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VPREB1 cDNA ORF clone, Homo sapiens(Human)

Gene Symbol VPREB1
Entrez Gene ID 7441
Full Name V-set pre-B cell surrogate light chain 1
Synonyms CD179a,IGI,IGVPB,VPREB
General protein information
Preferred Names

V-set pre-B cell surrogate light chain 1

Names

immunoglobulin iota chain
CD179 antigen-like family member A
pre-B lymphocyte 1
v(pre)B protein

Gene Type protein-coding
Organism Homo sapiens(Human)
Genome

22

22q11.22

Disorder MIM:

605141


mRNA and Protein(s)

mRNA Protein Name
NM_001303509.1 NP_001290438.1 immunoglobulin iota chain isoform 2
NM_007128.3 NP_009059.1 immunoglobulin iota chain isoform 1 precursor



Rattus norvegicus (Norway rat) Vpreb2 NP_001128260.1
Mus musculus (house mouse) Vpreb2 NP_058679.1
Canis lupus familiaris (dog) VPREB1 XP_543537.2
Mus musculus (house mouse) Vpreb1 NP_058678.1
Rattus norvegicus (Norway rat) Vpreb1 NP_001102315.1
Homo sapiens (human) VPREB1 NP_009059.1
Pan troglodytes (chimpanzee) VPREB1 XP_515010.2
Macaca mulatta (rhesus monkey) VPREB1 XP_001089831.1


Related articles in PubMed

VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.
Mangum DS, Downie J, Mason CC, Jahromi MS, Joshi D, Rodic V, Müschen M, Meeker N, Trede N, Frazer JK, Zhou Y, Cheng C, Jeha S, Pui CH, Willman CL, Harvey RC, Hunger SP, Yang JJ, Barnette P, Mullighan CG, Miles RR, Schiffman JD
Leukemia28(1)216-20(2014 Jan)

The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.
Yim SH, Chung YJ, Jin EH, Shim SC, Kim JY, Kim YS, Hu HJ, Shin SH, Pae HO, Zouali M, Chung HT
Molecular immunology48(11)1338-43(2011 Jun)

Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation.
Rossi B, Espeli M, Schiff C, Gauthier L
Journal of immunology (Baltimore, Md. : 1950)177(2)796-803(2006 Jul)

Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering.
Gauthier L, Rossi B, Roux F, Termine E, Schiff C
Proceedings of the National Academy of Sciences of the United States of America99(20)13014-9(2002 Oct)

The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.
Gisler R, Sigvardsson M
Journal of immunology (Baltimore, Md. : 1950)168(10)5130-8(2002 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Irrespective of subtype, Acute Lymphoblastic Leukemia with high levels of IGHM, IGLL1 and VPREB1 are arrested at the pre-B stage and correlate with good prognosis in high-risk pediatric B-cell precursor acute lymphoblastic leukemia.
Title: The Expression Pattern of the Pre-B Cell Receptor Components Correlates with Cellular Stage and Clinical Outcome in Acute Lymphoblastic Leukemia.

VPREB1 focal deletions are common in B-ALL and occur independent of V(D)J light chain recombination. Focal deletions of VPREB1 correlate with decreased expression levels and high-risk patients with focal deletions tend to have poorer overall survival
Title: VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.

The proportion of the individuals with <2 copies of the VPREB1 gene was significantly higher in the patient group than that in the controls, while that of the individuals with >2 copies was lower in the patient group than that in the controls.
Title: The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.

Observational study of gene-disease association. (HuGE Navigator)
Title: New genetic associations detected in a host response study to hepatitis B vaccine.

Pre-B cell integrins and their stromal cell ligands together with the pre-B cell receptor and galectin-1 form a homogeneous lattice at the contact area between bone marrow pre-B and stromal cells.
Title: Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation.

The following VPREB1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the VPREB1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1+/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

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***CloneID RefSeq Accession Definition **Vector *Turnaround time Price (USD) Select
OHu18799 NM_007128.3
Latest version!
Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 1, mRNA. pcDNA3.1+/C-(K)DYK or customized vector
in pcDNA3.1+/C-(K)DYK
$49.50-$69.30
$99.00
OHu61315 NM_001303509.1
Latest version!
Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 2, mRNA. pcDNA3.1+/C-(K)DYK or customized vector 7-9 $69.30
$99.00

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1 Clone 30% OFF
2-4 Clone 40% OFF
5 or more Clone 50% OFF
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.


