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TECTA cDNA ORF clone, Homo sapiens (human)

Gene Symbol TECTA
Entrez Gene ID 7007
Full Name tectorin alpha
Synonyms DFNA12, DFNA8, DFNB21
General protein information
Preferred Names
alpha-tectorin
Names
alpha-tectorin
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q22-q24

Summary The tectorial membrane is an extracellular matrix of the inner ear that contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia, and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals. Alpha-tectorin is one of the major noncollagenous components of the tectorial membrane. Mutations in the TECTA gene have been shown to be responsible for autosomal dominant nonsyndromic hearing impairment and a recessive form of sensorineural pre-lingual non-syndromic deafness. [provided by RefSeq, Jul 2008]. lac of sum
Disorder MIM:

602574

Disorder Html: Deafness, autosomal dominant 8/12, 601543 (3); Deafness, autosomal

mRNA and Protein(s)

mRNA Protein Name
NM_005422 NP_005413 alpha-tectorin precursor


Homo sapiens (human) TECTA NP_005413.2
Pan troglodytes (chimpanzee) TECTA XP_508823.2
Canis lupus familiaris (dog) TECTA XP_546475.2
Bos taurus (cattle) TECTA XP_003586997.1
Mus musculus (house mouse) Tecta NP_033373.2
Rattus norvegicus (Norway rat) Tecta NP_001100284.1
Gallus gallus (chicken) TECTA XP_004948075.1
Danio rerio (zebrafish) LOC561355 XP_689855.5
Xenopus (Silurana) tropicalis (western clawed frog) LOC100490936 XP_002935069.2


GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following TECTA gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the TECTA cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu25746 NM_005422 Homo sapiens tectorin alpha (TECTA), mRNA. pcDNA3.1+/C-(K)DYK or customized vector 30 $923.30
$1319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu25746
Clone ID Related Accession (Same CDS sequence) NM_005422
Accession Version NM_005422.2 Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 6468bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 15-MAR-2015
Organism Homo sapiens (human)
Product alpha-tectorin precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AP000646.4 and AP000826.5. This sequence is a reference standard in the RefSeqGene project. On Mar 29, 2007 this sequence version replaced gi:4885626. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments and orthologous data. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA2161674 [ECO:0000350] ##Evidence-Data-END##

