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QSOX1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol QSOX1
Entrez Gene ID 5768
Full Name quiescin sulfhydryl oxidase 1
Synonyms Q6,QSCN6
General protein information
Preferred Names

quiescin sulfhydryl oxidase 1

Names

sulfhydryl oxidase 1
quiescin Q6 sulfhydryl oxidase 1
testis tissue sperm-binding protein Li 62n
thiol oxidase 1

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

1

1q25.2

Summary This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder MIM:

603120


mRNA and Protein(s)

mRNA Protein Name
NM_002826.4 NP_002817.2 sulfhydryl oxidase 1 isoform a precursor
NM_001004128.2 NP_001004128.1 sulfhydryl oxidase 1 isoform b precursor



Pan troglodytes (chimpanzee) QSOX1 XP_003954475.1
Mus musculus (house mouse) Qsox1 NP_001020116.1
Rattus norvegicus (Norway rat) Qsox1 NP_001103368.1
Gallus gallus (chicken) QSOX1 NP_989456.1
Drosophila melanogaster (fruit fly) CG4670 NP_610852.1
Macaca mulatta (rhesus monkey) QSOX1 XP_001111489.2
Bos taurus (cattle) QSOX1 NP_001095544.1
Anopheles gambiae (African malaria mosquito) AgaP_AGAP007491 XP_564767.3
Caenorhabditis elegans (roundworm) T10H10.2 NP_508419.1
Danio rerio (zebrafish) qsox1 NP_001121836.1
Homo sapiens (human) QSOX1 NP_002817.2
Caenorhabditis elegans (roundworm) F47B7.2 NP_508652.1
Caenorhabditis elegans (roundworm) F35G2.1 NP_502314.1
Xenopus tropicalis (tropical clawed frog) qsox1 XP_002937004.1


Related articles in PubMed

Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.
Hanavan PD, Borges CR, Katchman BA, Faigel DO, Ho TH, Ma CT, Sergienko EA, Meurice N, Petit JL, Lake DF
Oncotarget6(21)18418-28(2015 Jul)

Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas.
Sobral AC, Neto VM, Traiano G, Percicote AP, Gugelmin ES, de Souza CM, Nakao L, Torres LF, de Noronha L
Diagnostic pathology1037(2015 Apr)

Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase.
Israel BA, Jiang L, Gannon SA, Thorpe C
Free radical biology & medicine69129-35(2014 Apr)

Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas.
Araújo DG, Nakao L, Gozzo P, Souza CD, Balderrama V, Gugelmin ES, Kuczynski AP, Olandoski M, de Noronha L
European journal of histochemistry : EJH58(1)2228(2014 Mar)

QSOX1 inhibits autophagic flux in breast cancer cells.
Poillet L, Pernodet N, Boyer-Guittaut M, Adami P, Borg C, Jouvenot M, Delage-Mourroux R, Despouy G
PloS one9(1)e86641(2014)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data indicate ebselen as an in vitro inhibitor of quiescin sulfhydryl oxidase 1 (QSOX1) enzymatic activity.
Title: Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.

QSOX1 immunoexpression was observed in the non-neoplastic cerebellum samples and the medulloblastoma samples
Title: Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas.

QSOX1 may be revealed as an important player in cancer detection and prognosis. Defining the mechanism(s) of QSOX1 activity in tumors and in in vivo models will provide important insights into how to target QSOX1 with anti-neoplastic agents.
Title: The emerging role of QSOX1 in cancer.

Examination of the unusual kinetics of QSOX1 toward cysteine and glutathione at low micromolar concentrations suggests that circulating QSOX1 is unlikely to significantly contribute to the oxidation of these monothiols in plasma
Title: Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase.

QSOX1 may be involved in neuroblastoma differentiation and regression and may thus function as a biomarker for identifying risk groups for this neoplasm.
Title: Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas.

