Gene Symbol | SUPT6H |
Entrez Gene ID | 6830 |
Full Name | SPT6 homolog, histone chaperone |
Synonyms | SPT6,SPT6H,emb-5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
ORF » Species Summary » Homo sapiens » SUPT6H cDNA ORF clone
Gene Symbol | SUPT6H |
Entrez Gene ID | 6830 |
Full Name | SPT6 homolog, histone chaperone |
Synonyms | SPT6,SPT6H,emb-5 |
General protein information |
|
Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Disorder MIM: |
mRNA | Protein | Name |
---|---|---|
XM_017024979.1 | XP_016880468.1 | transcription elongation factor SPT6 isoform X1 |
NM_003170.5 | NP_003161.2 | transcription elongation factor SPT6 |
XM_017024979.2 | XP_016880468.1 | transcription elongation factor SPT6 isoform X1 |
NM_003170.4 | NP_003161.2 | transcription elongation factor SPT6 |
NM_001320755.2 | NP_001307684.1 | transcription elongation factor SPT6 |
XM_017024978.1 | XP_016880467.1 | transcription elongation factor SPT6 isoform X1 |
NM_001320755.1 | NP_001307684.1 | transcription elongation factor SPT6 |
XM_017024980.1 | XP_016880469.1 | transcription elongation factor SPT6 isoform X2 |
SUPT6H | XP_001106850.2 | |
Canis lupus familiaris (dog) | SUPT6H | XP_537747.2 |
Caenorhabditis elegans (roundworm) | emb-5 | NP_497969.1 |
Magnaporthe oryzae (rice blast fungus) | MGG_11491 | XP_003718184.1 |
Arabidopsis thaliana (thale cress) | AT1G63210 | NP_176510.1 |
Gallus gallus (chicken) | SUPT6H | XP_423183.3 |
Schizosaccharomyces pombe (fission yeast) | spt6 | NP_594487.2 |
Drosophila melanogaster (fruit fly) | Spt6 | NP_651962.2 |
Kluyveromyces lactis | KLLA0B11385g | XP_452036.1 |
Eremothecium gossypii | AGOS_AAR031W | NP_982572.2 |
Neurospora crassa | NCU04611 | XP_958854.1 |
Arabidopsis thaliana (thale cress) | GTB1 | NP_001077775.1 |
Xenopus tropicalis (tropical clawed frog) | supt6h | NP_001072665.1 |
Homo sapiens (human) | SUPT6H | NP_003161.2 |
Pan troglodytes (chimpanzee) | SUPT6H | XP_001143115.2 |
Anopheles gambiae (African malaria mosquito) | AgaP_AGAP003619 | XP_313379.5 |
Saccharomyces cerevisiae (baker's yeast) | SPT6 | NP_011631.1 |
Bos taurus (cattle) | SUPT6H | NP_001180055.1 |
Mus musculus (house mouse) | Supt6 | NP_033323.2 |
Rattus norvegicus (Norway rat) | Supt6h | NP_001178749.1 |
Danio rerio (zebrafish) | supt6h | NP_660094.1 |
The integrase cofactor LEDGF/p75 associates with Iws1 and Spt6 for postintegration silencing of HIV-1 gene expression in latently infected cells.
G?rard A, S?g?ral E, Naughtin M, Abdouni A, Charmeteau B, Cheynier R, Rain JC, Emiliani S
Cell host & microbe17(1)107-17(2015 Jan)
SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.
Bedi U, Scheel AH, Hennion M, Begus-Nahrmann Y, R?schoff J, Johnsen SA
Oncogene34(4)465-73(2015 Jan)
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis.
Wang AH, Zare H, Mousavi K, Wang C, Moravec CE, Sirotkin HI, Ge K, Gutierrez-Cruz G, Sartorelli V
The EMBO journal32(8)1075-86(2013 Apr)
GeneRIFs: Gene References Into Functions What's a GeneRIF?
Altogether, these results indicate that a complex containing LEDGF/p75, Iws1, and Spt6 participates in regulating postintegration steps of HIV latency.
Title: The integrase cofactor LEDGF/p75 associates with Iws1 and Spt6 for postintegration silencing of HIV-1 gene expression in latently infected cells.
identified fibronectin, a component of the extracellular matrix and a mesenchymal marker, as a transcriptional target of Pak1 signaling
Title: SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms.
Spt6 is a unique histone chaperone capable of regulating the histone epigenetic state of both AID targets and the AID locus.
Title: The histone chaperone Spt6 is required for activation-induced cytidine deaminase target determination through H3K4me3 regulation.
Abolishing UL69's ability to interact with the SPT6 protein inhibited human cytomegalovirus replication.
Title: The cellular protein SPT6 is required for efficient replication of human cytomegalovirus.
These results show that intracellular levels of Spt6 are fine-tuned by PAAF1 and proteasome, which is required for HIV-1 transcription and extends to cellular genes implicated in cancer.
Title: Spt6 levels are modulated by PAAF1 and proteasome to regulate the HIV-1 LTR.
The following SUPT6H gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SUPT6H cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.