CloneID OHu18799
Clone ID Related Accession (Same CDS sequence) NM_007128.3
Accession Version NM_007128.3 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 438bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags COA
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-03-15
Organism Homo sapiens(Human)
Product immunoglobulin iota chain isoform 1 precursor
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG502270.1, BC017922.1 and AC245060.1. This sequence is a reference standard in the RefSeqGene project. On Jan 13, 2015 this sequence version replaced NM_007128.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG531255.1, BC017922.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
ATGTCCTGGG CTCCTGTCCT GCTCATGCTG TTTGTCTACT GCACAGGTTG TGGTCCTCAG 
CCGGTGCTGC ATCAGCCGCC GGCCATGTCC TCGGCCCTTG GAACCACAAT CCGCCTCACC
TGCACCCTGA GGAACGACCA TGACATCGGT GTGTACAGCG TCTACTGGTA CCAGCAGAGG
CCGGGCCACC CTCCCAGGTT CCTGCTGAGA TATTTCTCAC AATCAGACAA GAGCCAGGGC
CCCCAGGTCC CCCCTCGCTT CTCTGGATCC AAAGATGTGG CCAGGAACAG GGGGTATTTG
AGCATCTCTG AGCTGCAGCC TGAGGACGAG GCTATGTATT ACTGTGCTAT GGGGGCCCGC
AGCTCGGAGA AGGAGGAGAG GGAGAGGGAG TGGGAGGAAG AAATGGAACC CACTGCAGCC
AGGACACGTG TCCCTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_009059.1
CDS35..472
Misc Feature(1)10
Misc Feature(2)92..157
Misc Feature(3)110..382
Misc Feature(4)122..388
Misc Feature(5)158..202
Misc Feature(6)203..244
Misc Feature(7)245..277
Misc Feature(8)278..379
Exon (1)1..80
Exon (2)81..650
Translation

Target ORF information:

RefSeq Version NM_007128.3
Organism Homo sapiens(Human)
Definition Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 1, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_007128.3

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGTCCTGGG CTCCTGTCCT GCTCATGCTG TTTGTCTACT GCACAGGTTG TGGTCCTCAG 
CCGGTGCTGC ATCAGCCGCC GGCCATGTCC TCGGCCCTTG GAACCACAAT CCGCCTCACC
TGCACCCTGA GGAACGACCA TGACATCGGT GTGTACAGCG TCTACTGGTA CCAGCAGAGG
CCGGGCCACC CTCCCAGGTT CCTGCTGAGA TATTTCTCAC AATCAGACAA GAGCCAGGGC
CCCCAGGTCC CCCCTCGCTT CTCTGGATCC AAAGATGTGG CCAGGAACAG GGGGTATTTG
AGCATCTCTG AGCTGCAGCC TGAGGACGAG GCTATGTATT ACTGTGCTAT GGGGGCCCGC
AGCTCGGAGA AGGAGGAGAG GGAGAGGGAG TGGGAGGAAG AAATGGAACC CACTGCAGCC
AGGACACGTG TCCCTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

CloneID OHu61315
Clone ID Related Accession (Same CDS sequence) NM_001303509.1
Accession Version NM_001303509.1 Latest version! Documents for ORF clone product in dufault vector
Sequence Information ORF Nucleotide Sequence (Length: 435bp)
Protein sequence
SNP
Vector pcDNA3.1+/C-(K)DYK or customized vector User Manual
Clone information Clone Map MSDS
Tag on pcDNA3.1+/C-(K)DYK C terminal DYKDDDDK tags
ORF Insert Method CloneEZ® Seamless cloning technology
Insert Structure linear
Update Date 2017-03-15
Organism Homo sapiens(Human)
Product immunoglobulin iota chain isoform 2
Comment REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC245060.1. Transcript Variant: This variant (2) uses an alternate splice site in the coding region and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BG502270.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2154529, SAMEA2162823 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