The following QSOX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the QSOX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu16505 NM_001004128.2
Latest version!
Homo sapiens quiescin sulfhydryl oxidase 1 (QSOX1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $265.30
$379.00
OHu16609 NM_002826.4
Latest version!
Homo sapiens quiescin sulfhydryl oxidase 1 (QSOX1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 12-14 $265.30
$379.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu16505
Clone ID Related Accession (Same CDS sequence) NM_001004128.2
Accession Version NM_001004128.2 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 1815bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-04-26
Organism Homo sapiens(Human)
Product sulfhydryl oxidase 1 isoform b precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB137990.1, U97276.2, BX382719.2, BC017692.1, L42379.1 and AF361868.1. On Sep 22, 2004 this sequence version replaced NM_001004128.1. Transcript Variant: This variant (2) lacks an alternate coding segment compared to variant 1, that causes a frameshift. The resulting isoform (b) is shorter and has a distinct C-terminus compared to isoform a. Sequence Note: The 3' UTR of this gene may extend about 2 kbp further to another polyA site. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005685.1, SRR1803614.141114.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGAGGAGGT GCAACAGCGG CTCCGGGCCG CCGCCGTCGC TGCTGCTGCT GCTGCTGTGG 
CTGCTCGCGG TTCCCGGCGC TAACGCGGCC CCGCGGTCGG CGCTCTATTC GCCTTCCGAC
CCGCTGACGC TGCTGCAGGC GGACACGGTG CGCGGCGCGG TGCTGGGCTC CCGCAGCGCC
TGGGCCGTGG AGTTCTTCGC CTCCTGGTGC GGCCACTGCA TCGCCTTCGC CCCGACGTGG
AAGGCGCTGG CCGAAGACGT CAAAGCCTGG AGGCCGGCCC TGTATCTCGC CGCCCTGGAC
TGTGCTGAGG AGACCAACAG TGCAGTCTGC AGAGACTTCA ACATCCCTGG CTTCCCGACT
GTGAGGTTCT TCAAGGCCTT TACCAAGAAC GGCTCGGGAG CAGTATTTCC AGTGGCTGGT
GCTGACGTGC AGACACTGCG GGAGAGGCTC ATTGACGCCC TGGAGTCCCA TCATGACACG
TGGCCCCCAG CCTGTCCCCC ACTGGAGCCT GCCAAGCTGG AGGAGATTGA TGGATTCTTT
GCGAGAAATA ACGAAGAGTA CCTGGCTCTG ATCTTTGAAA AGGGAGGCTC CTACCTGGGT
AGAGAGGTGG CTCTGGACCT GTCCCAGCAC AAAGGCGTGG CGGTGCGCAG GGTGCTGAAC
ACAGAGGCCA ATGTGGTGAG AAAGTTTGGT GTCACCGACT TCCCCTCTTG CTACCTGCTG
TTCCGGAATG GCTCTGTCTC CCGAGTCCCC GTGCTCATGG AATCCAGGTC CTTCTATACC
GCTTACCTGC AGAGACTCTC TGGGCTCACC AGGGAGGCTG CCCAGACCAC AGTTGCACCA
ACCACTGCTA ACAAGATAGC TCCCACTGTT TGGAAATTGG CAGATCGCTC CAAGATCTAC
ATGGCTGACC TGGAATCTGC ACTGCACTAC ATCCTGCGGA TAGAAGTGGG CAGGTTCCCG
GTCCTGGAAG GGCAGCGCCT GGTGGCCCTG AAAAAGTTTG TGGCAGTGCT GGCCAAGTAT
TTCCCTGGCC GGCCCTTAGT CCAGAACTTC CTGCACTCCG TGAATGAATG GCTCAAGAGG
CAGAAGAGAA ATAAAATTCC CTACAGTTTC TTTAAAACTG CCCTGGACGA CAGGAAAGAG
GGTGCCGTTC TTGCCAAGAA GGTGAACTGG ATTGGCTGCC AGGGGAGTGA GCCGCATTTC
CGGGGCTTTC CCTGCTCCCT GTGGGTCCTC TTCCACTTCT TGACTGTGCA GGCAGCTCGG
CAAAATGTAG ACCACTCACA GGAAGCAGCC AAGGCCAAGG AGGTCCTCCC AGCCATCCGA
GGCTACGTGC ACTACTTCTT CGGCTGCCGA GACTGCGCTA GCCACTTCGA GCAGATGGCT
GCTGCCTCCA TGCACCGGGT GGGGAGTCCC AACGCCGCTG TCCTCTGGCT CTGGTCTAGC
CACAACAGGG TCAATGCTCG CCTTGCAGGT GCCCCCAGCG AGGACCCCCA GTTCCCCAAG
GTGCAGTGGC CACCCCGTGA ACTTTGTTCT GCCTGCCACA ATGAACGCCT GGATGTGCCC
GTGTGGGACG TGGAAGCCAC CCTCAACTTC CTCAAGGCCC ACTTCTCCCC AAGCAACATC
ATCCTGGACT TCCCTGCAGC TGGGTCAGCT GCCCGGAGGG ATGTGCAGAA TGTGGCAGCC
GCCCCAGAGC TGGCGATGGG AGCCCTGGAG CTGGAAAGCC GGAATTCAAC TCTGGACCCT
GGGAAGCCTG AGATGATGAA GTCCCCCACA AACACCACCC CACATGTGCC GGCTGAGGGA
CCTGAGCTTA TTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001004128.1
CDS76..1890
Misc Feature(1)193..531
Misc Feature(2)order(283..285,292..294)
Misc Feature(3)838..840
Misc Feature(4)1291..1578
Misc Feature(5)1351..1353
Exon (1)1..340
Exon (2)341..441
Exon (3)442..487
Exon (4)488..590
Exon (5)591..681
Exon (6)682..827
Exon (7)828..962
Exon (8)963..1092
Exon (9)1093..1215
Exon (10)1216..1363
Exon (11)1364..1543
Exon (12)1544..1881
Exon (13)1882..2583
Translation