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CloneID | OHu30035 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024979.1 , NM_003170.5 , XM_017024979.2 , NM_003170.4 , NM_001320755.2 , XM_017024978.1 , NM_001320755.1 | |
Accession Version | NM_003170.5 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5181bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-03 | |
Organism | Homo sapiens(human) | |
Product | transcription elongation factor SPT6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL833607.1, BC150268.1, BM727811.1 and AW135492.1. On Nov 23, 2018 this sequence version replaced NM_003170.4. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803615.228668.1, SRR1803612.146735.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000314616.11/ ENSP00000319104.6 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length. |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003161.2 |
CDS | 170..5350 |
Translation |
Target ORF information:
Target ORF information:
|
NM_003170.5 |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu30035 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024979.1 , NM_003170.5 , XM_017024979.2 , NM_003170.4 , NM_001320755.2 , XM_017024978.1 , NM_001320755.1 | |
Accession Version | NM_003170.4 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5181bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2017-10-02 | |
Organism | Homo sapiens(human) | |
Product | transcription elongation factor SPT6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL833607.1, BC150268.1, BM727811.1 and AW135492.1. On Mar 4, 2016 this sequence version replaced NM_003170.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.146735.1, SRR1803615.228668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_003161.2 |
CDS | 177..5357 |
Translation |
Target ORF information:
Target ORF information:
|
NM_003170.4 |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu30035 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024979.1 , NM_003170.5 , XM_017024979.2 , NM_003170.4 , NM_001320755.2 , XM_017024978.1 , NM_001320755.1 | |
Accession Version | NM_001320755.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5181bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-06-03 | |
Organism | Homo sapiens(human) | |
Product | transcription elongation factor SPT6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL833607.1, DB318397.1, BC150268.1, BM727811.1 and AW135492.1. On May 31, 2019 this sequence version replaced NM_001320755.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL833607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001307684.1 |
CDS | 272..5452 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001320755.2 |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu30035 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024979.1 , NM_003170.5 , XM_017024979.2 , NM_003170.4 , NM_001320755.2 , XM_017024978.1 , NM_001320755.1 | |
Accession Version | NM_001320755.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5181bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-03-11 | |
Organism | Homo sapiens(human) | |
Product | transcription elongation factor SPT6 | |
Comment | Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL833607.1, DB318397.1, BC150268.1, BM727811.1 and AW135492.1. On Mar 4, 2016 this sequence version replaced XM_005258027.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL833607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end. |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | NP_001307684.1 |
CDS | 279..5459 |
Translation |
Target ORF information:
Target ORF information:
|
NM_001320755.1 |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu30035 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024979.1 , NM_003170.5 , XM_017024979.2 , NM_003170.4 , NM_001320755.2 , XM_017024978.1 , NM_001320755.1 | |
Accession Version | XM_017024979.1 | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5181bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2016-06-05 | |
Organism | Homo sapiens(human) | |
Product | transcription elongation factor SPT6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016880468.1 |
CDS | 415..5595 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017024979.1 |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu30035 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024979.1 , NM_003170.5 , XM_017024979.2 , NM_003170.4 , NM_001320755.2 , XM_017024978.1 , NM_001320755.1 | |
Accession Version | XM_017024979.2 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5181bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | transcription elongation factor SPT6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017024979.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016880468.1 |
CDS | 416..5596 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017024979.2 |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu30035 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024979.1 , NM_003170.5 , XM_017024979.2 , NM_003170.4 , NM_001320755.2 , XM_017024978.1 , NM_001320755.1 | |
Accession Version | XM_017024978.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 5181bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | transcription elongation factor SPT6 isoform X1 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016880467.1 |
CDS | 338..5518 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017024978.1 |
1 | ATGTCTGATT TTGTGGAAAG CGAGGCTGAG GAGTCAGAGG AAGAATACAA TGATGAAGGC |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
CloneID | OHu87430 | |
Clone ID Related Accession (Same CDS sequence) | XM_017024980.1 | |
Accession Version | XM_017024980.1 Latest version! | Documents for ORF clone product in default vector |
Sequence Information | ORF Nucleotide Sequence (Length: 4812bp) Protein sequence SNP |
|
Vector | pcDNA3.1-C-(k)DYK or customized vector | User Manual |
Clone information | Clone Map | MSDS |
Tag on pcDNA3.1+/C-(K)DYK | C terminal DYKDDDDK tags | |
ORF Insert Method | CloneEZ™ Seamless cloning technology | |
Insert Structure | linear | |
Update Date | 2019-12-05 | |
Organism | Homo sapiens(human) | |
Product | transcription elongation factor SPT6 isoform X2 | |
Comment | Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END## |
1 | ATGTCAGATG ACGAGGACGA TGACGAGGAG GAATATGGCA AGGAGGAACA TGAAAAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
RefSeq | XP_016880469.1 |
CDS | 478..5289 |
Translation |
Target ORF information:
Target ORF information:
|
XM_017024980.1 |
1 | ATGTCAGATG ACGAGGACGA TGACGAGGAG GAATATGGCA AGGAGGAACA TGAAAAAGAA |
The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.
The integrase cofactor LEDGF/p75 associates with Iws1 and Spt6 for postintegration silencing of HIV-1 gene expression in latently infected cells. |
SUPT6H controls estrogen receptor activity and cellular differentiation by multiple epigenomic mechanisms. |
The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis. |