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
5521
5581
5641
5701
5761
5821
5881
5941
6001
6061
6121
6181
6241
6301
6361
6421
ATGAATTATT CATCATTCCT TAGAATTTGG GTCTCTTTCA TCTTCGCACT TGTACAGCAC 
CAAGCTCAGC CCAGGGAGCT CATGTATCCA TTTTGGCAGA ATGACACCAA AACCCCTAAA
GTAGATGATG GAAGCTCATC TGAGATTAAG TTGGCCATCC CAGTTTTCTT CTTTGGCGTT
CCTTACCGCA CTGTCTATGT CAATAACAAC GGAGTTGTTT CCTTCAATGT GCTAGTGAGC
CAGTTCACGC CAGAATCCTT TCCCCTGACA GATGGGAGAG CCTTCGTCGC CCCATTTTGG
GCAGATGTGC ACAATGGAAT TCGAGGCGAG ATCTATTACA GAGAGACCAT GGAGCCTGCC
ATCTTGAAAA GAGCCACCAA GGACATCAGG AAGTACTTCA AAGACATGGC AACCTTCTCT
GCCACTTGGG TTTTCATTGT GACATGGGAG GAAGTCACGT TTTATGGAGG CAGCAGCACC
ACACCTGTGA ACACCTTCCA GGCCGTCCTA GTGTCCGATG GCTCCTATAC ATTCACCCTC
TTCAATTATT ACGAAATCAA CTGGACCACG GGGACGGCGA GTGGCGGCGA CCCCCTGACA
GGTCTTGGTG GAGTGATGGC ACAGGCAGGA TTTAATGGTG GAAACCTCAC CAATTTCTTC
AGCCTCCCGG GGTCAAGAAC CCCCGAGATC GTGAATATCC AGGAGACCAC AAACGTCAAT
GTTCCAGGCC GCTGGGCATT TAAAGTTGAT GGAAAGGAAA TTGACCCAGC CAATGGCTGC
ACCTCAAGGG GACAATTCCT TCGGCGAGGG GAGGTGTTTT GGGATGACTT GAACTGCACC
GTCAAGTGCC GCTGTCTGGA TTTCAACAAT GAGATCTACT GCCAGGAGGC TTCCTGTAGC
CCCTACGAGG TGTGCGAACC CAAAGGCAAA TTCTTCTACT GCAGCGCTGT GGAGACCAGC
ACATGCGTGG TGTTTGGGGA GCCACACTAC CACACTTTTG ACGGCTTCCT CTTCCACTTC
CAAGGCTCCT GTGCCTACTT GCTGGCCCGA CAGTGTTTGC AGACTTCCAG CCTCCCTTTC
TTCAGTGTGG AGGCCAAGAA TGAACACCGC AGAGGTTCAG CCGTCTCCTG GGTGAAGGAG
CTCTCAGTGG AGGTGAATGG CTACAAGATT CTCATCCCCA AAGGAAGCTA TGGAAGAGTC
AAGGTTAATG ACCTAGTGAC TTCTTTGCCT GTCACCTTAG ACTTGGGGAC AGTGAAAATC
TACCAGAGTG GCATATCTAC TGCCGTGGAA ACAGATTTTG GGCTCTTAGT GACTTTTGAT
GGCCAGCACT ACGCCTCCAT TTCCGTCCCA GGCTCCTATA TAAACTCCAC CTGTGGACTC
TGTGGAAACT ATAATAAAAA CCCACTGGAT GACTTCCTCC GCCCGGATGG CAGGCCGGCC
ATGTCTGTCC TGGATCTGGG AGAGAGCTGG CGTGTGTACC ACGCAGACTG GAAGTGCGAC
TCCGGCTGCG TCGACAACTG CACCCAGTGC GACGCTGCCA CTGAAGCCCT CTACTTTGGC
TCTGACTACT GCGGCTTCCT CAACAAGACA GACGGCCCTC TGTGGGAGTG TGGCACTGTC
GTGGACCCCA CTGCTTTTGT GCACAGCTGC GTGTATGACC TGTGCAGTGT GAGGGACAAT
GGCACGCTCC TCTGCCAAGC CATCCAGGCC TATGCTCTTG TGTGCCAAGC CCTTGGCATT
CCAATTGGAG ACTGGCGAAC CCAGACTGGG TGTGTGTCCA CAGTGCAGTG CCCGAGCTTC
AGCCACTACT CCGTGTGCAC AAGCAGCTGC CCCGACACAT GCTCCGACCT GACGGCCTCG
CGGAACTGCG CCACGCCGTG CACAGAGGGC TGCGAGTGCA ACCAGGGCTT CGTCCTCAGC
ACCAGCCAGT GCGTCCCTCT GCACAAGTGC GGCTGCGACT TCGACGGCCA CTACTACACC
ATGGGGGAGT TCTTCTGGGC CACGGCCAAC TGCACTGTGC AATGCCTGTG CGAGGAGGGC
GGGGACGTCT ACTGCTTCAA CAAGACCTGC GGCAGCGGGG AGGTGTGCGC CGTGGAGGAC
GGCTACCAGG GCTGCTTCCC CAAGCGGGAG ACCGTGTGCC TGCTCAGCCA GAACCAGGTG
CTGCACACCT TTGACGGCGC CTCCTACGCC TTCCCCTCCG AGTTCTCCTA CACCCTCCTG
AAGACCTGCC CTGAGCGCCC AGAGTACTTG GAAATCGACA TCAACAAGAA GAAGCCCGAT
GCAGGACCTG CTTGGCTGCG GGGACTTCGG ATCCTGGTGG CCGACCAGGA GGTCAAGATA
GGAGGCATCG GGGCTTCGGA AGTCAAGTTG AATGGTCAGG AAGTGGAATT GCCTTTTTTC
CATCCTTCGG GGAAGCTGGA AATTTATCGA AACAAAAACA GTACGACAGT GGAGTCCAAG
GGCGTGGTGA CTGTCCAGTA CTCAGACATA GGTCTATTGT ACATCCGGCT GTCCACCACA