Target ORF information:

RefSeq Version NM_001004128.2
Organism Homo sapiens(Human)
Definition Homo sapiens quiescin sulfhydryl oxidase 1 (QSOX1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001004128.2

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
ATGAGGAGGT GCAACAGCGG CTCCGGGCCG CCGCCGTCGC TGCTGCTGCT GCTGCTGTGG 
CTGCTCGCGG TTCCCGGCGC TAACGCGGCC CCGCGGTCGG CGCTCTATTC GCCTTCCGAC
CCGCTGACGC TGCTGCAGGC GGACACGGTG CGCGGCGCGG TGCTGGGCTC CCGCAGCGCC
TGGGCCGTGG AGTTCTTCGC CTCCTGGTGC GGCCACTGCA TCGCCTTCGC CCCGACGTGG
AAGGCGCTGG CCGAAGACGT CAAAGCCTGG AGGCCGGCCC TGTATCTCGC CGCCCTGGAC
TGTGCTGAGG AGACCAACAG TGCAGTCTGC AGAGACTTCA ACATCCCTGG CTTCCCGACT
GTGAGGTTCT TCAAGGCCTT TACCAAGAAC GGCTCGGGAG CAGTATTTCC AGTGGCTGGT
GCTGACGTGC AGACACTGCG GGAGAGGCTC ATTGACGCCC TGGAGTCCCA TCATGACACG
TGGCCCCCAG CCTGTCCCCC ACTGGAGCCT GCCAAGCTGG AGGAGATTGA TGGATTCTTT
GCGAGAAATA ACGAAGAGTA CCTGGCTCTG ATCTTTGAAA AGGGAGGCTC CTACCTGGGT
AGAGAGGTGG CTCTGGACCT GTCCCAGCAC AAAGGCGTGG CGGTGCGCAG GGTGCTGAAC
ACAGAGGCCA ATGTGGTGAG AAAGTTTGGT GTCACCGACT TCCCCTCTTG CTACCTGCTG
TTCCGGAATG GCTCTGTCTC CCGAGTCCCC GTGCTCATGG AATCCAGGTC CTTCTATACC
GCTTACCTGC AGAGACTCTC TGGGCTCACC AGGGAGGCTG CCCAGACCAC AGTTGCACCA
ACCACTGCTA ACAAGATAGC TCCCACTGTT TGGAAATTGG CAGATCGCTC CAAGATCTAC
ATGGCTGACC TGGAATCTGC ACTGCACTAC ATCCTGCGGA TAGAAGTGGG CAGGTTCCCG
GTCCTGGAAG GGCAGCGCCT GGTGGCCCTG AAAAAGTTTG TGGCAGTGCT GGCCAAGTAT
TTCCCTGGCC GGCCCTTAGT CCAGAACTTC CTGCACTCCG TGAATGAATG GCTCAAGAGG
CAGAAGAGAA ATAAAATTCC CTACAGTTTC TTTAAAACTG CCCTGGACGA CAGGAAAGAG
GGTGCCGTTC TTGCCAAGAA GGTGAACTGG ATTGGCTGCC AGGGGAGTGA GCCGCATTTC
CGGGGCTTTC CCTGCTCCCT GTGGGTCCTC TTCCACTTCT TGACTGTGCA GGCAGCTCGG
CAAAATGTAG ACCACTCACA GGAAGCAGCC AAGGCCAAGG AGGTCCTCCC AGCCATCCGA
GGCTACGTGC ACTACTTCTT CGGCTGCCGA GACTGCGCTA GCCACTTCGA GCAGATGGCT
GCTGCCTCCA TGCACCGGGT GGGGAGTCCC AACGCCGCTG TCCTCTGGCT CTGGTCTAGC
CACAACAGGG TCAATGCTCG CCTTGCAGGT GCCCCCAGCG AGGACCCCCA GTTCCCCAAG
GTGCAGTGGC CACCCCGTGA ACTTTGTTCT GCCTGCCACA ATGAACGCCT GGATGTGCCC
