGTTCA ATGCCGTTGT CCGCTGGTCC GAGGCCGAGT GTCAGCGGCA GCAGCTGCAG 
GTGACGCCAG AGAACAGGCG GAAGGTTCTG GGCAAGGCCC TGGGCCTCAT TCGCTTCCCG 
CTCATGACCA TCGAGGAGTT CGCTGCAGGT CCCGCACAGT CGGGCATCCT GGTGGACCGC 
GAGGTGGTCA GCCTCTTCCT GCACTTCACC GTCAACCCCA AGCCACGAGT GGAGTTCATT 
GACCGGCCCC GCTGCTGCCT GCGTGGGAAG GAGTGCAGCA TCAACCGCTT CCAGCAGGTG 
GAGAGTCGCT GGGGCTACAG CGGGACCAGT GACCGCATCA GGTTCTCAGT CAACAAGCGC 
ATCTTCGTGG TGGGATTTGG GCTGTATGGA TCCATCCACG GGCCCACCGA CTACCAAGTG 
AACATCCAGA TTATTCACAC CGATAGCAAC ACCGTCTTGG GCCAGAACGA CACGGGCTTC 
AGCTGCGACG GCTCAGCCAG CACCTTCCGC GTCATGTTCA AGGAGCCGGT GGAGGTGCTG 
CCCAACGTCA ACTACACGGC CTGTGCCACG CTCAAGGGCC CAGACTCCCA CTACGGCACC 
AAAGGCCTGC GCAAGGTGAC ACACGAGTCG CCCACCACGG GCGCCAAGAC CTGCTTCACC 
TTTTGCTACG CGGCCGGGAA CAACAATGGC ACATCCGTGG AGGACGGCCA GATCCCCGAG 
GTCATCTTCT ACACCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_060267.2
CDS1..1578
Translation

Target ORF information:

RefSeq Version NM_017797.3
Organism Homo sapiens(human)
Definition Homo sapiens BTB domain containing 2 (BTBD2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_017797.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGGCGG GTGGGAGCGG CGGGCGTGCG TCGTGCCCGC CGGGGGTCGG GGTCGGCCCG 
GGCACGGGGG GCAGTCCCGG GCCCAGCGCC AACGCCGCCG CCACCCCGGC CCCCGGCAAC 
GCGGCCGCCG CCGCCGCCGC CGCCGCCGCC GCCGCCGCCG CCCCTGGGCC GACGCCGCCC 
GCCCCGCCGG GCCCCGGGAC AGACGCGCAG GCCGCGGGCG CGGAGCGGGC GGAGGAGGCG 
GCGGGCCCGG GGGCGGCGGC GCTGCAGCGC GAGGCCGCGT ACAACTGGCA GGCCAGCAAG 
CCCACCGTGC AGGAGCGCTT CGCCTTCCTC TTCAACAACG AGGTGCTGTG CGACGTGCAC 
TTCCTGGTGG GCAAGGGGCT CAGCTCGCAG CGCATCCCCG CGCACAGGTT CGTGCTGGCC 
GTGGGCAGCG CCGTCTTTGA TGCCATGTTC AACGGGGGAA TGGCCACAAC ATCCACGGAG 
ATTGAGCTGC CCGACGTGGA ACCCGCTGCC TTCCTCGCAC TGCTCAAGTT TCTCTACTCG 
GACGAGGTGC AGATTGGCCC GGAGACGGTG ATGACCACGC TATACACCGC CAAGAAGTAC 
GCGGTGCCAG CGCTCGAGGC CCATTGCGTG GAGTTCCTGA AGAAGAACCT GCGAGCCGAC 
AACGCCTTCA TGCTGCTCAC GCAGGCGCGA CTCTTCGATG AACCGCAGCT GGCCAGCCTG 
TGCCTGGAGA ACATCGACAA AAACACTGCA GACGCCATCA CCGCGGAGGG CTTCACCGAC 
ATTGACCTGG ACACGCTGGT GGCTGTCCTG GAGCGCGACA CACTGGGCAT CCGTGAGGTG 
CGGCTGTTCA ATGCCGTTGT CCGCTGGTCC GAGGCCGAGT GTCAGCGGCA GCAGCTGCAG 
GTGACGCCAG AGAACAGGCG GAAGGTTCTG GGCAAGGCCC TGGGCCTCAT TCGCTTCCCG 
CTCATGACCA TCGAGGAGTT CGCTGCAGGT CCCGCACAGT CGGGCATCCT GGTGGACCGC 
GAGGTGGTCA GCCTCTTCCT GCACTTCACC GTCAACCCCA AGCCACGAGT GGAGTTCATT 
GACCGGCCCC GCTGCTGCCT GCGTGGGAAG GAGTGCAGCA TCAACCGCTT CCAGCAGGTG 
GAGAGTCGCT GGGGCTACAG CGGGACCAGT GACCGCATCA GGTTCTCAGT CAACAAGCGC 
ATCTTCGTGG TGGGATTTGG GCTGTATGGA TCCATCCACG GGCCCACCGA CTACCAAGTG 
AACATCCAGA TTATTCACAC CGATAGCAAC ACCGTCTTGG GCCAGAACGA CACGGGCTTC 
AGCTGCGACG GCTCAGCCAG CACCTTCCGC GTCATGTTCA AGGAGCCGGT GGAGGTGCTG 
CCCAACGTCA ACTACACGGC CTGTGCCACG CTCAAGGGCC CAGACTCCCA CTACGGCACC 
AAAGGCCTGC GCAAGGTGAC ACACGAGTCG CCCACCACGG GCGCCAAGAC CTGCTTCACC 
TTTTGCTACG CGGCCGGGAA CAACAATGGC ACATCCGTGG AGGACGGCCA GATCCCCGAG 
GTCATCTTCT ACACCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu02912
Clone ID Related Accession (Same CDS sequence) NM_017797.3 , NM_017797.4
Accession Version NM_017797.4 Latest version! Documents for ORF clone product in default vector
Sequence Information ORF Nucleotide Sequence (Length: 1578bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ™ Seamless cloning technology
Insert Structure linear
Update Date 2019-12-22
Organism Homo sapiens(human)
Product BTB/POZ domain-containing protein 2
Comment Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004678.1, AF355797.1, BU849231.1, BC000564.2 and BC008035.2. On May 17, 2019 this sequence version replaced NM_017797.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF355797.1, BC094820.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142680 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000255608.9/ ENSP00000255608.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. 