TACTTCAATT GCACAGGGGG CTTGTGCGGC TTCTACAATG CCAACGCCAG TGACGAGTTC
TGTCTCCCCA ACGGCAAGTG CACGGACAAC CTGGCAGTGT TCCTGGAAAG CTGGACAACT
TTCGAGGAGA TCTGCAATGG AGAGTGTGGG GACCTGCTGA AGGCCTGCAA CAATGACTCG
GAGCTGCTCA AGTTTTATCG AAGCCGCTCC AGGTGCGGCA TCATCAACGA CCCCTCCAAC
AGCTCCTTCC TGGAGTGCCA TGGGGTGGTG AACGTCACTG CCTATTACCG CACCTGCCTT
TTCCGCCTGT GCCAGAGTGG GGGCAATGAG TCAGAGCTCT GTGACTCTGT GGCCCGGTAT
GCAAGCGCCT GCAAGAATGC GGACGTGGAG GTGGGGCCCT GGCGGACCTA TGACTTCTGC
CCACTGGAGT GCCCAGAGAA CAGCCACTTT GAGGAGTGCA TCACATGTAC AGAGACCTGT
GAGACCCTTA CCCTGGGCCC CATCTGCGTG GATAGCTGCT CTGAGGGATG TCAGTGTGAT
GAGGGCTATG CTCTACTGGG CAGCCAGTGT GTCACGCGGA GTGAGTGTGG CTGCAACTTT
GAGGGGCACC AACTTGCCAC CAATGAGACC TTCTGGGTGG ACCTGGACTG CCAGATCTTC
TGCTATTGCA GTGGCACAGA CAACAGGGTC CACTGCGAGA CCATTCCCTG CAAGGATGAT
GAGTACTGCA TGGAGGAAGG TGGCCTGTAC TACTGCCAAG CCCGCACCGA CGCCTCCTGC
ATCGTCTCAG GCTACGGCCA CTACCTCACC TTTGATGGCT TCCCCTTTGA CTTCCAGACC
AGCTGCCCAC TCATCCTGTG CACCACAGGA AGCAGGCCAA GCTCAGACTC TTTCCCCAAG
TTTGTTGTCA CAGCCAAGAA TGAGGACCGG GACCCGTCAC TGGCCTTGTG GGTTAAGCAG
GTGGACGTGA CCGTGTTTGG CTACAGCATC GTGATCCACC GAGCTTACAA GCACACTGTG
CTGGTCAACA GTGAACGGCT CTATCTGCCC CTGAAGCTGG GGCAAGGGAA GATAAATATC
TTTTCCTTTG GCTTCCACGT GGTGGTGGAA ACTGATTTTG GCCTGAAGGT TGTATATGAC
TGGAAGACCT TCCTGTCCAT CACAGTCCCT CGGAGCATGC AGAACAGCAC CTATGGTCTG
TGTGGCCGCT ACAACGGCAA CCCTGATGAT GACCTGGAGA TGCCCATGGG TCTGCTTGCA
TCGAGTGTCA ATGAGTTTGG GCAGAGCTGG GTGAAGAGGG ACACCTTCTG CCAGGTGGGC
TGTGGGGACC GCTGTCCGTC CTGTGCCAAG GTGGAAGGTT TCTCCAAAGT GCAGCAGCTG
TGCAGCCTGA TCCCCAACCA GAACGCTGCC TTCTCCAAGT GTCACAGCAA AGTTAACCCC
ACCTTCTTCT ATAAGAACTG CCTGTTTGAC TCTTGCATCG ATGGGGGCGC GGTGCAGACC
GCCTGCAGCT GGCTGCAGAA CTACGCCAGC ACCTGCCAGA CTCAGGGGAT TACGGTGACT
GGCTGGAGGA ATTACACGTC CTGCACTGTC ACCTGCCCTC CAAACAGCCA TTACGAGAGC
TGCGTGAGTG TCTGCCAGCC CCGCTGCGCC GCCATCCGCC TGAAGAGTGA CTGCAGCCAC
TACTGCGTGG AGGGCTGTCA CTGCGACGCT GGCTACGTCC TCAACGGCAA GAGCTGCATC
CTGCCCCACA GCTGCGGCTG CTACTCCGAT GGCAAATATT ACGAGCCCAA GCAGCTATTT
TGGAACAGCG ACTGCACGCG GCGCTGCCGC TGTTTCCGTC GCAACGTGAT TCAGTGCGAC
CCGCGCCAAT GCAAGTCAGA CGAGGAGTGT GCGCTGCGCA ACGGGGTGCG CGGCTGCTTC
AGCACCAAGA CCTCCTACTG CCTGGCGGCC GGCGGCGGCG TCTTCCGCAC CTTCGACGGC
GCCTTCCTGC GCTTCCCAGC CAACTGCGCC TTCGTGCTGT CCACCATCTG CCAGAAACTG
CCCGACATCT CCTTCCAGCT TATCATCAAC TTCGACAAGT GGTCGGCCCC CAACCTCACC
ATCATTTCGC CCGTCTACTT CTACATTAAC GAAGAGCAGA TTCTCATCAA CGACCGGAAC
ACGGTCAAGG TGAATGGCAC ACAAGTGAAT GTTCCATTTA TAACTGGTTT GGCAACCAAA
ATCTACAGCA GTGAGGGGTT TCTGGTGATT GACACCAGCC CAGACATCCA GATATACTAC
AATGGTTTCA ACGTCATTAA AATCAGCATC AGCGAGAGGC TGCAGAACAA AGTGTGCGGT
CTCTGTGGCA ACTTCAACGG GGACCTAACA GATGATTATG TGACCTTGCG AGGGAAGCCG
GTGGTAAGCA GCGTGGTGCT GGCCCAGAGC TGGAAAACCA ATGGCATGCA GAAGAGACCT
CTTGCCCCCA GCTGCAACGA GCTGCAGTTC TCACAGTATG CAGCCATGTG TGACAATGTG
CACATCCAGA AGATGCAGGG TGATGGCTAC TGCCTGAAGC TCACCGACAT GAAGGGCTTC
TTCCAGCCCT GCTATGGGCT TCTCGATCCC CTCCCATTCT ACGAGTCCTG CTACCTGGAC
GGCTGCTACA GCCACAAGAA GTTCCAGCTG TGCGGCTCCC TGGCCGCCTA CGGGGAGGCC
