Gene Symbol | RIC8A |
Entrez Gene ID | 60626 |
Full Name | RIC8 guanine nucleotide exchange factor A |
Synonyms | RIC8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » RIC8A cDNA ORF clone
gRNAs
Gene Symbol | RIC8A |
Entrez Gene ID | 60626 |
Full Name | RIC8 guanine nucleotide exchange factor A |
Synonyms | RIC8 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_017018107.2 | XP_016873596.1 | synembryn-A isoform X2 |
XM_017018107.1 | XP_016873596.1 | synembryn-A isoform X2 |
XM_005253052.4 | XP_005253109.1 | synembryn-A isoform X1 |
XM_005253052.3 | XP_005253109.1 | synembryn-A isoform X1 |
NM_001286134.1 | NP_001273063.1 | synembryn-A isoform 2 |
NM_021932.5 | NP_068751.4 | synembryn-A isoform 1 |
Homo sapiens (human) | RIC8A | NP_001273063.1 |
Rattus norvegicus (Norway rat) | Ric8a | NP_001093990.1 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP010793 | XP_318515.3 |
Canis lupus familiaris (dog) | RIC8A | XP_005631129.1 |
Mus musculus (house mouse) | Ric8 | NP_444424.1 |
RIC8A | XP_001083119.2 | |
Bos taurus (cattle) | RIC8A | NP_001015627.1 |
Danio rerio (zebrafish) | ric8a | NP_001005588.1 |
Pan troglodytes (chimpanzee) | RIC8A | XP_521700.2 |
Drosophila melanogaster (fruit fly) | ric8a | NP_572550.2 |
Xenopus tropicalis (tropical clawed frog) | ric8a | NP_989159.1 |
Gallus gallus (chicken) | RIC8A | NP_001026345.1 |
Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on G?(i3).
Tse MK, Morris CJ, Zhang M, Wong YH
Molecular and cellular biochemistry401(1-2)27-38(2015 Mar)
The guanine-exchange factor Ric8a binds to the Ca?? sensor NCS-1 to regulate synapse number and neurotransmitter release.
Romero-Pozuelo J, Dason JS, Mansilla A, Ba?os-Mateos S, Sardina JL, Chaves-Sanju?n A, Jurado-G?mez J, Santana E, Atwood HL, Hern?ndez-Hern?ndez ?, S?nchez-Barrena MJ, Ferr?s A
Journal of cell science127(Pt 19)4246-59(2014 Oct)
Resistance to inhibitors of cholinesterase (Ric)-8A and G?i contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity.
Boularan C, Kamenyeva O, Cho H, Kehrl JH
PloS one9(1)e86680(2014)
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.
Shameer K, Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P, Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm RL, Larson EB, McCarty CA, Roden DM, Jarvik GP, Kullo IJ
Human genetics133(1)95-109(2014 Jan)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Results confirmed that Ric-8A can directly bind to AGS3S but failed to facilitate Galpha(i)-induced suppression of adenylyl cyclase, suggesting that it may not serve as a guanine exchange factor for AGS3/Galpha(i/o)-GDP complex in a cellular environment.
Title: Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on G?(i3).
Human NCS-1 and Ric8a reproduce the binding and maintain the structural requirements at these key positions. Drosophila Ric8a and Galphas regulate synapse number and neurotransmitter release, and both are functionally linked to Frq2.
Title: The guanine-exchange factor Ric8a binds to the Ca?? sensor NCS-1 to regulate synapse number and neurotransmitter release.
Ric-8A co-localized with Vps34 at the midbody.
Title: Resistance to inhibitors of cholinesterase (Ric)-8A and G?i contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity.
The ubiquitination of Galphai2 and Galphaq is suppressed by expression of Ric-8A. The suppression likely requires Ric-8A interaction with these Galpha proteins; the C-terminal truncation of Galphaq and Galphai2 completely abrogates their interaction with Ric-8A.
Title: Ubiquitination of the heterotrimeric G protein ? subunits G?i2 and G?q is prevented by the guanine nucleotide exchange factor Ric-8A.
NCAM180 regulates Ric8A membrane localization and potentiates beta-adrenergic response
Title: NCAM180 regulates Ric8A membrane localization and potentiates ?-adrenergic response.
The following RIC8A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RIC8A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu14240 | |
Clone ID Related Accession (Same CDS sequence) | NM_021932.5 | |
Accession Version | NM_021932.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1614bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-21 | |
Organism | Homo sapiens(human) | |
Product | synembryn-A isoform 1 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC069287.7, AK026897.1 and AL136935.1. On Oct 30, 2013 this sequence version replaced NM_021932.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL136935.1, SRR1803611.241919.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_068751.4 |
CDS | 1345..2958 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu14387 | |
Clone ID Related Accession (Same CDS sequence) | NM_001286134.1 | |
Accession Version | NM_001286134.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1596bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-10-21 | |
Organism | Homo sapiens(human) | |
Product | synembryn-A isoform 2 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC069287.7, AK026897.1 and AL136935.1. On Oct 30, 2013 this sequence version replaced XM_005253053.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK026897.1, SRR1803615.231479.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end. |
1 | ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001273063.1 |
CDS | 1345..2940 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu44941 | |
Clone ID Related Accession (Same CDS sequence) | XM_005253052.4 , XM_005253052.3 | |
Accession Version | XM_005253052.4 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | synembryn-A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005253052.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005253109.1 |
CDS | 1156..2763 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu44941 | |
Clone ID Related Accession (Same CDS sequence) | XM_005253052.4 , XM_005253052.3 | |
Accession Version | XM_005253052.3 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1608bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | synembryn-A isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005253052.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_005253109.1 |
CDS | 519..2126 |
Translation |
Target ORF information:
Target ORF information:
|
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1 | ATGGAGCCCC GGGCGGTTGC AGAAGCCGTG GAGACGGGTG AGGAGGATGT GATTATGGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu92418 | |
Clone ID Related Accession (Same CDS sequence) | XM_017018107.2 , XM_017018107.1 | |
Accession Version | XM_017018107.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | synembryn-A isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017018107.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGTTG TACTGGAGTC CCTCAAGTGC CTGTGCAACC TCGTGCTCAG CAGCCCTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016873596.1 |
CDS | 1582..2847 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGATGTTG TACTGGAGTC CCTCAAGTGC CTGTGCAACC TCGTGCTCAG CAGCCCTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu92418 | |
Clone ID Related Accession (Same CDS sequence) | XM_017018107.2 , XM_017018107.1 | |
Accession Version | XM_017018107.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 1266bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | ![]() |
Clone information | Clone Map | ![]() |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | synembryn-A isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGGATGTTG TACTGGAGTC CCTCAAGTGC CTGTGCAACC TCGTGCTCAG CAGCCCTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016873596.1 |
CDS | 945..2210 |
Translation |
Target ORF information:
Target ORF information:
|
![]() |
1 | ATGGATGTTG TACTGGAGTC CCTCAAGTGC CTGTGCAACC TCGTGCTCAG CAGCCCTGTG |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
Activator of G protein signaling 3 forms a complex with resistance to inhibitors of cholinesterase-8A without promoting nucleotide exchange on G?(i3). |
The guanine-exchange factor Ric8a binds to the Ca?? sensor NCS-1 to regulate synapse number and neurotransmitter release. |
Resistance to inhibitors of cholinesterase (Ric)-8A and G?i contribute to cytokinesis abscission by controlling vacuolar protein-sorting (Vps)34 activity. |
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects. |