GTGTGGGACG TGGAAGCCAC CCTCAACTTC CTCAAGGCCC ACTTCTCCCC AAGCAACATC
ATCCTGGACT TCCCTGCAGC TGGGTCAGCT GCCCGGAGGG ATGTGCAGAA TGTGGCAGCC
GCCCCAGAGC TGGCGATGGG AGCCCTGGAG CTGGAAAGCC GGAATTCAAC TCTGGACCCT
GGGAAGCCTG AGATGATGAA GTCCCCCACA AACACCACCC CACATGTGCC GGCTGAGGGA
CCTGAGCTTA TTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu16609
Clone ID Related Accession (Same CDS sequence) NM_002826.4
Accession Version NM_002826.4 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 2244bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2016-10-06
Organism Homo sapiens(Human)
Product sulfhydryl oxidase 1 isoform a precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB137990.1, U97276.2, BX382719.2, BC017692.1 and L42379.1. On Sep 22, 2004 this sequence version replaced NM_002826.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a). Sequence Note: The 3' UTR of this gene may extend about 2 kbp further to another polyA site. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: U97276.2, AY358941.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGAGGAGGT GCAACAGCGG CTCCGGGCCG CCGCCGTCGC TGCTGCTGCT GCTGCTGTGG 
CTGCTCGCGG TTCCCGGCGC TAACGCGGCC CCGCGGTCGG CGCTCTATTC GCCTTCCGAC
CCGCTGACGC TGCTGCAGGC GGACACGGTG CGCGGCGCGG TGCTGGGCTC CCGCAGCGCC
TGGGCCGTGG AGTTCTTCGC CTCCTGGTGC GGCCACTGCA TCGCCTTCGC CCCGACGTGG
AAGGCGCTGG CCGAAGACGT CAAAGCCTGG AGGCCGGCCC TGTATCTCGC CGCCCTGGAC
TGTGCTGAGG AGACCAACAG TGCAGTCTGC AGAGACTTCA ACATCCCTGG CTTCCCGACT
GTGAGGTTCT TCAAGGCCTT TACCAAGAAC GGCTCGGGAG CAGTATTTCC AGTGGCTGGT
GCTGACGTGC AGACACTGCG GGAGAGGCTC ATTGACGCCC TGGAGTCCCA TCATGACACG
TGGCCCCCAG CCTGTCCCCC ACTGGAGCCT GCCAAGCTGG AGGAGATTGA TGGATTCTTT
GCGAGAAATA ACGAAGAGTA CCTGGCTCTG ATCTTTGAAA AGGGAGGCTC CTACCTGGGT
AGAGAGGTGG CTCTGGACCT GTCCCAGCAC AAAGGCGTGG CGGTGCGCAG GGTGCTGAAC
ACAGAGGCCA ATGTGGTGAG AAAGTTTGGT GTCACCGACT TCCCCTCTTG CTACCTGCTG
TTCCGGAATG GCTCTGTCTC CCGAGTCCCC GTGCTCATGG AATCCAGGTC CTTCTATACC
GCTTACCTGC AGAGACTCTC TGGGCTCACC AGGGAGGCTG CCCAGACCAC AGTTGCACCA
