Gene Symbol | PCTP |
Entrez Gene ID | 58488 |
Full Name | phosphatidylcholine transfer protein |
Synonyms | PC-TP,STARD2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » PCTP cDNA ORF clone
gRNAs
Gene Symbol | PCTP |
Entrez Gene ID | 58488 |
Full Name | phosphatidylcholine transfer protein |
Synonyms | PC-TP,STARD2 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
NM_021213.3 | NP_067036.2 | phosphatidylcholine transfer protein isoform 1 |
NM_001102402.2 | NP_001095872.1 | phosphatidylcholine transfer protein isoform 2 |
NM_001330377.2 | NP_001317306.1 | phosphatidylcholine transfer protein isoform 3 |
NM_001330377.1 | NP_001317306.1 | phosphatidylcholine transfer protein isoform 3 |
XM_017024913.1 | XP_016880402.1 | phosphatidylcholine transfer protein isoform X1 |
NM_001330378.1 | NP_001317307.1 | phosphatidylcholine transfer protein isoform 4 |
NM_021213.4 | NP_067036.2 | phosphatidylcholine transfer protein isoform 1 |
NM_001330378.2 | NP_001317307.1 | phosphatidylcholine transfer protein isoform 4 |
PCTP | XP_001104194.1 | |
Mus musculus (house mouse) | Pctp | NP_032822.2 |
Homo sapiens (human) | PCTP | NP_067036.2 |
Canis lupus familiaris (dog) | PCTP | XP_537685.2 |
Rattus norvegicus (Norway rat) | Pctp | NP_058921.1 |
Gallus gallus (chicken) | PCTP | XP_415652.1 |
Bos taurus (cattle) | PCTP | NP_777260.1 |
Pan troglodytes (chimpanzee) | PCTP | XP_511897.3 |
Danio rerio (zebrafish) | pctp | NP_001124258.1 |
Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.
Kong X, Simon LM, Holinstat M, Shaw CA, Bray PF, Edelstein LC
Thrombosis and haemostasis117(5)962-970(2017 May)
Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.
Hunter SM, Rowley SM, Clouston D, , Li J, Lupat R, Krishnananthan N, Risbridger G, Taylor R, Bolton D, Campbell IG, Thorne H
Urologic oncology34(3)120.e9-16(2016 Mar)
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.
Edelstein LC, Simon LM, Montoya RT, Holinstat M, Chen ES, Bergeron A, Kong X, Nagalla S, Mohandas N, Cohen DE, Dong JF, Shaw C, Bray PF
Nature medicine19(12)1609-16(2013 Dec)
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, , ,
American journal of human genetics85(5)628-42(2009 Nov)
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue.
Kang HW, Ribich S, Kim BW, Hagen SJ, Bianco AC, Cohen DE
Journal of lipid research50(11)2212-21(2009 Nov)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Mutations in PCTP gene is associated with prostate cancer
Title: Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer.
PC-TP contributes to the racial difference in PAR4-mediated platelet activation.
Title: Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic susceptibility to distinct bladder cancer subphenotypes.
Observational study of gene-disease association. (HuGE Navigator)
Title: PTEN identified as important risk factor of chronic obstructive pulmonary disease.