TGCCGCTCCT TCGGGATCCT TAGCACCGAG TGGATTGAGA AGGAGAATTG CTCAGGAGTG
GTTGAAGATC CCTGTGTGGG GGCGGACTGT CCCAACCGAA CTTGCGAGCT GGGCAATGGC
AGGGAGCTGT GTGGCTGCAT CGAGCCACCC CCCTATGGAA ATAACTCACA TGACATTATC
GATGCAGAGG TGACCTGCAA AGCAGCCCAA ATGGAAGTGT CCATATCTAA GTGCAAGCTC
TTCCAGCTCG GTTTTGAGAG GGAGGGCGTG AGGATCAATG ACAGACAGTG CACCGGCATC
GAGGGGGAAG ATTTTATCTC CTTTCAGATC AACAACACCA AAGGGAATTG TGGAAACATT
GTGCAGTCCA ATGGCACGCA TATCATGTAT AAAAACACAC TCTGGATCGA AAGCGCCAAC
AACACTGGCA ACATCATCAC CAGGGACCGC ACGATCAATG TGGAATTTTC ATGTGCTTAT
GAGCTGGATA TCAAGATCTC CTTGGATTCT GTTGTGAAGC CTATGCTAAG TGTAATTAAC
CTGACAGTTC CAACCCAAGA AGGCAGCTTC ATCACCAAGA TGGCTCTCTA CAAAAACGCC
TCCTACAAAC ATCCTTACCG CCAGGGTGAA GTAGTGTTGA CGACTCGAGA TGTGCTGTAT
GTAGGGGTTT TTGTGGTTGG AGCTGACGCC ACACATTTAA TCCTAACACT CAACAAATGC
TATGCCACAC CCACCCGAGA TAGCAATGAT AAGCTCCGAT ATTTCATCAT TGAAGGAGGG
TGTCAGAACC TCAAAGATAA CACCATTGGC ATCGAGGAGA ATGCAGTCTC CCTGACCTGT
CGCTTTCACG TCACCGTCTT TAAATTCATA GGGGATTACG ACGAAGTTCA CCTTCACTGT
GCAGTGTCAC TCTGCGACTC AGAAAAGTAC TCCTGTAAAA TCACTTGCCC ACACAATTCC
AGGATTGCCA CAGATTACAC AAAAGAGCCC AAAGAACAGA TCATTTCAGT GGGACCTATT
AGGAGAAAAA GGCTGGACTG GTGTGAGGAC AATGGAGGGT GTGAGCAGAT TTGCACGAGC
CGGGTGGATG GGCCTCTCTG CAGCTGTGTA ACAGGAACCC TGCAGGAGGA CGGCAAGAGC
TGCAGAGCCT CTAATTCTTC AATGGAACTT CAAGTCTGGA CGCTTCTTCT CATCATGATC
CAGATTTCAT TATGGCATTT TGTCTATAAA TCAGGCACGA CCTCATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_005413.2
CDS1..6468
Misc Feature(1)292..762(+)
Misc Feature(2)937..1431(+)
Misc Feature(3)1549..1773(+)
Misc Feature(4)1789..1950(+)
Misc Feature(5)1954..2118(+)
Misc Feature(6)2107..2595(+)
Misc Feature(7)2713..2943(+)
Misc Feature(8)2950..3108(+)
Misc Feature(9)3268..3771(+)
Misc Feature(10)3880..4104(+)
Misc Feature(11)4114..4275(+)
Misc Feature(12)4429..4914(+)
Misc Feature(13)5050..5274(+)
Misc Feature(14)5413..6171(+)
Misc Feature(15)6265..6363(+)
Exon (1)1..64
Gene:TECTA
Gene Synonym:
Exon (2)65..198
Gene:TECTA
Gene Synonym:
Exon (3)199..486
Gene:TECTA
Gene Synonym:
Exon (4)487..624
Gene:TECTA
Gene Synonym:
Exon (5)625..790
Gene:TECTA
Gene Synonym:
Exon (6)791..1203
Gene:TECTA
Gene Synonym:
Exon (7)1204..1774
Gene:TECTA
Gene Synonym:
Exon (8)1775..2367
Gene:TECTA
Gene Synonym:
Exon (9)2368..2941
Gene:TECTA
Gene Synonym:
Exon (10)2942..3543
Gene:TECTA
Gene Synonym:
Exon (11)3544..4105
Gene:TECTA
Gene Synonym:
Exon (12)4106..4305
Gene:TECTA
Gene Synonym:
Exon (13)4306..4689
Gene:TECTA
Gene Synonym:
Exon (14)4690..4976
Gene:TECTA
Gene Synonym:
Exon (15)4977..5272
Gene:TECTA
Gene Synonym:
Exon (16)5273..5383
Gene:TECTA
Gene Synonym:
Exon (17)5384..5586
Gene:TECTA
Gene Synonym:
Exon (18)5587..5750
Gene:TECTA
Gene Synonym:
Exon (19)5751..5999
Gene:TECTA
Gene Synonym:
Exon (20)6000..6162
Gene:TECTA
Gene Synonym:
Exon (21)6163..6250
Gene:TECTA
Gene Synonym:
Exon (22)6251..6367
Gene:TECTA
Gene Synonym:
Exon (23)6368..6468
Gene:TECTA
Gene Synonym:
Translation