1
61
121
181
241
301
361
421
ATGTCTGCAC CATGTCCTGG GCTCCTGTCC TGCTCATGCT GTTTGTCTAC TGCACAGCCG 
GTGCTGCATC AGCCGCCGGC CATGTCCTCG GCCCTTGGAA CCACAATCCG CCTCACCTGC
ACCCTGAGGA ACGACCATGA CATCGGTGTG TACAGCGTCT ACTGGTACCA GCAGAGGCCG
GGCCACCCTC CCAGGTTCCT GCTGAGATAT TTCTCACAAT CAGACAAGAG CCAGGGCCCC
CAGGTCCCCC CTCGCTTCTC TGGATCCAAA GATGTGGCCA GGAACAGGGG GTATTTGAGC
ATCTCTGAGC TGCAGCCTGA GGACGAGGCT ATGTATTACT GTGCTATGGG GGCCCGCAGC
TCGGAGAAGG AGGAGAGGGA GAGGGAGTGG GAGGAAGAAA TGGAACCCAC TGCAGCCAGG
ACACGTGTCC CTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

RefSeq NP_001290438.1
CDS24..458
Misc Feature(1)10
Misc Feature(2)96..368
Misc Feature(3)108..374
Exon (1)1..80
Exon (2)81..636
Translation

Target ORF information:

RefSeq Version NM_001303509.1
Organism Homo sapiens(Human)
Definition Homo sapiens V-set pre-B cell surrogate light chain 1 (VPREB1), transcript variant 2, mRNA.

Target ORF information:

Epitope DYKDDDDK
Bacterial selection AMPR
Mammalian selection NeoR
Vector pcDNA3.1+/C-(K)DYK
NM_001303509.1

ORF Insert Sequence:

1
61
121
181
241
301
361
421
ATGTCTGCAC CATGTCCTGG GCTCCTGTCC TGCTCATGCT GTTTGTCTAC TGCACAGCCG 
GTGCTGCATC AGCCGCCGGC CATGTCCTCG GCCCTTGGAA CCACAATCCG CCTCACCTGC
ACCCTGAGGA ACGACCATGA CATCGGTGTG TACAGCGTCT ACTGGTACCA GCAGAGGCCG
GGCCACCCTC CCAGGTTCCT GCTGAGATAT TTCTCACAAT CAGACAAGAG CCAGGGCCCC
CAGGTCCCCC CTCGCTTCTC TGGATCCAAA GATGTGGCCA GGAACAGGGG GTATTTGAGC
ATCTCTGAGC TGCAGCCTGA GGACGAGGCT ATGTATTACT GTGCTATGGG GGCCCGCAGC
TCGGAGAAGG AGGAGAGGGA GAGGGAGTGG GAGGAAGAAA TGGAACCCAC TGCAGCCAGG
ACACGTGTCC CTTGA

The stop codons will be deleted if pcDNA3.1+/C-(K)DYK vector is selected.

book

VPREB1 deletions occur independent of lambda light chain rearrangement in childhood acute lymphoblastic leukemia.
Leukemia28(1)216-20(2014 Jan)
Mangum DS,Downie J,Mason CC,Jahromi MS,Joshi D,Rodic V,Müschen M,Meeker N,Trede N,Frazer JK,Zhou Y,Cheng C,Jeha S,Pui CH,Willman CL,Harvey RC,Hunger SP,Yang JJ,Barnette P,Mullighan CG,Miles RR,Schiffman JD


book

The potential role of VPREB1 gene copy number variation in susceptibility to rheumatoid arthritis.
Molecular immunology48(11)1338-43(2011 Jun)
Yim SH,Chung YJ,Jin EH,Shim SC,Kim JY,Kim YS,Hu HJ,Shin SH,Pae HO,Zouali M,Chung HT


book

Clustering of pre-B cell integrins induces galectin-1-dependent pre-B cell receptor relocalization and activation.
Journal of immunology (Baltimore, Md. : 1950)177(2)796-803(2006 Jul)
Rossi B,Espeli M,Schiff C,Gauthier L


book

Galectin-1 is a stromal cell ligand of the pre-B cell receptor (BCR) implicated in synapse formation between pre-B and stromal cells and in pre-BCR triggering.
Proceedings of the National Academy of Sciences of the United States of America99(20)13014-9(2002 Oct)
Gauthier L,Rossi B,Roux F,Termine E,Schiff C


book

The human V-preB promoter is a target for coordinated activation by early B cell factor and E47.
Journal of immunology (Baltimore, Md. : 1950)168(10)5130-8(2002 May)
Gisler R,Sigvardsson M


 
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