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CCL13 cDNA ORF clone, Homo sapiens (human)

Gene Symbol CCL13
Entrez Gene ID 6357
Full Name chemokine (C-C motif) ligand 13
Synonyms CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1
General protein information
Preferred Names
C-C motif chemokine 13
Names
C-C motif chemokine 13
CK-beta-10
new CC chemokine 1
small-inducible cytokine A13
monocyte chemotactic protein 4
monocyte chemoattractant protein 4
small inducible cytokine subfamily A (Cys-Cys), member 13
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

17

17q11.2

Summary This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils, but not neutrophils. This chemokine plays a role in accumulation of leukocytes during inflammation. It may also be involved in the recruitment of monocytes into the arterial wall during artherosclerosis. [provided by RefSeq, Sep 2014]. lac of sum
Disorder MIM:

601391


mRNA and Protein(s)

mRNA Protein Name
NM_005408 NP_005399 C-C motif chemokine 13 precursor



Homo sapiens (human) CCL13 NP_005399.1
Pan troglodytes (chimpanzee) CCL13 XP_001174525.3
Macaca mulatta (Rhesus monkey) CCL13 XP_001113462.1
Mus musculus (house mouse) Ccl2 NP_035463.1
Rattus norvegicus (Norway rat) Ccl2 NP_113718.1


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following CCL13 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CCL13 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu29848
NM_005408 Homo sapiens chemokine (C-C motif) ligand 13 (CCL13), mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu29848
Clone ID Related Accession (Same CDS sequence) NM_005408
Accession Version NM_005408.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 297bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product C-C motif chemokine 13 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from U59808.1. On Aug 29, 2002 this sequence version replaced gi:4885586. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 12949249 ##RefSeq-Attributes-END## ##Evidence-Data-START## Transcript exon combination :: U59808.1, BG620880.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

1
61
121
181
241
ATGAAAGTCT CTGCAGTGCT TCTGTGCCTG CTGCTCATGA CAGCAGCTTT CAACCCCCAG 
GGACTTGCTC AGCCAGATGC ACTCAACGTC CCATCTACTT GCTGCTTCAC ATTTAGCAGT
AAGAAGATCT CCTTGCAGAG GCTGAAGAGC TATGTGATCA CCACCAGCAG GTGTCCCCAG
AAGGCTGTCA TCTTCAGAAC CAAACTGGGC AAGGAGATCT GTGCTGACCC AAAGGAGAAG
TGGGTCCAGA ATTATATGAA ACACCTGGGC CGGAAAGCTC ACACCCTGAA GACTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005399.1
CDS76..372
Misc Feature(1)49..51(+)
Misc Feature(2)145..147(+)
Misc Feature(3)151..153(+)
Misc Feature(4)151..153(+)
Misc Feature(5)154..156(+)
Misc Feature(6)154..156(+)
Misc Feature(7)163..165(+)
Misc Feature(8)175..342(+)
Misc Feature(9)175..342(+)
Misc Feature(10)181..342(+)
Misc Feature(11)181..297(+)
Misc Feature(12)181..294(+)
Misc Feature(13)181..216(+)
Misc Feature(14)187..342(+)
Misc Feature(15)193..288(+)
Misc Feature(16)232..336(+)
Misc Feature(17)244..249(+)
Misc Feature(18)274..282(+)
Exon (1)1..151
Gene:CCL13
Gene Synonym:
Exon (2)152..266
Gene:CCL13
Gene Synonym:
Exon (3)267..851
Gene:CCL13
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005408
Organism Homo sapiens (human)
Definition Homo sapiens chemokine (C-C motif) ligand 13 (CCL13), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005408

ORF Insert Sequence:

1
61
121
181
241
ATGAAAGTCT CTGCAGTGCT TCTGTGCCTG CTGCTCATGA CAGCAGCTTT CAACCCCCAG 
GGACTTGCTC AGCCAGATGC ACTCAACGTC CCATCTACTT GCTGCTTCAC ATTTAGCAGT
AAGAAGATCT CCTTGCAGAG GCTGAAGAGC TATGTGATCA CCACCAGCAG GTGTCCCCAG
AAGGCTGTCA TCTTCAGAAC CAAACTGGGC AAGGAGATCT GTGCTGACCC AAAGGAGAAG
TGGGTCCAGA ATTATATGAA ACACCTGGGC CGGAAAGCTC ACACCCTGAA GACTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

The multiple faces of CCL13 in immunity and inflammation
Inflammopharmacology 21 (6), 397-406 (2013)
Mendez-Enriquez E and Garcia-Zepeda EA.