Target ORF information:

RefSeq Version NM_005422
Organism Homo sapiens (human)
Definition Homo sapiens tectorin alpha (TECTA), mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_005422

ORF Insert Sequence:

1
61
121
181
241
301
361
421
481
541
601
661
721
781
841
901
961
1021
1081
1141
1201
1261
1321
1381
1441
1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
2101
2161
2221
2281
2341
2401
2461
2521
2581
2641
2701
2761
2821
2881
2941
3001
3061
3121
3181
3241
3301
3361
3421
3481
3541
3601
3661
3721
3781
3841
3901
3961
4021
4081
4141
4201
4261
4321
4381
4441
4501
4561
4621
4681
4741
4801
4861
4921
4981
5041
5101
5161
5221
5281
5341
5401
5461
5521
5581
5641
5701
5761
5821
5881
5941
6001
6061
6121
6181
6241
6301
6361
6421
ATGAATTATT CATCATTCCT TAGAATTTGG GTCTCTTTCA TCTTCGCACT TGTACAGCAC 
CAAGCTCAGC CCAGGGAGCT CATGTATCCA TTTTGGCAGA ATGACACCAA AACCCCTAAA
GTAGATGATG GAAGCTCATC TGAGATTAAG TTGGCCATCC CAGTTTTCTT CTTTGGCGTT
CCTTACCGCA CTGTCTATGT CAATAACAAC GGAGTTGTTT CCTTCAATGT GCTAGTGAGC
CAGTTCACGC CAGAATCCTT TCCCCTGACA GATGGGAGAG CCTTCGTCGC CCCATTTTGG
GCAGATGTGC ACAATGGAAT TCGAGGCGAG ATCTATTACA GAGAGACCAT GGAGCCTGCC
ATCTTGAAAA GAGCCACCAA GGACATCAGG AAGTACTTCA AAGACATGGC AACCTTCTCT
GCCACTTGGG TTTTCATTGT GACATGGGAG GAAGTCACGT TTTATGGAGG CAGCAGCACC
ACACCTGTGA ACACCTTCCA GGCCGTCCTA GTGTCCGATG GCTCCTATAC ATTCACCCTC
TTCAATTATT ACGAAATCAA CTGGACCACG GGGACGGCGA GTGGCGGCGA CCCCCTGACA
GGTCTTGGTG GAGTGATGGC ACAGGCAGGA TTTAATGGTG GAAACCTCAC CAATTTCTTC
AGCCTCCCGG GGTCAAGAAC CCCCGAGATC GTGAATATCC AGGAGACCAC AAACGTCAAT
GTTCCAGGCC GCTGGGCATT TAAAGTTGAT GGAAAGGAAA TTGACCCAGC CAATGGCTGC
ACCTCAAGGG GACAATTCCT TCGGCGAGGG GAGGTGTTTT GGGATGACTT GAACTGCACC
GTCAAGTGCC GCTGTCTGGA TTTCAACAAT GAGATCTACT GCCAGGAGGC TTCCTGTAGC
CCCTACGAGG TGTGCGAACC CAAAGGCAAA TTCTTCTACT GCAGCGCTGT GGAGACCAGC
ACATGCGTGG TGTTTGGGGA GCCACACTAC CACACTTTTG ACGGCTTCCT CTTCCACTTC
CAAGGCTCCT GTGCCTACTT GCTGGCCCGA CAGTGTTTGC AGACTTCCAG CCTCCCTTTC
TTCAGTGTGG AGGCCAAGAA TGAACACCGC AGAGGTTCAG CCGTCTCCTG GGTGAAGGAG
CTCTCAGTGG AGGTGAATGG CTACAAGATT CTCATCCCCA AAGGAAGCTA TGGAAGAGTC
AAGGTTAATG ACCTAGTGAC TTCTTTGCCT GTCACCTTAG ACTTGGGGAC AGTGAAAATC
TACCAGAGTG GCATATCTAC TGCCGTGGAA ACAGATTTTG GGCTCTTAGT GACTTTTGAT
GGCCAGCACT ACGCCTCCAT TTCCGTCCCA GGCTCCTATA TAAACTCCAC CTGTGGACTC
TGTGGAAACT ATAATAAAAA CCCACTGGAT GACTTCCTCC GCCCGGATGG CAGGCCGGCC
ATGTCTGTCC TGGATCTGGG AGAGAGCTGG CGTGTGTACC ACGCAGACTG GAAGTGCGAC
TCCGGCTGCG TCGACAACTG CACCCAGTGC GACGCTGCCA CTGAAGCCCT CTACTTTGGC
TCTGACTACT GCGGCTTCCT CAACAAGACA GACGGCCCTC TGTGGGAGTG TGGCACTGTC
GTGGACCCCA CTGCTTTTGT GCACAGCTGC GTGTATGACC TGTGCAGTGT GAGGGACAAT
GGCACGCTCC TCTGCCAAGC CATCCAGGCC TATGCTCTTG TGTGCCAAGC CCTTGGCATT