ACCACTGCTA ACAAGATAGC TCCCACTGTT TGGAAATTGG CAGATCGCTC CAAGATCTAC
ATGGCTGACC TGGAATCTGC ACTGCACTAC ATCCTGCGGA TAGAAGTGGG CAGGTTCCCG
GTCCTGGAAG GGCAGCGCCT GGTGGCCCTG AAAAAGTTTG TGGCAGTGCT GGCCAAGTAT
TTCCCTGGCC GGCCCTTAGT CCAGAACTTC CTGCACTCCG TGAATGAATG GCTCAAGAGG
CAGAAGAGAA ATAAAATTCC CTACAGTTTC TTTAAAACTG CCCTGGACGA CAGGAAAGAG
GGTGCCGTTC TTGCCAAGAA GGTGAACTGG ATTGGCTGCC AGGGGAGTGA GCCGCATTTC
CGGGGCTTTC CCTGCTCCCT GTGGGTCCTC TTCCACTTCT TGACTGTGCA GGCAGCTCGG
CAAAATGTAG ACCACTCACA GGAAGCAGCC AAGGCCAAGG AGGTCCTCCC AGCCATCCGA
GGCTACGTGC ACTACTTCTT CGGCTGCCGA GACTGCGCTA GCCACTTCGA GCAGATGGCT
GCTGCCTCCA TGCACCGGGT GGGGAGTCCC AACGCCGCTG TCCTCTGGCT CTGGTCTAGC
CACAACAGGG TCAATGCTCG CCTTGCAGGT GCCCCCAGCG AGGACCCCCA GTTCCCCAAG
GTGCAGTGGC CACCCCGTGA ACTTTGTTCT GCCTGCCACA ATGAACGCCT GGATGTGCCC
GTGTGGGACG TGGAAGCCAC CCTCAACTTC CTCAAGGCCC ACTTCTCCCC AAGCAACATC
ATCCTGGACT TCCCTGCAGC TGGGTCAGCT GCCCGGAGGG ATGTGCAGAA TGTGGCAGCC
GCCCCAGAGC TGGCGATGGG AGCCCTGGAG CTGGAAAGCC GGAATTCAAC TCTGGACCCT
GGGAAGCCTG AGATGATGAA GTCCCCCACA AACACCACCC CACATGTGCC GGCTGAGGGA
CCTGAGGCAA GTCGACCCCC GAAGCTGCAC CCTGGCCTCA GAGCTGCACC AGGCCAGGAG
CCTCCTGAGC ACATGGCAGA GCTTCAGAGG AATGAGCAGG AGCAGCCGCT TGGGCAGTGG
CACTTGAGCA AGCGAGACAC AGGGGCTGCA TTGCTGGCTG AGTCCAGGGC TGAGAAGAAC
CGCCTCTGGG GCCCTTTGGA GGTCAGGCGC GTGGGCCGCA GCTCCAAGCA GCTGGTCGAC
ATCCCTGAGG GCCAGCTGGA GGCCCGAGCT GGACGGGGCC GAGGCCAGTG GCTGCAGGTG
CTGGGAGGGG GCTTCTCTTA CCTGGACATC AGCCTCTGTG TGGGGCTCTA TTCCCTGTCC
TTCATGGGCC TGCTGGCCAT GTACACCTAC TTCCAGGCCA AGATAAGGGC CCTGAAGGGC
CATGCTGGCC ACCCTGCAGC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_002817.2
CDS76..2319
Misc Feature(1)193..531
Misc Feature(2)order(283..285,292..294)
Misc Feature(3)838..840
Misc Feature(4)1291..1578
Misc Feature(5)1351..1353
Misc Feature(6)2203..2265
Exon (1)1..340
Exon (2)341..441
Exon (3)442..487
Exon (4)488..590
Exon (5)591..681
Exon (6)682..827
Exon (7)828..962
Exon (8)963..1092
Exon (9)1093..1215
Exon (10)1216..1363
Exon (11)1364..1543
Exon (12)1544..3316
Translation