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGGCGG GTGGGAGCGG CGGGCGTGCG TCGTGCCCGC CGGGGGTCGG GGTCGGCCCG 
GGCACGGGGG GCAGTCCCGG GCCCAGCGCC AACGCCGCCG CCACCCCGGC CCCCGGCAAC 
GCGGCCGCCG CCGCCGCCGC CGCCGCCGCC GCCGCCGCCG CCCCTGGGCC GACGCCGCCC 
GCCCCGCCGG GCCCCGGGAC AGACGCGCAG GCCGCGGGCG CGGAGCGGGC GGAGGAGGCG 
GCGGGCCCGG GGGCGGCGGC GCTGCAGCGC GAGGCCGCGT ACAACTGGCA GGCCAGCAAG 
CCCACCGTGC AGGAGCGCTT CGCCTTCCTC TTCAACAACG AGGTGCTGTG CGACGTGCAC 
TTCCTGGTGG GCAAGGGGCT CAGCTCGCAG CGCATCCCCG CGCACAGGTT CGTGCTGGCC 
GTGGGCAGCG CCGTCTTTGA TGCCATGTTC AACGGGGGAA TGGCCACAAC ATCCACGGAG 
ATTGAGCTGC CCGACGTGGA ACCCGCTGCC TTCCTCGCAC TGCTCAAGTT TCTCTACTCG 
GACGAGGTGC AGATTGGCCC GGAGACGGTG ATGACCACGC TATACACCGC CAAGAAGTAC 
GCGGTGCCAG CGCTCGAGGC CCATTGCGTG GAGTTCCTGA AGAAGAACCT GCGAGCCGAC 
AACGCCTTCA TGCTGCTCAC GCAGGCGCGA CTCTTCGATG AACCGCAGCT GGCCAGCCTG 
TGCCTGGAGA ACATCGACAA AAACACTGCA GACGCCATCA CCGCGGAGGG CTTCACCGAC 
ATTGACCTGG ACACGCTGGT GGCTGTCCTG GAGCGCGACA CACTGGGCAT CCGTGAGGTG 
CGGCTGTTCA ATGCCGTTGT CCGCTGGTCC GAGGCCGAGT GTCAGCGGCA GCAGCTGCAG 
GTGACGCCAG AGAACAGGCG GAAGGTTCTG GGCAAGGCCC TGGGCCTCAT TCGCTTCCCG 
CTCATGACCA TCGAGGAGTT CGCTGCAGGT CCCGCACAGT CGGGCATCCT GGTGGACCGC 
GAGGTGGTCA GCCTCTTCCT GCACTTCACC GTCAACCCCA AGCCACGAGT GGAGTTCATT 
GACCGGCCCC GCTGCTGCCT GCGTGGGAAG GAGTGCAGCA TCAACCGCTT CCAGCAGGTG 
GAGAGTCGCT GGGGCTACAG CGGGACCAGT GACCGCATCA GGTTCTCAGT CAACAAGCGC 
ATCTTCGTGG TGGGATTTGG GCTGTATGGA TCCATCCACG GGCCCACCGA CTACCAAGTG 
AACATCCAGA TTATTCACAC CGATAGCAAC ACCGTCTTGG GCCAGAACGA CACGGGCTTC 
AGCTGCGACG GCTCAGCCAG CACCTTCCGC GTCATGTTCA AGGAGCCGGT GGAGGTGCTG 
CCCAACGTCA ACTACACGGC CTGTGCCACG CTCAAGGGCC CAGACTCCCA CTACGGCACC 
AAAGGCCTGC GCAAGGTGAC ACACGAGTCG CCCACCACGG GCGCCAAGAC CTGCTTCACC 
TTTTGCTACG CGGCCGGGAA CAACAATGGC ACATCCGTGG AGGACGGCCA GATCCCCGAG 
GTCATCTTCT ACACCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_060267.2
CDS12..1589
Translation

Target ORF information:

RefSeq Version NM_017797.4
Organism Homo sapiens(human)
Definition Homo sapiens BTB domain containing 2 (BTBD2), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
 NM_017797.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
ATGGCGGCGG GTGGGAGCGG CGGGCGTGCG TCGTGCCCGC CGGGGGTCGG GGTCGGCCCG 
GGCACGGGGG GCAGTCCCGG GCCCAGCGCC AACGCCGCCG CCACCCCGGC CCCCGGCAAC 
GCGGCCGCCG CCGCCGCCGC CGCCGCCGCC GCCGCCGCCG CCCCTGGGCC GACGCCGCCC 
GCCCCGCCGG GCCCCGGGAC AGACGCGCAG GCCGCGGGCG CGGAGCGGGC GGAGGAGGCG 
GCGGGCCCGG GGGCGGCGGC GCTGCAGCGC GAGGCCGCGT ACAACTGGCA GGCCAGCAAG 
CCCACCGTGC AGGAGCGCTT CGCCTTCCTC TTCAACAACG AGGTGCTGTG CGACGTGCAC 
TTCCTGGTGG GCAAGGGGCT CAGCTCGCAG CGCATCCCCG CGCACAGGTT CGTGCTGGCC 
GTGGGCAGCG CCGTCTTTGA TGCCATGTTC AACGGGGGAA TGGCCACAAC ATCCACGGAG 
ATTGAGCTGC CCGACGTGGA ACCCGCTGCC TTCCTCGCAC TGCTCAAGTT TCTCTACTCG 
GACGAGGTGC AGATTGGCCC GGAGACGGTG ATGACCACGC TATACACCGC CAAGAAGTAC 
GCGGTGCCAG CGCTCGAGGC CCATTGCGTG GAGTTCCTGA AGAAGAACCT GCGAGCCGAC 
AACGCCTTCA TGCTGCTCAC GCAGGCGCGA CTCTTCGATG AACCGCAGCT GGCCAGCCTG 
TGCCTGGAGA ACATCGACAA AAACACTGCA GACGCCATCA CCGCGGAGGG CTTCACCGAC 
ATTGACCTGG ACACGCTGGT GGCTGTCCTG GAGCGCGACA CACTGGGCAT CCGTGAGGTG 
CGGCTGTTCA ATGCCGTTGT CCGCTGGTCC GAGGCCGAGT GTCAGCGGCA GCAGCTGCAG 
GTGACGCCAG AGAACAGGCG GAAGGTTCTG GGCAAGGCCC TGGGCCTCAT TCGCTTCCCG 
CTCATGACCA TCGAGGAGTT CGCTGCAGGT CCCGCACAGT CGGGCATCCT GGTGGACCGC 
GAGGTGGTCA GCCTCTTCCT GCACTTCACC GTCAACCCCA AGCCACGAGT GGAGTTCATT 
GACCGGCCCC GCTGCTGCCT GCGTGGGAAG GAGTGCAGCA TCAACCGCTT CCAGCAGGTG 
GAGAGTCGCT GGGGCTACAG CGGGACCAGT GACCGCATCA GGTTCTCAGT CAACAAGCGC 
ATCTTCGTGG TGGGATTTGG GCTGTATGGA TCCATCCACG GGCCCACCGA CTACCAAGTG 
AACATCCAGA TTATTCACAC CGATAGCAAC ACCGTCTTGG GCCAGAACGA CACGGGCTTC 
AGCTGCGACG GCTCAGCCAG CACCTTCCGC GTCATGTTCA AGGAGCCGGT GGAGGTGCTG 
CCCAACGTCA ACTACACGGC CTGTGCCACG CTCAAGGGCC CAGACTCCCA CTACGGCACC 
AAAGGCCTGC GCAAGGTGAC ACACGAGTCG CCCACCACGG GCGCCAAGAC CTGCTTCACC 
TTTTGCTACG CGGCCGGGAA CAACAATGGC ACATCCGTGG AGGACGGCCA GATCCCCGAG 
GTCATCTTCT ACACCTAG

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

PubMed

book

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW


book

Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection.
Virology journal7332(2010 Nov)
Khurana B,Zhuang L,Moitra PK,Stantchev TS,Broder CC,Cutler ML,D'Arpa P


book

Gamma-radiation sensitivity and polymorphisms in RAD51L1 modulate glioma risk.
Carcinogenesis31(10)1762-9(2010 Oct)
Liu Y,Shete S,Wang LE,El-Zein R,Etzel CJ,Liang FW,Armstrong G,Tsavachidis S,Gilbert MR,Aldape KD,Xing J,Wu X,Wei Q,Bondy ML


book

Polymorphisms of LIG4, BTBD2, HMGA2, and RTEL1 genes involved in the double-strand break repair pathway predict glioblastoma survival.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology28(14)2467-74(2010 May)
Liu Y,Shete S,Etzel CJ,Scheurer M,Alexiou G,Armstrong G,Tsavachidis S,Liang FW,Gilbert M,Aldape K,Armstrong T,Houlston R,Hosking F,Robertson L,Xiao Y,Wiencke J,Wrensch M,Andersson U,Melin BS,Bondy M


book

Defining the human deubiquitinating enzyme interaction landscape.
Cell138(2)389-403(2009 Jul)
Sowa ME,Bennett EJ,Gygi SP,Harper JW