CCAATTGGAG ACTGGCGAAC CCAGACTGGG TGTGTGTCCA CAGTGCAGTG CCCGAGCTTC
AGCCACTACT CCGTGTGCAC AAGCAGCTGC CCCGACACAT GCTCCGACCT GACGGCCTCG
CGGAACTGCG CCACGCCGTG CACAGAGGGC TGCGAGTGCA ACCAGGGCTT CGTCCTCAGC
ACCAGCCAGT GCGTCCCTCT GCACAAGTGC GGCTGCGACT TCGACGGCCA CTACTACACC
ATGGGGGAGT TCTTCTGGGC CACGGCCAAC TGCACTGTGC AATGCCTGTG CGAGGAGGGC
GGGGACGTCT ACTGCTTCAA CAAGACCTGC GGCAGCGGGG AGGTGTGCGC CGTGGAGGAC
GGCTACCAGG GCTGCTTCCC CAAGCGGGAG ACCGTGTGCC TGCTCAGCCA GAACCAGGTG
CTGCACACCT TTGACGGCGC CTCCTACGCC TTCCCCTCCG AGTTCTCCTA CACCCTCCTG
AAGACCTGCC CTGAGCGCCC AGAGTACTTG GAAATCGACA TCAACAAGAA GAAGCCCGAT
GCAGGACCTG CTTGGCTGCG GGGACTTCGG ATCCTGGTGG CCGACCAGGA GGTCAAGATA
GGAGGCATCG GGGCTTCGGA AGTCAAGTTG AATGGTCAGG AAGTGGAATT GCCTTTTTTC
CATCCTTCGG GGAAGCTGGA AATTTATCGA AACAAAAACA GTACGACAGT GGAGTCCAAG
GGCGTGGTGA CTGTCCAGTA CTCAGACATA GGTCTATTGT ACATCCGGCT GTCCACCACA
TACTTCAATT GCACAGGGGG CTTGTGCGGC TTCTACAATG CCAACGCCAG TGACGAGTTC
TGTCTCCCCA ACGGCAAGTG CACGGACAAC CTGGCAGTGT TCCTGGAAAG CTGGACAACT
TTCGAGGAGA TCTGCAATGG AGAGTGTGGG GACCTGCTGA AGGCCTGCAA CAATGACTCG
GAGCTGCTCA AGTTTTATCG AAGCCGCTCC AGGTGCGGCA TCATCAACGA CCCCTCCAAC
AGCTCCTTCC TGGAGTGCCA TGGGGTGGTG AACGTCACTG CCTATTACCG CACCTGCCTT
TTCCGCCTGT GCCAGAGTGG GGGCAATGAG TCAGAGCTCT GTGACTCTGT GGCCCGGTAT
GCAAGCGCCT GCAAGAATGC GGACGTGGAG GTGGGGCCCT GGCGGACCTA TGACTTCTGC
CCACTGGAGT GCCCAGAGAA CAGCCACTTT GAGGAGTGCA TCACATGTAC AGAGACCTGT
GAGACCCTTA CCCTGGGCCC CATCTGCGTG GATAGCTGCT CTGAGGGATG TCAGTGTGAT
GAGGGCTATG CTCTACTGGG CAGCCAGTGT GTCACGCGGA GTGAGTGTGG CTGCAACTTT
GAGGGGCACC AACTTGCCAC CAATGAGACC TTCTGGGTGG ACCTGGACTG CCAGATCTTC
TGCTATTGCA GTGGCACAGA CAACAGGGTC CACTGCGAGA CCATTCCCTG CAAGGATGAT
GAGTACTGCA TGGAGGAAGG TGGCCTGTAC TACTGCCAAG CCCGCACCGA CGCCTCCTGC
ATCGTCTCAG GCTACGGCCA CTACCTCACC TTTGATGGCT TCCCCTTTGA CTTCCAGACC
AGCTGCCCAC TCATCCTGTG CACCACAGGA AGCAGGCCAA GCTCAGACTC TTTCCCCAAG
TTTGTTGTCA CAGCCAAGAA TGAGGACCGG GACCCGTCAC TGGCCTTGTG GGTTAAGCAG
GTGGACGTGA CCGTGTTTGG CTACAGCATC GTGATCCACC GAGCTTACAA GCACACTGTG
CTGGTCAACA GTGAACGGCT CTATCTGCCC CTGAAGCTGG GGCAAGGGAA GATAAATATC
TTTTCCTTTG GCTTCCACGT GGTGGTGGAA ACTGATTTTG GCCTGAAGGT TGTATATGAC
TGGAAGACCT TCCTGTCCAT CACAGTCCCT CGGAGCATGC AGAACAGCAC CTATGGTCTG
TGTGGCCGCT ACAACGGCAA CCCTGATGAT GACCTGGAGA TGCCCATGGG TCTGCTTGCA
TCGAGTGTCA ATGAGTTTGG GCAGAGCTGG GTGAAGAGGG ACACCTTCTG CCAGGTGGGC
TGTGGGGACC GCTGTCCGTC CTGTGCCAAG GTGGAAGGTT TCTCCAAAGT GCAGCAGCTG
TGCAGCCTGA TCCCCAACCA GAACGCTGCC TTCTCCAAGT GTCACAGCAA AGTTAACCCC
ACCTTCTTCT ATAAGAACTG CCTGTTTGAC TCTTGCATCG ATGGGGGCGC GGTGCAGACC
GCCTGCAGCT GGCTGCAGAA CTACGCCAGC ACCTGCCAGA CTCAGGGGAT TACGGTGACT
GGCTGGAGGA ATTACACGTC CTGCACTGTC ACCTGCCCTC CAAACAGCCA TTACGAGAGC