Target ORF information:

RefSeq Version NM_002826.4
Organism Homo sapiens(Human)
Definition Homo sapiens quiescin sulfhydryl oxidase 1 (QSOX1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_002826.4

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
ATGAGGAGGT GCAACAGCGG CTCCGGGCCG CCGCCGTCGC TGCTGCTGCT GCTGCTGTGG 
CTGCTCGCGG TTCCCGGCGC TAACGCGGCC CCGCGGTCGG CGCTCTATTC GCCTTCCGAC
CCGCTGACGC TGCTGCAGGC GGACACGGTG CGCGGCGCGG TGCTGGGCTC CCGCAGCGCC
TGGGCCGTGG AGTTCTTCGC CTCCTGGTGC GGCCACTGCA TCGCCTTCGC CCCGACGTGG
AAGGCGCTGG CCGAAGACGT CAAAGCCTGG AGGCCGGCCC TGTATCTCGC CGCCCTGGAC
TGTGCTGAGG AGACCAACAG TGCAGTCTGC AGAGACTTCA ACATCCCTGG CTTCCCGACT
GTGAGGTTCT TCAAGGCCTT TACCAAGAAC GGCTCGGGAG CAGTATTTCC AGTGGCTGGT
GCTGACGTGC AGACACTGCG GGAGAGGCTC ATTGACGCCC TGGAGTCCCA TCATGACACG
TGGCCCCCAG CCTGTCCCCC ACTGGAGCCT GCCAAGCTGG AGGAGATTGA TGGATTCTTT
GCGAGAAATA ACGAAGAGTA CCTGGCTCTG ATCTTTGAAA AGGGAGGCTC CTACCTGGGT
AGAGAGGTGG CTCTGGACCT GTCCCAGCAC AAAGGCGTGG CGGTGCGCAG GGTGCTGAAC
ACAGAGGCCA ATGTGGTGAG AAAGTTTGGT GTCACCGACT TCCCCTCTTG CTACCTGCTG
TTCCGGAATG GCTCTGTCTC CCGAGTCCCC GTGCTCATGG AATCCAGGTC CTTCTATACC
GCTTACCTGC AGAGACTCTC TGGGCTCACC AGGGAGGCTG CCCAGACCAC AGTTGCACCA
ACCACTGCTA ACAAGATAGC TCCCACTGTT TGGAAATTGG CAGATCGCTC CAAGATCTAC
ATGGCTGACC TGGAATCTGC ACTGCACTAC ATCCTGCGGA TAGAAGTGGG CAGGTTCCCG
GTCCTGGAAG GGCAGCGCCT GGTGGCCCTG AAAAAGTTTG TGGCAGTGCT GGCCAAGTAT
TTCCCTGGCC GGCCCTTAGT CCAGAACTTC CTGCACTCCG TGAATGAATG GCTCAAGAGG
CAGAAGAGAA ATAAAATTCC CTACAGTTTC TTTAAAACTG CCCTGGACGA CAGGAAAGAG
GGTGCCGTTC TTGCCAAGAA GGTGAACTGG ATTGGCTGCC AGGGGAGTGA GCCGCATTTC
CGGGGCTTTC CCTGCTCCCT GTGGGTCCTC TTCCACTTCT TGACTGTGCA GGCAGCTCGG
CAAAATGTAG ACCACTCACA GGAAGCAGCC AAGGCCAAGG AGGTCCTCCC AGCCATCCGA
GGCTACGTGC ACTACTTCTT CGGCTGCCGA GACTGCGCTA GCCACTTCGA GCAGATGGCT
GCTGCCTCCA TGCACCGGGT GGGGAGTCCC AACGCCGCTG TCCTCTGGCT CTGGTCTAGC
CACAACAGGG TCAATGCTCG CCTTGCAGGT GCCCCCAGCG AGGACCCCCA GTTCCCCAAG
GTGCAGTGGC CACCCCGTGA ACTTTGTTCT GCCTGCCACA ATGAACGCCT GGATGTGCCC
GTGTGGGACG TGGAAGCCAC CCTCAACTTC CTCAAGGCCC ACTTCTCCCC AAGCAACATC
ATCCTGGACT TCCCTGCAGC TGGGTCAGCT GCCCGGAGGG ATGTGCAGAA TGTGGCAGCC
GCCCCAGAGC TGGCGATGGG AGCCCTGGAG CTGGAAAGCC GGAATTCAAC TCTGGACCCT
GGGAAGCCTG AGATGATGAA GTCCCCCACA AACACCACCC CACATGTGCC GGCTGAGGGA
CCTGAGGCAA GTCGACCCCC GAAGCTGCAC CCTGGCCTCA GAGCTGCACC AGGCCAGGAG
CCTCCTGAGC ACATGGCAGA GCTTCAGAGG AATGAGCAGG AGCAGCCGCT TGGGCAGTGG
CACTTGAGCA AGCGAGACAC AGGGGCTGCA TTGCTGGCTG AGTCCAGGGC TGAGAAGAAC
CGCCTCTGGG GCCCTTTGGA GGTCAGGCGC GTGGGCCGCA GCTCCAAGCA GCTGGTCGAC
ATCCCTGAGG GCCAGCTGGA GGCCCGAGCT GGACGGGGCC GAGGCCAGTG GCTGCAGGTG
CTGGGAGGGG GCTTCTCTTA CCTGGACATC AGCCTCTGTG TGGGGCTCTA TTCCCTGTCC
TTCATGGGCC TGCTGGCCAT GTACACCTAC TTCCAGGCCA AGATAAGGGC CCTGAAGGGC
CATGCTGGCC ACCCTGCAGC CTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