Observational study of gene-disease association. (HuGE Navigator)
Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
The following PCTP gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PCTP cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu50562 | |
Clone ID Related Accession (Same CDS sequence) | NM_001330378.1 , NM_001330378.2 | |
Accession Version | NM_001330378.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-25 | |
Organism | Homo sapiens(human) | |
Product | phosphatidylcholine transfer protein isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE245218.1, AF151638.1, BM907258.1, AW369326.1 and AW298344.1. On Aug 29, 2016 this sequence version replaced XM_005257549.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM907258.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317307.1 |
CDS | 126..785 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001330378.1 |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu50562 | |
Clone ID Related Accession (Same CDS sequence) | NM_001330378.1 , NM_001330378.2 | |
Accession Version | NM_001330378.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 660bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-06 | |
Organism | Homo sapiens(human) | |
Product | phosphatidylcholine transfer protein isoform 4 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BE245218.1, AF151638.1, BM907258.1, AW369326.1 and AW298344.1. On May 31, 2019 this sequence version replaced NM_001330378.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7410571.174740.1, BM907258.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317307.1 |
CDS | 54..713 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001330378.2 |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu11252 | |
Clone ID Related Accession (Same CDS sequence) | NM_001102402.2 | |
Accession Version | NM_001102402.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 429bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-03 | |
Organism | Homo sapiens(human) | |
Product | phosphatidylcholine transfer protein isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009837.13, BM549250.1, AK058120.1, BC012084.1, AC091155.5 and BX648199.1. On Oct 15, 2010 this sequence version replaced NM_001102402.1. Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BM549250.1, SRR1803611.211776.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGACTCAG ATTACAGAAA ACAATGGGAC CAGTATGTTA AAGAACTCTA TGAACAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001095872.1 |
CDS | 449..877 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001102402.2 |
1 | ATGGACTCAG ATTACAGAAA ACAATGGGAC CAGTATGTTA AAGAACTCTA TGAACAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu11569 | |
Clone ID Related Accession (Same CDS sequence) | NM_021213.3 , NM_021213.4 | |
Accession Version | NM_021213.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-21 | |
Organism | Homo sapiens(human) | |
Product | phosphatidylcholine transfer protein isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM153142.1, BC012084.1, AC009837.13, AC091155.5 and BX648199.1. On Oct 15, 2010 this sequence version replaced NM_021213.2. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.24553.1, SRR1803616.106730.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_067036.2 |
CDS | 126..770 |
Translation |
Target ORF information:
Target ORF information:
|
NM_021213.3 |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu11569 | |
Clone ID Related Accession (Same CDS sequence) | NM_021213.3 , NM_021213.4 | |
Accession Version | NM_021213.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 645bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-24 | |
Organism | Homo sapiens(human) | |
Product | phosphatidylcholine transfer protein isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM153142.1, BC012084.1, AC009837.13, AC091155.5 and BX648199.1. On May 17, 2019 this sequence version replaced NM_021213.3. Transcript Variant: This variant (1) encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC012084.1, AK024667.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000268896.10/ ENSP00000268896.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_067036.2 |
CDS | 54..698 |
Translation |
Target ORF information:
Target ORF information:
|
NM_021213.4 |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu50563 | |
Clone ID Related Accession (Same CDS sequence) | NM_001330377.2 , NM_001330377.1 | |
Accession Version | NM_001330377.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-08-08 | |
Organism | Homo sapiens(human) | |
Product | phosphatidylcholine transfer protein isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009837.13 and AC091155.5. On Jun 1, 2019 this sequence version replaced NM_001330377.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.190066.1, SRR1163658.168171.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317306.1 |
CDS | 54..665 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001330377.2 |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu50563 | |
Clone ID Related Accession (Same CDS sequence) | NM_001330377.2 , NM_001330377.1 | |
Accession Version | NM_001330377.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 612bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-02-24 | |
Organism | Homo sapiens(human) | |
Product | phosphatidylcholine transfer protein isoform 3 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009837.13, AC091155.5 and BX648199.1. On Aug 29, 2016 this sequence version replaced XM_005257550.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.190066.1, SRR1803616.138525.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001317306.1 |
CDS | 126..737 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001330377.1 |
1 | ATGGAGCTGG CCGCCGGAAG CTTCTCGGAG GAGCAGTTCT GGGAGGCCTG CGCCGAGCTC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu87016 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024913.1 | |
Accession Version | XM_017024913.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 396bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | phosphatidylcholine transfer protein isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGACTCAG ATTACAGAAA ACAATGGGAC CAGTATGTTA AAGAACTCTA TGAACAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016880402.1 |
CDS | 424..819 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017024913.1 |
1 | ATGGACTCAG ATTACAGAAA ACAATGGGAC CAGTATGTTA AAGAACTCTA TGAACAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP. |
Searching for candidate genes in familial BRCAX mutation carriers with prostate cancer. |
Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c. |
Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. |
Mice lacking Pctp /StarD2 exhibit increased adaptive thermogenesis and enlarged mitochondria in brown adipose tissue. |