TGCGTGAGTG TCTGCCAGCC CCGCTGCGCC GCCATCCGCC TGAAGAGTGA CTGCAGCCAC
TACTGCGTGG AGGGCTGTCA CTGCGACGCT GGCTACGTCC TCAACGGCAA GAGCTGCATC
CTGCCCCACA GCTGCGGCTG CTACTCCGAT GGCAAATATT ACGAGCCCAA GCAGCTATTT
TGGAACAGCG ACTGCACGCG GCGCTGCCGC TGTTTCCGTC GCAACGTGAT TCAGTGCGAC
CCGCGCCAAT GCAAGTCAGA CGAGGAGTGT GCGCTGCGCA ACGGGGTGCG CGGCTGCTTC
AGCACCAAGA CCTCCTACTG CCTGGCGGCC GGCGGCGGCG TCTTCCGCAC CTTCGACGGC
GCCTTCCTGC GCTTCCCAGC CAACTGCGCC TTCGTGCTGT CCACCATCTG CCAGAAACTG
CCCGACATCT CCTTCCAGCT TATCATCAAC TTCGACAAGT GGTCGGCCCC CAACCTCACC
ATCATTTCGC CCGTCTACTT CTACATTAAC GAAGAGCAGA TTCTCATCAA CGACCGGAAC
ACGGTCAAGG TGAATGGCAC ACAAGTGAAT GTTCCATTTA TAACTGGTTT GGCAACCAAA
ATCTACAGCA GTGAGGGGTT TCTGGTGATT GACACCAGCC CAGACATCCA GATATACTAC
AATGGTTTCA ACGTCATTAA AATCAGCATC AGCGAGAGGC TGCAGAACAA AGTGTGCGGT
CTCTGTGGCA ACTTCAACGG GGACCTAACA GATGATTATG TGACCTTGCG AGGGAAGCCG
GTGGTAAGCA GCGTGGTGCT GGCCCAGAGC TGGAAAACCA ATGGCATGCA GAAGAGACCT
CTTGCCCCCA GCTGCAACGA GCTGCAGTTC TCACAGTATG CAGCCATGTG TGACAATGTG
CACATCCAGA AGATGCAGGG TGATGGCTAC TGCCTGAAGC TCACCGACAT GAAGGGCTTC
TTCCAGCCCT GCTATGGGCT TCTCGATCCC CTCCCATTCT ACGAGTCCTG CTACCTGGAC
GGCTGCTACA GCCACAAGAA GTTCCAGCTG TGCGGCTCCC TGGCCGCCTA CGGGGAGGCC
TGCCGCTCCT TCGGGATCCT TAGCACCGAG TGGATTGAGA AGGAGAATTG CTCAGGAGTG
GTTGAAGATC CCTGTGTGGG GGCGGACTGT CCCAACCGAA CTTGCGAGCT GGGCAATGGC
AGGGAGCTGT GTGGCTGCAT CGAGCCACCC CCCTATGGAA ATAACTCACA TGACATTATC
GATGCAGAGG TGACCTGCAA AGCAGCCCAA ATGGAAGTGT CCATATCTAA GTGCAAGCTC
TTCCAGCTCG GTTTTGAGAG GGAGGGCGTG AGGATCAATG ACAGACAGTG CACCGGCATC
GAGGGGGAAG ATTTTATCTC CTTTCAGATC AACAACACCA AAGGGAATTG TGGAAACATT
GTGCAGTCCA ATGGCACGCA TATCATGTAT AAAAACACAC TCTGGATCGA AAGCGCCAAC
AACACTGGCA ACATCATCAC CAGGGACCGC ACGATCAATG TGGAATTTTC ATGTGCTTAT
GAGCTGGATA TCAAGATCTC CTTGGATTCT GTTGTGAAGC CTATGCTAAG TGTAATTAAC
CTGACAGTTC CAACCCAAGA AGGCAGCTTC ATCACCAAGA TGGCTCTCTA CAAAAACGCC
TCCTACAAAC ATCCTTACCG CCAGGGTGAA GTAGTGTTGA CGACTCGAGA TGTGCTGTAT
GTAGGGGTTT TTGTGGTTGG AGCTGACGCC ACACATTTAA TCCTAACACT CAACAAATGC
TATGCCACAC CCACCCGAGA TAGCAATGAT AAGCTCCGAT ATTTCATCAT TGAAGGAGGG
TGTCAGAACC TCAAAGATAA CACCATTGGC ATCGAGGAGA ATGCAGTCTC CCTGACCTGT
CGCTTTCACG TCACCGTCTT TAAATTCATA GGGGATTACG ACGAAGTTCA CCTTCACTGT
GCAGTGTCAC TCTGCGACTC AGAAAAGTAC TCCTGTAAAA TCACTTGCCC ACACAATTCC
AGGATTGCCA CAGATTACAC AAAAGAGCCC AAAGAACAGA TCATTTCAGT GGGACCTATT
AGGAGAAAAA GGCTGGACTG GTGTGAGGAC AATGGAGGGT GTGAGCAGAT TTGCACGAGC
CGGGTGGATG GGCCTCTCTG CAGCTGTGTA ACAGGAACCC TGCAGGAGGA CGGCAAGAGC
TGCAGAGCCT CTAATTCTTC AATGGAACTT CAAGTCTGGA CGCTTCTTCT CATCATGATC
CAGATTTCAT TATGGCATTT TGTCTATAAA TCAGGCACGA CCTCATAA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