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Ebselen inhibits QSOX1 enzymatic activity and suppresses invasion of pancreatic and renal cancer cell lines.
Oncotarget6(21)18418-28(2015 Jul)
Hanavan PD,Borges CR,Katchman BA,Faigel DO,Ho TH,Ma CT,Sergienko EA,Meurice N,Petit JL,Lake DF


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Immunohistochemical expression of sulfhydryl oxidase (QSOX1) in pediatric medulloblastomas.
Diagnostic pathology1037(2015 Apr)
Sobral AC,Neto VM,Traiano G,Percicote AP,Gugelmin ES,de Souza CM,Nakao L,Torres LF,de Noronha L


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Disulfide bond generation in mammalian blood serum: detection and purification of quiescin-sulfhydryl oxidase.
Free radical biology & medicine69129-35(2014 Apr)
Israel BA,Jiang L,Gannon SA,Thorpe C


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Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas.
European journal of histochemistry : EJH58(1)2228(2014 Mar)
Araújo DG,Nakao L,Gozzo P,Souza CD,Balderrama V,Gugelmin ES,Kuczynski AP,Olandoski M,de Noronha L


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QSOX1 inhibits autophagic flux in breast cancer cells.
PloS one9(1)e86641(2014)
Poillet L,Pernodet N,Boyer-Guittaut M,Adami P,Borg C,Jouvenot M,Delage-Mourroux R,Despouy G


 
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