book

Correlation of MCP-4 and high-sensitivity C-reactive protein as a marker of inflammation in obesity and chronic periodontitis
Cytokine 61 (3), 772-777 (2013)
Pradeep AR, Kumari M, Kalra N and Priyanka N.


book

Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Nature 491 (7422), 119-124 (2012)
Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP, Hui KY, Lee JC, Schumm LP, Sharma Y, Anderson CA, Essers J, Mitrovic M, Ning K, Cleynen I, Theatre E, Spain SL, Raychaudhuri S, Goyette P, Wei Z, Abraham C, Achkar JP, Ahmad T, Amininejad L, Ananthakrishnan AN, Andersen V, Andrews JM, Baidoo L, Balschun T, Bampton PA, Bitton A, Boucher G, Brand S, Buning C, Cohain A, Cichon S, D'Amato M, De Jong D, Devaney KL, Dubinsky M, Edwards C, Ellinghaus D, Ferguson LR, Franchimont D, Fransen K, Gearry R, Georges M, Gieger C, Glas J, Haritunians T, Hart A, Hawkey C, Hedl M, Hu X, Karlsen TH, Kupcinskas L, Kugathasan S, Latiano A, Laukens D, Lawrance IC, Lees CW, Louis E, Mahy G, Mansfield J, Morgan AR, Mowat C, Newman W, Palmieri O, Ponsioen CY, Potocnik U, Prescott NJ, Regueiro M, Rotter JI, Russell RK, Sanderson JD, Sans M, Satsangi J, Schreiber S, Simms LA, Sventoraityte J, Targan SR, Taylor KD, Tremelling M, Verspaget HW, De Vos M, Wijmenga C, Wilson DC, Winkelmann J, Xavier RJ, Zeissig S, Zhang B, Zhang CK, Zhao H, Silverberg MS, Annese V, Hakonarson H, Brant SR, Radford-Smith G, Mathew CG, Rioux JD, Schadt EE, Daly MJ, Franke A, Parkes M, Vermeire S, Barrett JC and Cho JH.


book

Estrogen inhibits apoptosis and promotes CC motif chemokine ligand 13 expression on synovial fibroblasts in rheumatoid arthritis
Immunopharmacol Immunotoxicol 34 (5), 852-857 (2012)
Yamaguchi A, Nozawa K, Fujishiro M, Kawasaki M, Takamori K, Ogawa H, Sekigawa I and Takasaki Y.


book

A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci
PLoS Genet. 8 (3), E1002559 (2012)
Kenny EE, Pe'er I, Karban A, Ozelius L, Mitchell AA, Ng SM, Erazo M, Ostrer H, Abraham C, Abreu MT, Atzmon G, Barzilai N, Brant SR, Bressman S, Burns ER, Chowers Y, Clark LN, Darvasi A, Doheny D, Duerr RH, Eliakim R, Giladi N, Gregersen PK, Hakonarson H, Jones MR, Marder K, McGovern DP, Mulle J, Orr-Urtreger A, Proctor DD, Pulver A, Rotter JI, Silverberg MS, Ullman T, Warren ST, Waterman M, Zhang W, Bergman A, Mayer L, Katz S, Desnick RJ, Cho JH and Peter I.


book

Many chemokines including CCL20/MIP-3alpha display antimicrobial activity
J. Leukoc. Biol. 74 (3), 448-455 (2003)
Yang D, Chen Q, Hoover DM, Staley P, Tucker KD, Lubkowski J and Oppenheim JJ.


book

Monocyte chemotactic protein-4: tissue-specific expression and signaling through CC chemokine receptor-2
J. Leukoc. Biol. 61 (3), 353-360 (1997)
Godiska R, Chantry D, Raport CJ, Schweickart VL, Trong HL and Gray PW.


book

Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3
J. Immunol. 157 (12), 5613-5626 (1996)
Garcia-Zepeda EA, Combadiere C, Rothenberg ME, Sarafi MN, Lavigne F, Hamid Q, Murphy PM and Luster AD.


book

A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2
Genomics 34 (2), 236-240 (1996)
Naruse K, Ueno M, Satoh T, Nomiyama H, Tei H, Takeda M, Ledbetter DH, Coillie EV, Opdenakker G, Gunge N, Sakaki Y, Iio M and Miura R.


book

Monocyte chemotactic protein 4 (MCP-4), a novel structural and functional analogue of MCP-3 and eotaxin
J. Exp. Med. 183 (5), 2379-2384 (1996)
Uguccioni M, Loetscher P, Forssmann U, Dewald B, Li H, Lima SH, Li Y, Kreider B, Garotta G, Thelen M and Baggiolini M.


 
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