Identification of a Novel TECTA mutation in a Chinese DFNA8/12 family with prelingual progressive sensorineural hearing impairment
PLoS ONE 8 (7), E70134 (2013)
Li Z, Guo Y, Lu Y, Li J, Jin Z, Li H, Lu Y, Dai P, Han D, Cheng J and Yuan H.


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GWAS-based association between RWDD3 and TECTA variants and paclitaxel induced neuropathy could not be confirmed in Scandinavian ovarian cancer patients
Acta Oncol 52 (4), 871-874 (2013)
Bergmann,T.K., Vach,W., Feddersen,S., Eckhoff,L., Green,H., Herrstedt,J. and Brosen,K.


book

Aberrant transcript produced by a splice donor site deletion in the TECTA gene is associated with autosomal dominant deafness in a Brazilian family
Gene 511 (2), 280-284 (2012)
Lezirovitz K, Batissoco AC, Lima FT, Auricchio MT, Nonose RW, dos Santos SR, Guilherme L, Oiticica J and Mingroni-Netto RC.


book

TECTA mutations in Japanese with mid-frequency hearing loss affected by zona pellucida domain protein secretion
J. Hum. Genet. 57 (9), 587-592 (2012)
Moteki H, Nishio SY, Hashimoto S, Takumi Y, Iwasaki S, Takeichi N, Fukuda S and Usami S.


book

Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies
J. Biol. Chem. 287 (26), 21584-21598 (2012)
Kammerer R, Ruttiger L, Riesenberg R, Schauble C, Krupar R, Kamp A, Sunami K, Eisenried A, Hennenberg M, Grunert F, Bress A, Battaglia S, Schrewe H, Knipper M, Schneider MR and Zimmermann W.


book

Mutations in the human alpha-tectorin gene cause autosomal dominant non-syndromic hearing impairment
Nat. Genet. 19 (1), 60-62 (1998)
Verhoeven K, Van Laer L, Kirschhofer K, Legan PK, Hughes DC, Schatteman I, Verstreken M, Van Hauwe P, Coucke P, Chen A, Smith RJ, Somers T, Offeciers FE, Van de Heyning P, Richardson GP, Wachtler F, Kimberling WJ, Willems PJ, Govaerts PJ and Van Camp G.


book

Mapping of the alpha-tectorin gene (TECTA) to mouse chromosome 9 and human chromosome 11: a candidate for human autosomal dominant nonsyndromic deafness
Genomics 48 (1), 46-51 (1998)
Hughes DC, Legan PK, Steel KP and Richardson GP.


book

A gene for autosomal dominant nonsyndromic hearing loss (DFNA12) maps to chromosome 11q22-24
Am. J. Hum. Genet. 60 (5), 1168-1173 (1997)
Verhoeven K, Van Camp G, Govaerts PJ, Balemans W, Schatteman I, Verstreken M, Van Laer L, Smith RJ, Brown MR, Van de Heyning PH, Somers T, Offeciers FE and Willems PJ.


book

Nonsyndromic hearing impairment: unparalleled heterogeneity
Am. J. Hum. Genet. 60 (4), 758-764 (1997)
Van Camp G, Willems PJ and Smith RJ.


book

Deafness and Hereditary Hearing Loss Overview
(in) Pagon RA, Adam MP, Ardinger HH, Bird TD, Dolan CR, Fong CT, Smith RJH and Stephens K (Eds.); GENEREVIEWS(R); (1993)
Smith,R.J.H., Shearer,A.E., Hildebrand,M.S. and Van Camp,G.


 
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